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1. 发明申请

US20140112841A1 DEVICE AND METHOD FOR REMOVING A SUPERNATANT OF A LIQUID SAMPLE, AND USE OF A VALVE DEVICE HAVING A SOLUBLE MEMBRANE 有权
标题翻译：用于去除液体样品的超级液体的装置和方法，以及使用具有可溶膜的阀装置
公开(公告)号：US20140112841A1
公开(公告)日：2014-04-24
申请号：US14006992
申请日：2012-03-23
申请人： Boehringer Ingelheim Microparts GmbH
发明人： Christian Schoen , Tanja Thiele
IPC分类号： B01L3/00
CPC分类号： B01L3/5021 , A61M1/34 , A61M1/3403 , B01D63/00 , B01D71/10 , B01D2311/2676 , B01J19/00 , B01L3/14 , B01L2300/0864 , B01L2400/0677 , C12Q1/22 , E21B25/00 , E21B25/08 , G01N33/49 , G01N33/80
摘要： A device and a method for separating a supernatant of a liquid sample are proposed, in which an outlet is closed off by a water-soluble membrane that dissolves after a certain length of time so that the supernatant of the sample is automatically drained away after centrifugation. The water-soluble membrane may in principle may also be used for other purposes for temporarily retaining a liquid in a holding chamber.
摘要翻译：提出了一种用于分离液体样品的上清液的装置和方法，其中通过在一定时间后溶解的水溶性膜封闭出口，使得离心后样品的上清液自动排出。原则上，水溶性膜也可以用于将液体暂时保持在保持室中的其它目的。

2. 发明授权

US10363559B2 Apparatus for the separation of plasma 有权
公开(公告)号：US10363559B2
公开(公告)日：2019-07-30
申请号：US15358185
申请日：2016-11-22
申请人： Boehringer Ingelheim Microparts GmbH
发明人： Gert Blankenstein , Holger Bartos , Ralf-Peter Peters , Christian Schoen
IPC分类号： B01L3/00 , B01D29/01 , B01D63/08 , B01D29/05 , G01N33/49 , B01D61/18
摘要： The invention relates to an apparatus for separating blood and at the same time an apparatus (1) for absorbing blood (19) and separating components such as blood plasma, as a sample liquid (2), having a feed device (13) for receiving the blood (2), a separating device (15) for separating blood components as the sample liquid (2), a channel (3) which takes up the sample liquid (2) preferably exclusively by capillary forces and a fill device for filling the channel (3) with sample liquid (2) in an inlet or feed region (18) of the channel (3), wherein the separating device (15), particularly a membrane, is domed, more particularly convexly shaped and projects with the apex of the convex shape into the filling device in the direction of filling.

3. 发明申请

US20190113418A1 TESTING SYSTEM AND TESTING METHOD 审中-公开
公开(公告)号：US20190113418A1
公开(公告)日：2019-04-18
申请号：US15765895
申请日：2016-10-06
申请人： BOEHRINGER INGELHEIM MICROPARTS GMBH
发明人： Joachim EICHER , Jutta EIGEMANN , Johannes GESER , Andreas PETERS , Hans-Juergen KOELBEL
IPC分类号： G01M99/00
摘要： A system for testing the proper functioning of an atomiser for dispensing a fluid in the form of an aerosol is proposed, wherein the system comprises the atomiser and a test apparatus, wherein the atomiser comprises a container holding the fluid, and a housing part for inserting and/or replacing the container, wherein the container is movable relative to the housing part in order to dispense the fluid and the test apparatus comprises a measuring device for measuring the movement of the container when the fluid is dispensed. In addition, a method for testing the proper functioning of an atomiser for dispensing a fluid in the form of an aerosol is proposed, wherein the atomiser comprises a container holding the fluid, and a housing part for inserting and/or replacing the container, wherein the container is moved relative to the housing part in order to dispense the fluid and the movement of the container is measured and/or analysed when the fluid is dispensed.

4. 发明申请

US20140114240A1 DEVICE AND METHOD FOR ACTUATING A CARPULE 有权
标题翻译：用于执行卡片的装置和方法
公开(公告)号：US20140114240A1
公开(公告)日：2014-04-24
申请号：US14002024
申请日：2012-02-27
申请人： BOEHRINGER INGELHEIM MICROPARTS GMBH
发明人： Thorsten Joedicke , Berthold Lange , Thomas Willms , Ying Yu
IPC分类号： A61M5/315
CPC分类号： A61M5/31596 , A61M5/2448 , A61M5/3146 , A61M5/31511 , A61M35/003 , A61M2005/2451 , A61M2005/2474 , A61M2005/31518 , A61M2205/583 , A61M2207/00
摘要： A device and a method are proposed for actuating a carpule, in which a piston is displaced in the carpule by means of a ram that is telescopically extensible by rotation, and in this way a liquid medicament formulation is expelled. For carrying out different processes, different operating movements are provided, particularly the operation of an operating element in different directions and/or the operation of different operating elements. This promotes simple, intuitive and safe operation.
摘要翻译：提出一种装置和方法，用于致动胡椒，其中通过旋转可伸缩地延伸的活塞在活塞中移动活塞，并且以这种方式排出液体药物制剂。为了执行不同的过程，提供了不同的操作移动，特别是操作元件在不同方向上的操作和/或不同操作元件的操作。这促进了简单，直观和安全的操作。

