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1. 发明申请

US20080022808A1 TUBE CAPPER/DECAPPER 有权
标题翻译： TUBE CAPPER / DECAPPER
公开(公告)号：US20080022808A1
公开(公告)日：2008-01-31
申请号：US11780526
申请日：2007-07-20
申请人： Stephen Owen , Justin Owen , Adrian Neil Bargh
发明人： Stephen Owen , Justin Owen , Adrian Neil Bargh
IPC分类号： B67B7/18
CPC分类号： G01N35/026 , B01L3/50825 , G01N2035/0405
摘要： A capper/de-capper system 1 has a rack support 10 for supporting a rack 11 containing a plurality of capped tubes 31 in a given position. A head unit 12 supports a two-dimensional array of capping/de-capping spindles 13, each of which includes a clutch 133 and a capping/de-capping spigot 131 or socket, the spindles being aligned with the tube positions defined in the rack. A drive mechanism 108 moves the tubes and the head unit relatively towards and away from one another in use, when a rack containing capped tubes is disposed in the rack support, causing engagement and disengagement of the capping/de-capping spigots or sockets with and from the tube caps 32. A spindle drive system 15-22 provides simultaneous rotation of the capping/de-capping spigots or sockets together after engagement with the caps, either to detach caps from the tubes or attach caps to the tubes.
摘要翻译：封盖/去盖系统1具有支架10，用于支撑在给定位置上容纳多个封盖管31的支架11。头单元12支撑封盖/去盖主轴13的二维阵列，每个阵列包括离合器133和封盖/脱帽插口131或插座，所述主轴与限定在机架中的管位置对准。驱动机构108在使用时使管和头单元彼此相对移动并远离彼此，当将包含封盖的管的架设置在机架支撑件中时，使得封盖/脱盖插口或插座与从管帽32。主轴驱动系统15-22在与盖接合之后提供封盖/脱帽插口或插座同时旋转，以便将盖从管上分离或者将帽附接到管上。

2. 发明授权

US08563301B2 Bioreactor systems and associated methods of processing bioreactor vessels 有权
标题翻译：生物反应器系统和加工生物反应器容器的相关方法
公开(公告)号：US08563301B2
公开(公告)日：2013-10-22
申请号：US12801559
申请日：2010-06-15
申请人： Adrian Neil Bargh
发明人： Adrian Neil Bargh
IPC分类号： C12M1/02 , C12M3/00 , B01F7/00
CPC分类号： C12M23/44 , C12M23/06 , C12M23/42 , C12M23/50 , C12M27/02 , C12M41/48
摘要： A bioreactor processing unit (10) includes at least one cell culture module (200) comprising: a base (202) including a receiving station (204) for removably receiving a plurality of bioreactor vessels (400) at respective locations (206); and a clamp plate (240). The clamp plate (240) is removably connectable to the base (202). The system further includes a drive mechanism (226) and multiple fluid conduits. When the system is to be used for an experiment run, vessels (400) are loaded into the receiving station (204) and the clamp plate (240) is connected to the base (202), forming a connection between the drive mechanism and the vessels, for transmitting input motion from the drive mechanism (226) into multiple rotary motion outputs for turning a stirrer (416) in each vessel (400). At the same time, connection of the clamp plate to the base forms a fluid connection between the multiple fluid conduits and an input port (412) in each respective vessel via associated multiple outlet ports (256) in the clamp plate and associated fluid connectors. The system further includes at least one sensor (126a, 126b) that is mounted so as to be movable to a position adjacent to each respective vessel location (206) for monitoring the contents of each vessel (400).
摘要翻译：生物反应器处理单元（10）包括至少一个细胞培养模块（200），其包括：基部（202），包括用于在相应位置（206）可移除地接收多个生物反应器容器（400）的接收站（204）和夹板（240）。夹板（240）可拆卸地连接到基座（202）。该系统还包括驱动机构（226）和多个流体管道。当系统用于实验运行时，容器（400）被装载到接收站（204）中，并且夹板（240）连接到基座（202），形成驱动机构和用于将来自驱动机构（226）的输入运动传送到用于转动每个容器（400）中的搅拌器（416）的多个旋转运动输出。同时，夹板与底座的连接通过夹板中的相关多个出口（256）和相关联的流体连接器在多个流体管道和每个相应容器中的输入端口（412）之间形成流体连接。该系统还包括至少一个传感器（126a，126b），其安装成可移动到与每个相应容器位置（206）相邻的位置，用于监测每个容器（400）的内容物。

