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1. 发明授权

US10154981B2 Use of a feed composition for reducing methane emission in ruminants, and/or to improve ruminant performance 有权
公开(公告)号：US10154981B2
公开(公告)日：2018-12-18
申请号：US14119990
申请日：2012-05-25
申请人： Stephane Duval , Irmgard Immig , Maik Kindermann , Gilbert Weber
发明人： Stephane Duval , Irmgard Immig , Maik Kindermann , Gilbert Weber
IPC分类号： A23K50/30 , A23K20/163 , A23K20/10 , A61K31/21 , A61K31/221 , A61K31/24 , A61K31/255 , A61K31/275 , A61K31/34 , A61K31/351 , A61K31/4406 , A61K31/04 , A61K31/44 , A23K20/105 , A23K20/195 , A23K50/10 , A61K9/00 , A61K31/215 , A61K31/22 , A61K31/23 , A61K31/235 , A61K31/35 , A61K45/06
摘要： The present invention relates to the field of reduction of methane emission in ruminants. Particularly, it relates to the use of a feed composition or a feed additive comprising at least one antibiotic and at least one organic molecule substituted at any position with at least one nitrooxy group for reducing the production of methane emanating from the digestive activities of ruminants, and/or to improve the ruminant performance.

2. 发明申请

US20090186373A1 Pyrimidines reacting with O6-Alkylguanine-DNA alkyltransferase 有权
标题翻译：嘧啶与O6-烷基鸟嘌呤-DNA烷基转移酶反应
公开(公告)号：US20090186373A1
公开(公告)日：2009-07-23
申请号：US11918936
申请日：2006-04-25
申请人： Maik Kindermann , Markus Schwab
发明人： Maik Kindermann , Markus Schwab
IPC分类号： C12Q1/02 , C07D405/12 , G01N33/68
CPC分类号： C07D239/47 , C07D405/12 , C07D495/04
摘要： The invention relates to pyrimidines suitable as substrates for O6-alkylguanine-DNA alkyltransferases (AGT) of formula (I) wherein R1 is hydrogen, lower alkyl, halogen, cyano, trifluoromethyl or azido; R2 is a linker; and L is a label or a plurality of same or different labels. The invention further relates to methods of transferring a label from pyrimidines of formula (I) to O6-alkylguanine-DNA alkyltransferases (AGT) and AGT fusion proteins.
摘要翻译：本发明涉及适合作为式（I）的O6-烷基鸟嘌呤-DNA烷基转移酶（AGT）的底物的嘧啶，其中R 1是氢，低级烷基，卤素，氰基，三氟甲基或叠氮基; R2是连接体; L是标签或多个相同或不同的标签。本发明还涉及将标记从式（I）的嘧啶转移到O6-烷基鸟嘌呤-DNA烷基转移酶（AGT）和AGT融合蛋白的方法。

3. 发明申请

US20140147529A1 USE OF NITROOXY ORGANIC MOLECULES IN FEED FOR REDUCING METHANE EMISSION IN RUMINANTS, AND/OR TO IMPROVE RUMINANT PERFORMANCE 有权
标题翻译：在饲料中使用硝基有机分子以减少发酵中的甲烷排放和/或提高发酵剂性能
公开(公告)号：US20140147529A1
公开(公告)日：2014-05-29
申请号：US13996026
申请日：2011-12-20
申请人： Stephane Duval , Maik Kindermann
发明人： Stephane Duval , Maik Kindermann
IPC分类号： C07C203/04 , C07D493/04 , C07D213/82 , C07D307/72 , A61K31/21 , A23K1/18 , A61K31/4406 , A61K31/345 , A61K31/22 , A61K31/216 , A61K45/06 , A23K1/16 , C07C311/03 , A61K31/34
CPC分类号： C07C203/04 , A23K20/10 , A23K20/105 , A23K20/111 , A23K20/121 , A23K50/10 , A61K31/04 , A61K31/045 , A61K31/08 , A61K31/18 , A61K31/21 , A61K31/216 , A61K31/22 , A61K31/24 , A61K31/275 , A61K31/34 , A61K31/345 , A61K31/4406 , A61K45/06 , C07C207/02 , C07C207/04 , C07C255/11 , C07C311/03 , C07C311/24 , C07D213/82 , C07D307/72 , C07D493/04 , Y02P60/56
摘要： The present invention relates to a method for reducing the production of methane emanating from the digestive activities of a ruminant and/or for improving ruminant animal performance by using, as active compound at least one organic molecule substituted at any position with at least one nitrooxy group, or a salt thereof, which is administrated to the animal together with the feed. The invention also relates to the use of these compounds in feed and feed additives such as premix, concentrates and total mixed ration (TMR) or in the form of a bolus.
摘要翻译：本发明涉及通过使用至少一个有机分子在至少一个硝基氧基取代的有机分子作为活性化合物，减少由反刍动物的消化活性产生的甲烷和/或改善反刍动物性能的方法，或其盐，其与饲料一起施用于动物。本发明还涉及这些化合物在饲料和饲料添加剂如预混物，浓缩物和总混合比例（TMR）中或在丸剂形式中的用途。