5. 发明授权

US09409171B2 Microfluidic structure having recesses 有权
标题翻译：具有凹槽的微流体结构
公开(公告)号：US09409171B2
公开(公告)日：2016-08-09
申请号：US14719503
申请日：2015-05-22
申请人： Boehringer Ingelheim MicroParts GmbH
发明人： Dirk Kurowski , Oliver Paul
IPC分类号： B01L3/00 , B01D35/00 , G01N33/50
CPC分类号： B01L3/502746 , B01L3/5027 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2200/0642 , B01L2200/0684 , B01L2300/0809 , B01L2300/0858 , B01L2300/0864 , B01L2400/0406 , B01L2400/084 , B01L2400/086
摘要： The invention relates to a microfluidic structure (1), comprising at least one cavity (10) having at least one inlet opening (11) and at least one outlet opening (12), wherein the cavity (10) can be filled with a liquid or a liquid can flow through the cavity and at least one element (13) is provided inside the cavity (10), which element stops the flow of the liquid at least temporarily and/or diverts the flow of the liquid at least in some regions within the cavity (10).According to the invention, the at least one element (13) is formed by a recess (13) introduced into a wall of the cavity (10), which recess (13) has at least one first region (14) at which the liquid stops at least temporarily and/or is diverted at least in some regions and at least one second region (15) at which the liquid preferably flows into the recess (13).Such a microfluidic structure makes it possible to fill the cavity (10) without air inclusions. Thereby, the useful volume of the cavity (10) is not limited, and the production costs of a microfluidic component (2) having such a microfluidic structure (1) can be kept low.
摘要翻译：本发明涉及一种微流体结构（1），其包括具有至少一个入口（11）和至少一个出口开口（12）的至少一个空腔（10），其中所述空腔（10）可以填充有液体或液体可以流过空腔，并且至少一个元件（13）设置在空腔（10）内部，该元件至少在一些区域中至少暂时流动和/或转移液体的流动在腔（10）内。根据本发明，所述至少一个元件（13）由引入所述空腔（10）的壁中的凹部（13）形成，所述凹部（13）具有至少一个第一区域（14），所述液体至少在一些区域和/或至少一个第二区域（15）中至少临时停止和/或转向，液体优选地流入所述凹部（13）中的至少一个第二区域（15）。这种微流体结构使得可以填充空腔（10）而没有空气夹杂物。因此，空腔（10）的有用体积不受限制，并且可以将具有这种微流体结构（1）的微流体组分（2）的生产成本保持为低。

6. 发明申请

US20150251182A1 Microfluidic Structure Having Recesses 审中-公开
标题翻译：具有凹陷的微流体结构
公开(公告)号：US20150251182A1
公开(公告)日：2015-09-10
申请号：US14719503
申请日：2015-05-22
申请人： Boehringer Ingelheim MicroParts GmbH
发明人： Dirk KUROWSKI , Oliver PAUL
IPC分类号： B01L3/00
CPC分类号： B01L3/502746 , B01L3/5027 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2200/0642 , B01L2200/0684 , B01L2300/0809 , B01L2300/0858 , B01L2300/0864 , B01L2400/0406 , B01L2400/084 , B01L2400/086
摘要： The invention relates to a microfluidic structure (1), comprising at least one cavity (10) having at least one inlet opening (11) and at least one outlet opening (12), wherein the cavity (10) can be filled with a liquid or a liquid can flow through the cavity and at least one element (13) is provided inside the cavity (10), which element stops the flow of the liquid at least temporarily and/or diverts the flow of the liquid at least in some regions within the cavity (10).According to the invention, the at least one element (13) is formed by a recess (13) introduced into a wall of the cavity (10), which recess (13) has at least one first region (14) at which the liquid stops at least temporarily and/or is diverted at least in some regions and at least one second region (15) at which the liquid preferably flows into the recess (13).Such a microfluidic structure makes it possible to fill the cavity (10) without air inclusions. Thereby, the useful volume of the cavity (10) is not limited, and the production costs of a microfluidic component (2) having such a microfluidic structure (1) can be kept low.
摘要翻译：本发明涉及一种微流体结构（1），其包括具有至少一个入口（11）和至少一个出口开口（12）的至少一个空腔（10），其中所述空腔（10）可以填充有液体或液体可以流过空腔，并且至少一个元件（13）设置在空腔（10）内部，该元件至少在一些区域中至少暂时流动和/或转移液体的流动在腔（10）内。根据本发明，所述至少一个元件（13）由引入所述空腔（10）的壁中的凹部（13）形成，所述凹部（13）具有至少一个第一区域（14），所述液体至少在一些区域和/或至少一个第二区域（15）中至少临时停止和/或转向，液体优选地流入所述凹部（13）中的至少一个第二区域（15）。这种微流体结构使得可以填充空腔（10）而没有空气夹杂物。因此，空腔（10）的有用体积不受限制，并且可以将具有这种微流体结构（1）的微流体组分（2）的生产成本保持为低。

