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1. 发明授权

US06994718B2 Distal protection device for filtering and occlusion 失效
标题翻译：用于过滤和遮挡的远端保护装置
公开(公告)号：US06994718B2
公开(公告)日：2006-02-07
申请号：US10694944
申请日：2003-10-29
申请人： Adam Groothuis , Jack Pryor
发明人： Adam Groothuis , Jack Pryor
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61B17/12109 , A61B17/12136 , A61F2002/018 , A61F2230/0006 , A61F2230/0071 , A61F2230/0076
摘要： An elongate distal protection device includes an intraluminal filter-occluder combination positioned at a distal end thereof. An expandable occluder is disposed within an expandable filter such that the filter and occluder are independently deployable. During use, the expanded occluder may be used first to stop embolic particles for aspiration thereof. Then, the occluder may be collapsed, leaving the filter expanded to capture any remaining embolic particles.
摘要翻译：细长远端保护装置包括位于其远端的管腔内过滤器 - 封堵器组合。可膨胀封堵器设置在可扩张过滤器内，使得过滤器和封堵器可独立展开。在使用期间，可以首先使用扩张的闭塞器来阻止栓塞颗粒吸入。然后，闭塞器可能被塌缩，使得过滤器膨胀以捕获任何剩余的栓塞颗粒。

2. 发明申请

US20050096691A1 Distal protection device for filtering and occlusion 失效
标题翻译：用于过滤和遮挡的远端保护装置
公开(公告)号：US20050096691A1
公开(公告)日：2005-05-05
申请号：US10694944
申请日：2003-10-29
申请人： Adam Groothuis , Jack Pryor
发明人： Adam Groothuis , Jack Pryor
IPC分类号： A61B17/12 , A61F2/01 , A61M29/00
CPC分类号： A61F2/013 , A61B17/12109 , A61B17/12136 , A61F2002/018 , A61F2230/0006 , A61F2230/0071 , A61F2230/0076
摘要： An elongate distal protection device includes an intraluminal filter-occluder combination positioned at a distal end thereof. An expandable occluder is disposed within an expandable filter such that the filter and occluder are independently deployable. During use, the expanded occluder may be used first to stop embolic particles for aspiration thereof. Then, the occluder may be collapsed, leaving the filter expanded to capture any remaining embolic particles.
摘要翻译：细长远端保护装置包括位于其远端的管腔内过滤器 - 封堵器组合。可膨胀封堵器设置在可扩张过滤器内，使得过滤器和封堵器可独立展开。在使用期间，可以首先使用扩张的闭塞器来阻止栓塞颗粒吸入。然后，闭塞器可能被塌缩，使得过滤器膨胀以捕获任何剩余的栓塞颗粒。

3. 发明授权

US10022222B2 Systems and methods for treating lumenal valves 有权
公开(公告)号：US10022222B2
公开(公告)日：2018-07-17
申请号：US12899231
申请日：2010-10-06
申请人： Adam Groothuis , Adrian Ebner , Peter Markham , Elazer R. Edelman
发明人： Adam Groothuis , Adrian Ebner , Peter Markham , Elazer R. Edelman
IPC分类号： A61F2/24
摘要： The present embodiments relate to systems and methods for treating lumenal valves. Particularly, and in accordance with one aspect, the present disclosure is directed to methods and systems for partial or complete replacement of lumenal valves. An exemplary catheter in accordance with the disclosure includes an elongate body having a proximal end and a distal end, and a retractable sheath mounted on the elongate body proximate the distal end. The sheath and elongate body cooperating to define a first annularly-shaped compartment between the body and sheath. The catheter further includes a valve prosthesis mounted in the compartment, the prosthesis having proximal and distal ends connected to a means for deploying the valve prosthesis from the catheter.

