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1. 发明授权

US4108995A Hydroxyhexyl-alkylxanthines and pharmaceutical compositions containing hydroxyhexyl-alkylxanthines 失效
标题翻译：含羟基丙氨酸的羟基二甲基氨基甲酸酯和药物组合物
公开(公告)号：US4108995A
公开(公告)日：1978-08-22
申请号：US485869
申请日：1974-07-05
申请人： Werner Mohler , Manfred Jayme , Heinz-Joachim Hinze , Jaromir Komarek , Mario Reiser , Alfons Soder
发明人： Werner Mohler , Manfred Jayme , Heinz-Joachim Hinze , Jaromir Komarek , Mario Reiser , Alfons Soder
IPC分类号： C07D473/06 , C07D473/08 , C07D473/10 , A61K31/52
CPC分类号： C07D473/08 , C07D473/06 , C07D473/10
摘要： Compound of the formula ##STR1## wherein one of the groups R.sub.1, R.sub.2 and R.sub.3 is a hydroxyalkyl group containing from 4 to 8 carbon atoms, one of the other two, which may be the same or different, is an alkyl group containing from 2 to 12 carbon atoms and the third one is an alkyl group containing from 1 to 12 carbon atoms or a hydrogen atom, R.sub.2 however being an alkyl or hydroxyalkyl group, at least one of the groups R.sub.1, R.sub.2 and R.sub.3 containing at least 5 carbon atoms, a process for their preparation and a pharmaceutical composition containing said compounds.

2. 发明授权

US4576947A Pharmaceutical compositions 失效
标题翻译：药物组合物
公开(公告)号：US4576947A
公开(公告)日：1986-03-18
申请号：US543114
申请日：1983-11-10
申请人： Heinz-Joachim Hinze , Alfons Soder , Kurt Popendiker
发明人： Heinz-Joachim Hinze , Alfons Soder , Kurt Popendiker
IPC分类号： A61K9/16 , C07D473/06 , C07D473/08 , C07D473/10 , A61K31/52
CPC分类号： C07D473/06 , A61K9/1617 , C07D473/08 , C07D473/10
摘要： A pharmaceutical composition containing as an essential ingredient a compound of the formula ##STR1## wherein one of the groups R.sub.1, R.sub.2 and R.sub.3 is an .omega.- or (.omega.-1)-hydroxyalkyl group having from 5 to 8 carbon atoms in which the hydroxy group is separated from the xanthine nucleus by at least 2 carbon atoms, radicals R.sub.1 and R.sub.3 which are no hydroxylalkyl group, are hydrogen or methyl and equal or different, and R.sub.2 is said hydroxyalkyl group or methyl, a compound of formula (I) and a pharmaceutical product for treatment of diseases involving insufficiency of cerebral blood flow.
摘要翻译：一种药物组合物，其含有下式化合物作为必需成分：其中R1，R2和R3中的一个是具有5-8个碳原子的ω-或（ω-1） - 羟烷基，其中羟基与黄嘌呤核分离至少2个碳原子，不含羟基烷基的基团R 1和R 3是氢或甲基等同或不同，R 2是所述羟烷基或甲基，式（ I）和用于治疗涉及脑血流量不足的疾病的药物产品。

3. 发明授权

US4515795A Pharmaceutical compositions 失效
标题翻译：药物组合物
公开(公告)号：US4515795A
公开(公告)日：1985-05-07
申请号：US774648
申请日：1977-03-04
申请人： Heinz-Joachim Hinze , Alfons Soder , Kurt Popendiker
发明人： Heinz-Joachim Hinze , Alfons Soder , Kurt Popendiker
IPC分类号： C07D473/06 , C07D473/08 , C07D473/10 , A61K31/52
CPC分类号： C07D473/08 , C07D473/06 , C07D473/10
摘要： A pharmaceutical composition containing as an essential ingredient a compound of the formula ##STR1## wherein one of the groups R.sub.1, R.sub.2 and R.sub.3 is an .omega.- or (.omega.-1)-hydroxyalkyl group having from 5 to 8 carbon atoms in which the hydroxy group is separated from the xanthine nucleus by at least 2 carbon atoms, radicals R.sub.1 and R.sub.3 which are no hydroxyalkyl group, are hydrogen or methyl and equal or different, and R.sub.2 is said hydroxyalkyl group or methyl, a compound of formula (I) and a pharmaceutical product for treatment of diseases involving insufficiency of cerebral blood flow.
摘要翻译：一种药物组合物，其含有下式化合物作为必需成分：其中R1，R2和R3中的一个是具有5-8个碳原子的ω-或（ω-1） - 羟烷基，其中羟基与黄嘌呤核分离至少2个碳原子，不含羟烷基的基团R 1和R 3是氢或甲基且相同或不同，并且R 2是所述羟烷基或甲基，式（ I）和用于治疗涉及脑血流量不足的疾病的药物产品。

