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1. 发明授权

US07479369B2 Use of eukaryotic genes affecting spindle formation or microtubule function during cell division for diagnosis and treatment of proliferative diseases 失效
标题翻译：在细胞分裂过程中影响纺锤体形成或微管功能的真核基因的使用，用于诊断和治疗增殖性疾病
公开(公告)号：US07479369B2
公开(公告)日：2009-01-20
申请号：US10572004
申请日：2004-09-15
申请人： Christophe Echeverri , Anthony Hyman , Pierre Gönczy , Birte Sönnichsen , Steven Jones , Andrew Walsh , Liisa Koski
发明人： Christophe Echeverri , Anthony Hyman , Pierre Gönczy , Birte Sönnichsen , Steven Jones , Andrew Walsh , Liisa Koski
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： A01K67/0336 , A01K2217/058 , A01K2227/703 , A01K2267/0331 , C07K14/4738 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2320/12
摘要： The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in spindle formation or microtubule function during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.
摘要翻译：本发明涉及几种秀丽隐杆线虫基因及其相应基因产物在细胞分裂期间纺锤体形成或微管功能中的重要功能作用，可通过RNA介导的干扰（RNAi）和鉴定和分离鉴定所述基因的功能直系同源物包括所有生物功能衍生物本发明还涉及所述基因和基因产物（包括所述直系同源物）在抗增殖剂的开发或分离中的用途，特别是其在适当的筛选测定中的用途，以及它们用于诊断和治疗增殖性和其他疾病。特别地，本发明涉及从所述基因衍生的小干扰RNA用于治疗增殖性疾病的用途。

2. 发明授权

US07368248B2 Eukaryotic cell division genes and their use in diagnosis and treatment of proliferative diseases 失效
标题翻译：真核细胞分裂基因及其在增殖性疾病诊断和治疗中的应用
公开(公告)号：US07368248B2
公开(公告)日：2008-05-06
申请号：US10415657
申请日：2001-11-09
申请人： Christophe Echeverri , Pierre Goenczy , Anthony Hyman , Steven Jones , Karen Oegema , Matthew Kirkham
发明人： Christophe Echeverri , Pierre Goenczy , Anthony Hyman , Steven Jones , Karen Oegema , Matthew Kirkham
IPC分类号： G01N33/53
CPC分类号： C07K14/43545 , A61K38/00
摘要： The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in cell division and proliferation processes that could be identified by means of RNA-medicated interference (RNAi) and to the identification and isolation of functional orthologues of said genes including all biologically-active derivatives thereof. The invention further relates to the use of said gene products (including said orthologues) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative diseases.
摘要翻译：本发明涉及几种秀丽隐杆线虫基因及其相应基因产物在细胞分裂和增殖过程中的重要功能作用，可以通过RNA药物干扰（RNAi）和识别和分离功能性直向同源物的所述基因，包括其所有生物活性衍生物。本发明还涉及所述基因产物（包括所述直系同源物）在抗增殖剂的开发或分离中的用途，特别是其在适当的筛选测定中的用途，以及它们在增殖性疾病的诊断和治疗中的应用。

3. 发明申请

US20070042981A1 Use of eukaryotic genes affecting chromatin separation for diagnosis and treatment of proliferative diseases 审中-公开
标题翻译：使用影响染色质分离的真核基因来诊断和治疗增殖性疾病
公开(公告)号：US20070042981A1
公开(公告)日：2007-02-22
申请号：US10572123
申请日：2004-09-15
申请人： Christophe Echeverri , Anthony Hyman , Pierre Gonczy , Birte Sonnichsen , Steven Jones , Andrew Walsh , Liisa Koski
发明人： Christophe Echeverri , Anthony Hyman , Pierre Gonczy , Birte Sonnichsen , Steven Jones , Andrew Walsh , Liisa Koski
IPC分类号： A61K48/00 , A61K39/395 , A61K38/55 , C12Q1/68 , G01N33/574
CPC分类号： C12N15/113 , A61K38/16 , A61K39/00 , A61K48/00 , C07K14/43545 , C07K14/43581 , C07K14/47 , C12N2799/021 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/57496
摘要： The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in chromatin separation during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof. The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.
摘要翻译：本发明涉及几种秀丽隐杆线虫基因及其相应的基因产物在细胞分裂期间染色质分离中的重要功能作用，可以通过RNA介导的干扰（RNAi）和识别和分离功能直系同源物的所述基因包括其所有生物功能衍生物。本发明还涉及所述基因和基因产物（包括所述直系同源物）在抗增殖剂的开发或分离中的用途，特别是其在适当的筛选测定中的用途，以及它们在增殖性和其它疾病的诊断和治疗中的用途。特别地，本发明涉及从所述基因衍生的小干扰RNA用于治疗增殖性疾病的用途。

