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1. 发明授权

US10500230B2 Kidney-derived cells and methods of use in tissue repair and regeneration 有权
公开(公告)号：US10500230B2
公开(公告)日：2019-12-10
申请号：US11871045
申请日：2007-10-11
申请人： David C. Colter , Agnieszka Seyda , Charito S. Buensuceso , Anna Gosiewska
发明人： David C. Colter , Agnieszka Seyda , Charito S. Buensuceso , Anna Gosiewska
IPC分类号： C12N5/071 , A61K35/22 , A61K35/12
CPC分类号： A61K35/22 , C12N5/0686 , C12N5/0687 , A61K35/12 , C12N2533/40
摘要： Isolated or purified mammalian kidney-derived cell populations from mammalian kidney tissue are provided. Methods are provided for the isolation and purification of the mammalian kidney-derived cell population. Methods for treating kidney disease are provided by administration of the isolated or purified mammalian kidney-derived cell population to a mammalian subject.

2. 发明授权

US09498501B2 Postpartum cells derived from umbilical cord tissue, and methods of making and using the same 有权
公开(公告)号：US09498501B2
公开(公告)日：2016-11-22
申请号：US12389305
申请日：2009-02-19
申请人： Sanjay Mistry , Anthony J. Kihm , Ian R. Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Sanjay Mistry , Anthony J. Kihm , Ian R. Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
IPC分类号： C12N5/073 , A61K35/51 , A61K35/50 , C12N5/074 , A61K45/06 , A61K35/12
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.

3. 发明授权

US08722034B2 hUTC as therapy for Alzheimer's disease 有权
标题翻译： hUTC作为阿尔茨海默病的治疗
公开(公告)号：US08722034B2
公开(公告)日：2014-05-13
申请号：US12748170
申请日：2010-03-26
申请人： Anthony J. Kihm , Anna Gosiewska
发明人： Anthony J. Kihm , Anna Gosiewska
IPC分类号： A61K48/00 , A61K35/50 , C12N5/00 , A61K35/48 , C12N5/073 , C12N5/10 , C12N15/63
CPC分类号： A61K35/51 , A61K35/12 , A61K35/50 , C12N5/0605 , C12N5/10 , C12N15/63 , C12N2509/00 , C12N2510/00
摘要： Methods for treating Alzheimer's disease, or the symptoms of Alzheimer's disease, are provided. Some embodiments are to methods for treatment comprising administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells, such as cell derivatives. Some embodiments are to methods for treatment comprising hUTC. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
摘要翻译：提供了治疗阿尔茨海默病的方法或阿尔茨海默病的症状。一些实施方案涉及治疗方法，包括施用从人脐带组织获得的细胞，或施用包含这种细胞的药物组合物或由这样的细胞制备，例如细胞衍生物。一些实施方案涉及包含hUTC的治疗方法。还提供了用于本发明方法的药物组合物，以及用于实施该方法的试剂盒。

4. 发明授权

US08318483B2 Postpartum cells derived from umbilical cord tissue, and methods of making and using the same 有权
标题翻译：来自脐带组织的产后细胞，以及制造和使用它们的方法
公开(公告)号：US08318483B2
公开(公告)日：2012-11-27
申请号：US11481456
申请日：2006-07-06
申请人： Sanjay Mistry , Anthony J. Kihm , Ian Ross Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Anna Gosiewska
发明人： Sanjay Mistry , Anthony J. Kihm , Ian Ross Harris , Alexander M. Harmon , Darin J. Messina , Agnieszka Seyda , Anna Gosiewska
IPC分类号： C12N5/00
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
摘要翻译：公开了源自人脐带的细胞及其治疗用途的方法。描述了相对于其细胞表面标志物的细胞的分离技术，培养方法和详细表征，基因表达及其营养因子的分泌。

