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1. 发明申请

US20110085936A1 Methods and Apparatus for Reducing Count of Infectious Agents in Intravenous Access Systems 失效
标题翻译：静脉注射系统中传染物计数减少的方法与装置
公开(公告)号：US20110085936A1
公开(公告)日：2011-04-14
申请号：US12751365
申请日：2010-03-31
申请人： Eyal Haytman , Assaf Deutsch , Eliahu Pewzner
发明人： Eyal Haytman , Assaf Deutsch , Eliahu Pewzner
IPC分类号： A61L2/08 , G21G5/00
CPC分类号： A61L2/084 , A61L2202/23 , A61N5/0624
摘要： Methods and apparatus for preventing patient bloodstream infection by microorganisms during administration of various medications or fluids through IV lines. In particular, the invention reduces contamination of IV lines, connecters, stopcock valves, manifolds, ports, etc. by means of irradiation by violet and/or blue light. Each embodiment comprises a source of violet and/or blue light and an optical element optically coupled to that light source for shaping the radiation pattern of the light emitted by the light source. Preferably, a light-emitting diode or a laser diode that emits light in the desired wavelength can be used. The optical element, optically coupled to the light source, is embedded or installed in or attached to a component of an IV set, the emitted light being directed to a “point of entry” or any other stagnation point of an IV set.
摘要翻译：在通过IV线施用各种药物或液体期间预防微生物患者血液感染的方法和装置。特别地，本发明通过紫外线和/或蓝光的照射来减少IV线，连接器，旋塞阀，歧管，端口等的污染。每个实施例包括紫色和/或蓝色光源和与该光源光耦合的光学元件，用于对由光源发射的光的辐射图进行整形。优选地，可以使用发射所需波长的光的发光二极管或激光二极管。与光源光学耦合的光学元件被嵌入或安装在IV组件的一个部件中或附着于IV组件的组件上，所发射的光被引导到IV组的“进入点”或任何其它停滞点。

2. 发明申请

US20110036787A1 PARTICLE SEPARATION 审中-公开
标题翻译：颗粒分离
公开(公告)号：US20110036787A1
公开(公告)日：2011-02-17
申请号：US12854943
申请日：2010-08-12
申请人： Mordechai DEUTSCH , Assaf DEUTSCH
发明人： Mordechai DEUTSCH , Assaf DEUTSCH
IPC分类号： B01D29/66
CPC分类号： A61M1/3627 , A61M2205/7563
摘要： Apparatus for increasing a concentration of large particles in a mixture which includes the large particles and smaller particles, including a flow chamber, a filtrate accepting chamber, a filtering component separating the flow chamber from the filtrate accepting chamber, the filtering component including a plurality of pores passing therethrough, characterized by further including means for generating a flow of the fluid in the flow chamber, with a flow component in a direction parallel to a surface of the filtering component sufficient to substantially prevent particles from adhering to the filtering component and clogging the pores. A method of increasing a concentration of large particles in a mixture which includes the large particles and smaller particles, including providing a flow chamber and a filtrate accepting chamber separated by a filtering component, the filtering component including a plurality of pores passing therethrough, and placing a fluid with the mixture in the flow chamber, characterized by causing the fluid with the mixture to flow in the flow chamber, with a flow component parallel to a surface of the filtering component sufficient to substantially prevent particles from adhering to the filtering component and clogging the pores, thereby increasing the concentration of the larger particles relative to the concentration of the smaller particles in the mixture. Related apparatus and methods are also described.
摘要翻译：用于增加包括大颗粒和较小颗粒的混合物中的大颗粒浓度的装置，包括流动室，滤液接收室，将流动室与滤液接收室分离的过滤组分，过滤组分包括多个通过其中的孔，其特征在于还包括用于在流动室中产生流体的流动的装置，其中流动分量在平行于过滤组件的表面的方向上，足以基本上防止颗粒粘附到过滤组件并阻塞毛孔一种增加包含大颗粒和较小颗粒的混合物中的大颗粒浓度的方法，包括提供由过滤组分分离的流动室和滤液接收室，过滤组分包括通过其中的多个孔，并将在流动室中具有混合物的流体，其特征在于使混合物中的流体在流动室中流动，其中流动分量平行于过滤组分的表面足以基本上防止颗粒粘附到过滤组分并堵塞孔，从而相对于混合物中较小颗粒的浓度增加了较大颗粒的浓度。还描述了相关装置和方法。