4. 发明授权

US4115569A Cyclic diamine derivatives 失效
标题翻译：环二胺衍生物
公开(公告)号：US4115569A
公开(公告)日：1978-09-19
申请号：US606488
申请日：1975-08-21
申请人： Rolf-Ortwin Weber , Alfons Soder , Istvan Boksay
发明人： Rolf-Ortwin Weber , Alfons Soder , Istvan Boksay
IPC分类号： A61K31/495 , C07D405/06 , C07D409/14 , C07D295/10
CPC分类号： C07D409/14 , A61K31/495 , C07D405/06
摘要： A compound having the general formula or an acid addition salt thereof ##STR1## in which formula R.sub.1 is selected from the group consisting ofA. an at least mononuclear heterocyclic group having 4 to 10 carbon atoms in the ring system bound to the group ##STR2## through a carbon atom and containing at least one oxygen, nitrogen or sulphur atom,B. substitution products of (A) containing at least one substituent selected from the group consisting of halogen, trifluoromethyl, hydroxy, alkoxy of 1 to 3 carbon atoms, unsubstituted amino, amino substituted by up to two alkyl groups each having 1 to 3 carbon atoms and alkyl groups having 1 to 6 carbon atoms,X is oxygen, sulphur or an NH-group,Y is an alkylene group having 1 to 3 carbon atoms in the chain, or an alkylene group having 1 to 3 carbon atoms in the chain substituted by (a) up to 3 alkyl groups each having up to 3 carbon atoms and a total of not more than 8 carbon atoms, or (b) substituted by one or two phenyl groups,R.sub.2 is selected from the group consisting ofC. an at least mononuclear carbocyclic or heterocyclic group having 4 to 10 carbon atoms in the ring system, containing but one heteroatom in a ring,D. substitution products of (C) containing at least one substituent selected from the group consisting of nitro, halogen, trifluoromethyl, alkyl having 1 to 6 carbon atoms, hydroxy, alkoxy having 1 to 3 carbon atoms, unsubstituted amino groups and amino groups substituted by up to two alkyl groups each having 1 to 3 carbon atoms,R.sub.3 is hydrogen or up to two substituents selected from alkyl groups having up to 2 carbon atoms and phenyl groups.n is 2 or 3;A process for its preparation and a pharmaceutical composition containing said compound (I).
摘要翻译：具有通式的化合物或其酸加成盐，其中式R1选自A.在环系中结合有至少单个的具有4至10个碳原子的单核杂环基含有至少一个氧原子，氮原子或硫原子的基团“IMAGE”，B.含有至少一个选自卤素，三氟甲基，羟基，1〜3的烷氧基的取代基的（A）碳原子，未取代的氨基，被至多两个各自具有1至3个碳原子的烷基和具有1至6个碳原子的烷基取代的氨基，X是氧，硫或NH-基，Y是具有1至该链中的3个碳原子或链中具有1至3个碳原子的亚烷基被（a）至多3个各自具有至多3个碳原子和总共不超过8个碳原子的烷基取代，或（ b）被一个或两个苯基取代，R2是sele 在环系中具有4-10个碳原子的至少单核碳环或杂环基团，在环中含有一个杂原子，D.含有至少一个选自以下的取代基的取代产物：（C）由硝基，卤素，三氟甲基，具有1至6个碳原子的烷基，羟基，具有1至3个碳原子的烷氧基，未取代的氨基和被至多两个各自具有1至3个碳原子的烷基取代的氨基，R3，是氢或至多两个选自具有至多2个碳原子的烷基和苯基的取代基。