4. 发明授权

US08227602B2 Labelling of fusion proteins with synthetic probes 有权
标题翻译：用合成探针标记融合蛋白
公开(公告)号：US08227602B2
公开(公告)日：2012-07-24
申请号：US12309554
申请日：2007-07-24
申请人： Arnaud Gautier , Kai Johnsson , Maik Kindermann , Alexandre Juillerat , Florent Beaufils
发明人： Arnaud Gautier , Kai Johnsson , Maik Kindermann , Alexandre Juillerat , Florent Beaufils
IPC分类号： C07D239/02
CPC分类号： G01N33/581 , C07D239/47 , C07D403/14 , C07D405/12 , C07D487/04 , C12N9/12 , C12Q1/48
摘要： The invention relates to new proteins called alkylcytosine transferases (ACTs) derived from O6-alkylguanine-DNA alkyltransferase, and to substrates for ACTs specifically transferring a label to these ACTs and to fusion proteins comprising these. The substrates according of the invention are substituted cytosines of formula (I) wherein R1 is an aromatic or a heteroaromatic group, or an optionally substituted unsaturated alkyl, cycloalkyl or heterocyclyl group with the double bond connected to OCH2—; R2 is a linker; and L is a label or a plurality of same or different labels. The invention further relates to methods of transferring label L from these substrates of formula (I) to ACTs and ACT fusion proteins. The system of ACT-compound of formula (I) is particularly suitable for double labelling studies together with the known system O6-alkylguanine-DNA alkyltransferase (AGT)-benzylguanines.
摘要翻译：本发明涉及从O6-烷基鸟嘌呤-DNA烷基转移酶衍生的称为烷基胞嘧啶转移酶（ACT）的新蛋白质，以及特异性将标记转移至这些ACT的ACT的底物和包含它们的融合蛋白。根据本发明的底物是其中R 1是芳族或杂芳族基团的式（I）的取代的胞嘧啶或具有与OCH 2连接的双键的任选取代的不饱和烷基，环烷基或杂环基; R2是连接体; L是标签或多个相同或不同的标签。本发明还涉及将标记L从这些式（I）底物转移到ACT和ACT融合蛋白的方法。式（I）的ACT-化合物的系统特别适用于已知的系统O6-烷基鸟嘌呤-DNA烷基转移酶（AGT） - 苄基胍的双重标记研究。

5. 发明授权

US08163479B2 Specific substrates for O6-alkylguanine-DNA alkyltransferase 有权
标题翻译： O6-烷基鸟嘌呤-DNA烷基转移酶的特异性底物
公开(公告)号：US08163479B2
公开(公告)日：2012-04-24
申请号：US10591162
申请日：2005-03-01
申请人： Hughes Jaccard , Kai Johnsson , Maik Kindermann , India Christina Sielaff
发明人： Hughes Jaccard , Kai Johnsson , Maik Kindermann , India Christina Sielaff
IPC分类号： C07D473/18 , C07D519/00 , C07D495/04 , C07D473/40
CPC分类号： C07D473/18
摘要： The invention relates to substrates for O6-alkylguanine-DNA alkyltransferases (AGT) of formula R1-A-X—CH2—R3—R4-L1, wherein A is a group recognized by AGT as a substrate, X is oxygen or sulfur, R1 is a group —R2-L2 or a group R5, R2 and R4 are, independently of each other, a linker, R3 is an aromatic or a heteroaromatic group, or an optionally substituted unsaturated alkyl, cycloalkyl or heterocyclyl group with the double bond connected to CH2, R5 is arylmethyl or heteroarylmethyl or an optionally substituted cycloalkyl, cycloalkenyl or heterocyclyl group, L1 is a label, a plurality of same or different labels, a bond connecting R4 to A forming a cyclic substrate, or a further group —R3—CH2—X-A-R1, and L2 is a label or a plurality of same or different labels. The invention further relates to methods of transferring a label from these substrates to O6-alkylguanine-DNA alkyltransferases (AGT) and AGT fusion proteins.
摘要翻译：本发明涉及式R1-AX-CH2-R3-R4-L1的O6-烷基鸟嘌呤-DNA烷基转移酶（AGT）的底物，其中A为被AGT识别为底物的基团，X为氧或硫，R1为基团-R2-L2或基团R5，R2和R4彼此独立地是连接基，R3是芳族或杂芳族基团，或任选取代的不饱和烷基，环烷基或杂环基，其双键与CH2连接 R 5是芳基甲基或杂芳基甲基或任选取代的环烷基，环烯基或杂环基，L1是标记，多个相同或不同的标记，连接R4与A形成环状底物的键或另外的基团-R 3 -CH 2 - XA-R1和L2是标签或多个相同或不同的标签。本发明还涉及将标记从这些底物转移到O6-烷基鸟嘌呤-DNA烷基转移酶（AGT）和AGT融合蛋白的方法。

