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1. 发明授权

US09610447B2 Systems and methods for selecting pacing vectors based on site of latest activation for use with implantable cardiac rhythm management devices 有权
公开(公告)号：US09610447B2
公开(公告)日：2017-04-04
申请号：US13436578
申请日：2012-03-30
申请人： Cecilia Qin Xi , Diana Gavales , Andrew Miller , Andrew W. McGarvey , Zachary Briggs , David Bishop , Sharon Standage , Anil Keni , Richard Block , Heidi Hellman , Taryn Smith
发明人： Cecilia Qin Xi , Diana Gavales , Andrew Miller , Andrew W. McGarvey , Zachary Briggs , David Bishop , Sharon Standage , Anil Keni , Richard Block , Heidi Hellman , Taryn Smith
IPC分类号： A61N1/36 , A61N1/368
CPC分类号： A61N1/3686
摘要： Techniques are provided for use with an implantable cardiac stimulation device equipped with a multi-pole left ventricular (LV) lead and a right ventricular (RV) lead for identifying suitable pacing vectors. In one example, RV-LV delay times are measured while using different electrodes of the LV lead as cathodes for sensing. The LV electrode having the longest RV-LV delay time is identified and LV capture thresholds and diaphragmatic stimulation thresholds are measured for pacing vectors that employ that LV electrode as a cathode. Assuming at least one vector employing the selected LV electrode is found to have acceptable thresholds, the vector is selected for use in delivering pacing therapy with the selected LV electrode. If none of the pacing vectors employing the selected LV electrode has acceptable thresholds, another LV electrode is selected and the procedure is repeated. Examples with a multi-pole RV lead are also described.

2. 发明授权

US07865232B1 Method and system for automatically calibrating ischemia detection parameters 有权
标题翻译：自动校准缺血检测参数的方法和系统
公开(公告)号：US07865232B1
公开(公告)日：2011-01-04
申请号：US11835256
申请日：2007-08-07
申请人： Harish Krishnaswamy , Anil Keni
发明人： Harish Krishnaswamy , Anil Keni
IPC分类号： A61N1/362
CPC分类号： A61B5/0452 , A61B5/7203 , A61N1/3702 , A61N1/37247 , G16H40/40 , G16H40/63
摘要： A method and system for automatically determining ischemia detection parameters are provided. The method includes obtaining a baseline trace indicative of a cardiac behavior, determining an ischemia detection window based on at least one physiologic state indicator within the baseline trace, and automatically identifying a fiducial point based on the baseline segment trace. The baseline trace includes a baseline segment within the ischemia detection window; where the ischemia detection window and the fiducial point may constitute ischemia detection parameters.
摘要翻译：提供了一种自动确定缺血检测参数的方法和系统。该方法包括获得指示心脏行为的基线迹线，基于基线迹线内的至少一个生理状态指示符确定缺血检测窗口，以及基于基线段迹线自动识别基准点。基线迹线包括缺血检测窗口内的基线段; 其中缺血检测窗口和基准点可以构成缺血检测参数。

3. 发明申请

US20130261687A1 SYSTEMS AND METHODS FOR SELECTING PACING VECTORS BASED ON SITE OF LATEST ACTIVATION FOR USE WITH IMPLANTABLE CARDIAC RHYTHM MANAGEMENT DEVICES 有权
标题翻译：基于最新激活位置选择投影矢量的系统和方法，用于使用可移植的心脏RHYTHM管理设备
公开(公告)号：US20130261687A1
公开(公告)日：2013-10-03
申请号：US13436578
申请日：2012-03-30
申请人： Cecilia Qin Xi , Diana Gavales , Andrew Miller , Andrew W. McGarvey , Zachary Briggs , David Bishop , Sharon Standage , Anil Keni , Richard Block , Heidi Hellman , Taryn Smith
发明人： Cecilia Qin Xi , Diana Gavales , Andrew Miller , Andrew W. McGarvey , Zachary Briggs , David Bishop , Sharon Standage , Anil Keni , Richard Block , Heidi Hellman , Taryn Smith
IPC分类号： A61N1/368
CPC分类号： A61N1/3686
摘要： Techniques are provided for use with an implantable cardiac stimulation device equipped with a multi-pole left ventricular (LV) lead and a right ventricular (RV) lead for identifying suitable pacing vectors. In one example, RV-LV delay times are measured while using different electrodes of the LV lead as cathodes for sensing. The LV electrode having the longest RV-LV delay time is identified and LV capture thresholds and diaphragmatic stimulation thresholds are measured for pacing vectors that employ that LV electrode as a cathode. Assuming at least one vector employing the selected LV electrode is found to have acceptable thresholds, the vector is selected for use in delivering pacing therapy with the selected LV electrode. If none of the pacing vectors employing the selected LV electrode has acceptable thresholds, another LV electrode is selected and the procedure is repeated. Examples with a multi-pole RV lead are also described.
摘要翻译：技术提供用于配备有多极左心室（LV）引线和右心室（RV）引线的可植入心脏刺激装置，用于识别合适的起搏向量。在一个示例中，测量RV-LV延迟时间，同时使用LV引线的不同电极作为用于感测的阴极。识别具有最长RV-LV延迟时间的LV电极，并测量采用该LV电极作为阴极的起搏向量的LV捕获阈值和膈肌刺激阈值。假设使用所选择的LV电极的至少一个载体被发现具有可接受的阈值，则选择该载体用于与选定的LV电极递送起搏治疗。如果没有采用所选择的LV电极的起搏向导具有可接受的阈值，则选择另一LV电极并重复该过程。还描述了具有多极RV引线的示例。

