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1. 发明申请

US20190038661A1 NEW COMPOSITIONS 审中-公开
公开(公告)号：US20190038661A1
公开(公告)日：2019-02-07
申请号：US16077044
申请日：2017-02-10
申请人： Albert MIHRANYAN
发明人： Albert MIHRANYAN
IPC分类号： A61K31/717 , A61K9/16
摘要： There is provided a pharmaceutical composition comprising cellulose obtained from algae, or a derivative of said cellulose, and an active pharmaceutical ingredient (e.g. from Type 2 and 4 BCS class), wherein the active pharmaceutical ingredient is in a predominantly amorphous form. Compositions of the invention find particularly utility as formulations comprising BCS Type 2 and 4 drugs, including NSAIDs or other drugs, that may be employed in the treatment of migraine or dysmenorrhea, as well as formulations comprising other poorly soluble active ingredients where rapid release in vivo is advantageous.

2. 发明授权

US08975309B2 Vinyl alcohol co-polymer cryogels, vinyl alcohol co-polymers, and methods and products thereof 有权
标题翻译：乙烯醇共聚物冷冻凝胶，乙烯醇共聚物及其方法和产品
公开(公告)号：US08975309B2
公开(公告)日：2015-03-10
申请号：US12998077
申请日：2009-09-14
申请人： Maria Stromme , Albert Mihranyan
发明人： Maria Stromme , Albert Mihranyan
IPC分类号： A61F2/00 , C08F220/12 , C08F220/18 , C08F16/06 , A61K9/00 , C08F218/08 , A61K47/34 , A61L27/52 , A61K9/06 , A61L27/16 , A61K9/19 , A61K9/70 , C08J5/18 , C08F220/06 , C08F220/56
CPC分类号： A61L27/16 , A61K9/0014 , A61K9/0024 , A61K9/0031 , A61K9/006 , A61K9/0065 , A61K9/06 , A61K9/19 , A61K9/7007 , A61K47/34 , A61L27/52 , C08F8/12 , C08F218/08 , C08F220/06 , C08F220/56 , C08J5/18 , C08L29/04
摘要： A cryogel-forming vinyl alcohol co-polymer is operable to form a cryogel, i.e., a hydrogel formed by crytropic gelation, in an aqueous solution at a concentration of less than about 10% by weight, in the absence of a chemical cross-linking agent and in the absence of an emulsifier. In one embodiment, a vinyl alcohol co-polymer cryogel comprises at least about 75% by weight water and a vinyl alcohol co-polymer, wherein the vinyl alcohol co-polymer is operable to form a cryogel in an aqueous solution at a concentration of less than about 10% by weight, in the absence of a chemical cross-linking agent and in the absence of an emulsifier. In another embodiment, a vinyl alcohol co-polymer cryogel comprises at least about 75% by weight water and a vinyl alcohol co-polymer comprising a saponified product of a vinyl acetate co-polymer formed from at least about 80% by weight of vinyl acetate monomer, and (i) at least about 3% by weight of acrylamide monomer or a mixture of acrylamide monomer and acrylic acid monomer, or (ii) at least about 5% by weight acrylic acid monomer. The vinyl acetate co-polymer, vinyl alcohol co-polymer and vinyl alcohol co-polymer cryogel may be formed according to particular methods, and the vinyl alcohol co-polymer cryogels may be used in various applications including biomedical implants and thin films and for delivery of therapeutic or cosmetic agents.
摘要翻译：低温凝胶形成乙烯醇共聚物可操作以在不存在化学交联的情况下，以小于约10重量％的浓度在水溶液中形成冷冻凝胶，即通过热溶胶凝胶形成的水凝胶并且在不存在乳化剂的情况下。在一个实施方案中，乙烯醇共聚物冷冻凝胶包含至少约75重量％的水和乙烯醇共聚物，其中乙烯醇共聚物可操作以在浓度较低的水溶液中形成冷冻凝胶在不存在化学交联剂的条件下和在不存在乳化剂的条件下进行。在另一个实施方案中，乙烯醇共聚物冷冻凝胶包含至少约75重量％的水和包含由至少约80重量％的乙酸乙烯酯形成的乙酸乙烯酯共聚物的皂化产物的乙烯醇共聚物单体，和（i）至少约3重量％的丙烯酰胺单体或丙烯酰胺单体和丙烯酸单体的混合物，或（ii）至少约5重量％的丙烯酸单体。可以根据具体方法形成乙酸乙烯酯共聚物，乙烯醇共聚物和乙烯醇共聚物冷冻凝胶，并且乙烯醇共聚物冷冻凝胶可用于各种应用，包括生物医学植入物和薄膜并用于递送的治疗或化妆品。