5. 发明授权

US4091095A Phosphinyl compounds 失效
标题翻译：磷化合物
公开(公告)号：US4091095A
公开(公告)日：1978-05-23
申请号：US702604
申请日：1976-07-06
申请人： Alfons Soder , Klaus Perrey
发明人： Alfons Soder , Klaus Perrey
IPC分类号： C07F9/53 , C07F9/58 , A61K31/66 , C07C101/50
CPC分类号： C07F9/582 , C07F9/5304
摘要： A phosphinyl derivative of formula ##STR1## wherein X is selected from the group consisting of a carbon atom with a hydrogen atom attached thereto and a nitrogen atom,R.sup.1 isA. a phenyl radical,B. a quinolyl radical,C. one of the radicals (a) and (b) being substituted by at least one substituent selected from the group consisting of halogen, trifluoromethyl and 1 to 3 alkyl radicals having in total up to 4 carbon atoms,R.sup.2 is selected from the group consisting of a dialkylphosphinylalkyl radical and a dialkyl phosphinyl-hydroxyalkyl radical each of said radicals R.sup.2 having a total of from 3 to 7 carbon atomsAnd acid addition salts thereof, pharmaceutical preparations containing said derivatives.
摘要翻译：式其中X选自具有与其连接的氢原子的碳原子和氮原子，式为“IMAGE”的氧膦基衍生物，R1为A.苯基放射性，B.喹啉衍生物，C. （A）和（B）由至少一个由卤素，三氟甲磺酸和1至3个碱基组成的组选择的一个取代基取代，其具有总计4个碳原子，R2选自二烷基氧膦基烷基和二烷基氧膦基 - 羟烷基，每个所述基团R 2具有总共3至7个碳原子和其酸加成盐，含有所述衍生物的药物制剂。

6. 发明授权

US4762833A 2,4,6-tris-tertiary-butylamino-1,3,5-triazine useful for the prophylaxis and treatment of epilepsy and anxiety states 失效
标题翻译：可用于预防和治疗癫痫和焦虑状态的2,4,6-三叔丁基氨基-1,3,5-三嗪
公开(公告)号：US4762833A
公开(公告)日：1988-08-09
申请号：US33628
申请日：1987-04-03
申请人： Alfred Kreutzberger , Alfons Soder , Hermann J. Gerhards
发明人： Alfred Kreutzberger , Alfons Soder , Hermann J. Gerhards
IPC分类号： C07D251/70 , A61K31/53 , A61P25/08 , A61P25/20 , C07D251/54
CPC分类号： A61K31/53
摘要： 2,4,6-Tris-tertiary-butylamino-1,3,5-triazine of the formula I ##STR1## for the prophylaxis and treatment of epilepsy and anxiety states, and the use for the preparation of a medicament for the prophylaxis and treatment of epilepsy and anxiety states, are described.
摘要翻译：用于预防和治疗癫痫和焦虑状态的式I的2,4,6-三叔丁基氨基-1,3,5-三嗪以及用于预防和治疗药物的用途并描述了治疗癫痫和焦虑状态。

