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1. 发明申请

US20120015355A1 SIZE STANDARDS FOR USE IN NUCLEIC ACID ANALYSIS 有权
标题翻译：用于核酸分析的大小标准
公开(公告)号：US20120015355A1
公开(公告)日：2012-01-19
申请号：US13000597
申请日：2009-06-29
申请人： Valerie Carol Tucker , Pieris Koumi , Andrew Hopwood , Keith Elliot
发明人： Valerie Carol Tucker , Pieris Koumi , Andrew Hopwood , Keith Elliot
IPC分类号： C12Q1/68 , C25B7/00 , C07H21/00
CPC分类号： C12Q1/68 , C12Q2565/125 , C12Q2545/101 , C12Q2525/204 , C12Q2537/143
摘要： A size standard, kit includes a size standard, method of defining a size standard and method of analysis using a size standard. The size standard is intended to include size standard elements which have a size greater than and/or less than and/or different from the components of a sample which are to be sized. This means that the same characteristic unit, such as a dye, can be used to label the component and the size standard. A further characteristic unit, from amongst a limited number of such characteristic units is liberated from use only on size standards for use on components. The method is therefore particularly useful in multiplex amplification of STRs.
摘要翻译：尺寸标准，套件包括尺寸标准，使用尺寸标准定义尺寸标准的方法和分析方法。尺寸标准旨在包括具有大于和/或小于和/或不同于尺寸的样品的组分的尺寸的尺寸标准元件。这意味着可以使用相同的特征单元，例如染料来标记组分和尺寸标准。从有限数量的这种特征单元中的另一个特征单元仅在组件上使用的尺寸标准上被使用。因此，该方法在STR的多重扩增中特别有用。

2. 发明申请

US20100221726A1 RELATING TO DEVICES 审中-公开
标题翻译：相关设备
公开(公告)号：US20100221726A1
公开(公告)日：2010-09-02
申请号：US12703046
申请日：2010-02-09
申请人： Frederic Zenhausern , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Jianing Yang , Xiaojia Chen , Matthew Estes , John Lee-Edghill , Nina Moran , Andrew Hopwood , Pieris Koumi
发明人： Frederic Zenhausern , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Jianing Yang , Xiaojia Chen , Matthew Estes , John Lee-Edghill , Nina Moran , Andrew Hopwood , Pieris Koumi
IPC分类号： C12Q1/68 , C12M1/34 , B01D57/02
CPC分类号： B01L3/502761 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L7/525 , C12Q1/6806 , C25B9/00 , G01N1/10 , G01N21/01 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44791 , G01N2021/6484 , G01N2201/062 , G01N2201/0846 , Y10T436/143333
摘要： A method of analysis, instrument for analysis and device for use in such an instrument are provided, which perform a number of processes need to reach a useful result in the context of a wide variety of samples. The sequence of those processes being optimised. A device, instrument using the device and method of use are also provided which offer reliable performance of a heating based process, with minimal condensation and/or sample loss issues.
摘要翻译：提供了一种分析方法，用于分析仪器和用于这种仪器的设备，其执行许多过程需要在各种样品的上下文中获得有用的结果。这些过程的顺序被优化。还提供了使用该装置和使用方法的装置，仪器，其具有基于加热的工艺的可靠性能，具有最小的冷凝和/或样品损失问题。

3. 发明申请

US20070065876A1 Marking 审中-公开
标题翻译：标记
公开(公告)号：US20070065876A1
公开(公告)日：2007-03-22
申请号：US11601176
申请日：2006-11-17
申请人： Jonathan Wetton , Andrew Hopwood
发明人： Jonathan Wetton , Andrew Hopwood
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q2563/185
摘要： The invention provides a marking system, markers and methods of use of such marking systems and markers which enable unique marking of articles and subsequent detection of that marking. In particular the invention provides a marking system, the marking system comprising a plurality of different DNA fragment types, each of the plurality of different DNA fragment types comprising a plurality of different length DNA fragments and a method in which a sample of the DNA fragment type is taken, amplified and analysed to determine the identity of the marker for an article.
摘要翻译：本发明提供了标记系统，标记和使用这种标记系统和标记的方法，其使得可以对物品进行唯一标记并随后检测该标记。特别地，本发明提供了一种标记系统，所述标记系统包括多个不同的DNA片段类型，所述多个不同DNA片段类型中的每一个包括多个不同长度的DNA片段，以及DNA片段类型的样品被采集，扩增和分析以确定物品的标记的身份。