3. 发明申请

US20050053665A1 Nicotine formulations and use thereof 审中-公开
标题翻译：尼古丁制剂及其用途
公开(公告)号：US20050053665A1
公开(公告)日：2005-03-10
申请号：US10935658
申请日：2004-09-07
申请人： Ragnar Ek , Albert Mihranyan , Sven-Borje Andersson , Bengt Bosson , Nils-Olof Lindberg
发明人： Ragnar Ek , Albert Mihranyan , Sven-Borje Andersson , Bengt Bosson , Nils-Olof Lindberg
IPC分类号： A61K9/00 , A61K9/14 , A61K9/22 , A61K9/68 , A61K9/70 , A61K31/4439 , A61K31/465
CPC分类号： A61K9/0075 , A61K9/0056 , A61K9/0058 , A61K9/006 , A61K9/146 , A61K9/7053 , A61K9/7084 , A61K31/4439 , A61K31/465
摘要： Nicotine-containing pharmaceutical compositions wherein nicotine is absorbed into and/or adsorbed onto cellulose of non-seed organism origin, especially cellulose from algae, bacteria and/or fungi.
摘要翻译：含尼古丁的药物组合物，其中尼古丁被吸收到非种子生物来源的纤维素上和/或吸附，特别是来自藻类，细菌和/或真菌的纤维素。

4. 发明授权

US11253821B2 Preparation and use of cellulose nanofiber membrane 有权
公开(公告)号：US11253821B2
公开(公告)日：2022-02-22
申请号：US15558338
申请日：2015-03-18
申请人： Albert Mihranyan
发明人： Albert Mihranyan
IPC分类号： B01D71/10 , B01D67/00 , B01D69/02 , D21H25/04 , D21H11/18 , D21H17/02 , D21H21/52
摘要： A filtration membrane comprising cellulose fibres, the membrane having a pore size distribution such that the modal pore diameter is between 10 nm and 25 nm and/or wherein less than 5% of the pore volume comprises pores of greater than 40 nm and having a total porosity greater than 30%.

5. 发明申请

US20180065092A1 PREPARATION AND USE OF CELLULOSE NANOFIBER MEMBRANE 审中-公开
公开(公告)号：US20180065092A1
公开(公告)日：2018-03-08
申请号：US15558338
申请日：2015-03-18
申请人： ALBERT MIHRANYAN
发明人： ALBERT MIHRANYAN
IPC分类号： B01D71/10 , B01D69/02 , B01D67/00 , D21H11/18 , D21H17/02 , D21H21/52 , D21H25/04
CPC分类号： B01D71/10 , B01D67/0004 , B01D67/0083 , B01D67/009 , B01D69/02 , B01D2323/283 , B01D2323/30 , D21H11/18 , D21H17/02 , D21H21/52 , D21H25/04
摘要： A filtration membrane comprising cellulose fibres, the membrane having a pore size distribution such that the modal pore diameter is between 10 nm and 25 nm and/or wherein less than 5% of the pore volume comprises pores of greater than 40 nm and having a total porosity greater than 30%.