4. 发明授权

US08226709B2 Method and system for plicating tissue in a minimally invasive medical procedure for the treatment of mitral valve regurgitation 有权
标题翻译：用于治疗二尖瓣反流的微创医疗程序中的组织的方法和系统
公开(公告)号：US08226709B2
公开(公告)日：2012-07-24
申请号：US12249388
申请日：2008-10-10
申请人： Adam Groothuis , Matthew Krever , Timothy Lash , Rudolph Cedro , Ted Bachman , Paul D'Antonio , Erin Black , Daniel H. Olsen , Salvatore G. Caldarise , Natalie D. Macon , Paritosh Dhawale
发明人： Adam Groothuis , Matthew Krever , Timothy Lash , Rudolph Cedro , Ted Bachman , Paul D'Antonio , Erin Black , Daniel H. Olsen , Salvatore G. Caldarise , Natalie D. Macon , Paritosh Dhawale
IPC分类号： A61F2/24 , A61B17/10
CPC分类号： A61F2/2466 , A61B17/00234 , A61B17/29 , A61B2017/00243 , A61B2017/00292 , A61B2017/2905 , A61B2017/2923 , A61B2017/2925 , A61B2017/2927 , A61B2017/2939 , A61B2017/2946
摘要： A system and method for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter having a prolapseable or curved tip. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a “C” shaped retainer with deformable ends is deployed by the plication device in order to retain the plicated tissue in the plicated form. A transseptal approach may be used to plicate and retain tissue on the atrial side of the mitral valve to achieve a reduction in mitral valve regurgitation.
摘要翻译：描述了通过使用由保持器固定的环形或相邻组织的一个或多个点进行重新形成二尖瓣环的治疗二尖瓣反流的系统和方法。该系统包括四个装置来实现这种经皮直接瓣膜瓣成形术。第一个是具有可脱垂或弯曲的尖端的交叉导管。第二，偏转引导导管用于提供用于将折叠装置引导到二尖瓣环的下瓣区域的适当位置的装置。第三，折叠装置然后用于在二尖瓣环的亚瓣膜区域进行。肿。第四，通过打浆装置展开具有可变形端部的“C”形保持器，以便将复制的组织保持在复制形式中。经口途径可用于将二尖瓣心房侧的组织挽留并保留，以减少二尖瓣反流。

5. 发明申请

US20070093857A1 Devices and methods for treating mitral valve regurgitation 审中-公开
标题翻译：用于治疗二尖瓣反流的装置和方法
公开(公告)号：US20070093857A1
公开(公告)日：2007-04-26
申请号：US11586201
申请日：2006-10-25
申请人： Campbell Rogers , Adam Groothuis
发明人： Campbell Rogers , Adam Groothuis
IPC分类号： A61B17/10
CPC分类号： A61B17/0644 , A61B17/068 , A61B17/08 , A61B17/10 , A61B17/1285 , A61B2017/00243
摘要： A medical device, method and system of treating the lumenal system of a patient are provided. The medical device includes a tissue plicator adapted and configured to form a plication of tissue proximate a target region of a patient. The medical device further includes a retainer applicator operatively associated with the tissue plicator. The retainer applicator is adapted and configured to apply a retainer to the plication to maintain the plication after the medical device is removed from the patient. In accordance with a further aspect, the tissue plicator may plicate tissue by mechanically clamping the tissue and/or may plicate the tissue at least in part by applying suction thereto. The system can be used to plicate tissue proximate the mitral valve of a patient. The plication can be formed temporarily or permanently.
摘要翻译：提供了一种治疗患者的腔内系统的医疗装置，方法和系统。医疗装置包括适于并构造为在患者的目标区域附近形成组织的褶皱的组织矫正器。医疗装置还包括与组织矫正器可操作地相关联的保持器施加器。保持器施加器被适配和构造成在将医疗装置从病人身上移开之后，将保持器施加到折片以维持折痕。根据另一方面，组织矫正器可以通过机械地夹紧组织和/或可以至少部分地通过向其施加吸力而使组织折叠组织。该系统可用于在患者的二尖瓣附近折叠组织。可以暂时或永久地形成折射。

6. 发明申请

US20130310924A1 SYSTEMS AND METHODS FOR TREATING LUMENAL VALVES 有权
标题翻译：用于处理阀门的系统和方法
公开(公告)号：US20130310924A1
公开(公告)日：2013-11-21
申请号：US13868226
申请日：2013-04-23
申请人： Adam Groothuis , Adrian Ebner , Peter Markham , Elazer Edelman
发明人： Adam Groothuis , Adrian Ebner , Peter Markham , Elazer Edelman
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/2412 , A61F2/2427 , A61F2/2463 , A61F2/2475
摘要： The present embodiments relate to systems and methods for treating lumenal valves. Particularly, and in accordance with one aspect, the present disclosure is directed to methods and systems for partial or complete replacement of lumenal valves. An exemplary catheter in accordance with the disclosure includes an elongate body having a proximal end and a distal end, and a retractable sheath mounted on the elongate body proximate the distal end. The sheath and elongate body cooperating to define a first annularly-shaped compartment between the body and sheath. The catheter further includes a valve prosthesis mounted in the compartment, the prosthesis having proximal and distal ends connected to a means for deploying the valve prosthesis from the catheter.
摘要翻译：本实施例涉及用于治疗腔内瓣膜的系统和方法。特别地，根据一个方面，本公开涉及用于部分或完全更换管腔瓣膜的方法和系统。根据本公开的示例性导管包括具有近端和远端的细长主体，以及靠近远端安装在细长主体上的可伸缩护套。鞘和细长体配合以在主体和鞘之间限定第一环形形状的隔室。导管还包括安装在隔室中的瓣膜假体，假体具有近端和远端连接到用于从导管展开瓣膜假体的装置。