4. 发明申请

US20160187293A1 ELECTROPHORESIS SYSTEM 审中-公开
标题翻译：电泳系统
公开(公告)号：US20160187293A1
公开(公告)日：2016-06-30
申请号：US14124986
申请日：2012-06-11
申请人： Frederic ZENHAUSERN , Alan NORDQUIST , Ralf LENIGK , Cedric HURTH , Jianing YANG , Xiaojia CHEN , Matthew ESTES , John LEE-EDGHILL , Nina MORAN , Andrew HOPWOOD , Pieris KOUMI
发明人： Frederic ZENHAUSERN , Alan NORDQUIST , Ralf LENIGK , Cedric HURTH , Jianing YANG , Xiaojia CHEN , Matthew ESTES , John LEE-EDGHILL , Nina MORAN , Andrew HOPWOOD , Pieris KOUMI
IPC分类号： G01N27/447
CPC分类号： G01N27/44756
摘要： An electrophoresis device where the end of the electrophoresis channel has a part that extends vertically. The electrophoresis channel includes a first access port at one end of the channel and a second port at the other end of the channel, which are in the same horizontal plane. In this way, there is a less than 0.1% hydrostatic pressure differential between two ports and the performance of the device is improved.
摘要翻译：一种电泳装置，其中电泳通道的末端具有垂直延伸的部分。电泳通道包括在通道的一端的第一进入口和处于相同水平面的通道的另一端的第二端口。以这种方式，两个端口之间的静水压差小于0.1％，提高了设备的性能。

5. 发明授权

US08640555B2 Performance 失效
标题翻译：性能
公开(公告)号：US08640555B2
公开(公告)日：2014-02-04
申请号：US12703025
申请日：2010-02-09
申请人： Frederic Zenhausern , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Jianing Yang , Xiaojia Chen , John Lee-Edghill , Nina Moran , Andrew Hopwood , Pieris Koumi
发明人： Frederic Zenhausern , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Jianing Yang , Xiaojia Chen , John Lee-Edghill , Nina Moran , Andrew Hopwood , Pieris Koumi
IPC分类号： G01N1/22
CPC分类号： B01L3/502761 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L7/525 , C12Q1/6806 , C25B9/00 , G01N1/10 , G01N21/01 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44791 , G01N2021/6484 , G01N2201/062 , G01N2201/0846 , Y10T436/143333
摘要： Instruments, devices and methods of analysis are provided which fully integrate a significant number of process steps in a continuous operation. Accurate positioning and full contact between components is also provided by the relative movement the designs allow. An effect interface between a low cost disposable cartridge or device and the instrument to process it is also detailed.
摘要翻译：提供了仪器，设备和分析方法，它们在连续操作中充分整合了大量的工艺步骤。组件之间的精确定位和完全接触也可以通过设计允许的相对运动来提供。低成本的一次性盒式磁盘或装置与处理它的仪器之间的效果接口也是详细的。

