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1. 发明授权

US06248877B1 Solid phase synthesis of organic compounds via phosphitylating reagents 失效
标题翻译：通过磷酸化试剂固相合成有机化合物
公开(公告)号：US06248877B1
公开(公告)日：2001-06-19
申请号：US09287076
申请日：1999-04-06
申请人： Alex G. Bonner , Lawrence S. Udell
发明人： Alex G. Bonner , Lawrence S. Udell
IPC分类号： C07H1900
CPC分类号： C07H21/00 , B01J19/0046 , B01J2219/00497 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00686 , B01J2219/0072 , C07B2200/11 , C40B40/00
摘要： Methods for preparing organic compounds, such as oligonucleotides, on solid supports are described. Libraries of the compounds and methods of using the compounds are also disclosed.
摘要翻译：描述了在固体支持物上制备有机化合物如寡核苷酸的方法。还公开了化合物的文库和使用该化合物的方法。

2. 发明授权

US06479296B1 Solid phase precipitation and extraction 失效
标题翻译：固相沉淀和提取
公开(公告)号：US06479296B1
公开(公告)日：2002-11-12
申请号：US09610761
申请日：2000-07-06
申请人： Alex G. Bonner , Lawrence S. Udell , William A. Creasey , Stephen Duly , Richard A. Laursen
发明人： Alex G. Bonner , Lawrence S. Udell , William A. Creasey , Stephen Duly , Richard A. Laursen
IPC分类号： G01N3300
CPC分类号： C07K1/30 , C07K1/36
摘要： A new method, solid phase precipitation and extraction (SPPE), is disclosed and is particularly advantageous for purifying mixtures of synthetic peptides directly from a cleavage/deprotection mixture.
摘要翻译：公开了一种新的固相沉淀和萃取（SPPE）方法，特别有利于直接从裂解/脱保护混合物纯化合成肽的混合物。

3. 发明授权

US5011861A Membranes for solid phase protein sequencing 失效
标题翻译：用于固相蛋白测序的膜
公开(公告)号：US5011861A
公开(公告)日：1991-04-30
申请号：US212430
申请日：1988-06-28
申请人： James M. Coull , Darryl J. Rappin , Hubert Koester , Malcolm G. Pluskal , Michael J. Steuck , Alex G. Bonner
发明人： James M. Coull , Darryl J. Rappin , Hubert Koester , Malcolm G. Pluskal , Michael J. Steuck , Alex G. Bonner
IPC分类号： G01N33/50 , B29C67/00 , C07K17/08 , C08J5/18 , C12N11/08 , C12Q1/00 , G01N27/447 , G01N33/545
CPC分类号： G01N33/545 , C07K17/08
摘要： A membrane suitable for immobilizing peptides and proteins is disclosed. The membrane is a flexible, polymeric, porous membrane which contains functional groups capable of covalently linking the peptides and proteins. The functional groups can be provided by reacting the membrane itself or a coating thereon with nucleophiles which provide --NH.sub.2, --SH, --OH or --COOH functionality to the membrane surface. Additionally, surfaces containing --NH.sub.2 groups can be further reacted with diisothiocyantes to provide an isothiocyanate functionality having enhanced covalent binding characteristics.

4. 发明授权

US4153416A Process and apparatus for pulse labelling protein material in the Edman degradation process 失效
标题翻译： Edman降解过程中用于脉冲标记蛋白质材料的方法和设备
公开(公告)号：US4153416A
公开(公告)日：1979-05-08
申请号：US803689
申请日：1977-06-06
申请人： Alex G. Bonner , Marcus J. Horn
发明人： Alex G. Bonner , Marcus J. Horn
IPC分类号： G01N33/60 , G01N33/68 , G01N1/18 , C07C103/52
CPC分类号： G01N33/60 , G01N33/6824
摘要： A process and apparatus for pulse labelling protein material for high sensitivitiy sequence analysis of protein material by Edman degradation technique comprising an isolated, auxiliary unit for storing a radioactive coupling reagent together with tubes, valves and controls for interrupting the Edman process, for pumping a measure of radioactive coupling reagent into the reaction vessel, a timer for controlling duration of contact between the radioactive reagent, and the protein material to maximize the coupling reaction therebetween, and thereafter reactivating the Edman process to admit nonradioactive coupling reagent to the vessel and to drive the coupling reaction to completion.
摘要翻译：用于通过Edman降解技术对蛋白质材料进行高灵敏度序列分析的蛋白质材料的脉冲标记蛋白质材料的方法和装置，其包括用于储存放射性偶联试剂的隔离的辅助单元以及用于中断Edman方法的管，阀和控制器，用于泵送测量放射性偶联剂进入反应容器，定时器用于控制放射性试剂与蛋白质材料之间的接触持续时间，以最大程度地发挥其间的偶联反应，然后重新激活埃德曼过程，以将非放射性偶联剂引入容器并驱动偶联反应完成。

