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1. 发明授权

US5254662A Biostable polyurethane products 失效
标题翻译：生物稳定聚氨酯产品
公开(公告)号：US5254662A
公开(公告)日：1993-10-19
申请号：US885927
申请日：1992-05-18
申请人： Michael Szycher , Andrew M. Reed
发明人： Michael Szycher , Andrew M. Reed
IPC分类号： A61L27/18 , C08G18/10 , C08G18/44 , C08G18/42
CPC分类号： C08G18/44 , A61L27/18 , C08G18/10
摘要： Polyurethane products having long-term biostability in combination with a low modulus of elasticity and a high ultimate tensile strength and other desireable mechanical properties which are particularly useful as leads for implantable pacemakers, as vascular grafts, as mammary prostheses, and as other products which are intended to be placed within the body of a mammal for extended periods with no substantial degradation of the product. The polyurethanes are prepared from the reaction of an organic diisocyanate, preferably an aliphatic or cycloaliphatic diisocyanate with polycarbonate glycol chained extended with diol, diamine or a mixture of diamine and alkanolamine.
摘要翻译：具有长期生物稳定性和低弹性模量以及高极限拉伸强度和其它期望的机械性能的聚氨酯产品，其特别用作植入式起搏器的导线，作为血管移植物，作为乳房假体，以及其它产品意在长期放置在哺乳动物的体内，没有产品的显着降解。聚氨酯由有机二异氰酸酯，优选脂肪族或脂环族二异氰酸酯与与二醇链接的聚碳酸酯二醇或二胺和链烷醇胺的混合物反应制备。

2. 发明授权

US5098500A Adhesive-faced porous absorbent sheet and method of making same 失效
标题翻译：粘合面多孔吸收性片材及其制造方法
公开(公告)号：US5098500A
公开(公告)日：1992-03-24
申请号：US481512
申请日：1990-02-15
申请人： Andrew M. Reed , Ian N. Askill
发明人： Andrew M. Reed , Ian N. Askill
IPC分类号： A61F13/00 , A61F13/02 , A61F13/15 , A61L15/26 , A61L15/42 , A61L15/58
CPC分类号： A61L15/26 , A61F13/023 , A61L15/425 , A61L15/58 , A61F2013/00255 , A61F2013/53081 , Y10T156/1056 , Y10T156/1057
摘要： A sheet-form material suitable as wound dressing and having enhanced moisture control properties is disclosed. This sheet-form material includes a porous sheet of absorbent, elastomeric segmented polyurethane having an open pore structure and an apertured adhesive facing on one side of the porous sheet. A liquid impermeable but water vapor permeable backing may be provided on the opposite side of the porous sheet, if desired. Also disclosed is a method for forming an apertured adhesive facing for the sheet-form material.
摘要翻译：公开了一种适合作为伤口敷料并具有增强的防潮性能的片状材料。该片状材料包括具有开孔结构的吸收性多孔片，弹性体分段聚氨酯和面向多孔片一侧的多孔粘合剂。如果需要，可以在多孔片的相对侧上设置不透液体但透水性的背衬。还公开了一种用于形成面向片状材料的多孔粘合剂的方法。

3. 发明授权

US4849458A Segmented polyether polyurethane 失效
标题翻译：分段聚醚聚氨酯
公开(公告)号：US4849458A
公开(公告)日：1989-07-18
申请号：US208153
申请日：1988-06-17
申请人： Andrew M. Reed , Ian N. Askill , Willis W. Weber
发明人： Andrew M. Reed , Ian N. Askill , Willis W. Weber
IPC分类号： A61F13/00 , C08G18/12 , C08G18/48 , C08G18/65 , C08G18/66 , C08G18/76 , C08J5/18
CPC分类号： C08G18/7671 , C08G18/12 , C08G18/4808
摘要： A hydrophilic, segmented polyether polyurethane-urea that exhibits an increase in tensile strength and elongation when wet with water and is capable of forming visually clear films permeable to water vapor is disclosed.

