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1. 发明申请

US20130233501A1 MODIFICATION OF XYLAN 审中-公开
标题翻译： XYLAN的修改
公开(公告)号：US20130233501A1
公开(公告)日：2013-09-12
申请号：US13703223
申请日：2011-06-07
申请人： Willem Heber Van Zyl , Annie Fabian Abel Chimphango , Johann Ferdinand Gorgens
发明人： Willem Heber Van Zyl , Annie Fabian Abel Chimphango , Johann Ferdinand Gorgens
IPC分类号： D21H17/24
CPC分类号： D21H17/24 , C09D105/14 , C12P19/04 , C12P2203/00 , C12Y302/01055 , C12Y302/01139 , D21C9/005 , D21H11/20
摘要： The invention provides a method of modifying soluble xylan which contains glucuronic acid and/or arabinose side chains so that it can be adsorbed onto other substrates. The method includes the steps of enzymatically modifying the xylan by selectively removing glucuronic acid and/or arabinose side chains from the xylan with α-D-glucuronidase and/or α-L-arabinofuranosidase, and allowing the modified xylan to adsorb onto the substrate. The substrate may be a cellulosic substrate like pulp or paper or a non-cellulosic substrate. The enzymes are able to remove a sufficient number of the xylan side chains so as to decrease water solubility of the xylan, induce xylan precipitation and allow adsorption of the xylan onto other substrates. A pulping process which incorporates modification of xylan and adsorption onto cellulosic material is also provided, as are products which contain the modified xylan.
摘要翻译：本发明提供了一种修饰含有葡糖醛酸和/或阿拉伯糖侧链的可溶性木聚糖的方法，使其可以吸附到其它底物上。该方法包括以下步骤：通过用α-D-葡糖醛酸糖苷酶和/或α-L-阿拉伯呋喃糖苷酶选择性地除去来自木聚糖的葡糖醛酸和/或阿拉伯糖侧链，并且使改性的木聚糖吸附在基材上，酶促改性木聚糖。基材可以是纤维素基质如纸浆或纸或非纤维素基质。酶能够除去足够数量的木聚糖侧链，以降低木聚糖的水溶性，诱导木聚糖沉淀并允许木聚糖吸附到其它底物上。还提供了将木聚糖修饰和吸附到纤维素材料上的制浆方法，以及含有改性木聚糖的产品。

2. 发明申请

US20130089592A1 METHOD OF PRODUCING A HYDROGEL 审中-公开
标题翻译：生产水凝胶的方法
公开(公告)号：US20130089592A1
公开(公告)日：2013-04-11
申请号：US13703228
申请日：2011-06-07
申请人： Willem Heber Van Zyl , Annie Fabian Abel Chimphango , Johann Ferdinand Gorgens
发明人： Willem Heber Van Zyl , Annie Fabian Abel Chimphango , Johann Ferdinand Gorgens
IPC分类号： A61K47/36 , A61K9/48 , C12P19/04 , A61K38/44
CPC分类号： A61K47/36 , A61K9/06 , A61K9/4833 , A61K9/5161 , A61K38/44 , B82Y5/00 , C08L5/14 , C12N11/04 , C12N11/10 , C12P19/04 , C12P19/14 , Y10S977/906
摘要： The invention provides a method of enzymatically modifying xylan by selectively removing glucuronic acid and/or arabinose side chains from the xylan with a-D-glucuronidase and/or a-L-arabinofuranosidase, and allowing the modified xylan to form into a hydrogel when the xylan becomes insoluble. A bioactive substance, such as a protein, enzyme, antimicrobial agent, bactericide or pharmaceutical compound can be added to the xylan so that the substance is encapsulated within the hydrogel or incorporated onto its surface. The hydrogel can be used as a drug delivery agent, such as for sustained-release or targeted drug delivery, rectal drug delivery or a dressing for a wound, burn or scar. The hydrogel can also be used as a coating, such as on medical gloves, catheters, surgical drainage systems, utensils or the like, or can be used in a scaffold for tissue engineering.
摘要翻译：本发明提供了一种通过用α-葡萄糖醛酸酶和/或α-阿拉伯呋喃糖苷酶选择性地除去来自木聚糖的葡糖醛酸和/或阿拉伯糖侧链来酶促修饰木聚糖的方法，并且当木聚糖变得不溶时，允许改性的木聚糖形成水凝胶。可以将生物活性物质如蛋白质，酶，抗微生物剂，杀菌剂或药物化合物加入到木聚糖中，使得物质被包封在水凝胶内或并入其表面。水凝胶可用作药物递送剂，例如用于缓释或靶向药物递送，直肠药物递送或用于伤口，烧伤或瘢痕的敷料。水凝胶也可以用作涂层，例如在医用手套，导管，手术排液系统，器具等上，或者可以用于组织工程的支架中。

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