5. 发明授权

US08747669B1 Method and apparatus for the filtration of biological samples 失效
标题翻译：用于生物样品过滤的方法和装置
公开(公告)号：US08747669B1
公开(公告)日：2014-06-10
申请号：US12856677
申请日：2010-08-15
申请人： Alex G. Bonner , Gaston de los Reyes
发明人： Alex G. Bonner , Gaston de los Reyes
IPC分类号： B01D63/00 , B01D35/00 , B01D41/00 , B01D11/00 , B01D61/00
CPC分类号： B01D63/10 , B01D61/14 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/18 , B01D61/22 , B01D63/02 , B01D63/066 , B01D2311/04 , B01D2313/08 , B01D2315/14 , B01D2315/16 , B01D2317/022 , B01D2319/022 , B01L3/50255 , B01L2200/12 , B01L2300/0829 , B01L2300/0838 , B01L2300/0858 , B01L2400/049 , G01N1/4005 , G01N2001/4088 , B01D2311/2649 , B01D2311/14 , B01D2311/25
摘要： A separation module and method are disclosed for processing a liquid sample and providing high conversion by operating a single-pass tangential-flow process without a recirculation loop. In one embodiment, the separation module includes three reservoirs and has at least one long, thin channel with a large ratio of channel membrane area to: channel void volume; volume of a sample feed reservoir; and volume of the feed sample. In another embodiment, the separation module includes an external feed reservoir, an external retentate reservoir fluidly and a first vacuum source adapted to apply a first vacuum to the separation element disposed within the housing. The single-pass TFF separation element and single-pass process provides high conversion while operating with relatively low pressure sources. Certain embodiments disclosed herein can be used for the separation of blood.
摘要翻译：公开了用于处理液体样品并通过操作没有再循环回路的单程切向流程提供高转换的分离模块和方法。在一个实施例中，分离模块包括三个储存器，并且具有至少一个长通道，通道膜面积比大于：通道空隙体积; 样品进料槽的体积; 和饲料样品的体积。在另一个实施例中，分离模块包括外部进料储存器，流体上的外部滞留物储存器和适于将第一真空施加到设置在壳体内的分离元件的第一真空源。单通TFF分离元件和单通道过程在使用相对较低的压力源进行操作时提供高转换率。本文公开的某些实施方案可用于分离血液。

6. 发明授权

US4155714A Process and apparatus for conversion of atz to pth amino acid derivatives of proteins 失效
标题翻译：转化蛋白质的氨基酸衍生物的方法和装置
公开(公告)号：US4155714A
公开(公告)日：1979-05-22
申请号：US892400
申请日：1978-03-31
申请人： Alex G. Bonner , Marcus J. Horn
发明人： Alex G. Bonner , Marcus J. Horn
IPC分类号： B01J19/00 , C40B40/10 , C40B60/14 , C07C103/52
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00418 , B01J2219/00686 , B01J2219/00689 , B01J2219/00725 , C40B40/10 , C40B60/14
摘要： A process and apparatus for the conversion of anilinothiazolino amino acid derivatives of peptides and proteins for use with conventional sequencers in the overall Edman degradation process. The apparatus comprises a modular unit separate from the sequencer having an independently programmable control and flow actuating and directing means including a source of pressurized nitrogen, a conversion reagent container, a wash solvent container, a reaction vessel, and a plurality of interconnecting tubes and valves controlled so as to regulate the amounts and durations of all fluids entering and leaving said reaction vessel under gas pressure.The process comprises performing the steps of conversion, sample recovery, drying and washing at temperatures below but near to the respective boiling points of both the reagent and the solvent, and under reflux tower conditions. A specific embodiment employs anhydrous methanolic hydrogen chloride for the reagent and dichloroethane methanol (7:3) for the solvent, and both the conversion and the washing are done at 65.degree. C., in a reaction vessel comprising a lower, heated portion, and an upper, cooled portion where the reflux action takes place both during the conversion and washing steps.
摘要翻译：用于在总体Edman降解过程中用于与常规测序仪一起使用的肽和蛋白质的苯酰噻唑啉氨基酸衍生物的方法和装置。该装置包括与定序器分离的模块化单元，其具有独立可编程控制和流动致动和引导装置，其包括加压氮源，转换试剂容器，洗涤溶剂容器，反应容器和多个互连管和阀控制以调节在气体压力下进入和离开所述反应容器的所有流体的量和持续时间。

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