4. 发明授权

US4813966A Biocompatible microporous polymeric materials and methods of making same 失效
标题翻译：生物相容性微孔聚合材料及其制备方法
公开(公告)号：US4813966A
公开(公告)日：1989-03-21
申请号：US92643
申请日：1987-09-03
申请人： D. Keith Gilding , Andrew M. Reed , Ian N. Askill , Stephen G. Briana
发明人： D. Keith Gilding , Andrew M. Reed , Ian N. Askill , Stephen G. Briana
IPC分类号： A61L15/16 , A61F2/00 , A61F2/06 , A61F13/00 , A61F13/15 , A61L15/26 , A61L15/42 , A61L27/00 , A61L27/18 , B29C47/00 , C08J5/02 , C08J9/28
CPC分类号： C08J9/28 , A61F13/00995 , A61F13/0289 , A61F2/062 , A61L15/26 , A61L15/425 , A61L27/18 , B29C47/0021 , B29C47/8895 , A61F2013/00093 , A61F2013/00119 , A61F2013/00217 , A61F2013/15048 , A61F2013/530481 , A61F2250/0023 , B29C47/0023 , C08J2201/0544 , Y10T428/249953
摘要： A microporous biocompatible material is formed by preparing a segmented polyether urethane urea solution containing 25%.+-.1.5% solids dissolved in a solvent. The solution has sufficient viscosity to be preshaped and formed into the desired thickness of the finished article, then immediately immersed into a precipitation bath in which the solvent in the solution is miscible for a time interval sufficient to cause the solution to set up into an opaque elastomeric article. The article is immediately removed from the bath, any excess solvent extracted and then dried at a temperature on the order of 35.degree. C. to 70.degree. C. followed by heat treating by annealing for approximately sixty minutes at a temperature at 100.degree. C. to 130.degree. C. The void volume of the membrane solution is controlled to within the 50% to 80% range and the pore size from ca
摘要翻译：通过制备溶解在溶剂中的含有25％±1.5％固体的分段聚醚聚氨酯脲溶液形成微孔生物相容性材料。该溶液具有足够的粘度以预成型并形成成品的所需厚度，然后立即浸入沉淀浴中，其中溶液中的溶剂可混溶一段足以使溶液变成不透明的时间间隔弹性制品。立即从浴中取出制品，抽出任何多余的溶剂，然后在35℃至70℃的温度下干燥，然后在100℃的温度下退火约60分钟进行热处理。至130℃。膜溶液的空隙体积控制在50％至80％范围内，孔径从约0.1至数μm。以及它们之间的孔和固体结构的形状，从而能够根据其预期的应用和用途对材料的特性和结构进行密切控制，以及跨越材料的厚度的结构特性和孔隙的过度变化。

5. 发明授权

US4955905A Method and apparatus for monitoring pressure of human tissue expansion devices 失效
标题翻译：用于监测人体组织扩张装置的压力的方法和装置
公开(公告)号：US4955905A
公开(公告)日：1990-09-11
申请号：US371523
申请日：1989-06-26
申请人： Andrew M. Reed
发明人： Andrew M. Reed
IPC分类号： A61B17/03 , A61B19/00
CPC分类号： A61B90/06 , A61B90/02
摘要： A pressure monitor for use in connection with tissue expander envelopes implanted beneath the tissue of the skin wherein a liquid is injected into the envelope to cause expansion of the skin or tissue and additional liquid is periodically injected to cause progressively increased expansion of the tissue. The tissue monitor includes means extablishing direct communication between the pressure monitor and the liquid injected under pressure whereby the monitor will provide a reading of the internal liquid pressure in the envelope. The method comprises the steps of implanting an inflatable envelope beneath the skin, injecting a sterile solution under pressure through a fill line communicating with the envelope, interrupting the flow of liquid under pressure into the envelope, sensing the pressure level of liquid injected into the envelope, and adjusting the pressure level when necessary either by removing from or injecting liquid into the envelope.
摘要翻译：用于与植入皮肤组织下方的组织扩张器信封相关联的压力监视器，其中将液体注入到外壳中以引起皮肤或组织的膨胀，并且周期性地注入额外的液体以引起组织的逐渐增加的扩张。组织监测器包括在压力监测器和在压力下注入的液体之间直接连通的装置，由此监测器将提供对信封中内部液体压力的读数。该方法包括以下步骤：在皮肤下方注入可充气的包膜，在压力下将无菌溶液注入通过与外壳连通的填充线，中断液体在压力下的流动进入外壳，感测注入到外壳中的液体的压力水平并且当需要时通过从液体中移出或注入到信封中来调节压力水平。

6. 发明授权

US5653699A Spyrosorbent wound dressings for exudate management 失效
标题翻译：用于渗出物管理的吸收性伤口敷料
公开(公告)号：US5653699A
公开(公告)日：1997-08-05
申请号：US305273
申请日：1994-09-13
申请人： Andrew M. Reed , Jon M. Potter , Michael Szycher
发明人： Andrew M. Reed , Jon M. Potter , Michael Szycher
IPC分类号： A61F13/00 , A61F13/02
CPC分类号： A61F13/023 , A61F2013/0074 , A61F2013/00748 , A61F2013/00876
摘要： A sheet-form composite suitable as a spyrosorbent wound dressing and exhibiting differential moisture vapor transport rate properties is disclosed. The sheet-form composite includes a hydrophilic, monolithic film layer characterized by having a differential ratio of wet to dry moisture transport rate greater than 1 and a dry moisture transport rate greater than about 2,600 g/m.sup.2 /24 hrs. This film layer is laminated to a hydrophilic exudate transport layer. The exudate transport layer can itself be, or can further include, a hydrophilic pressure sensitive adhesive applied in a continuous or discontinuous pattern. The sheet-form composite has a moisture vapor transport rate of greater than 2,000 g/m.sup.2 /24 hrs when dry, and a wet to dry moisture vapor transport rate ratio in the range of about 1.5 to about 10.
摘要翻译：公开了一种适合作为间接吸收剂伤口敷料并呈现差别水汽输送速率性质的片状复合材料。片状复合材料包括亲水的整体膜层，其特征在于具有大于1的湿湿干燥输送速率的差异比率以及大于约2,600g / m 2/24小时的干燥水分输送速率。将该膜层层合到亲水性渗出物输送层上。渗出物输送层本身可以是或可以进一步包括以连续或不连续图案施加的亲水性压敏粘合剂。片状复合材料在干燥时具有大于2,000g / m 2/24小时的湿气输送速率，以及在约1.5至约10的范围内的湿湿蒸汽输送速率比。

