专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09928587B2 Analysis, secure access to, and transmission of array images 有权
公开(公告)号：US09928587B2
公开(公告)日：2018-03-27
申请号：US15010597
申请日：2016-01-29
申请人： BioArray Solutions, Ltd.
发明人： Michael Seul , Xiongwu Xia , Chiu Chau , Scott Determan
IPC分类号： G06K9/00 , G06T7/00 , G01N33/566 , G06T7/33 , G06T7/11 , G06T7/155
CPC分类号： G06T7/0012 , G01N33/566 , G06K9/00 , G06K9/00147 , G06K2209/07 , G06T7/11 , G06T7/155 , G06T7/33 , G06T2207/10064 , G06T2207/20152 , G06T2207/30072
摘要： Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain encoding information, so as to preserve confidentiality.

2. 发明授权

US09670534B2 Methods for array assembly and detection involving elongation of self-complementary looped probes 有权
公开(公告)号：US09670534B2
公开(公告)日：2017-06-06
申请号：US14449569
申请日：2014-08-01
申请人： BioArray Solutions, Ltd.
发明人： Michael Seul , Yi Zhang , Sukanta Banerjee , Jiacheng Yang , Chiu Chau
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6818 , C12Q1/6827 , C12Q2565/1015 , C12Q2537/143 , C12Q2533/101 , C12Q2535/125 , C12Q2525/301
摘要： Disclosed herein are methods for array assembly and detection. The methods can use an incubation chamber containing a suspension of nucleic acid targets, polymerase and a set of oligonucleotide probes bound to magnetic beads in a randomly dispersed state. Each probe can have a target binding domain that is complementary to a target nucleic acid, a closing domain with a sequence that is complementary to the sequence of the target binding domain, and a joining region between the binding domain and the closing domain, which is not complementary to the target nucleic acid. Method steps can include providing the incubation chamber, placing the incubation chamber in a magnetic trap, generating a magnetic field that induces the magnetic beads to migrate towards a substrate and, once in proximity to the substrate, to interact with each other repulsively and reorganize into arrays, and imaging the array.

3. 发明授权

US09611507B2 Arrays of microparticles and methods of preparation thereof 有权
公开(公告)号：US09611507B2
公开(公告)日：2017-04-04
申请号：US14486598
申请日：2014-09-15
申请人： Bioarray Solutions, Ltd.
发明人： Michael Seul , Chiu Wo Chau , Hui Huang , Sukanta Banerjee , Jiacheng Yang , Ye Hong
IPC分类号： C12Q1/68 , B01J19/00 , G01N33/543
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00274 , B01J2219/00317 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00545 , B01J2219/00648 , B01J2219/00662 , G01N33/54306 , C12Q2563/149
摘要： This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities specific to a given target analyte. The high unit density arrays of this invention are formed on chips which may be combined to form multichip arrays according to the methods described herein. The chips and/or multichip arrays of this invention are useful for chemical and biological assays.

4. 发明申请

US20140262782A1 METHOD OF MAKING A MICROBEAD ARRAY WITH ATTACHED BIOMOLECULES 有权
标题翻译：用连接的生物分子制备微阵列阵列的方法
公开(公告)号：US20140262782A1
公开(公告)日：2014-09-18
申请号：US14181028
申请日：2014-02-14
申请人： Bioarray Solutions, Ltd
发明人： Michael Seul
IPC分类号： G01N27/447
CPC分类号： B01J19/0046 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00713 , B01L3/502707 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2200/0663 , B01L2200/0668 , B01L2300/0636 , B01L2300/0816 , B01L2300/0864 , B01L2300/0877 , B01L2300/089 , B01L2400/0415 , B01L2400/0427 , B01L2400/0454 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B40/04 , G01N15/1468 , G01N27/447 , G01N33/54313 , G01N33/54386 , G01N33/6845 , G01N2015/149 , G01N2015/1497 , G02B3/0012 , G02B3/0056 , G02B3/0075 , H05H3/04 , Y10S435/808 , Y10S435/81 , Y10S435/814 , Y10S436/806 , Y10S436/808 , Y10S436/809 , Y10T436/25125 , C12Q2565/501 , C12Q2563/155 , C12Q2565/607
摘要： A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relics on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.
摘要翻译：一种用于在诸如氧化硅的绝缘电极和电解质溶液之间的界面处操作胶体颗粒和生物分子的方法和装置。表面附近颗粒的光控电动组装依靠三个功能元件的组合：交流电场引起的平面聚集体组装; 电解质/氧化硅/硅界面的图案化以在组装过程上施加空间控制; 并通过外部照明实现对装配过程的实时控制。本发明提供一组基本操作，使得能够对几种类型的颗粒和生物分子的平面阵列的创建和放置以及阵列形状和尺寸的操纵进行交互式控制。本发明使得能够以阵列格式进行诊断测定和生化分析的样品制备和处理以及这些操作的功能整合。此外，本发明提供了用于产生具有所需性质的材料表面和用于制造表面安装光学部件的步骤。