7. 发明授权

US4374990A Cyclic diamine derivatives 失效
标题翻译：环二胺衍生物
公开(公告)号：US4374990A
公开(公告)日：1983-02-22
申请号：US88338
申请日：1979-10-26
申请人： Rolf-Ortwin Weber , Alfons Soder , Istvan Boksay
发明人： Rolf-Ortwin Weber , Alfons Soder , Istvan Boksay
IPC分类号： C07D209/42 , A61K31/495 , A61K31/55 , A61P9/08 , A61P25/04 , A61P25/18 , A61P25/24 , A61P25/26 , A61P29/00 , A61P31/04 , C07D209/50 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/12 , C07D307/54 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/85 , C07D309/08 , C07D309/28 , C07D311/04 , C07D311/22 , C07D311/58 , C07D333/20 , C07D333/38 , C07D403/06 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D405/02
CPC分类号： C07D405/06 , A61K31/495 , C07D409/14 , Y10S514/906
摘要： A compound having the general formula or an acid addition salt thereof ##STR1## in which formula R.sub.1 is selected from the group consisting of(A) an at least mononuclear heterocyclic group having 4 to 10 carbon atoms in the ring system bound to the group ##STR2## through a carbon atom and containing at least one oxygen, nitrogen or sulphur atom,(B) substitution products of (A) containing at least one substituent selected from the group consisting of halogen, trifluoromethyl, hydroxy, alkoxy of 1 to 3 carbon atoms, unsubstituted amino, amino substituted by up to two alkyl groups each having 1 to 3 carbon atoms and alkyl groups having 1 to 6 carbon atoms,X is oxygen, sulphur or an NH-group,Y is an alkylene group having 1 to 3 carbon atoms in the chain, or an alkylene group having 1 to 3 carbon atoms in the chain substituted by (a) up to 3 alkyl groups each having up to 3 carbon atoms and a total of not more than 8 carbon atoms, or (b) substituted by one or two phenyl groups,R.sub.2 is selected from the group consisting of(c) an at least mononuclear carbocyclic or heterocyclic group having 4 to 10 carbon atoms in the ring system, containing but one heteroatom in a ring,(D) substitution products of (C) containing at least one substituent selected from the group consisting of nitro, halogen, trifluoromethyl, alkyl having 1 to 6 carbon atoms, hydroxy, alkoxy having 1 to 3 carbon atoms, unsubstituted amino groups and amino groups substituted by up to two alkyl groups each having 1 to 3 carbon atoms,R.sub.3 is hydrogen or up to two substituents selected from alkyl groups having up to 2 carbon atoms and phenyl groups. n is 2 or 3; a process for its preparation and a pharmaceutical composition containing said compound (I).
摘要翻译：具有通式的化合物或其酸加成盐，其中式R 1选自（A）环系中具有4至10个碳原子的至少单核杂环基，其结合到通过碳原子并含有至少一个氧，氮或硫原子的基团，（B）含有至少一个选自卤素，三氟甲基，羟基，烷氧基的取代基的（A）的取代产物1 至3个碳原子，未取代的氨基，被至多两个各自具有1至3个碳原子的烷基和具有1至6个碳原子的烷基取代的氨基，X是氧，硫或NH-基，Y是具有链中有1至3个碳原子，或链中具有1至3个碳原子的亚烷基被（a）最多3个具有多达3个碳原子的烷基和总共不超过8个碳原子的烷基取代，或（b）被一个或两个苯基取代，R 2是se 由（c）环系中具有4至10个碳原子的至少单核碳环或杂环基团组成的基团，其在环中含有一个杂原子;（D）含有至少一个取代基的（C）取代产物选自硝基，卤素，三氟甲基，具有1至6个碳原子的烷基，羟基，具有1至3个碳原子的烷氧基，未取代的氨基和被至多两个各自具有1至3个碳原子的烷基取代的氨基。，R 3是氢或至多两个选自具有至多2个碳原子的烷基和苯基的取代基。