6. 发明申请

US20130323737A1 METHOD AND SYSTEM FOR ANALYZING A SAMPLE 审中-公开
标题翻译：用于分析样品的方法和系统
公开(公告)号：US20130323737A1
公开(公告)日：2013-12-05
申请号：US13816394
申请日：2011-08-10
申请人： Frederic Zenhausern , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Jianing Yang , Xiaojia Chen , Matthew Estes , John Lee-Edghill , Nina Moran , Andrew Hopwood , Pieris Koumi
发明人： Frederic Zenhausern , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Jianing Yang , Xiaojia Chen , Matthew Estes , John Lee-Edghill , Nina Moran , Andrew Hopwood , Pieris Koumi
IPC分类号： C12Q1/68 , G01N27/447
CPC分类号： C12Q1/6846 , G01N27/447 , G01N35/00029
摘要： A method and system for analysing a sample are provided, wherein one or more process steps and/or sample processors are provided separately from the instrument, for instance a sample receiving step and sample preparation step and sample extraction step and sample retention step and/or purification step and washing step and elution step, and one or more process steps and/or sample processors provided by the instrument as an integrated set, the one or more process steps and/or sample processors provided by the instrument including a sample receiving step and amplification step and denaturing step and investigation step and detection step and results analysis step and results output step. Other combinations of the split in location of the steps are possible. The optimisation of the split allows the accurate processing by a cartridge based instrument of the sample, whilst fully interfacing with a variety of sample collection and/or preparation approaches.
摘要翻译：提供了一种用于分析样品的方法和系统，其中与仪器分开提供一个或多个处理步骤和/或样品处理器，例如样品接收步骤和样品制备步骤以及样品提取步骤和样品保留步骤和/或纯化步骤和洗涤步骤和洗脱步骤，以及由仪器提供的一个或多个工艺步骤和/或样品处理器作为集成组，由仪器提供的一个或多个工艺步骤和/或样品处理器，包括样品接收步骤和扩增步骤和变性步骤及检测步骤及结果分析步骤及结果输出步骤。步骤的位置分割的其他组合是可能的。分割的优化允许通过样品的基于墨盒的仪器进行精确的处理，同时完全与各种样品收集和/或制备方法接口。

7. 发明申请

US20130210163A1 ANALYSIS 审中-公开
标题翻译：分析
公开(公告)号：US20130210163A1
公开(公告)日：2013-08-15
申请号：US13819403
申请日：2011-08-24
申请人： Andrew Hopwood , Nina Moran , Pieris Koumi , John Lee-Edghill
发明人： Andrew Hopwood , Nina Moran , Pieris Koumi , John Lee-Edghill
IPC分类号： G01N1/28
CPC分类号： G01N1/28 , G01N1/02 , G01N2001/007 , G01N2001/022 , G01N2001/027 , G01N2001/028 , Y10T436/25
摘要： A method for collecting a sample and/or analysing a sample is provided, together with kits for use therein, in which the method includes using the kit and wherein an identifier is provided on one or more of the devices and/or containers and/or packaging which can be recorded and which is used to link the identity of the identifier for one or more of those identifiers to one or more of the identities for one or more of the other identifiers. In this way, the different devices, containers, pieces of equipment, reagents and stages used in the collection and/or analysis can be linked together for future reference. This ensures the correct processing of the sample and the correct attributing of the end results to it. Checks or other enquiries can be made on each of the different devices etc to validate the results if necessary.
摘要翻译：提供了用于收集样品和/或分析样品的方法以及用于其中的试剂盒，其中该方法包括使用该试剂盒，并且其中在一个或多个装置和/或容器上提供标识符和/或可以记录的包装，以及用于将一个或多个这些标识符的标识符的身份链接到一个或多个其他标识符的一个或多个身份。以这种方式，收集和/或分析中使用的不同设备，容器，设备，试剂和阶段可以链接在一起，以备将来参考。这可以确保样品的正确处理以及最终结果的正确归属。可以在每个不同设备等上进行检查或其他查询，以在必要时验证结果。

8. 发明申请

US20130137103A1 ANALYSIS 审中-公开
公开(公告)号：US20130137103A1
公开(公告)日：2013-05-30
申请号：US13594471
申请日：2012-08-24
申请人： Frederic Zenhausern , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Andrew Hopwood , Pieris Koumi , Gill Tully
发明人： Frederic Zenhausern , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Andrew Hopwood , Pieris Koumi , Gill Tully
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6848 , C12Q2545/113
摘要： A method of analysing a sample includes providing a first part of the sample and a second part of the sample. A first analysis is conducted on the first part of the sample and the results of the first analysis are considered. A second analysis is conducted on the second part of the sample, the second analysis being conducted according to a procedure using a value for each of one or more characteristics of the procedure. The consideration of the results of the first analysis is used to determine whether the value for one or more of the characteristics of the procedure is changed to a different value. The second analysis is started before the results of the first analysis are obtained.

