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    • 1. 发明申请
    • PREFILLED CONTAINER INSERT FOR MIXING TWO OR MORE INGREDIENTS FOR USE IN A PHARMACEUTICAL CONTAINER SYSTEM
    • 用于混合两种或更多成分用于药物容器系统的预混合容器插入
    • US20110186451A1
    • 2011-08-04
    • US13058348
    • 2009-08-10
    • Pontus DersjöAnders Löfgren
    • Pontus DersjöAnders Löfgren
    • B65D25/08
    • B65B29/10A61J1/1406A61J1/2027A61J1/2093B65D51/002B65D51/285
    • The present invention relates to pharmaceutical container systems, and to prefilled container inserts for use therein, for mixing two or more ingredients of a pharmaceutical product. The prefilled container insert of one embodiment comprises a molded container casing having walls, a bottom and an open top for receiving a solid component, a resilient stopper for sealing the open top of the molded container casing, and a bottom disc formed by a weakening rim in the bottom periphery of the molded container casing. The bottom disc is openable to allow mixing of the prefilled solid component with a diluents fluid of the pharmaceutical container system by introducing a spike through the resilient stopper applying a pushing force on the bottom disc, by which force the weakening rim is broken and the container is opened. The prefilled container insert of a further embodiment comprises a molded container casing having walls, a bottom and an open top for receiving an inner open cylinder and a solid component, a resilient stopper for sealing the open top of the molded container casing, and a bottom disc formed by a weakening rim in the bottom periphery of the molded container casing. The bottom disc is openable to allow mixing of the prefilled solid component with a diluents fluid of the pharmaceutical container system by applying a pushing force onto the top of the molded container compressing the casing and forcing the inner cylinder to push on the bottom disc, by which force the weakening rim is broken and the container insert is opened.
    • 本发明涉及药物容器系统和用于其中的预装容器插入物,用于混合药物产品的两种或多种成分。 一个实施例的预填充容器插入件包括具有壁,模制容器壳体的底部和开口顶部的模制容器壳体,用于密封模制容器壳体的开口顶部的弹性塞子和由弱化轮缘 在模制容器壳体的底部周边。 底盘可打开以允许预填充的固体组分与药物容器系统的稀释液混合,通过引入尖端穿过弹性塞,在底盘上施加推力,通过该力将弱化边缘破坏,容器 开了 另一实施例的预装容器插入件包括具有壁的模制容器壳体,底部和用于容纳内部开口圆柱体和固体部件的开口顶部,用于密封模制的容器壳体的开口顶部的弹性塞子,以及底部 圆盘由模制的容器壳体的底部周边的弱化边缘形成。 底盘可打开,以允许预填充的固体组分与药物容器系统的稀释液混合,通过将压力施加到压缩壳体的模制容器的顶部并迫使内筒推动底盘上, 这迫使弱化边缘被破坏并且容器插入物被打开。