6. 发明申请

US20110230567A1 VINYL ALCOHOL CO-POLYMER CRYOGELS, VINYL ALCOHOL CO-POLYMERS, AND METHODS AND PRODUCTS THEREOF 审中-公开
标题翻译：乙烯醇共聚物聚合物，乙烯醇共聚物及其制备方法和产品
公开(公告)号：US20110230567A1
公开(公告)日：2011-09-22
申请号：US12998077
申请日：2009-09-14
申请人： Maria Stromme , Albert Mihranyan
发明人： Maria Stromme , Albert Mihranyan
IPC分类号： A61K47/30 , C08F16/06 , C08F2/22 , C08L29/04 , C08J3/075 , C08J9/28 , C08L89/00 , A61L27/16
CPC分类号： A61L27/16 , A61K9/0014 , A61K9/0024 , A61K9/0031 , A61K9/006 , A61K9/0065 , A61K9/06 , A61K9/19 , A61K9/7007 , A61K47/34 , A61L27/52 , C08F8/12 , C08F218/08 , C08F220/06 , C08F220/56 , C08J5/18 , C08L29/04
摘要： A cryogel-forming vinyl alcohol co-polymer is operable to form a cryogel, i.e., a hydrogel formed by crytropic gelation, in an aqueous solution at a concentration of less than about 10% by weight, in the absence of a chemical cross-linking agent and in the absence of an emulsifier. In one embodiment, a vinyl alcohol co-polymer cryogel comprises at least about 75% by weight water and a vinyl alcohol co-polymer, wherein the vinyl alcohol co-polymer is operable to form a cryogel in an aqueous solution at a concentration of less than about 10% by weight, in the absence of a chemical cross-linking agent and in the absence of an emulsifier. In another embodiment, a vinyl alcohol co-polymer cryogel comprises at least abut 75% by weight water and a vinyl alcohol co-polymer comprising a saponified product of a vinyl acetate co- polymer formed from at least about 80% by weight of vinyl acetate monomer, and (i) at least about 3% by weight of acrylamide monomer or a mixture of acrylamide monomer and acrylic acid monomer, or (ii) at least about 5% by weight acrylic acid monomer. The vinyl acetate co- polymer, vinyl alcohol co-polymer and vinyl alcohol co-polymer cryogel may be formed according to particular methods, and the vinyl alcohol co-polymer cryogels may be used in various applications including biomedical implants and thin films and for delivery of therapeutic or cosmetic agents.
摘要翻译：低温凝胶形成乙烯醇共聚物可操作以在不存在化学交联的情况下，以小于约10重量％的浓度在水溶液中形成冷冻凝胶，即通过热溶胶凝胶形成的水凝胶并且在不存在乳化剂的情况下。在一个实施方案中，乙烯醇共聚物冷冻凝胶包含至少约75重量％的水和乙烯醇共聚物，其中乙烯醇共聚物可操作以在浓度较低的水溶液中形成冷冻凝胶在不存在化学交联剂的条件下和在不存在乳化剂的条件下进行。在另一个实施方案中，乙烯醇共聚物冷冻凝胶包含至少约75重量％的水和包含由至少约80重量％的乙酸乙烯酯形成的乙酸乙烯酯共聚物的皂化产物的乙烯醇共聚物单体，和（i）至少约3重量％的丙烯酰胺单体或丙烯酰胺单体和丙烯酸单体的混合物，或（ii）至少约5重量％的丙烯酸单体。可以根据具体方法形成乙酸乙烯酯共聚物，乙烯醇共聚物和乙烯醇共聚物冷冻凝胶，并且乙烯醇共聚物冷冻凝胶可用于各种应用，包括生物医学植入物和薄膜并用于递送的治疗或化妆品。

7. 发明申请

US20090317437A1 CELLULOSE GEL FORMULATIONS 审中-公开
标题翻译：纤维素凝胶制剂
公开(公告)号：US20090317437A1
公开(公告)日：2009-12-24
申请号：US12096047
申请日：2006-12-06
申请人： Albert Mihranyan , Maria Strömme
发明人： Albert Mihranyan , Maria Strömme
IPC分类号： A61K9/00 , A61K47/38 , A23L1/48 , C09D101/02
CPC分类号： C08L5/00 , A23L29/262 , A23L33/24 , A61K8/042 , A61K8/63 , A61K8/731 , A61K8/9706 , A61K9/0014 , A61K47/38 , A61L27/20 , A61Q19/00 , C08J3/122 , C08J2301/02 , C08L1/02 , C08L1/286 , C08L5/04 , C08L2666/26
摘要： The invention relates to dispersible cellulose powder compositions comprising non-seed cellulose powder derived from algae, fungi or tunicates, which compositions are useful in a variety of products such as food products, pharmaceuticals, cosmetics, paints, biocompatible materials for artificial tissue engineering and implantable biomaterials and relates to methods for preparing non-seed cellulose powder compositions.
摘要翻译：本发明涉及包含衍生自藻类，真菌或衣壳的非种子纤维素粉末的可分散纤维素粉末组合物，该组合物可用于各种产品，例如食品，药物，化妆品，油漆，用于人造组织工程的生物相容性材料和可植入生物材料，涉及制备非种子纤维素粉末组合物的方法。