5. 发明申请

US20140257858A1 Providing Real-time Interaction Between Users and Providers of Genetically Characterized Blood Products 审中-公开
标题翻译：提供用户与遗传表征血液制品供应商之间的实时互动
公开(公告)号：US20140257858A1
公开(公告)日：2014-09-11
申请号：US14281190
申请日：2014-05-19
申请人： Bioarray Solutions, Ltd.
发明人： Michael Seul , Robert Danehy
IPC分类号： G06F19/00
CPC分类号： G16H40/20 , G06F19/3481 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16B20/00 , G16B40/00 , G16B50/00 , G16H10/60 , Y02A90/22 , Y02A90/26
摘要： Disclosed is a registry system, including member institutions, in which transfusion donors and recipients are registered following genotyping, which would typically take place in a member institution, or a member institution would have access to the genotyping information, if performed outside. The registry database can be accessed and searched by members seeking samples of particular type(s). Systems are disclosed for maintaining economic viability of genotyping in connection with transfusions, by maximizing the number of units placed with the minimal number of candidate donors typed. Genotyping of potential donors, and product supply, is matched to forecasted demand. Genotyping can also be limited to the more clinically relevant markers. The registry system can also be Integrated with one format of assay which generates an image for analysis, whereby the imaged results can be analyzed and redacted by experts in a central location, and then transmitted back to the patient or their representative.
摘要翻译：披露了一个注册系统，包括成员机构，其中输血捐赠者和接受者在基因分型之后注册，通常在成员机构中进行注册，或者成员机构如果在外部执行，则可以访问基因分型信息。可以通过搜索特定类型的样本的成员访问和搜索注册表数据库。公开了系统，用于通过最大限度地利用输入的候选捐赠者的数量最大化来维持与输血相关的基因分型的经济可行性。潜在捐赠者的基因分型和产品供应与预测需求相匹配。基因分型也可以限于更临床相关的标记物。注册表系统也可以集成一种形式的测定法，其生成用于分析的图像，由此，成像结果可以由中心位置的专家分析和编辑，然后传送回患者或其代表。

6. 发明授权

US10407718B2 Optimization of gene expression analysis using immobilized capture probes 有权
公开(公告)号：US10407718B2
公开(公告)日：2019-09-10
申请号：US15491127
申请日：2017-04-19
申请人： BioArray Solutions, Ltd.
发明人： Michael Seul , Sukanta Banerjee , Jiacheng Yang , Tatiana Vener
IPC分类号： C12Q1/6832 , C12Q1/6809 , C12Q1/6834 , C12Q1/6837
摘要： Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including a method of preventing a significant reduction in duplexes detectable in a hybridization assay involving (i) selecting probe lengths for sets of oligonucleotide probes, wherein probes include different subsequences such that at least one subsequence is complementary to a subsequence in a cognate target; wherein probes for longer cognate targets are longer in length than probes for shorter cognate targets, (ii) selecting, for each set of probes, a density of oligonucleotides probes attached per unit area on a solid phase carrier which is below a limit at which the significant reduction in detectable duplexes is predicated to take place, (iii) producing the probes and affixing them to different solid phase carriers at the selected density, and (iv) annealing targets to the probes, wherein signal intensities of probes and targets of different lengths are about the same.

7. 发明申请

US20170218437A1 Optimization Of Gene Expression Analysis Using Immobilized Capture Probes 审中-公开
公开(公告)号：US20170218437A1
公开(公告)日：2017-08-03
申请号：US15491127
申请日：2017-04-19
申请人： BioArray Solutions, Ltd.
发明人： Michael SEUL , Sukanta Banerjee , Jiacheng YANG , Tatiana Vener
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6832 , B01J2219/00459 , B01J2219/00576 , B01J2219/00608 , B01J2219/00648 , B01J2219/00722 , C12Q1/6809 , C12Q1/6834 , C12Q1/6837 , C12Q2537/143 , C12Q2565/501 , C12Q2565/507 , C12Q2533/101 , C12Q2565/514 , C12Q2565/519
摘要： Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target “engineering”, as well as methods of assay signal analysis relating to the modulation of the probe-target affinity constant, K by a variety of factors including the elastic properties of target strands and layers of immobilized (“grafted”) probes; and assay methodologies relating to: the tuning of assay signal intensities including dynamic range compression and on-chip signal amplification; the combination of hybridization-mediated and elongation-mediated detection for the quantitative determination of abundance of messages displaying a high degree of sequence similarity, including, for example, the simultaneous determination of the relative expression levels, and identification of the specific class of, untranslated AU-rich subsequences located near the 3′ terminus of mRNA; and a new method of subtractive differential gene expression analysis which requires only a single color label.