4. 发明授权

US3536404A Automatic data storage and printing system 失效
标题翻译：自动数据存储和打印系统
公开(公告)号：US3536404A
公开(公告)日：1970-10-27
申请号：US3536404D
申请日：1968-04-29
申请人： ROBERT ANTHONY HYMAN , ENGLISH ELECTRIC COMPUTERS LTD
发明人： HYMAN ROBERT ANTHONY
IPC分类号： G06K17/00 , G11C13/04 , G03B
CPC分类号： G06K17/0016 , G11C13/04

5. 发明申请

US20070093438A1 Use of eukaryotic genes affecting spindle formation or microtubule function during cell division for diagnosis and treatment of proliferative diseases 失效
标题翻译：在细胞分裂过程中影响纺锤体形成或微管功能的真核基因的使用，用于诊断和治疗增殖性疾病
公开(公告)号：US20070093438A1
公开(公告)日：2007-04-26
申请号：US10572004
申请日：2004-09-15
申请人： Christophe Echeverri , Anthony Hyman , Pierre Gonczy , Birte Sonnichsen , Steven Jones , Andrew Walsh , Liisa Koski
发明人： Christophe Echeverri , Anthony Hyman , Pierre Gonczy , Birte Sonnichsen , Steven Jones , Andrew Walsh , Liisa Koski
IPC分类号： A61K48/00 , C40B40/08 , C40B30/06
CPC分类号： A01K67/0336 , A01K2217/058 , A01K2227/703 , A01K2267/0331 , C07K14/4738 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2320/12
摘要： The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in spindle formation or microtubule function during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.
摘要翻译：本发明涉及几种秀丽隐杆线虫基因及其相应基因产物在细胞分裂期间纺锤体形成或微管功能中的重要功能作用，可通过RNA介导的干扰（RNAi）和鉴定和分离鉴定所述基因的功能直系同源物包括所有生物功能衍生物本发明还涉及所述基因和基因产物（包括所述直系同源物）在抗增殖剂的开发或分离中的用途，特别是其在适当的筛选测定中的用途，以及它们用于诊断和治疗增殖性和其他疾病。特别地，本发明涉及从所述基因衍生的小干扰RNA用于治疗增殖性疾病的用途。

6. 发明授权

US06195152B1 Accessory for use in copying bound materials 失效
标题翻译：用于复制装订材料的附件
公开(公告)号：US06195152B1
公开(公告)日：2001-02-27
申请号：US09436993
申请日：1999-11-09
申请人： Miles Anthony Hyman
发明人： Miles Anthony Hyman
IPC分类号： G03B2752
CPC分类号： G03G15/605 , G03G2215/00282 , H04N1/1013 , H04N2201/0422 , H04N2201/0434
摘要： The invention provides an accessory for use in copying a page of a bound material using a copier having a scanning window and an optical reader on one side of the window. The accessory includes a page engaging member for engaging a face of the page to be copied, the page engaging member having a light transmitting element engageable with a main portion of the face, and a side edge engageable with the face near a binding region of the bound material. The light transmitting element is adapted to transmit light from the copier to the main portion and back to the copier for processing by the optical reader. The accessory further includes a locator coupled to the page engaging member for locating the page in a selected position relative to the light transmitting element and means coupled to the page engaging member for positioning the accessory relative to the copier with the light transmitting element in registration with the window. When the accessory is so positioned, the page of the bound material may be placed face down against the page engaging member in a selected position using the locator with the main portion of the face engaging the light transmitting element and the side edge engaging the face near the binding region such that an opposite page or pages of the bound material can be made to extend beyond said side edge in a direction towards the window to minimize stress to the binding region and to ensure that the page to be copied will lie effectively flat for the purpose of producing a clear or complete copy.
摘要翻译：本发明提供了一种用于使用具有扫描窗口的复印机和在窗口的一侧上的光学读取器来复制装订材料的页面的附件。附件包括用于接合要复制的页面的页面的页面接合构件，所述页面接合构件具有可与面部的主要部分接合的光透射元件和与所述面部的接合区域附近的面接合绑定材料。光发射元件适于将光从复印机传送到主要部分并且返回到复印机以由光学读取器进行处理。附件还包括联接到页面接合构件的定位器，用于将页面相对于光传输元件定位在选定位置，以及耦合到页面接合构件的装置，用于相对于复印机定位附件，光传输元件与窗户。当附件如此定位时，使用定位器将装订材料的页面面朝下放置在选定位置上，其中主体部分接合透光元件并且侧边缘接近面部装订区域使得可以使相对的页面或装订材料的页面沿着朝向窗口的方向延伸超过所述侧边缘，以使对结合区域的应力最小化，并确保要复制的页面有效地平坦，以便制作清晰或完整的副本的目的。