6. 发明申请

US20110207157A1 Labelling of Fusion Proteins With Synthetic Probes 有权
标题翻译：用合成探针标记融合蛋白
公开(公告)号：US20110207157A1
公开(公告)日：2011-08-25
申请号：US12309554
申请日：2007-07-24
申请人： Arnaud Gautier , Kai Johnsson , Maik Kindermann , Alexandrc Juillerat , Florent Beaufils
发明人： Arnaud Gautier , Kai Johnsson , Maik Kindermann , Alexandrc Juillerat , Florent Beaufils
IPC分类号： C12Q1/48 , C12N9/10 , C40B30/00 , C07D239/47 , C07D405/12 , C07D403/14 , C07D495/04 , C07D493/10 , C12N9/96
CPC分类号： G01N33/581 , C07D239/47 , C07D403/14 , C07D405/12 , C07D487/04 , C12N9/12 , C12Q1/48
摘要： The invention relates to new proteins called alkylcytosine transferases (ACTs) derived from O6-alkylguanine-DNA alkyltransferase, and to substrates for ACTs specifically transferring a label to these ACTs and to fusion proteins comprising these. The substrates according of the invention are substituted cytosines of formula (I) wherein R1 is an aromatic or a heteroaromatic group, or an optionally substituted unsaturated alkyl, cycloalkyl or heterocyclyl group with the double bond connected to OCH2—; R2 is a linker; and L is a label or a plurality of same or different labels. The invention further relates to methods of transferring label L from these substrates of formula (I) to ACTs and ACT fusion proteins. The system of ACT-compound of formula (I) is particularly suitable for double labelling studies together with the known system O6-alkylguanine-DNA alkyltransferase (AGT)-benzylguanines.
摘要翻译：本发明涉及从O6-烷基鸟嘌呤-DNA烷基转移酶衍生的称为烷基胞嘧啶转移酶（ACT）的新蛋白质，以及将这些ACT特异性转移标记物的ACT和包含这些酶的融合蛋白质的底物。根据本发明的底物是其中R 1是芳族或杂芳族基团的式（I）的取代的胞嘧啶或具有与OCH 2连接的双键的任选取代的不饱和烷基，环烷基或杂环基; R2是连接体; L是标签或多个相同或不同的标签。本发明还涉及将标记L从这些式（I）底物转移到ACT和ACT融合蛋白的方法。式（I）的ACT-化合物的系统特别适用于已知的系统O6-烷基鸟嘌呤-DNA烷基转移酶（AGT） - 苄基胍的双重标记研究。

7. 发明申请

US20110059018A1 COVALENTLY BINDING IMAGING PROBES 审中-公开
标题翻译：大量绑定成像探针
公开(公告)号：US20110059018A1
公开(公告)日：2011-03-10
申请号：US12860544
申请日：2010-08-20
申请人： Karl-Ulrich WENDT , Maik KINDERMANN , Catherine MINIEJEW , Anja GLOBISCH
发明人： Karl-Ulrich WENDT , Maik KINDERMANN , Catherine MINIEJEW , Anja GLOBISCH
IPC分类号： A61K49/00 , C07D295/215 , C07D295/155 , C07D487/04 , C07D413/12 , C07D495/04 , C07D311/82 , C07D403/06 , C12Q1/02 , G01N21/00
CPC分类号： C07D295/215 , C07D209/14 , C07D311/82 , C07D487/04 , C07D495/04
摘要： The present invention relates to molecular probes of the formula (I) L1-R1-L-A-X (I) as defined herein that allow for the observation of the catalytic activity of a selected caspase, cathepsin, MMP and carboxypeptidase in in vitro assays, in cells or in multicellular organisms, a method for their preparation and the use thereof.
摘要翻译：本发明涉及如本文所定义的式（I）L1-R1-LAX（I）的分子探针，其允许在体外测定中观察细胞中所选择的胱天蛋白酶，组织蛋白酶，MMP和羧肽酶的催化活性或多细胞生物体，其制备方法及其用途。