8. 发明申请

US20160340723A1 Multiplexed Analysis Of Polymorphic Loci By Concurrent Interrogation And Enzyme-Mediated Detection 审中-公开
标题翻译：通过并发询问和酶介导检测多态位点的多重分析
公开(公告)号：US20160340723A1
公开(公告)日：2016-11-24
申请号：US15228377
申请日：2016-08-04
申请人： BioArray Solutions, Ltd.
发明人： Alice Xiang Li , Ghazala Hashmi , Michael SEUL
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6837 , C12Q1/6858 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , C12Q2565/537 , C12Q2535/125 , C12Q2527/107
摘要： The invention provides methods and processes for the identification of polymorphisms at one ore more designated sites, without interference from non-designated sites located within proximity of such designated sites. Probes are provided capable of interrogation of such designated sites in order to determine the composition of each such designated site. By the methods of this invention, one ore more mutations within the CFTR gene and the HLA gene complex can be identified.
摘要翻译：本发明提供了在一个或多个指定地点识别多态性的方法和过程，而不受位于该指定位点附近的非指定位点的干扰。提供能够询问这些指定地点的探测器，以确定每个这样的指定地点的组成。通过本发明的方法，可以鉴定CFTR基因和HLA基因复合体之间一个以上的突变。

9. 发明申请

US20160267650A1 ANALYSIS, SECURE ACCESS TO, AND TRANSMISSION OF ARRAY IMAGES 有权
标题翻译：分析，安全访问和传输阵列图像
公开(公告)号：US20160267650A1
公开(公告)日：2016-09-15
申请号：US15010597
申请日：2016-01-29
申请人： BioArray Solutions, Ltd.
发明人： Michael SEUL , Xiongwu Xia , Chiu CHAU , Scott DETERMAN
IPC分类号： G06T7/00 , G01N33/566 , G06K9/00
CPC分类号： G06T7/0012 , G01N33/566 , G06K9/00 , G06K9/00147 , G06K2209/07 , G06T7/11 , G06T7/155 , G06T7/33 , G06T2207/10064 , G06T2207/20152 , G06T2207/30072
摘要： Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain encoding information, so as to preserve confidentiality.
摘要翻译：系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中许多受体与微粒或微珠相关。编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以影响解码。从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

10. 发明申请

US20160002714A1 AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TARGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION 审中-公开
标题翻译：多重探测目标相互作用模式的自动分析：模式匹配与识别
公开(公告)号：US20160002714A1
公开(公告)日：2016-01-07
申请号：US14851844
申请日：2015-09-11
申请人： BioArray Solutions, Ltd.
发明人： Xiongwu XIA , Michael SEUL
IPC分类号： C12Q1/68 , G06F19/22
CPC分类号： C12Q1/6827 , G16B20/00 , G16B30/00
摘要： Disclosed are methods and algorithms (and their implementation) supporting the automated analysis and interactive review and refinement (“redaction”) of the analysis within an integrated software environment, for automated allele assignments. The implementation, preferably with a software system and a program referred to as the Automated Allele Assignment (“AAA”) program, provides a multiplicity of functionalities including: data management by way of an integrated interface to a portable database to permit visualizing, importing, exporting and creating customizable summary reports; system configuration (“Set-up”) including user authorization, training set analysis and probe masking; Pattern Analysis including string matching and probe flipping; and Interactive Redaction combining real-time database computations and “cut-and-paste” editing, generating “warning” statements and supporting annotation. It also includes a thresholding function, a method of setting thresholds, a method of refining thresholds by matching an experimental binary string (“reaction pattern”) setting for that probe, probe masking of signals produced by probes which do not contribute significantly to discriminating among alleles.
摘要翻译：公开的方法和算法（及其实现）支持在集成软件环境中进行自动化等位基因分配的自动分析和交互式审查和细化（“编辑”）分析。优选地使用软件系统和称为自动等位基因分配（“AAA”）程序的程序的实现提供了多种功能，包括：通过与便携式数据库的集成接口的数据管理，以允许可视化，导入，出口和创建可定制的汇总报告; 系统配置（“设置”），包括用户授权，训练集分析和探测屏蔽; 模式分析包括字符串匹配和探针翻转; 和Interactive Redaction将实时数据库计算和“剪切和粘贴”编辑相结合，生成“警告”语句和支持注释。它还包括阈值功能，设置阈值的方法，通过匹配用于该探针的实验二进制串（“反应模式”）设置来精确化阈值的方法，探针对由探针产生的信号进行探针掩蔽，所述探针不对显着区别于等位基因

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式