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1. 再颁专利

USRE36744E Nasal administration of benzodiazepine hypnotics 失效
公开(公告)号：USRE36744E
公开(公告)日：2000-06-20
申请号：US213498
申请日：1994-03-16
申请人： Arthur H. Goldberg
发明人： Arthur H. Goldberg
IPC分类号： A61K9/00 , A61K31/55 , A01N43/62 , A61L9/04
CPC分类号： A61K9/0043 , A61K31/55
摘要： Nasal administration of benzodiazepines is described as providing improved therapeutic effects as compared to conventional delivery techniques. The compositions comprise a benzodiazepine hypnotic in a pharmaceutically acceptable nasal carrier.

2. 发明授权

US4454140A Nasal administration of dextromethorphan 失效
标题翻译：鼻内给药右美沙芬
公开(公告)号：US4454140A
公开(公告)日：1984-06-12
申请号：US415209
申请日：1982-09-07
申请人： Arthur H. Goldberg , Meyer Matluck , Joseph A. Ranucci
发明人： Arthur H. Goldberg , Meyer Matluck , Joseph A. Ranucci
IPC分类号： A61K31/485
CPC分类号： A61K31/485 , Y10S514/85
摘要： The invention relates to a novel method of administering dextromethorphan, a known anti-tussive agent used for the suppresion of coughs due to colds and allergies. The novel method utilizes dosage forms of dextromethorphan which are adapted for nasal administration.
摘要翻译：本发明涉及一种施用右美沙芬的新方法，已知的抗咳嗽剂用于抑制由于感冒和过敏引起的咳嗽。该新方法利用适于鼻内给药的右美沙芬剂型。

3. 发明授权

US5221698A Bioactive composition 失效
标题翻译：生物组成
公开(公告)号：US5221698A
公开(公告)日：1993-06-22
申请号：US722511
申请日：1991-06-27
申请人： Gordon L. Amidon , Ramachandran Chandrasekharan , Arthur H. Goldberg
发明人： Gordon L. Amidon , Ramachandran Chandrasekharan , Arthur H. Goldberg
IPC分类号： A01N25/02 , A01N25/10 , A01N25/24 , A61K9/00 , A61K47/30 , A61K47/32 , A61K47/38 , C08L1/00 , C08L1/08 , C08L33/00 , C08L33/02 , C08L71/02
CPC分类号： A61K47/32 , A01N25/24 , A61K47/38 , A61K9/0019 , A61K9/0043 , Y10S514/944
摘要： An improved bioactive agent delivery composition and method of application are described. The composition comprises a bioactive agent, a hydrophilic polymer in an incompletely hydrated state and a substantially water-miscible solvent system. The agent and polymer are essentially dissolved in the solvent system to form a sprayable composition having a viscosity of less than 350 cP. Upon dilution with water, the viscosity of the composition increases to in excess of 1,000 cP to produce a retentive coating at the site of application which provides enhanced bioavailability of the agent.
摘要翻译：描述了改进的生物活性剂递送组合物和应用方法。组合物包含生物活性剂，不完全水合状态的亲水性聚合物和基本上与水混溶的溶剂体系。试剂和聚合物基本上溶解在溶剂体系中以形成粘度小于350cP的可喷雾组合物。当用水稀释时，组合物的粘度增加到超过1,000cP，以在施用部位产生保持性涂层，从而提高了药剂的生物利用度。

4. 发明授权

US06268368B1 Anionic exchange polymer complexes of buspirone 失效
标题翻译：丁螺环酮的阴离子交换聚合物配合物
公开(公告)号：US06268368B1
公开(公告)日：2001-07-31
申请号：US09516232
申请日：2000-03-01
申请人： Arthur H. Goldberg , Ahmed Adel Sakr
发明人： Arthur H. Goldberg , Ahmed Adel Sakr
IPC分类号： A61K31495
CPC分类号： A61K31/506 , A61K9/2027 , A61K9/2054 , A61K31/495 , A61K47/585
摘要： A controlled release form of buspirone medicament is described. This medicament comprises a buspirone in intimate admixture with an anionic exchange polymer complexing agent. These components form a complex upon the addition of water and thereby permit improved dosing of buspirone to achieve a more targeted therapeutic effect in patients.
摘要翻译：描述了丁螺环酮药物的控释形式。该药物包含与阴离子交换聚合物络合剂紧密混合的丁螺环酮。这些组分在添加水时形成复合物，从而允许改善剂量的丁螺环酮以在患者中达到更有针对性的治疗效果。

5. 发明授权

US5242949A Treating classic migraine 失效
标题翻译：治疗经典幻影
公开(公告)号：US5242949A
公开(公告)日：1993-09-07
申请号：US850566
申请日：1992-03-13
申请人： Arthur H. Goldberg , Leonard Lachman
发明人： Arthur H. Goldberg , Leonard Lachman
IPC分类号： A61K45/00 , A61K31/135 , A61K31/138 , A61K31/165 , A61K31/22 , A61K31/40 , A61K31/405 , A61K31/535 , A61K31/54 , A61P25/04 , A61P25/06 , A61P43/00
CPC分类号： A61K31/40 , A61K31/135 , A61K31/165 , A61K31/535 , Y10S514/944 , Y10S514/969
摘要： This invention relates to a method for treating classical migraine headaches. Pursuant to this method, a therapeutic amount of .beta.-adrenergic-blocking agent is administered to a person suffering a migraine attack promptly upon onset of aura. The invention further relates to a method wherein the blocking agent is nasally administered.
摘要翻译：本发明涉及治疗经典偏头痛的方法。根据该方法，治疗量的β-肾上腺素能阻断剂在光环发生时立即给予患有偏头痛发作的人。本发明还涉及一种其中封闭剂经鼻给药的方法。