7. 发明授权

US4906240A Adhesive-faced porous absorbent sheet and method of making same 失效
标题翻译：粘合面多孔吸收性片材及其制造方法
公开(公告)号：US4906240A
公开(公告)日：1990-03-06
申请号：US150539
申请日：1988-02-01
申请人： Andrew M. Reed , Ian N. Askill
发明人： Andrew M. Reed , Ian N. Askill
IPC分类号： A61F13/02 , A61F13/00 , A61F13/15 , A61L15/26 , A61L15/42 , A61L15/58
CPC分类号： A61L15/26 , A61F13/023 , A61L15/425 , A61L15/58 , A61F2013/00255 , A61F2013/53081
摘要： A sheet-form material suitable as wound dressing and having enhanced moisture control properties is disclosed. This sheet-form material includes a porous sheet of absorbent, elastomeric segmented polyurethane having an open pore structure and an apertured adhesive facing on one side of the porous sheet. A liquid impermeable but water vapor permeable backing may be provided on the opposite side of the porous sheet, if desired. Also disclosed is a method for forming an apertured adhesive facing for the sheet-form material.

8. 发明授权

US4704130A Biocompatible microporous polymeric materials and methods of making same 失效
标题翻译：生物相容性微孔聚合材料及其制备方法
公开(公告)号：US4704130A
公开(公告)日：1987-11-03
申请号：US788850
申请日：1985-10-18
申请人： D. Keith Gilding , Andrew M. Reed , Ian N. Askill , Stephen G. Briana
发明人： D. Keith Gilding , Andrew M. Reed , Ian N. Askill , Stephen G. Briana
IPC分类号： A61L15/16 , A61F2/00 , A61F2/06 , A61F13/00 , A61F13/15 , A61L15/26 , A61L15/42 , A61L27/00 , A61L27/18 , B29C47/00 , C08J5/02 , C08J9/28 , B29C41/52 , C08J9/00
CPC分类号： C08J9/28 , A61F13/00995 , A61F13/0289 , A61F2/062 , A61L15/26 , A61L15/425 , A61L27/18 , B29C47/0021 , B29C47/8895 , A61F2013/00093 , A61F2013/00119 , A61F2013/00217 , A61F2013/15048 , A61F2013/530481 , A61F2250/0023 , B29C47/0023 , C08J2201/0544 , Y10T428/249953
摘要： A microporous biocompatible material is formed by preparing a segmented polyether urethane urea solution containing 25%.+-.1.5% solids dissolved in a solvent. The solution has sufficient viscosity to be preshaped and formed into the desired thickness of the finished article, then immediately immersed into a precipitation bath in which the solvent in the solution is miscible for a time interval sufficient to cause the solution to set up into an opaque elastomeric article. The article is immediately removed from the bath, any excess solvent extracted and then dried at a temperature on the order of 35.degree. C. to 70.degree. C. followed by heat treating by annealing for approximately sixty minutes at a temperature at 100.degree. C. to 130.degree. C. The void volume of the membrane solution is controlled to within the 50% to 80% range and the pore size from ca
摘要翻译：通过制备溶解在溶剂中的含有25％±1.5％固体的分段聚醚聚氨酯脲溶液形成微孔生物相容性材料。该溶液具有足够的粘度以预成型并形成成品的所需厚度，然后立即浸入沉淀浴中，其中溶液中的溶剂可混溶一段足以使溶液变成不透明的时间间隔弹性制品。立即从浴中取出制品，抽出任何多余的溶剂，然后在35℃至70℃的温度下干燥，然后在100℃的温度下退火约60分钟进行热处理。至130℃。膜溶液的空隙体积控制在50％至80％范围内，孔径从约0.1至数μm。以及它们之间的孔和固体结构的形状，从而能够根据其预期的应用和用途对材料的特性和结构进行密切控制，以及跨越材料的厚度的结构特性和孔隙的过度变化。

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