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1. 发明授权

US07605127B2 Truncated hepatocyte growth factor variant protein HGF/NK2 有权
标题翻译：截短肝细胞生长因子变体蛋白HGF / NK2
公开(公告)号：US07605127B2
公开(公告)日：2009-10-20
申请号：US10283769
申请日：2002-10-30
申请人： Andrew M. L. Chan , Jeffrey S. Rubin , Donald P. Bottaro , Stuart A. Aaronson , Stephen J. Stahl , Paul T. Wingfield , Vittoria Cioce
发明人： Andrew M. L. Chan , Jeffrey S. Rubin , Donald P. Bottaro , Stuart A. Aaronson , Stephen J. Stahl , Paul T. Wingfield , Vittoria Cioce
IPC分类号： C07K14/475 , A61K38/18
CPC分类号： A61K38/193 , C07K14/4753 , A61K2300/00
摘要： The present invention relates to a novel truncated form of heptocyte growth factor (HGF) which specifically antagonizes the activity of HGF and to a novel truncated form of HGF that is a partial HGF agonist. In particular, the present invention relates to the purification, molecular cloning, recombinant expression of the truncated HGF variants and related pharmaceutical compositions. The present invention further relates to the utilization of the small HGF variants to either inhibit HGF mitogenesis or stimulate HGF mitogenesis in cells expressing the receptor for HGF.
摘要翻译：本发明涉及特异性拮抗HGF的活性的新型截短形式的肝细胞生长因子（HGF）和作为部分HGF激动剂的新型截短形式的HGF。特别地，本发明涉及截短的HGF变体和相关药物组合物的纯化，分子克隆，重组表达。本发明还涉及小HGF变体在表达HGF受体的细胞中抑制HGF有丝分裂或刺激HGF有丝分裂发生的用途。

2. 发明授权

US06225088B1 DNA encoding plasminogen-like growth factor (PLGF) and related embodiments 失效
标题翻译：编码纤溶酶原样生长因子（PLGF）的DNA和相关实施方案
公开(公告)号：US06225088B1
公开(公告)日：2001-05-01
申请号：US09170573
申请日：1998-10-13
申请人： Jeffrey S. Rubin , Andrew M. L. Chan , Stuart A. Aaronson
发明人： Jeffrey S. Rubin , Andrew M. L. Chan , Stuart A. Aaronson
IPC分类号： C12N1518
CPC分类号： C07K14/4753 , A61K38/193 , A61K2300/00
摘要： The present invention relates to a potent mitogenic growth factor called plasminogen-like growth factor (PLGF) isolated from conditioned medium of human lung fibroblasts. The protein has an apparent molecular weight under reducing conditioning of 87 kDa and is structurally related to hepatocyte growth factor (HGF); however unlike HGF, which appears to be specific for hepatic cells, PLGF stimulates a wide spectrum of target cells including melanocytes, endothelial cells and epithelial cells but excludes fibroblast cells. The present invention further relates to recombinant cloned DNA fragments and expression cell systems expressing biologically active PLGF. The availability of purified PLGF as well as immunological and molecular probes should facilitate the study of proliferative disorders in which the factor plays an important role.
摘要翻译：本发明涉及从人肺成纤维细胞的条件培养基中分离的称为纤溶酶原样生长因子（PLGF）的有效促有丝分裂生长因子。该蛋白质在87 kDa的还原调节下具有明显的分子量，并且在结构上与肝细胞生长因子（HGF）有关; 然而，不同于似乎对肝细胞特异性的HGF，PLGF刺激大范围的靶细胞，包括黑素细胞，内皮细胞和上皮细胞，但不包括成纤维细胞。本发明还涉及表达生物活性PLGF的重组克隆DNA片段和表达细胞系统。纯化的PLGF以及免疫学和分子探针的可用性应有助于研究增殖性疾病，其中该因子起重要作用。

3. 发明授权

US06566098B1 DNA encoding truncated hepatocyte growth factor variants 失效
标题翻译：编码截短的肝细胞生长因子变体的DNA
公开(公告)号：US06566098B1
公开(公告)日：2003-05-20
申请号：US08484841
申请日：1995-06-07
申请人： Andrew M. L. Chan , Jeffrey S. Rubin , Donald P. Bottaro , Stuart A. Aaronson
发明人： Andrew M. L. Chan , Jeffrey S. Rubin , Donald P. Bottaro , Stuart A. Aaronson
IPC分类号： C12N1518
CPC分类号： A61K38/193 , C07K14/4753 , A61K2300/00
摘要： The present invention relates to a novel truncated forms of hepatocyte growth factor (HGF) which specifically antagonizes the activity of HGF and to a novel truncated form of HGF that is a partial HGF agonist. In particular, the present invention relates to the purification, molecular cloning, recombinant expression of the truncated HGF variants and related pharmaceutical compositions. The present invention further relates to the utilization of the small HGF variants to either inhibit HGF mitogenesis or stimulate HGF mitogenesis in cells expressing the receptor for HGF.
摘要翻译：本发明涉及特异性拮抗HGF的活性和作为部分HGF激动剂的新型截短形式的HGF的肝细胞生长因子（HGF）的新型截短形式。特别地，本发明涉及截短的HGF变体和相关药物组合物的纯化，分子克隆，重组表达。本发明还涉及小HGF变体在表达HGF受体的细胞中抑制HGF有丝分裂或刺激HGF有丝分裂发生的用途。