3. 发明授权

US07674433B2 Tube for storing fluid 失效
标题翻译：用于储存流体的管
公开(公告)号：US07674433B2
公开(公告)日：2010-03-09
申请号：US10802871
申请日：2004-03-18
申请人： Philip Russel James Smith , Adrian Neil Bargh
发明人： Philip Russel James Smith , Adrian Neil Bargh
IPC分类号： B01L3/00
CPC分类号： B01L3/50855 , B01L3/5082 , B01L9/06 , B01L2200/025 , B01L2300/021 , B01L2300/041 , B01L2300/0851 , G01N21/03
摘要： A tube for storing micro-liter volumes is provided. The tube is open at one end and comprises a body portion of substantially square cross section; a shoulder portion at one end of the body portion and providing the open end of the tube, the cross section of the shoulder portion being greater than that of the body portion; and a formation providing a snap fit connector portion at the other end.
摘要翻译：提供了用于存储微量体积的管。管在一端开口并且包括基本正方形横截面的主体部分; 在主体部分的一端处的肩部并且提供管的开口端，肩部的横截面大于主体部分的横截面; 以及在另一端提供卡扣配合连接器部分的结构。

4. 发明申请

US20080299652A1 SHAKING APPARATUS FOR CELL CULTURE INCUBATOR OR THE LIKE 审中-公开
标题翻译：细胞培养器或类似器具的SHAKING APPARATUS
公开(公告)号：US20080299652A1
公开(公告)日：2008-12-04
申请号：US12125277
申请日：2008-05-22
申请人： Stephen OWEN , Adrian Neil BARGH
发明人： Stephen OWEN , Adrian Neil BARGH
IPC分类号： B01F11/00 , C12M1/02 , B01F15/06 , C12M3/00
CPC分类号： B01F11/0014 , B01F11/0008 , C12M23/48 , C12M23/50 , C12M27/16 , C12M41/14
摘要： An apparatus for shaking a plurality of vessels, for example in an incubator, has at least one rotatable support 10 (101,102) defining a plurality of support locations for vessels 50 at predefined positions 12 around an upright axis and the support or supports 10 are rotatable around the upright axis to move the vessels between a number of positions about the axis for insertion and removal of the vessels onto and from the support(s) respectively. A drive transmission system 38,381 (39,391) connects the support to a drive motor 382 (392), whereby the support can be rotated to a desired position for loading or unloading of a vessel to or from a respective support location 12. A drive mechanism 33, 36 (37). 35 is operable to move each support location eccentrically about an axis independently of the rotation of the support about the upright axis, so that vessels disposed on the support can be shaken. The drive mechanism includes an elongate shaft 33 and the drive transmission system includes a hollow shaft 38 (39) disposed around the elongate shaft of the drive mechanism.
摘要翻译：用于摇动多个容器（例如在培养箱中）的装置具有至少一个可旋转的支撑件10（101,102），该可转动的支撑件10（101,102）限定在围绕垂直轴线的预定位置12处的容器50的多个支撑位置，并且支撑件或支撑件10可旋转围绕竖直轴线移动容器在围绕轴线的多个位置之间，用于分别插入和移出容器。驱动传动系统38,381（39,391）将支撑件连接到驱动马达382（392），由此支撑件可以旋转到期望的位置，以将容器装载到或从相应的支撑位置12卸载。驱动机构33 ，36（37）。 35可操作地使每个支撑位置围绕轴线偏心地移动，而不依赖于支撑件围绕竖直轴线的旋转，使得设置在支撑件上的容器可以摇动。驱动机构包括细长轴33，并且驱动传动系统包括设置在驱动机构的细长轴周围的中空轴38（39）。