9. 发明申请

US20120183956A1 SAMPLE HANDLING 审中-公开
标题翻译：样品处理
公开(公告)号：US20120183956A1
公开(公告)日：2012-07-19
申请号：US13389569
申请日：2010-08-10
申请人： Gary Ross , Sebastian Wetherall , Owen Evans , Andrew Hopwood , Nina Moran
发明人： Gary Ross , Sebastian Wetherall , Owen Evans , Andrew Hopwood , Nina Moran
IPC分类号： C12Q1/68 , C12M1/00
CPC分类号： G01N1/44 , A61B10/0051 , A61B10/0096 , A61B2010/0216 , B01L3/502715 , B01L3/5029 , B01L3/50825 , B01L7/52 , B01L2200/025 , B01L2200/0621 , B01L2200/0689 , B01L2200/141 , B01L2200/147 , B01L2200/16 , B01L2300/041 , B01L2300/044 , B01L2300/049 , B01L2300/0672 , B01L2300/069 , B01L2300/0832 , B01L2300/0861 , B01L2300/1805 , B01L2400/0475 , B01L2400/0478 , B01L2400/0644 , B01L2400/0683 , C12N15/1003 , C12Q1/6806 , G01N1/28
摘要： The invention provides containers and methods of use for the storage, transportation and preparation of samples, such as DNA samples for analysis. The container is pre-provided with the reagents in sealed chambers. The sample can be introduced and the container manipulated to release the reagents, provide the necessary conditions and give a fully prepared sample. The container can then be engaged with an analysis device to identify characteristics of the sample or perform other operations thereon.
摘要翻译：本发明提供用于储存，运输和制备样品的容器和方法，例如用于分析的DNA样品。容器在密封室中预先装有试剂。可以引入样品并操作容器以释放试剂，提供必要的条件并给出完全准备的样品。然后可以将容器与分析装置接合以识别样品的特征或在其上执行其它操作。

10. 发明申请

US20100267092A1 COMPONENTS 审中-公开
标题翻译：组件
公开(公告)号：US20100267092A1
公开(公告)日：2010-10-21
申请号：US12703037
申请日：2010-02-09
申请人： Frederic ZENHAUSERN , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Jianing Yang , Xiaojia Chen , Matthew Estes , John Lee-Edghill , Nina Moran , Andrew Hopwood , Pieris Koumi , Zhi Cai
发明人： Frederic ZENHAUSERN , Alan Nordquist , Ralf Lenigk , Cedric Hurth , Jianing Yang , Xiaojia Chen , Matthew Estes , John Lee-Edghill , Nina Moran , Andrew Hopwood , Pieris Koumi , Zhi Cai
IPC分类号： C12P19/34 , C12M1/36 , C12M1/00 , G01N33/48 , B65G53/66
CPC分类号： B01L3/502761 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L7/525 , C12Q1/6806 , C25B9/00 , G01N1/10 , G01N21/01 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44791 , G01N2021/6484 , G01N2201/062 , G01N2201/0846 , Y10T436/143333
摘要： A method and device structure are provided which enable an archive sample to be collected and detached relative to a device within which a series of processes, such as PCR are being provided. A chamber structure and method of use are provided in which a controlled and precise volume is obtained by control of the relative resistance to flow through various channels.
摘要翻译：提供了一种方法和设备结构，其使得能够相对于在其中提供诸如PCR的一系列过程的设备来收集和分离归档样本。提供了一种室结构和使用方法，其中通过控制通过各种通道的相对阻力获得受控和精确的体积。

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