8. 发明授权

US4312861A Pharmaceutical compositions containing N-alkyl-N-(nuclearly-substituted) benzylamines having vasotonia-regulating activity 失效
标题翻译：含有N-烷基-N-（核取代的）苄胺的药物组合物具有调节血管的活性
公开(公告)号：US4312861A
公开(公告)日：1982-01-26
申请号：US806272
申请日：1977-06-13
申请人： Istvan Boksay , Alfons Soder , Volkher Bollmann , Rolf-Ortwin Weber
发明人： Istvan Boksay , Alfons Soder , Volkher Bollmann , Rolf-Ortwin Weber
IPC分类号： A61K31/13 , A61K31/135 , A61K31/66 , A61P9/00 , A61P9/06 , A61P9/08 , C07C67/00 , C07C209/00 , C07C209/08 , C07C209/26 , C07C209/50 , C07C211/27 , C07C211/29 , C07C213/00 , C07C213/02 , C07C215/08 , C07C217/08 , C07C301/00 , C07C307/02 , C07F9/32 , C07F9/53 , A01N33/02 , A01N57/00
CPC分类号： C07F9/5304
摘要： Aralkylamines of the formula:R.sup.1 --CH.sub.2 --N(R.sup.3)--R.sup.2whereinR.sup.1 is a phenyl substituted by one of:(I) alkyls,(II) halo and(III) nitro;R.sup.2 is(IV) alkyl having from 4 to 10 carbon atoms, four of which are in one chain,(V) alkyl interrupted by an oxygen atom, i.e. an alkoxyalkyl or ether radical, or(VI) hydroxyalkyl wherein the alkyl is either (IV) or (V) and the hydroxy is the sole substituent;R.sup.3 is a hydrogen atom, alkyl having from 1 to 4 carbon atoms or such alkyl substituted by a dialkylphosphinyl group;a physiologically-compatible acid-addition salt thereof and a pharmaceutical composition containing such compound(s) as active ingredient(s) are valuable in view of the physiological activity, e.g. vasotonic, capillary sealing and antiarrhythmic, of the aralkylamines and their physiologically-compatible acid-addition salts.
摘要翻译：下式的芳烷基胺：R1-CH2-N（R3）-R2其中R1是被下列之一取代的苯基：（I）烷基，（Ⅱ）卤素和（Ⅲ）硝基; R2是具有4至10个碳原子的（IV）烷基，其中4个是一个链，（V）被氧原子间隔的烷基，即烷氧基烷基或醚基，或（Ⅵ）羟烷基，其中烷基是（ IV）或（V），羟基是唯一的取代基; R3是氢原子，具有1至4个碳原子的烷基或被二烷基氧膦基取代的烷基; 考虑到生理活性，其生理学相容的酸加成盐和含有作为活性成分的化合物的药物组合物是有价值的。血管紧张素，毛细血管密封和抗心律不齐的芳烷基胺及其生理相容的酸加成盐。

9. 发明授权

US4207321A Pharmaceutical compositions containing xanthines 失效
标题翻译：含有黄嘌呤的药物组合物
公开(公告)号：US4207321A
公开(公告)日：1980-06-10
申请号：US947508
申请日：1978-10-02
申请人： Harald Furrer , Alfons Soder , Jaromir Komarek , Heinz-Joachim Hinze , Gerhard Munch
发明人： Harald Furrer , Alfons Soder , Jaromir Komarek , Heinz-Joachim Hinze , Gerhard Munch
IPC分类号： C07D473/06 , C07D473/12
CPC分类号： C07D473/06
摘要： A pharmaceutical composition having as an essential ingredient a compound of the formula ##STR1## wherein one to three of R.sup.1, R.sup.2 and R.sup.3 represent an alkenyl group having from 4 to 8 carbon atoms, the other ones are alkyl having from 1 to 12 carbon atoms, and R.sup.1 may also be hydrogen, the compounds themselves and a process for preparing them.
摘要翻译：一种具有式（I）化合物作为必需成分的药物组合物，其中R1，R2和R3中的一至三个表示具有4-8个碳原子的烯基，另一个是具有1个至12个碳原子，并且R 1也可以是氢，化合物本身及其制备方法。

10. 发明授权

US4182624A Imidazole carboxylic acids and derivatives thereof 失效
标题翻译：咪唑羧酸及其衍生物
公开(公告)号：US4182624A
公开(公告)日：1980-01-08
申请号：US925546
申请日：1978-07-17
申请人： Alfons Soder , Hermann Bieringer , Helmut Burstell , Peter Langeluddeke , Burkhard Sachse
发明人： Alfons Soder , Hermann Bieringer , Helmut Burstell , Peter Langeluddeke , Burkhard Sachse
IPC分类号： A01N43/50 , C07D233/90 , A01N9/22
CPC分类号： C07D233/90
摘要： Benzhydryl-imidazole derivatives having carboxyl functions in the imidazole ring have valuable properties in plant protection and growth regulation in agriculture and horticulture. They are also effective as antimycotis, fungicides and herbicides and can be used for combating plant-pathogenic bacteria.
摘要翻译：在咪唑环中具有羧基功能的二苯甲基 - 咪唑衍生物在植物保护和农业和园艺生长调节中具有重要的性质。它们也作为抗真菌，杀真菌剂和除草剂而有效，可用于对抗植物病原菌。

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