3. 发明申请

US20050234315A1 Diagnosis of body metabolic emergency state 有权
标题翻译：诊断身体代谢紧急状态
公开(公告)号：US20050234315A1
公开(公告)日：2005-10-20
申请号：US10508232
申请日：2003-03-06
申请人： Avraham Mayevsky , Eliahu Pewzner , Assaf Deutsch , Tamar Manor
发明人： Avraham Mayevsky , Eliahu Pewzner , Assaf Deutsch , Tamar Manor
IPC分类号： A61B5/00
CPC分类号： A61B5/4519 , A61B5/0059 , A61B5/0084 , A61B5/14546 , A61B5/412
摘要： An apparatus, system and method are provided for diagnosing the degree of body metabolic emergency state. A non-vital organ with respect to the metabolic emergency state is first chosen. One or more tissue viability parameters including at least one of NADH and Flavoprotein (Fp) concentration are monitored in the non-vital organ, whereupon the degree of body metabolic emergency state may be determined based on the monitored tissue viability parameters.
摘要翻译：提供了用于诊断身体代谢紧急状态的装置，系统和方法。首先选择关于代谢紧急状态的非重要器官。在非重要器官中监测包括NADH和黄素蛋白（Fp）浓度中的至少一种浓度的一种或多种组织生存力参数，从而可以基于所监测的组织存活力参数来确定身体代谢紧急状态的程度。

4. 发明授权

US09145540B1 Device for the study of living cells 有权
标题翻译：用于研究活细胞的装置
公开(公告)号：US09145540B1
公开(公告)日：2015-09-29
申请号：US12712232
申请日：2010-02-25
申请人： Mordechai Deutsch , Assaf Deutsch
发明人： Mordechai Deutsch , Assaf Deutsch
IPC分类号： C12M1/00 , C12M3/00 , C12M1/34 , C12M1/12
CPC分类号： G01N15/10 , B01L3/5025 , B01L3/502761 , B01L2200/027 , B01L2200/0668 , B01L2200/12 , B01L2300/0654 , B01L2300/069 , B01L2300/0819 , B01L2300/0822 , B01L2300/0864 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2300/163 , C12M23/10 , C12M23/12 , C12M23/22 , C12M25/06 , C12M41/46 , C12N2533/30 , C12N2533/40 , G01N1/312 , G01N2015/0065 , G01N2015/1006 , Y10T156/1041
摘要： A device for performing a cell study. The device comprises a plate having a plurality of wells, each configured for containing aqueous solution and having a well bottom with a plurality of picowells and a plurality of biosensors each configured for measuring at least one cell characteristic while being in contact with the aqueous solution in a respective the well. The position of each the biosensor in a respective the well is limited by at least one pin.
摘要翻译：用于进行细胞研究的装置。该装置包括具有多个孔的板，每个孔被构造成用于容纳水溶液并且具有多个小孔的井底和多个生物传感器，每个生物传感器被配置用于在与水溶液接触的同时测量至少一个电池特性一个相应的井。每个生物传感器在相应的井中的位置由至少一个销限制。

5. 发明申请

US20110014688A1 PICO LITER WELL HOLDING DEVICE AND METHOD OF MAKING THE SAME 有权
标题翻译： PICO LITER井保持装置及其制造方法
公开(公告)号：US20110014688A1
公开(公告)日：2011-01-20
申请号：US12890668
申请日：2010-09-26
申请人： Mordechai Deutsch , Assaf Deutsch
发明人： Mordechai Deutsch , Assaf Deutsch
IPC分类号： C12M1/34 , C12M1/00 , B29C59/02
CPC分类号： C12M23/22 , B01L3/5025 , B01L3/5027 , B01L3/502761 , B01L3/5085 , B01L2200/0668 , B01L2200/12 , B01L2300/0654 , B01L2300/069 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2300/163 , C12M23/12 , C12N2533/30 , C12N2533/40 , Y10T156/1041
摘要： The present invention broadly comprises a holding device for studying cells comprising at least one cavity adapted to receive cells in a medium consisting essentially of water, the cavity having a substrate and a generally inert wall, wherein the substrate includes a surface for receiving the medium, and wherein the surface includes a multiplicity of pico liter wells and is characterized in that the substrate is substantially translucent and has a refractive index equal to the refractive index of the medium. The invention further comprises a method of making the holding device comprising providing a carrier plate, applying an adhesive layer to the carrier plate, depositing a curable substrate on the adhesive layer, applying a second layer of adhesive to the substrate, attaching a wall structure to the second layer of adhesive, forming a multiplicity of pico liter wells in the substrate, curing the substrate, and removing the template.
摘要翻译：本发明广泛地包括用于研究细胞的保持装置，其包括适于在基本上由水组成的介质中接收细胞的至少一个空腔，所述腔体具有基底和通常为惰性的壁，其中所述基底包括用于接收介质的表面，并且其中所述表面包括多个微微孔，并且其特征在于，所述基底基本上是半透明的并且具有等于所述介质的折射率的折射率。本发明还包括一种制造保持装置的方法，包括提供载体板，将粘合剂层施加到载体板上，将可固化基材沉积在粘合剂层上，将第二层粘合剂施加到基材上，将壁结构连接到第二层粘合剂，在基材中形成多个微米级的孔，固化基材，并除去模板。