5. 发明授权

US06317648B1 Customer specific packaging line having containers with tag means containing medication order information 失效
标题翻译：客户特定的包装线具有包含药物订单信息的标签装置的容器
公开(公告)号：US06317648B1
公开(公告)日：2001-11-13
申请号：US08923844
申请日：1997-09-04
申请人： Nicholas J. Sleep , Andrew H. Proudfoot , Stephen Owen , Adrian Neil Bargh , Michael Kennedy
发明人： Nicholas J. Sleep , Andrew H. Proudfoot , Stephen Owen , Adrian Neil Bargh , Michael Kennedy
IPC分类号： G06F700
CPC分类号： G06Q10/087 , B65B5/103 , B65B35/10 , B65B65/003 , B65G1/1376 , B65G2201/0244 , B65G2201/0261 , B65G2203/0216 , Y02P90/10
摘要： An automated packaging line for filling large and small orders, of one or more bottles, each bottle filled with a respective one of a plurality of different pharmaceutical tablets, in a single run. An intelligent data carrying puck carries each bottle, including therein information describing, among others, the bottle, the customer, the order, the pharmaceutical, the bottle size and label information. Puck handling stations (PHS) are dispersed throughout the line, to verify a number of operations implemented on the line and to reject a puck at the earliest opportunity, while permitting subsequent rejection by a subsequent PHS. The PHS units are substantially identical, with DIP switch modifying operation of the controlling software thereof to implement different features at different points on the line.
摘要翻译：一种自动化包装线，用于在单次运行中填充大小订单，一个或多个瓶子，每个瓶子填充有多个不同药物片剂中的相应的一个。携带冰球的智能数据携带每个瓶子，其中包括描述瓶子，客户，订单，制药，瓶子尺寸和标签信息的信息。圆盘处理站（PHS）分散在整条生产线上，以验证在线实施的一些操作，并尽早拒绝冰球，同时允许后续小灵通的后续排除。 PHS单元基本相同，DIP开关改变其控制软件的操作，以在线上的不同点实现不同的特征。

6. 发明申请

US20110003323A1 Bioreactor systems and associated methods of processing bioreactor vessels 有权
标题翻译：生物反应器系统和加工生物反应器容器的相关方法
公开(公告)号：US20110003323A1
公开(公告)日：2011-01-06
申请号：US12801559
申请日：2010-06-15
申请人： Adrian Neil Bargh
发明人： Adrian Neil Bargh
IPC分类号： C12Q1/02 , C12M1/00 , C12M1/34
CPC分类号： C12M23/44 , C12M23/06 , C12M23/42 , C12M23/50 , C12M27/02 , C12M41/48
摘要： A bioreactor processing unit (10) includes at least one cell culture module (200) comprising: a base (202) including a receiving station (204) for removably receiving a plurality of bioreactor vessels (400) at respective locations (206); and a clamp plate (240). The clamp plate (240) is removably connectable to the base (202). The system further includes a drive mechanism (226) and multiple fluid conduits. When the system is to be used for an experiment run, vessels (400) are loaded into the receiving station (204) and the clamp plate (240) is connected to the base (202), forming a connection between the drive mechanism and the vessels, for transmitting input motion from the drive mechanism (226) into multiple rotary motion outputs for turning a stirrer (416) in each vessel (400). At the same time, connection of the clamp plate to the base forms a fluid connection between the multiple fluid conduits and an input port (412) in each respective vessel via associated multiple outlet ports (256) in the clamp plate and associated fluid connectors. The system further includes at least one sensor (126a, 126b) that is mounted so as to be movable to a position adjacent to each respective vessel location (206) for monitoring the contents of each vessel (400).
摘要翻译：生物反应器处理单元（10）包括至少一个细胞培养模块（200），其包括：基部（202），包括用于在相应位置（206）可移除地接收多个生物反应器容器（400）的接收站（204）和夹板（240）。夹板（240）可拆卸地连接到基座（202）。该系统还包括驱动机构（226）和多个流体管道。当系统用于实验运行时，容器（400）被装载到接收站（204）中，并且夹板（240）连接到基座（202），形成驱动机构和用于将来自驱动机构（226）的输入运动传送到用于转动每个容器（400）中的搅拌器（416）的多个旋转运动输出。同时，夹板与底座的连接通过夹板中的相关多个出口（256）和相关联的流体连接器在多个流体管道和每个相应容器中的输入端口（412）之间形成流体连接。该系统还包括至少一个传感器（126a，126b），其安装成可移动到与每个相应容器位置（206）相邻的位置，用于监测每个容器（400）的内容物。