5. 发明授权

US07163920B2 Peptide with osteogenic activity 有权
标题翻译：具有成骨活性的肽
公开(公告)号：US07163920B2
公开(公告)日：2007-01-16
申请号：US10674516
申请日：2003-09-30
申请人： Sridevi Dhanaraj , Anna Gosiewska , Ali Rezania , George A. Heavner , Xuanhan Lin , Chin-Feng Yi
发明人： Sridevi Dhanaraj , Anna Gosiewska , Ali Rezania , George A. Heavner , Xuanhan Lin , Chin-Feng Yi
IPC分类号： A61F2/28 , A61K38/08 , C07K7/06
CPC分类号： A61K38/08 , A61K31/375 , A61K31/573 , A61K31/661 , A61K35/32 , A61K38/18 , A61K45/06 , A61L27/227 , A61K2300/00
摘要： The present invention provides a composition including an isolated or recombinant peptide component that has osteogenic cell proliferative activity. The peptide, which promotes proliferation of osteoblasts, is useful for treatment of fractures, as a filler in deficient sites of bone, for inhibition of decrease in bone substance related to osteoporosis and periodontic diseases, and for prevention of fractures associated with osteoporosis and rheumatoid arthritis. The peptide, or cells that have been genetically engineered to produce the peptide, can be combined with a bone-compatible matrix to facilitate slow release of the peptide to a treatment site and/or provide a structure for developing bone.
摘要翻译：本发明提供了包含具有成骨细胞增殖活性的分离或重组的肽组分的组合物。促进成骨细胞增殖的肽可用于治疗骨折，作为骨缺损部位的填充物，用于抑制与骨质疏松症和牙周病相关的骨质减少，以及用于预防与骨质疏松症和类风湿性关节炎相关的骨折。已经经遗传工程化以产生肽的肽或细胞可以与骨相容性基质组合以促进肽缓慢释放到治疗部位和/或提供用于发展骨的结构。

6. 发明申请

US20060234376A1 Repair and regeneration of ocular tissue using postpartum-derived cells 审中-公开
标题翻译：使用产后来源的细胞修复和再生眼组织
公开(公告)号：US20060234376A1
公开(公告)日：2006-10-19
申请号：US11317574
申请日：2005-12-23
申请人： Sanjay Mistry , Darin Messina , Ian Harris , Alexander Harmon , Anthony Kihm , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
发明人： Sanjay Mistry , Darin Messina , Ian Harris , Alexander Harmon , Anthony Kihm , Agnieszka Seyda , Chin-Feng Yi , Anna Gosiewska
IPC分类号： C12N5/08
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of ocular tissue using the postpartum-derived cells are also disclosed.
摘要翻译：公开了产自产后脐带和胎盘的细胞。还公开了使用产后来源细胞再生或修复眼组织的药物组合物，装置和方法。

7. 发明申请

US20050214377A1 Microparticles for cell delivery 审中-公开
标题翻译：用于细胞传递的微粒
公开(公告)号：US20050214377A1
公开(公告)日：2005-09-29
申请号：US11081247
申请日：2005-03-16
申请人： Sanjay Mistry , Iksoo Chun , Darin Messina , Anna Gosiewska
发明人： Sanjay Mistry , Iksoo Chun , Darin Messina , Anna Gosiewska
IPC分类号： A61K9/14 , A61K9/16 , A61K9/50 , A61K35/12 , A61K35/30 , A61K35/51
CPC分类号： A61K9/0024 , A61K9/1647 , A61K9/167 , A61K35/12 , A61K35/30 , A61K35/51 , A61K38/1858 , A61K2300/00
摘要： The invention relates to microparticles and compositions containing the microparticles for use in delivering viable cells to specific regions in the body for treatment of diseases in the body, and to methods of treatment of such diseases, where the microparticles include a core containing an effective amount of a biologically active agent distributed there through, and a cell attached to the surface of the core, and where the compositions contain the microparticles and a vehicle for the microparticles.
摘要翻译：本发明涉及含有用于将活细胞递送到体内特定区域以用于治疗身体疾病的微粒和组合物的微粒和组合物，以及治疗这些疾病的方法，其中微粒包括含有有效量通过其分布的生物活性剂和附着于芯表面的细胞，组合物含有微粒和微粒载体。

8. 发明授权

US06712850B2 Porous tissue scaffolds for the repair and regeneration of dermal tissue 有权
标题翻译：多孔组织支架用于修复和再生真皮组织
公开(公告)号：US06712850B2
公开(公告)日：2004-03-30
申请号：US10016808
申请日：2001-11-30
申请人： Murty Narayan Vyakarnam , Mark Charles Zimmerman , Anna Gosiewska
发明人： Murty Narayan Vyakarnam , Mark Charles Zimmerman , Anna Gosiewska
IPC分类号： A61F210
CPC分类号： A61L27/56 , A61L27/18 , Y10S623/924 , Y10S623/925 , Y10S623/926 , C08L67/04
摘要： The present invention is a synthetic, biocompatible, bioabsorbable, porous foam tissue scaffolds possessing physicochemical properties suitable for use in the repair and regeneration of dermal tissue and to methods of preparing the foam scaffold.
摘要翻译：本发明是具有适合用于真皮组织的修复和再生的物理化学性质的合成，生物相容性，生物可吸收的多孔泡沫组织支架和制备泡沫支架的方法。