8. 发明授权

US09266814B2 Use of nitrooxy organic molecules in feed for reducing methane emission in ruminants, and/or to improve ruminant performance 有权
标题翻译：在饲料中使用硝基氧有机分子来减少反刍动物中的甲烷排放，和/或改善反刍动物的表现
公开(公告)号：US09266814B2
公开(公告)日：2016-02-23
申请号：US13996026
申请日：2011-12-20
申请人： Stephane Duval , Maik Kindermann
发明人： Stephane Duval , Maik Kindermann
IPC分类号： A23K1/16 , A61K45/06 , A61K31/00 , A61K41/00 , C07C203/04 , A23K1/18 , A61K31/21 , A61K31/216 , A61K31/22 , A61K31/34 , A61K31/345 , A61K31/4406 , C07C311/03 , C07D213/82 , C07D307/72 , C07D493/04
CPC分类号： C07C203/04 , A23K20/10 , A23K20/105 , A23K20/111 , A23K20/121 , A23K50/10 , A61K31/04 , A61K31/045 , A61K31/08 , A61K31/18 , A61K31/21 , A61K31/216 , A61K31/22 , A61K31/24 , A61K31/275 , A61K31/34 , A61K31/345 , A61K31/4406 , A61K45/06 , C07C207/02 , C07C207/04 , C07C255/11 , C07C311/03 , C07C311/24 , C07D213/82 , C07D307/72 , C07D493/04 , Y02P60/56
摘要： The present invention relates to a method for reducing the production of methane emanating from the digestive activities of a ruminant and/or for improving ruminant animal performance by using, as active compound at least one organic molecule substituted at any position with at least one nitrooxy group, or a salt thereof, which is administrated to the animal together with the feed. The invention also relates to the use of these compounds in feed and feed additives such as premix, concentrates and total mixed ration (TMR) or in the form of a bolus.
摘要翻译：本发明涉及通过使用至少一个有机分子在至少一个硝基氧基取代的有机分子作为活性化合物来减少由反刍动物的消化活性产生的甲烷和/或改善反刍动物性能的方法，或其盐，其与饲料一起施用于动物。本发明还涉及这些化合物在饲料和饲料添加剂如预混物，浓缩物和总混合比例（TMR）中或在丸剂形式中的用途。

9. 发明授权

US08784871B2 Nitrooxy alkanoic acids and derivatives thereof in feed for reducing methane emission in ruminants, and/or to improve ruminant performance 有权
标题翻译：用于还原反刍动物甲烷排放的饲料中的硝基氧基链烷酸及其衍生物和/或改善反刍动物性能
公开(公告)号：US08784871B2
公开(公告)日：2014-07-22
申请号：US13514165
申请日：2010-12-10
申请人： Stephane Duval , Maik Kindermann
发明人： Stephane Duval , Maik Kindermann
IPC分类号： A23K1/18
CPC分类号： C07C203/04 , A23K20/105 , A23K20/174 , A23K50/10 , A61K31/21 , A61K31/215 , A61K45/06 , C07C235/06 , Y02P60/56
摘要： The present invention relates to a method for reducing the production of methane emanating from the digestive activities of a ruminant and or for improving ruminant animal performance by using, as active compound at least one nitrooxy alkanoic acid and/or derivative thereof, which is administrated to the animal together with the feed. The invention also relates to the use of these compounds in feed and feed additives such as premix, concentrates and total mixed ration (TMR) or in the form of a bolus.
摘要翻译：本发明涉及一种通过使用至少一种硝基氧基链烷酸和/或其衍生物作为活性化合物来降低由反刍动物的消化活性产生的甲烷的产生和/或用于改善反刍动物性能的方法。动物与饲料一起。本发明还涉及这些化合物在饲料和饲料添加剂如预混物，浓缩物和总混合比例（TMR）中或在丸剂形式中的用途。

10. 发明授权

US08771644B2 Imaging probes 有权
标题翻译：成像探头
公开(公告)号：US08771644B2
公开(公告)日：2014-07-08
申请号：US12549017
申请日：2009-08-27
申请人： Karl-Ulrich Wendt , Maik Kindermann , Anja Globisch
发明人： Karl-Ulrich Wendt , Maik Kindermann , Anja Globisch
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00 , A61B6/00
CPC分类号： C12Q1/37 , C07K5/06026 , C07K5/06078 , C07K5/0812 , C07K5/0827 , C07K5/1016 , C07K7/06
摘要： The present invention relates to molecular probes of the formula (I) {L1-R1-L}n-A-CO—NH—R2-L2 (I) as defined herein that allow for the observation of the catalytic activity of a selected cathepsin in in vitro assays, in cells or in multicellular organisms, a method for their preparation and the use thereof.
摘要翻译：本发明涉及如本文所定义的式（I）{L1-R1-L} nA-CO-NH-R2-L2（I）的分子探针，其允许观察所选组织蛋白酶的催化活性体外测定，细胞或多细胞生物体，其制备方法及其应用。

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