6. 发明申请

US20100247386A1 PICO LITER WELL HOLDING DEVICE AND METHOD OF MAKING THE SAME 有权
标题翻译： PICO LITER井保持装置及其制造方法
公开(公告)号：US20100247386A1
公开(公告)日：2010-09-30
申请号：US12742730
申请日：2008-11-13
申请人： Mordechai Deutsch , Assaf Deutsch
发明人： Mordechai Deutsch , Assaf Deutsch
IPC分类号： B01L3/00 , B29C47/00 , B32B38/04 , B32B38/06
CPC分类号： B01L3/5085 , B01L3/502761 , B01L2200/12 , B01L2300/044 , B01L2300/0654 , B01L2300/0819 , B01L2300/0822 , B01L2300/0887 , C12M23/12 , C12M23/22 , C12M23/38
摘要： Described herein are embossing methods for forming pico liter well arrays (and other structures), arrangements of such pico liter well arrays, for example, in arrays of pico liter well areas, and methods of forming templates for such embossing. Also described as wells with a refractive index similar to that of an aqueous medium used for supporting cells in the wells.
摘要翻译：这里描述的是用于形成微微公升阵列（和其它结构）的压花方法，这种微微升阵列的布置，例如以pico升井区域排列，以及形成用于这种压花的模板的方法。还描述为具有类似于用于支撑孔中的细胞的水性介质的折射率的孔。

7. 发明申请

US20070292837A1 Multiwell Plate 有权
标题翻译：多孔板
公开(公告)号：US20070292837A1
公开(公告)日：2007-12-20
申请号：US10565240
申请日：2004-07-20
申请人： Mordechai Deutsch , Max Herzberg , Reuven Tirosh , Assaf Deutsch
发明人： Mordechai Deutsch , Max Herzberg , Reuven Tirosh , Assaf Deutsch
IPC分类号： C12Q1/00 , B01L3/00 , B23P17/04 , C12M3/00 , C12N11/00
CPC分类号： C12M23/12 , B01L3/5085 , B01L2200/0668 , B01L2200/12 , B01L2300/04 , B01L2300/069 , B01L2300/0819 , B01L2300/0829 , B01L2300/0893 , B01L2300/0896 , B01L2400/0409 , B01L2400/0454 , B01L2400/0457 , B01L2400/0487 , B29C39/026 , B29C65/002 , B29C65/48 , B29K2101/12 , B29L2009/00 , B29L2031/712 , C12M23/20 , C12N11/04 , G01N33/5008 , Y10T29/49
摘要： A mulitwell plate having a plurality of picowells on the bottom of the wells of the plate as well as methods of producing the mulitwell plate are provided. Provided is also a method of handling living cells by providing an ordered array of living cells immobilized in a non-fluid matrix, contacting the living cells with a stimulus; and detecting a response to the stimulus. The present invention is also of a method of producing an ordered array of living cells.
摘要翻译：提供了一种在板的孔的底部具有多个皮纹的多孔板以及多孔板的制造方法。还提供了通过提供固定在非流体基质中的活细胞的有序阵列来使活细胞与刺激物接触来处理活细胞的方法; 并检测对刺激的响应。本发明也是生产活细胞有序阵列的方法。

8. 发明授权

US09975118B2 Device for the study of living cells 有权
公开(公告)号：US09975118B2
公开(公告)日：2018-05-22
申请号：US12810868
申请日：2008-12-25
申请人： Mordechai Deutsch , Assaf Deutsch
发明人： Mordechai Deutsch , Assaf Deutsch
IPC分类号： B01L3/00 , C12M1/32 , C12M1/00
CPC分类号： B01L3/5027 , B01L3/502715 , B01L3/5085 , B01L2200/027 , B01L2200/0668 , B01L2300/041 , B01L2300/0809 , B01L2300/0822 , B01L2300/0887 , B01L2300/0893 , B01L2300/123 , B01L2400/0406 , C12M23/12 , C12M23/22 , Y10T29/49826
摘要： A cell study device, comprising, a base layer, a planar conduit defining layer, including a conduit cut out of the layer; and a planar cover layer which defines a capillary flow channel in said conduit layer, said conduit layer and said cover layer acting as side walls for said capillary flow channel, wherein said layers are formed of materials that do not interfere with cell behavior over a period of at least 5 hours when loaded with aqueous solution.