4. 发明授权

US5821223A Method of stimulating cell growth with a novel broad spectrum human lung fibroblast-derived mitogen 失效
标题翻译：用新型广谱人肺成纤维细胞衍生的丝裂原诱导细胞生长的方法
公开(公告)号：US5821223A
公开(公告)日：1998-10-13
申请号：US238742
申请日：1994-05-05
申请人： Jeffrey S. Rubin , Andrew M.-L. Chan , Stuart A. Aaronson
发明人： Jeffrey S. Rubin , Andrew M.-L. Chan , Stuart A. Aaronson
IPC分类号： A61K38/00 , A61K38/19 , C07K14/475 , C12N15/18 , C12N15/19 , A61K38/18
CPC分类号： C07K14/4753 , A61K38/193
摘要： The present invention relates to a potent mitogenic growth factor called plasminogen-like growth factor (PLGF) isolated from conditioned medium of human lung fibroblasts. The protein has an apparent molecular weight under reducing conditions of 87 kDa and is structurally related to hepatocyte growth factor (HGF); however unlike HGF, which was reported to be specific for hepatic cells, PLGF stimulates a wide spectrum of target cells including melanocytes, endothelial cells and epithelial cells but excludes fibroblast cells. The present invention further relates to recombinant cloned DNA fragments and expression cell systems expressing biologically active PLGF. The availability of purified PLGF as well as immunological and molecular probes should facilitate the study of proliferative disorders in which the factor plays an important role.
摘要翻译：本发明涉及从人肺成纤维细胞的条件培养基中分离的称为纤溶酶原样生长因子（PLGF）的有效促有丝分裂生长因子。该蛋白质在87 kDa的还原条件下具有表观分子量，并且在结构上与肝细胞生长因子（HGF）有关; 然而，不同于据报道对肝细胞特异性的HGF，PLGF刺激广谱的靶细胞，包括黑素细胞，内皮细胞和上皮细胞，但不包括成纤维细胞。本发明还涉及表达生物活性PLGF的重组克隆DNA片段和表达细胞系统。纯化的PLGF以及免疫学和分子探针的可用性应有助于研究增殖性疾病，其中该因子起重要作用。

5. 发明授权

US5648273A Hepatic growth factor receptor is the MET proto-oncogene 失效
标题翻译：肝细胞生长因子受体是MET原癌基因
公开(公告)号：US5648273A
公开(公告)日：1997-07-15
申请号：US642971
申请日：1991-01-18
申请人： Donald P. Bottaro , Jeffery S. Rubin , Donna Faletto , Andrew M.-L. Chan , George F. Vande Woude , Stuart A. Aaronson
发明人： Donald P. Bottaro , Jeffery S. Rubin , Donna Faletto , Andrew M.-L. Chan , George F. Vande Woude , Stuart A. Aaronson
IPC分类号： C07K17/00 , A61K38/00 , A61K38/18 , A61K38/19 , A61K38/48 , A61K39/395 , A61P35/00 , C07K14/475 , C07K14/52 , C07K14/705 , C07K14/71 , C07K14/82 , C07K16/00 , C07K16/22 , C07K16/24 , C07K16/28 , C07K16/32 , C07K19/00 , C12N5/06 , C12N5/08 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/574 , G01N33/576 , G01N33/68
CPC分类号： G01N33/6872 , A61K38/193 , C07K14/4753 , C07K14/71 , C07K14/82 , C07K16/22 , C07K16/32 , C12Q1/6813 , C12Q1/6886 , G01N33/57446 , C12Q2600/158
摘要： The present invention relates to a complex comprising hepatocyte growth factor (HGF) and met proto-oncogene protein. The present invention also relates to methods for detecting the presence of HGF ligand, met proto-oncogene receptor and methods for isolating either the ligand or receptor or complex comprising both. The present invention further relates to methods of diagnostic proliferative disorders and diseases such as hepatitis or hepatocarcinogenesis by detecting these ligand-receptor pairs.
摘要翻译：本发明涉及包含肝细胞生长因子（HGF）和met原癌基因蛋白的复合物。本发明还涉及用于检测HGF配体，met原癌基因受体的存在的方法和用于分离包含两者的配体或受体或复合物的方法。本发明还涉及通过检测这些配体 - 受体对来诊断增殖性疾病和诸如肝炎或肝癌发生的疾病的方法。

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