7. 发明授权

US07648827B2 Use of eukaryotic genes affecting cell cycle control or cell cycle progression for diagnosis and treatment of proliferative diseases 失效
标题翻译：使用影响细胞周期控制或细胞周期进程的真核基因来诊断和治疗增殖性疾病
公开(公告)号：US07648827B2
公开(公告)日：2010-01-19
申请号：US10572289
申请日：2004-09-15
申请人： Christophe Echeverri , Anthony Hyman , Pierre Gönczy , Birte Sönnichsen , Steven Jones , Andrew Walsh , Liisa Koski
发明人： Christophe Echeverri , Anthony Hyman , Pierre Gönczy , Birte Sönnichsen , Steven Jones , Andrew Walsh , Liisa Koski
IPC分类号： G01N33/574
CPC分类号： C12N15/113 , A61K38/17 , A61K39/00 , A61K48/00 , C07K14/43545 , C07K14/43581 , C07K14/4738 , C12Q1/6886 , C12Q2600/136 , G01N33/574 , G01N33/6893 , G01N2500/00
摘要： The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in cell cycle progression during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof. The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.
摘要翻译：本发明涉及几种秀丽隐杆线虫基因及其相应的基因产物在细胞分裂期间细胞周期进程中的重要功能作用，可通过RNA介导的干扰（RNAi）鉴定和鉴定和分离功能所述基因的直向同源物包括其所有生物功能衍生物。本发明还涉及所述基因和基因产物（包括所述直系同源物）在抗增殖剂的开发或分离中的用途，特别是其在适当的筛选测定中的用途，以及它们在增殖性和其它疾病的诊断和治疗中的用途。特别地，本发明涉及从所述基因衍生的小干扰RNA用于治疗增殖性疾病的用途。

8. 发明申请

US20050101773A1 Genes required for viability and/or reproduction in c. elegans and their use in the development of anti-nematode agents 审中-公开
标题翻译： c。生存能力和/或繁殖所需的基因。线虫及其用于开发抗线虫剂
公开(公告)号：US20050101773A1
公开(公告)日：2005-05-12
申请号：US10415656
申请日：2001-11-09
申请人： Christophe Echeverri , Pierre Goenczy , Anthony Hyman , Steven Jones , Karen Oegema , Matthew Kirkham
发明人： Christophe Echeverri , Pierre Goenczy , Anthony Hyman , Steven Jones , Karen Oegema , Matthew Kirkham
IPC分类号： G01N33/50 , A61K31/7052 , A61K38/00 , A61K39/395 , A61K48/00 , A61P33/00 , C07K14/435 , C07K14/44 , C07K16/20 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , C07H21/02 , C07H21/04
CPC分类号： C07K14/43545
摘要： The present invention relates to several C. elegans genes and gene products identified by means of RNA-mediated interference (RNAi) as required for the viability, growth or reproduction of nematodes and to functional orthologues of said genes and gene products found in other nematode species, including all biologically-active derivatives thereof. The invention also comprises the use of said genes and gene products in the development of anti-nematode or other pesticidal agents and in methods for diagnosis and treatment of diseases associated with the infection or presence of nematodes.
摘要翻译：本发明涉及通过RNA介导的干扰（RNAi）鉴定的几种秀丽隐杆线虫基因和基因产物，其是线虫的活力，生长或繁殖以及所述基因的功能直向同源物以及在其它线虫种中发现的基因产物，包括其所有生物活性衍生物。本发明还包括所述基因和基因产物在抗线虫或其它杀虫剂的开发中的用途以及用于诊断和治疗与感染或存在线虫有关的疾病的方法。

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