9. 发明授权

US06656488B2 Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering 有权
标题翻译：生物可吸收袋，含有组织工程不同生物吸收率的生物可吸收材料
公开(公告)号：US06656488B2
公开(公告)日：2003-12-02
申请号：US09832700
申请日：2001-04-11
申请人： Chin-Feng Yi , Anna Gosiewska , Susan Roweton
发明人： Chin-Feng Yi , Anna Gosiewska , Susan Roweton
IPC分类号： A61F200
CPC分类号： A61L27/52 , A61L27/58
摘要： A device for tissue engineering is formed of a porous bioabsorbable bag containing at least two bioabsorbable materials having different rates of bioabsorption such as beads of different degrading rates and a bioabsorbable binding gel such as fibrin that binds the bioabsorbable materials in relation to each other. Slow degrading beads and the bag may be made of a copolymer of poly(L-lactide) and poly(glycolide), and fast degrading beads may be made of gelatin. The bag may contain cells and/or wound healing stimulants such as growth factors. Hydrolyzing enzymes may be used to enhance biodegradation of polymers. The device can be used to promote in-growth of host tissue into a void by inserting the bag with its contents into the void and conforming the bag to a desired shape. The binding gel may be injected into the bag after being placed in the void .
摘要翻译：用于组织工程的装置由含有至少两种具有不同生物吸收速率的生物可吸收材料（例如不同降解率的珠子）和生物可吸收结合凝胶（例如纤维蛋白）的多孔生物可吸收袋形成，其结合生物可吸收材料相互之间。缓慢降解的珠和袋可以由聚（L-丙交酯）和聚（乙交酯）的共聚物制成，并且快速降解的珠可以由明胶制成。袋子可以含有细胞和/或伤口愈合兴奋剂如生长因子。水解酶可用于增强聚合物的生物降解。该装置可用于通过将其内含物插入到空隙中并将袋符合到期望的形状来促进宿主组织的生长成为空隙。结合凝胶在放入空隙后可以注入袋中。

10. 发明授权

US08491883B2 Treatment of amyotrophic lateral sclerosis using umbilical derived cells 有权
标题翻译：使用脐带血细胞治疗肌萎缩性侧索硬化
公开(公告)号：US08491883B2
公开(公告)日：2013-07-23
申请号：US13026995
申请日：2011-02-14
申请人： Anna Gosiewska , Alexander M. Harmon , Anthony J. Kihm , Carri H. Fang , Sridevi Dhanaraj
发明人： Anna Gosiewska , Alexander M. Harmon , Anthony J. Kihm , Carri H. Fang , Sridevi Dhanaraj
IPC分类号： C12N5/00 , C12N5/071 , C12N5/074 , C12N5/077
CPC分类号： C12N5/0605 , A61K35/12 , C12N5/0607 , C12N5/0622 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/12 , C12N2501/13 , C12N2501/21 , C12N2501/23 , C12N2501/385 , C12N2501/41 , C12N2502/02 , C12N2502/03 , C12N2506/02 , C12N2506/025 , C12N2506/03 , C12N2509/00 , C12N2533/50
摘要： This invention relates to methods of treating amyotrophic lateral sclerosis. In particular, the invention provides for methods of treating amyotrophic lateral sclerosis by administering umbilical cord tissue-derived cells, an effective amount of a substantially homogenous population of umbilical cord tissue-derived cells or a pharmaceutical composition comprising umbilical cord tissue-derived cells to a patient.
摘要翻译：本发明涉及治疗肌萎缩性侧索硬化症的方法。特别地，本发明提供了通过施用脐带组织来源的细胞，有效量的基本上均匀的脐带组织来源的细胞群或包含脐带组织来源的细胞的药物组合物来治疗肌萎缩性侧索硬化的方法患者。

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