7. 发明授权

US07845149B2 Tube capper/decapper 有权
标题翻译：管封头/开瓶器
公开(公告)号：US07845149B2
公开(公告)日：2010-12-07
申请号：US11780526
申请日：2007-07-20
申请人： Stephen Owen , Justin Owen , Adrian Neil Bargh
发明人： Stephen Owen , Justin Owen , Adrian Neil Bargh
IPC分类号： B65B7/28
CPC分类号： G01N35/026 , B01L3/50825 , G01N2035/0405
摘要： A capper/de-capper system 1 has a rack support 10 for supporting a rack 11 containing a plurality of capped tubes 31 in a given position. A head unit 12 supports a two-dimensional array of capping/de-capping spindles 13, each of which includes a clutch 133 and a capping/de-capping spigot 131 or socket, the spindles being aligned with the tube positions defined in the rack. A drive mechanism 108 moves the tubes and the head unit relatively towards and away from one another in use, when a rack containing capped tubes is disposed in the rack support, causing engagement and disengagement of the capping/de-capping spigots or sockets with and from the tube caps 32. A spindle drive system 15-22 provides simultaneous rotation of the capping/de-capping spigots or sockets together after engagement with the caps, either to detach caps from the tubes or attach caps to the tubes.
摘要翻译：封盖/去盖系统1具有支架10，用于支撑在给定位置上容纳多个封盖管31的支架11。头单元12支撑封盖/去盖主轴13的二维阵列，每个阵列包括离合器133和封盖/脱帽插口131或插座，所述主轴与限定在机架中的管位置对准。驱动机构108在使用时使管和头单元彼此相对移动并远离彼此，当将包含封盖的管的架设置在机架支撑件中时，使得封盖/脱盖插口或插座与主轴驱动系统15-22在与盖接合之后提供封盖/脱帽插口或插座的同时旋转，以从盖上卸下盖子或将盖子附接到管子上。

8. 外观设计

USD534658S1 Culture vessel block 有权
标题翻译：文化容器块
公开(公告)号：USD534658S1
公开(公告)日：2007-01-02
申请号：US29217953
申请日：2004-11-23
申请人： Adrian Neil Bargh
设计人： Adrian Neil Bargh

9. 外观设计

USD529184S1 Filter block 有权
标题翻译：过滤块
公开(公告)号：USD529184S1
公开(公告)日：2006-09-26
申请号：US29223777
申请日：2005-02-18
申请人： Adrian Neil Bargh , Timothy Iain Mead , Scott Morley , Yevgeniy Margolin
设计人： Adrian Neil Bargh , Timothy Iain Mead , Scott Morley , Yevgeniy Margolin

10. 发明授权

US06522945B2 Customer specific packaging line 失效
公开(公告)号：US06522945B2
公开(公告)日：2003-02-18
申请号：US09975053
申请日：2001-10-12
申请人： Nicholas J. Sleep , Andrew H. Proudfoot , Stephen Owen , Adrian Neil Bargh , Michael Kennedy
发明人： Nicholas J. Sleep , Andrew H. Proudfoot , Stephen Owen , Adrian Neil Bargh , Michael Kennedy
IPC分类号： G06F1700
CPC分类号： G06Q10/087 , B65B5/103 , B65B35/10 , B65B65/003 , B65G1/1376 , B65G2201/0244 , B65G2201/0261 , B65G2203/0216 , Y02P90/10
摘要： An automated packaging line has capability of filling large and small orders, of one or more bottles, each bottle filled with a respective one of a plurality of different pharmaceutical tablets, in a single run. Structure is provided for filling orders for an individual consumer, for a pharmacist, and for a wholesaler, simultaneously, using differently sized bottles, and providing customized labels for each bottle. A flexible filler station simultaneously fills plural bottles with respective tablets. An intelligent data carrying puck carries each bottle, including therein information describing, among others, the bottle, the customer, the order, the pharmaceutical, the bottle size and label information. Puck handling stations (PHS) are dispersed throughout the line, to verify a number of operations implemented on the line and to reject a puck at the earliest opportunity, while permitting subsequent rejection by a subsequent PHS. The PHS units are substantially identical, with DIP switch modifying operation of the controlling software thereof to implement different features at different points on the line. The pucks are recycled after each pass along the line. An initializing PHS wipes clean the puck data storage and, in a fail safe operation, marks it as a reject. The flexible filler station must mark the puck acceptable. Each subsequent PHS, following the flexible filler station, following a capper and following a label printer, may reject the puck if marked as a reject or if failing to meet various criteria

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