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1. 发明授权

US08545889B2 Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms 有权
公开(公告)号：US08545889B2
公开(公告)日：2013-10-01
申请号：US11448523
申请日：2006-06-06
申请人： Gary T. Norman , Kalyan S. Nuguru , Arun F. Amin , Sarath Chandar
发明人： Gary T. Norman , Kalyan S. Nuguru , Arun F. Amin , Sarath Chandar
IPC分类号： A61K9/14 , A61K9/20 , A61K9/26 , A61K9/46
CPC分类号： A61K47/26 , A61K9/0056 , A61K9/1694 , A61K9/2018 , A61K9/2081 , A61K31/137 , A61K31/167 , A61K31/439 , A61K31/485
摘要： The present invention comprises a co-processed carbohydrate system, and formulations produced therefrom, which formulations are directly compressible into solid dosage forms, some of which rapidly and completely dissolve or disintegrate in the oral cavity within 60 seconds. The invention also comprises the solid dosage forms produced by directly compressing the co-processed carbohydrate system, some of which, when placed in the oral cavity, shall dissolve or disintegrate, preferably within about 60 seconds.

2. 发明申请

US20080107729A1 Orally disintegrating compositions 审中-公开
标题翻译：口腔崩解组合物
公开(公告)号：US20080107729A1
公开(公告)日：2008-05-08
申请号：US11805871
申请日：2007-05-23
申请人： Arun F. Amin , Sarath Chandar , Adrian Gilbert , Dannit Licht , Gary T. Norman , Shuli Patashnik
发明人： Arun F. Amin , Sarath Chandar , Adrian Gilbert , Dannit Licht , Gary T. Norman , Shuli Patashnik
IPC分类号： A61K9/20 , A61K47/10
CPC分类号： A61K9/2018 , A61K9/0056
摘要： This invention provides a solid pharmaceutical composition comprising an active ingredient (e.g., rasagiline) or a pharmaceutically acceptable salt thereof, and particles having a non-filamentous microstructure of at least two sugar alcohols. This invention also provides a solid pharmaceutical composition comprising an active ingredient (e.g., rasagiline) or a pharmaceutically acceptable salt thereof, a mixture of a disintegrant, a flow agent and particles having a non-filamentous microstructure of at least two sugar alcohols, a supplemental sugar alcohol, a supplemental flow agent, and a supplemental disintegrant. Finally, this invention provides a process of making such solid pharmaceutical compositions.
摘要翻译：本发明提供一种固体药物组合物，其包含活性成分（例如雷沙吉兰）或其药学上可接受的盐，以及具有至少两种糖醇的非丝状微结构的颗粒。本发明还提供一种固体药物组合物，其包含活性成分（例如雷沙吉兰）或其药学上可接受的盐，崩解剂，流动剂和具有至少两种糖醇的非丝状微结构的颗粒的混合物，补充剂糖醇，补充流剂和补充崩解剂。最后，本发明提供制备这种固体药物组合物的方法。

3. 发明授权

US07118765B2 Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms 有权
公开(公告)号：US07118765B2
公开(公告)日：2006-10-10
申请号：US10274227
申请日：2002-10-18
申请人： Gary Telfer Norman , Kalyan S. Nuguru , Arun F. Amin , Sarath Chandar
发明人： Gary Telfer Norman , Kalyan S. Nuguru , Arun F. Amin , Sarath Chandar
IPC分类号： A61K9/14 , A61K9/20 , A61K9/28 , A61K47/00
CPC分类号： A61K47/26 , A61K9/0056 , A61K9/1694 , A61K9/2018 , A61K9/2081 , A61K31/137 , A61K31/167 , A61K31/439 , A61K31/485
摘要： The present invention comprises a co-processed carbohydrate system, and formulations produced therefrom, which formulations are directly compressible into solid dosage forms, some of which rapidly and completely dissolve or disintegrate in the oral cavity within 60 seconds. The invention also comprises the solid dosage forms produced by directly compressing the co-processed carbohydrate system, some of which, when placed in the oral cavity, shall dissolve or disintegrate, preferably within about 60 seconds.

4. 发明授权

US07208186B2 Chewing gum formulation and method of making the same 失效
标题翻译：口香糖配方及制作方法
公开(公告)号：US07208186B2
公开(公告)日：2007-04-24
申请号：US10422502
申请日：2003-04-24
申请人： Gary T. Norman , Arun F. Amin
发明人： Gary T. Norman , Arun F. Amin
IPC分类号： A23G4/08
CPC分类号： A23G4/18 , A23G4/06 , A23G4/064 , A23V2002/00 , A61K9/0058 , A23V2200/20 , A23V2200/202 , A23V2250/64 , A23V2250/15
摘要： The present invention involves a novel chewing gum formulation and a method of making the same. The chewing gum formulation is used to form a final chewing gum composition which contains an active ingredient which is released from the chewing gum as the gum is masticated in the mouth of the user. The chewing gum made from the chewing gum composition of the present invention is initially a compressed body, such as a tablet, which quickly dissociates into a multiplicity of small pieces upon initial chewing followed by a reformation of the pieces into a coherent mass of chewing gum after a few seconds of chewing. Both the chewing gum formulation and the chewing gum composition are in the form of a free-flowing particulate which is capable of being directly compressed at high speed by a standard tableting machine into chewing gum tablets.
摘要翻译：本发明涉及一种新型口香糖制剂及其制备方法。口香糖制剂用于形成最终口香糖组合物，其含有当口香糖在口腔中咀嚼时从口香糖释放的活性成分。由本发明的口香糖组合物制成的口香糖最初是压缩体，例如片剂，其在初次咀嚼时迅速解离成多个小块，随后将片重新成型成口香糖块几秒钟之后咀嚼。口香糖配方和口香糖组合物均为自由流动颗粒的形式，其能够通过标准压片机直接压缩成口香糖片剂。

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