9. 发明授权

US07888110B2 Pico liter well holding device and method of making the same 有权
标题翻译： Pico升保持装置及其制作方法
公开(公告)号：US07888110B2
公开(公告)日：2011-02-15
申请号：US11940996
申请日：2007-11-15
申请人： Mordechai Deutsch , Assaf Deutsch
发明人： Mordechai Deutsch , Assaf Deutsch
IPC分类号： C12M1/34 , C12M3/00 , C12M1/22
CPC分类号： C12M23/22 , B01L3/5025 , B01L3/5027 , B01L3/502761 , B01L3/5085 , B01L2200/0668 , B01L2200/12 , B01L2300/0654 , B01L2300/069 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2300/163 , C12M23/12 , C12N2533/30 , C12N2533/40 , Y10T156/1041
摘要： The present invention broadly comprises a holding device for studying cells comprising at least one cavity adapted to receive cells in a medium consisting essentially of water, the cavity having a substrate and a generally inert wall, wherein the substrate includes a surface for receiving the medium, and wherein the surface includes a multiplicity of pico liter wells and is characterized in that the substrate is substantially translucent and has a refractive index equal to the refractive index of the medium The invention further comprises a method of making the holding device comprising providing a carrier plate, applying an adhesive layer to the carrier plate, depositing a curable substrate on the adhesive layer, applying a second layer of adhesive to the substrate, attaching a wall structure to the second layer of adhesive, forming a multiplicity of pico liter wells in the substrate, curing the substrate, and removing the template.
摘要翻译：本发明广泛地包括用于研究细胞的保持装置，其包括适于在基本上由水组成的介质中接收细胞的至少一个空腔，所述腔体具有基底和通常为惰性的壁，其中所述基底包括用于接收介质的表面，并且其中所述表面包括多个微微孔，并且其特征在于，所述基底基本上是半透明的并且具有等于所述介质的折射率的折射率。本发明还包括制造所述保持装置的方法，所述保持装置包括提供载体板将粘合剂层施加到载体板上，将可固化基材沉积在粘合剂层上，向基材施加第二层粘合剂，将壁结构附着到第二层粘合剂上，在基材中形成多个pico升孔，固化基材，并除去模板。

10. 发明申请

US20080063572A1 PICO LITER WELL HOLDING DEVICE AND METHOD OF MAKING THE SAME 有权
标题翻译： PICO LITER井保持装置及其制造方法
公开(公告)号：US20080063572A1
公开(公告)日：2008-03-13
申请号：US11940996
申请日：2007-11-15
申请人： Mordechai Deutsch , Assaf Deutsch
发明人： Mordechai Deutsch , Assaf Deutsch
IPC分类号： B01L3/00 , B05D3/00 , B05D3/06
CPC分类号： C12M23/22 , B01L3/5025 , B01L3/5027 , B01L3/502761 , B01L3/5085 , B01L2200/0668 , B01L2200/12 , B01L2300/0654 , B01L2300/069 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2300/163 , C12M23/12 , C12N2533/30 , C12N2533/40 , Y10T156/1041
摘要： The present invention broadly comprises a holding device for studying cells comprising at least one cavity adapted to receive cells in a medium consisting essentially of water, the cavity having a substrate and a generally inert wall, wherein the substrate includes a surface for receiving the medium, and wherein the surface includes a multiplicity of pico liter wells and is characterized in that the substrate is substantially translucent and has a refractive index equal to the refractive index of the medium The invention further comprises a method of making the holding device comprising providing a carrier plate, applying an adhesive layer to the carrier plate, depositing a curable substrate on the adhesive layer, applying a second layer of adhesive to the substrate, attaching a wall structure to the second layer of adhesive, forming a multiplicity of pico liter wells in the substrate, curing the substrate, and removing the template.
摘要翻译：本发明广泛地包括用于研究细胞的保持装置，其包括适于在基本上由水组成的介质中接收细胞的至少一个空腔，所述腔体具有基底和通常为惰性的壁，其中所述基底包括用于接收介质的表面，并且其中所述表面包括多个微微孔，并且其特征在于，所述基底基本上是半透明的并且具有等于所述介质的折射率的折射率。本发明还包括制造所述保持装置的方法，所述保持装置包括提供载体板将粘合剂层施加到载体板上，将可固化基材沉积在粘合剂层上，向基材施加第二层粘合剂，将壁结构附着到第二层粘合剂上，在基材中形成多个pico升孔，固化基材，并除去模板。

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