6. 发明授权

US4950664A Nasal administration of benzodiazepine hypnotics 失效
标题翻译：鼻内给药苯二氮卓催眠药
公开(公告)号：US4950664A
公开(公告)日：1990-08-21
申请号：US245031
申请日：1988-09-16
申请人： Arthur H. Goldberg
发明人： Arthur H. Goldberg
IPC分类号： C07D243/24 , A61K9/00 , A61K9/08 , A61K9/10 , A61K31/55 , A61K31/551 , A61P25/20 , C07D243/16 , C07D243/18 , C07D487/04
CPC分类号： A61K31/55 , A61K9/0043
摘要： Nasal administration of benzodiazepines is described as providing improved therapeutic effects as compared to conventional delivery techniques. The compositions comprise a benzodiazepine hypnotic in a pharmaceutically acceptable nasal carrier.
摘要翻译：苯扎地他定的鼻内给药被描述为提供与常规递送技术相比改进的治疗效果。组合物包含在药学上可接受的鼻载体中催眠的苯并二氮杂。

7. 发明授权

US4349531A Novel dosage form 失效
公开(公告)号：US4349531A
公开(公告)日：1982-09-14
申请号：US81759
申请日：1979-10-04
申请人： Arthur R. Mlodozeniec , Arthur H. Goldberg
发明人： Arthur R. Mlodozeniec , Arthur H. Goldberg
IPC分类号： A61J3/00 , A61K9/20 , A61K9/28 , A61K9/70 , A61K9/24
CPC分类号： A61K9/2072 , A61J3/00 , A61K9/2095 , A61K9/28 , A61K9/70 , A61F2013/0296
摘要： Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.

8. 发明授权

US4083741A Novel dosage form 失效
标题翻译：新型剂型
公开(公告)号：US4083741A
公开(公告)日：1978-04-11
申请号：US709159
申请日：1976-07-27
申请人： Arthur H. Goldberg
发明人： Arthur H. Goldberg
IPC分类号： A61J3/00 , A61K9/20 , A61K9/28 , A61K9/70 , B65H81/00
CPC分类号： A61J3/00 , A61K9/2072 , A61K9/2095 , A61K9/28 , A61K9/70 , A61F2013/0296 , Y10T156/1016
摘要： Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Inclued in the scope of the disclosed invention are certain apparatus and methods of manufacture.
摘要翻译：药物剂型包括其上沉积有或在其上至少部分地具有颗粒药物的可食性网状物，其后制备并完成了所述腹板，其没有在外表面上暴露的药物的药学上优选的固体剂型。剂型具有药物释放的一致性，其可以被控制到严格的规格。所公开的固体剂型通过高速自动化设备制备，并且其制备方法的特征在于在线进行的非破坏性的质量控制分析和性能评估，并集成到制造操作中。在所公开的发明的范围内包含某些装置和制造方法。

9. 发明授权

US5707653A Ulcer treating composition comprising sufalcrate and antibiotic 失效
标题翻译：包含硫酸钙和抗生素的溃疡治疗组合物
公开(公告)号：US5707653A
公开(公告)日：1998-01-13
申请号：US544444
申请日：1995-11-17
申请人： Arthur H. Goldberg
发明人： Arthur H. Goldberg
IPC分类号： A61K31/70
CPC分类号： A61K31/70
摘要： Pharmaceutical compositions comprising an antibiotic adsorbed onto a disaccharide polysulfate-aluminum compound such as sucralfate are effective for the treatment of ulcers. The composition adherently coats the ulcer, protecting it while imparting an antibiotic activity which accelerates healing.
摘要翻译：包含吸附在二糖多硫酸盐 - 铝化合物如硫糖铝上的抗生素的药物组合物对于治疗溃疡是有效的。该组合物粘附地涂覆溃疡，保护它，同时赋予加速愈合的抗生素活性。

10. 发明授权

US5498636A Treatment of angina pectoris 失效
标题翻译：治疗心绞痛
公开(公告)号：US5498636A
公开(公告)日：1996-03-12
申请号：US349149
申请日：1994-12-02
申请人： Arthur H. Goldberg , Leonard Lachman
发明人： Arthur H. Goldberg , Leonard Lachman
IPC分类号： A61K31/00 , A61K31/138 , A61K31/165 , A61K31/166 , A61K31/404 , A61K31/5377 , A61K31/535 , A61K31/135 , A61K31/405
CPC分类号： A61K31/5377 , A61K31/00 , A61K31/138 , A61K31/165 , A61K31/166 , A61K31/404
摘要： This invention relates to a method for treating angina pectoris. Pursuant to this method, a .beta.-adrenergic-blocking agent is administered acutely to a person having angina to provide an essentially immediate, therapeutic amount of bioavailable blocking agent. The invention further relates to a method wherein the blocking agent is nasally administered for this purpose.
摘要翻译：本发明涉及治疗心绞痛的方法。根据该方法，将β-肾上腺素能阻断剂急性施用于具有心绞痛的人，以提供基本上即时的治疗量的生物可利用的封闭剂。本发明还涉及一种方法，其中所述封闭剂为此目的经鼻给药。

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