4. 发明授权

US08108037B1 Methods and systems for identifying a vector for monitoring ischemia 有权
标题翻译：识别用于监测缺血的载体的方法和系统
公开(公告)号：US08108037B1
公开(公告)日：2012-01-31
申请号：US12834596
申请日：2010-07-12
申请人： Harish Krishnaswamy , Anil Keni
发明人： Harish Krishnaswamy , Anil Keni
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/6846
摘要： Methods and systems may identify a vector or a vector configuration, such as a combination of electrodes, for monitoring ischemia. The method may include: selecting a first combination of sensors as a first candidate to be used for monitoring ischemia; detecting a shift in a ST segment of one of an electrocardiogram and a cardiac electrogram using the first candidate; selecting a second combination of sensors as a second candidate to be used for monitoring ischemia; detecting a shift in a ST segment of one of an electrocardiogram and a cardiac electrogram using the second candidate; comparing the ST shifts for the first and second candidates; and identifying one of the first and second candidates for monitoring ischemia based on the comparison. A multi-electrode implantable cardiac device may include a controller configured to effectuate such functions.
摘要翻译：方法和系统可以识别用于监测缺血的载体或载体构型，例如电极的组合。该方法可以包括：选择传感器的第一组合作为用于监测缺血的第一候选物; 使用所述第一候选来检测心电图和心电图之一的ST段的移位; 选择传感器的第二组合作为用于监测缺血的第二候选者; 使用所述第二候选来检测心电图和心电图之一的ST段的移位; 比较第一和第二候选人的ST班次; 并且基于该比较来识别用于监测缺血的第一和第二候选者之一。多电极可植入心脏设备可以包括被配置为实现这样的功能的控制器。

5. 发明授权

US07778698B1 Method and systems for identifying a vector for monitoring ischemia 有权
标题翻译：识别用于监测缺血的载体的方法和系统
公开(公告)号：US07778698B1
公开(公告)日：2010-08-17
申请号：US11760479
申请日：2007-06-08
申请人： Harish Krishnaswamy , Anil Keni
发明人： Harish Krishnaswamy , Anil Keni
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/6846
摘要： Methods and systems may identify a vector or a vector configuration, such as a combination of electrodes, for monitoring ischemia. The method may include: selecting a first combination of sensors as a first candidate to be used for monitoring ischemia; detecting a shift in a ST segment of one of an electrocardiogram and a cardiac electrogram using the first candidate; selecting a second combination of sensors as a second candidate to be used for monitoring ischemia; detecting a shift in a ST segment of one of an electrocardiogram and a cardiac electrogram using the second candidate; comparing the ST shifts for the first and second candidates; and identifying one of the first and second candidates for monitoring ischemia based on the comparison. A multi-electrode implantable cardiac device may include a controller configured to effectuate such functions.
摘要翻译：方法和系统可以识别用于监测缺血的载体或载体构型，例如电极的组合。该方法可以包括：选择传感器的第一组合作为用于监测缺血的第一候选物; 使用所述第一候选来检测心电图和心电图之一的ST段的移位; 选择传感器的第二组合作为用于监测缺血的第二候选者; 使用所述第二候选来检测心电图和心电图之一的ST段的移位; 比较第一和第二候选人的ST班次; 并且基于该比较来识别用于监测缺血的第一和第二候选者之一。多电极可植入心脏设备可以包括被配置为实现这样的功能的控制器。

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