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1. 发明授权

US4332789A Pharmaceutical unit dosage forms 失效
标题翻译：药物单位剂型
公开(公告)号：US4332789A
公开(公告)日：1982-06-01
申请号：US827284
申请日：1977-08-24
申请人： Arthur R. Mlodozeniec
发明人： Arthur R. Mlodozeniec
IPC分类号： A61J3/00 , A61K9/20 , A61K9/28 , A61K9/70
CPC分类号： A61K9/2095 , A61J3/00 , A61K9/2072 , A61K9/28 , A61K9/70 , A61F2013/0296
摘要： Pharmaceutical dosage forms comprising an edible web having deposited theron or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.
摘要翻译：药物剂型包括具有沉积的神经元或至少部分地沉积有颗粒药物的可食性网状物，此后将网状物制成并完成至没有药物暴露在外表面上的药学上优选的固体剂型。剂型具有药物释放的一致性，其可以被控制到严格的规格。所公开的固体剂型通过高速自动化设备制备，并且其制备方法的特征在于在线进行的非破坏性的质量控制分析和性能评估，并集成到制造操作中。包括在所公开的发明的范围内的是某些装置和制造方法。

2. 发明授权

US4307555A System for producing dosage forms 失效
标题翻译：生产剂型的制剂
公开(公告)号：US4307555A
公开(公告)日：1981-12-29
申请号：US81710
申请日：1979-10-04
申请人： Arthur R. Mlodozeniec , Arthur H. Goldberg
发明人： Arthur R. Mlodozeniec , Arthur H. Goldberg
IPC分类号： A61J3/00 , A61K9/20 , A61K9/28 , A61K9/70 , B65B57/00 , B65B9/06
CPC分类号： A61K9/2072 , A61J3/00 , A61K9/2095 , A61K9/28 , A61K9/70 , A61F2013/0296
摘要： Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.
摘要翻译：药物剂型包括其上沉积有或在其上至少部分地具有颗粒药物的可食性网状物，其后制备并完成了所述腹板，其没有在外表面上暴露的药物的药学上优选的固体剂型。剂型具有药物释放的一致性，其可以被控制到严格的规格。所公开的固体剂型通过高速自动化设备制备，并且其制备方法的特征在于在线进行的非破坏性的质量控制分析和性能评估，并集成到制造操作中。包括在所公开的发明的范围内的是某些装置和制造方法。

3. 发明授权

US4128445A Manufacture of pharmaceutical unit dosage forms 失效
公开(公告)号：US4128445A
公开(公告)日：1978-12-05
申请号：US825746
申请日：1977-08-18
申请人： August Sturzenegger , Arthur R. Mlodozeniec , Edward S. Lipinsky
发明人： August Sturzenegger , Arthur R. Mlodozeniec , Edward S. Lipinsky
IPC分类号： A61J3/00 , A61K9/20 , A61K9/28 , A61K9/70
CPC分类号： A61J3/00 , A61K9/2072 , A61K9/2095 , A61K9/28 , A61K9/70 , A61F2013/0296 , Y10T156/101
摘要： Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.

4. 发明授权

US4478822A Drug delivery system utilizing thermosetting gels 失效
标题翻译：使用热固性凝胶的药物输送系统
公开(公告)号：US4478822A
公开(公告)日：1984-10-23
申请号：US495239
申请日：1983-05-16
申请人： John L. Haslam , Takeru Higuchi , Arthur R. Mlodozeniec
发明人： John L. Haslam , Takeru Higuchi , Arthur R. Mlodozeniec
IPC分类号： A61K9/20 , A61K47/18 , A61K31/74 , A61K31/135 , A61K31/19 , A61K31/415 , A61K31/435 , A61K31/54 , A61K31/66 , A61K31/70
CPC分类号： A61K9/2031 , A61K47/18 , Y10S514/912
摘要： This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a liquid at room temperature but forms a semi-solid or gel at the body temperature in the body cavity.
摘要翻译：本发明涉及用于将药物输送到体腔的独特药物递送系统。药物递送系统包括药物和聚合物，使得药物递送系统在室温下为液体，但在体腔内的体温形成半固体或凝胶。

5. 发明授权

US4474753A Topical drug delivery system utilizing thermosetting gels 失效
标题翻译：使用热固性凝胶的局部药物输送系统
公开(公告)号：US4474753A
公开(公告)日：1984-10-02
申请号：US495321
申请日：1983-05-16
申请人： John L. Haslam , Takeru Higuchi , Arthur R. Mlodozeniec
发明人： John L. Haslam , Takeru Higuchi , Arthur R. Mlodozeniec
IPC分类号： A61K47/18 , A61K31/74 , A61K31/135 , A61K31/19 , A61K31/415 , A61K31/435 , A61K31/54 , A61K31/66 , A61K31/70
CPC分类号： A61K9/0014 , A61K47/18 , Y10S514/873 , Y10S514/912
摘要： This invention relates to a unique drug delivery system for application to the skin which drug delivery system is a liquid at room temperature, but when administered topically to the skin becomes a semi-solid or gel when warmed by the body.
摘要翻译：本发明涉及一种适用于皮肤的独特药物递送系统，药物递送系统在室温下为液体，但当局部给予皮肤时，当由身体加热时变成半固体或凝胶。

6. 发明授权

US4349531A Novel dosage form 失效
公开(公告)号：US4349531A
公开(公告)日：1982-09-14
申请号：US81759
申请日：1979-10-04
申请人： Arthur R. Mlodozeniec , Arthur H. Goldberg
发明人： Arthur R. Mlodozeniec , Arthur H. Goldberg
IPC分类号： A61J3/00 , A61K9/20 , A61K9/28 , A61K9/70 , A61K9/24
CPC分类号： A61K9/2072 , A61J3/00 , A61K9/2095 , A61K9/28 , A61K9/70 , A61F2013/0296
摘要： Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.