7. 发明授权

US11224703B2 Microstructured nozzle and production thereof 有权
公开(公告)号：US11224703B2
公开(公告)日：2022-01-18
申请号：US16075025
申请日：2017-02-02
申请人： Boehringer Ingelheim MicroParts GmbH
发明人： Klaus Kadel , Lothar Keydel
IPC分类号： A61M11/00 , B05B1/14 , B29C45/37 , B81C99/00 , B29C33/42 , A61M15/02 , A61M15/00 , B29C45/26 , B29L31/00 , B29C45/00 , B29C33/32 , B29C33/30 , B29K705/08
摘要： The invention relates to a nozzle for use in a device for administering a liquid medical formulation, to a method for producing the nozzle in the form of a microfluidic component and to a tool for producing microstructures of the microfluidic component. The nozzle is formed by a plastics plate with groove-like microstructures which are covered by a plastics cover on the longitudinal side in a fixed manner. The production method includes a moulding process in which a moulding tool is used, which moulding tool has complementary metal microstructures which have been produced from a semiconductor material in an electrodeposition process by means of a master component.

8. 发明申请

US20170165666A1 APPARATUS FOR THE SEPARATION OF PLASMA 审中-公开
公开(公告)号：US20170165666A1
公开(公告)日：2017-06-15
申请号：US15358185
申请日：2016-11-22
申请人： Boehringer Ingelheim Microparts GmbH
发明人： Gert BLANKENSTEIN , Holger BARTOS , Ralf-Peter PETERS , Christian SCHOEN
IPC分类号： B01L3/00 , B01D29/01 , B01D29/05 , G01N33/49 , B01D63/08
CPC分类号： B01L3/502753 , B01D29/014 , B01D29/05 , B01D61/18 , B01D63/08 , B01D63/087 , B01D63/088 , B01D2201/0415 , B01D2201/44 , B01L3/502715 , B01L2300/0681 , B01L2300/0864 , B01L2400/0406 , G01N33/491
摘要： The invention relates to an apparatus for separating blood and at the same time an apparatus (1) for absorbing blood (19) and separating components such as blood plasma, as a sample liquid (2), having a feed device (13) for receiving the blood (2), a separating device (15) for separating blood components as the sample liquid (2), a channel (3) which takes up the sample liquid (2) preferably exclusively by capillary forces and a fill device for filling the channel (3) with sample liquid (2) in an inlet or feed region (18) of the channel (3), wherein the separating device (15), particularly a membrane, is domed, more particularly convexly shaped and projects with the apex of the convex shape into the filling device in the direction of filling.

9. 发明申请

US20140134595A1 DEVICE AND METHOD FOR FILTERING BLOOD 有权
标题翻译：用于过滤血液的装置和方法
公开(公告)号：US20140134595A1
公开(公告)日：2014-05-15
申请号：US14006996
申请日：2012-03-23
申请人： BOEHRINGER INGELHEIM MICROPARTS GMBH
发明人： Dirk Kurowski , Dirk Osterloh , Ying Yu
IPC分类号： G01N1/40
CPC分类号： G01N1/4005 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502753 , B01L2200/027 , B01L2300/0681 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487
摘要： The invention relates to a device and a method for filtering a liquid sample, wherein first capillary-driven filtration occurs and, after initial filling, pressure-operated filtration is performed by applying a vacuum or a positive pressure.
摘要翻译：本发明涉及一种用于过滤液体样品的装置和方法，其中发生第一毛细管驱动的过滤，并且在初始填充之后，通过施加真空或正压进行压力操作的过滤。

10. 发明授权

US10809162B2 Testing system and testing method 有权
公开(公告)号：US10809162B2
公开(公告)日：2020-10-20
申请号：US15765895
申请日：2016-10-06
申请人： BOEHRINGER INGELHEIM MICROPARTS GMBH
发明人： Joachim Eicher , Jutta Eigemann , Johannes Geser , Andreas Peters , Hans-Juergen Koelbel
IPC分类号： G01M99/00 , A61M15/00 , B05B11/00 , B05B15/40
摘要： A system for testing the proper functioning of an atomiser for dispensing a fluid in the form of an aerosol is proposed, wherein the system comprises the atomiser and a test apparatus, wherein the atomiser comprises a container holding the fluid, and a housing part for inserting and/or replacing the container, wherein the container is movable relative to the housing part in order to dispense the fluid and the test apparatus comprises a measuring device for measuring the movement of the container when the fluid is dispensed. In addition, a method for testing the proper functioning of an atomiser for dispensing a fluid in the form of an aerosol is proposed, wherein the atomiser comprises a container holding the fluid, and a housing part for inserting and/or replacing the container, wherein the container is moved relative to the housing part in order to dispense the fluid and the movement of the container is measured and/or analysed when the fluid is dispensed.

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