8. 发明授权

US11278563B2 Rapid release pharmaceutical formulations containing algal cellulose 有权
公开(公告)号：US11278563B2
公开(公告)日：2022-03-22
申请号：US16077044
申请日：2017-02-10
申请人： Albert Mihranyan
发明人： Albert Mihranyan
IPC分类号： A61K31/717 , A61K31/192 , A61K9/14 , A61K31/405 , A61K31/565 , A61K31/5415 , A61K31/196 , A61K9/16 , A61P29/00 , A61K31/166 , A61K31/57
摘要： There is provided a pharmaceutical composition comprising cellulose obtained from algae, or a derivative of said cellulose, and an active pharmaceutical ingredient (e.g. from Type 2 and 4 BCS class), wherein the active pharmaceutical ingredient is in a predominantly amorphous form. Compositions of the invention find particularly utility as formulations comprising BCS Type 2 and 4 drugs, including NSAIDs or other drugs, that may be employed in the treatment of migraine or dysmenorrhea, as well as formulations comprising other poorly soluble active ingredients where rapid release in vivo is advantageous.

9. 发明授权

US08920971B2 Composite materials including an intrinsically conducting polymer, and methods and devices 有权
标题翻译：复合材料，包括固有导电聚合物，以及方法和装置
公开(公告)号：US08920971B2
公开(公告)日：2014-12-30
申请号：US12743796
申请日：2008-11-26
申请人： Maria Strömme , Leif Nyholm , Albert Mihranyan
发明人： Maria Strömme , Leif Nyholm , Albert Mihranyan
IPC分类号： H01M4/02 , H01M4/66 , H01M4/1399 , H01G9/00 , H01M4/13 , H01M4/139 , C08J7/04 , H01M10/0525 , D06M15/61 , H01M4/04 , H01B1/12 , H01M4/137
CPC分类号： H01B1/127 , C08G2261/3221 , C08G2261/94 , C08J7/047 , D06M15/61 , H01G9/155 , H01G11/56 , H01M4/045 , H01M4/13 , H01M4/137 , H01M4/139 , H01M4/1399 , H01M4/661 , H01M4/667 , H01M10/0525 , H01M2004/021 , Y02E60/122 , Y02E60/13 , Y02P70/54 , Y10T428/1331
摘要： A composite material in the form of a continuous structure comprises an intrinsically conducting polymer (ICP) layer coated on a substrate, the composite material having a surface area of at least 0.1 m2/g, at least 1 m2/g, or at least 5 m2/g. Methods of manufacturing the composite material comprise coating the substrate with a layer of the intrinsically conducting polymer. Electrochemical or electrical devices comprise at least one component formed of the composite material.
摘要翻译：连续结构形式的复合材料包括涂覆在基材上的固有导电聚合物（ICP）层，所述复合材料具有至少0.1m 2 / g，至少1m 2 / g或至少5m 2的表面积 m2 / g。制造复合材料的方法包括用本体导电聚合物层涂覆基底。电化学或电气装置包括由复合材料形成的至少一个部件。

10. 发明申请

US20130012474A1 Cellulose Gel Formulations 审中-公开
标题翻译：纤维素凝胶制剂
公开(公告)号：US20130012474A1
公开(公告)日：2013-01-10
申请号：US13618235
申请日：2012-09-14
申请人： Albert Mihranyan , Maria Strömme
发明人： Albert Mihranyan , Maria Strömme
IPC分类号： C08B15/00 , A23L1/0534 , A61K31/717 , C09D101/00 , A61K47/38 , A61K8/73
CPC分类号： C08L5/00 , A23L29/262 , A23L33/24 , A61K8/042 , A61K8/63 , A61K8/731 , A61K8/9706 , A61K9/0014 , A61K47/38 , A61L27/20 , A61Q19/00 , C08J3/122 , C08J2301/02 , C08L1/02 , C08L1/286 , C08L5/04 , C08L2666/26
摘要： The invention relates to dispersible cellulose powder compositions comprising non-seed cellulose powder derived from algae, fungi or tunicates, which compositions are useful in a variety of products such as food products, pharmaceuticals, cosmetics, paints, biocompatible materials for artificial tissue engineering and implantable biomaterials and relates to methods for preparing non-seed cellulose powder compositions.
摘要翻译：本发明涉及包含衍生自藻类，真菌或衣壳的非种子纤维素粉末的可分散纤维素粉末组合物，该组合物可用于各种产品，例如食品，药物，化妆品，油漆，用于人造组织工程的生物相容性材料和可植入生物材料，涉及制备非种子纤维素粉末组合物的方法。

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