7. 发明授权

US4474752A Drug delivery system utilizing thermosetting gels 失效
标题翻译：使用热固性凝胶的药物输送系统
公开(公告)号：US4474752A
公开(公告)日：1984-10-02
申请号：US495240
申请日：1983-05-16
申请人： John L. Haslam , Takeru Higuchi , Arthur R. Mlodozeniec
发明人： John L. Haslam , Takeru Higuchi , Arthur R. Mlodozeniec
IPC分类号： A61K47/18 , A61K31/415 , A61K31/135 , A61K31/19 , A61K31/435 , A61K31/54 , A61K31/66 , A61K31/70 , A61K31/74
CPC分类号： A61K47/18 , A61K9/0019 , Y10S514/822 , Y10S514/825 , Y10S514/826 , Y10S514/866 , Y10S514/906 , Y10S514/944
摘要： Present invention provides a unique drug delivery device for delivering drug by injection into a body. The drug delivery system comprises the drug and polymer which is a liquid at room temperature and a semi-solid or gel at the body temperature.
摘要翻译：本发明提供了一种用于通过注射到体内输送药物的独特药物递送装置。药物递送系统包括在室温下为液体的药物和聚合物，以及在体温下的半固体或凝胶。

8. 发明授权

US4474751A Ophthalmic drug delivery system utilizing thermosetting gels 失效
标题翻译：使用热固性凝胶的眼药物递送系统
公开(公告)号：US4474751A
公开(公告)日：1984-10-02
申请号：US495238
申请日：1983-05-16
申请人： John L. Haslam , Takeru Higuchi , Arthur R. Mlodozeniec
发明人： John L. Haslam , Takeru Higuchi , Arthur R. Mlodozeniec
IPC分类号： A61K47/34 , A61K9/00 , A61K9/06 , A61K9/08 , A61K47/18 , A61K49/00 , A61K31/74 , A61K31/135 , A61K31/19 , A61K31/415 , A61K31/435 , A61K31/54 , A61K31/66 , A61K31/70
CPC分类号： A61K9/0048 , A61K47/18 , Y10S514/912
摘要： This invention describes the application of selected polymers as novel drug delivery systems which use the body temperature and pH to induce a liquid to gel transition of the polymer which contains a drug or therapeutic agent therein. The goal of such a delivery system is to achieve a greater degree of bioavailability or sustained concentration of a drug.
摘要翻译：本发明描述了所选择的聚合物作为新的药物递送系统的应用，其使用体温和pH来诱导其中含有药物或治疗剂的聚合物的液体至凝胶转变。这种输送系统的目的是获得更高程度的生物利用度或药物的持续浓度。

9. 发明授权

US4197289A Novel dosage forms 失效
标题翻译：新型剂型
公开(公告)号：US4197289A
公开(公告)日：1980-04-08
申请号：US933709
申请日：1978-08-15
申请人： August Sturzenegger , Arthur R. Mlodozeniec , Edward S. Lipinsky
发明人： August Sturzenegger , Arthur R. Mlodozeniec , Edward S. Lipinsky
IPC分类号： A61J3/00 , A61K9/20 , A61K9/22 , A61K9/28 , A61K9/70 , A61K9/24 , A61K9/44
CPC分类号： A61K9/2072 , A61J3/00 , A61K9/2095 , A61K9/28 , A61K9/70 , A61F2013/0296
摘要： Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The doseage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.
摘要翻译：药物剂型包括其上沉积有或在其上至少部分地具有颗粒药物的可食性网状物，其后制备并完成了所述腹板，其没有在外表面上暴露的药物的药学上优选的固体剂型。剂量形式具有可以控制到严格规格的药物释放的一致性。所公开的固体剂型通过高速自动化设备制备，并且其制备方法的特征在于在线进行的非破坏性的质量控制分析和性能评估，并集成到制造操作中。包括在所公开的发明的范围内的是某些装置和制造方法。

10. 发明授权

US4128444A Manufacture of pharmaceutical unit dosage forms 失效
标题翻译：制药单位剂型
公开(公告)号：US4128444A
公开(公告)日：1978-12-05
申请号：US823363
申请日：1977-08-10
申请人： Arthur R. Mlodozeniec
发明人： Arthur R. Mlodozeniec
IPC分类号： A61J3/00 , A61K9/20 , A61K9/28 , A61K9/70 , A61K9/10
CPC分类号： A61J3/00 , A61K9/2072 , A61K9/2095 , A61K9/28 , A61K9/70 , A61F2013/0296
摘要： Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.
摘要翻译：药物剂型包括其上沉积有或在其上至少部分地具有颗粒药物的可食性网状物，其后制备并完成了所述腹板，其没有在外表面上暴露的药物的药学上优选的固体剂型。剂型具有药物释放的一致性，其可以被控制到严格的规格。所公开的固体剂型通过高速自动化设备制备，并且其制备方法的特征在于在线进行的非破坏性的质量控制分析和性能评估，并集成到制造操作中。包括在所公开的发明的范围内的是某些装置和制造方法。

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