7. 发明申请

US20090105815A1 PUSH-IN RETAINER SYSTEM FOR USE IN THE DIRECT PLICATION ANNULOPLASTY TREATMENT OF MITRAL VALVE REGURGITATION 审中-公开
标题翻译：用于直接电镀的推入式保持器系统用于治疗门静脉注射
公开(公告)号：US20090105815A1
公开(公告)日：2009-04-23
申请号：US12249675
申请日：2008-10-10
申请人： Matthew Krever , Daniel H. Olsen , Rudolph Cedro , Erin Black , Adam Groothuis , Natalie D. Macon
发明人： Matthew Krever , Daniel H. Olsen , Rudolph Cedro , Erin Black , Adam Groothuis , Natalie D. Macon
IPC分类号： A61F2/24
CPC分类号： A61F2/2466 , A61B17/00234 , A61B17/29 , A61B2017/00243 , A61B2017/00292 , A61B2017/2905 , A61B2017/2923 , A61B2017/2925 , A61B2017/2927 , A61B2017/2939 , A61B2017/2946
摘要： A system for using a barbed tubular retainer in the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular tissue each fixed by a retaining clip is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make placations in the subvalvular region of the mitral valve annulus. Fourth, a barbed tubular retainer deployed by the plication device in order to retain the plicated tissue in the plicated form. Alternatively, the fourth device is a retainer delivery catheter that enables delivery of a barbed tubular retainer that is attached to its distal end over the outside of the plication device.
摘要翻译：描述了一种使用有刺的管状保持器来治疗二尖瓣反流的系统，其通过使用由固定夹固定的环形组织的一个或多个引导来重新形成二尖瓣环。该系统包括四个装置来实现这种经皮直接瓣膜瓣成形术。第一个是交叉导管。第二，偏转引导导管用于提供用于将折叠装置引导到二尖瓣环的下瓣区域的适当位置的装置。第三，折叠装置然后用于在二尖瓣环的下瓣区域进行安置。第四，由折弯装置展开的带刺的管状保持器，以便将复制的组织保持在复杂的形式中。或者，第四装置是保持器输送导管，其能够输送穿过折叠装置的外部附接到其远端的有刺的管状保持器。

8. 发明申请

US20090105814A1 METHOD AND SYSTEM FOR PLICATING TISSUE IN A MINIMALLY INVASIVE MEDICAL PROCEDURE FOR THE TREATMENT OF MITRAL VALVE REGURGITATION 有权
标题翻译：用于治疗微孔注射的微型入侵医疗程序中的组织方法和系统
公开(公告)号：US20090105814A1
公开(公告)日：2009-04-23
申请号：US12249388
申请日：2008-10-10
申请人： Adam Groothuis , Matthew Krever , Timothy Lash , Rudolph Cedro , Ted Bachman , Paul D'Antonio , Erin Black , Daniel H. Olsen , Salvatore G. Caldarise , Natalie D. Macon , Paritosh Dhawale
发明人： Adam Groothuis , Matthew Krever , Timothy Lash , Rudolph Cedro , Ted Bachman , Paul D'Antonio , Erin Black , Daniel H. Olsen , Salvatore G. Caldarise , Natalie D. Macon , Paritosh Dhawale
IPC分类号： A61F2/24
CPC分类号： A61F2/2466 , A61B17/00234 , A61B17/29 , A61B2017/00243 , A61B2017/00292 , A61B2017/2905 , A61B2017/2923 , A61B2017/2925 , A61B2017/2927 , A61B2017/2939 , A61B2017/2946
摘要： A system and method for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter having a prolapseable or curved tip. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a “C” shaped retainer with deformable ends is deployed by the plication device in order to retain the plicated tissue in the plicated form. A transseptal approach may be used to plicate and retain tissue on the atrial side of the mitral valve to achieve a reduction in mitral valve regurgitation.
摘要翻译：描述了通过使用由保持器固定的环形或相邻组织的一个或多个点进行重新形成二尖瓣环的治疗二尖瓣反流的系统和方法。该系统包括四个装置来实现这种经皮直接瓣膜瓣成形术。第一个是具有可脱垂或弯曲的尖端的交叉导管。第二，偏转引导导管用于提供用于将折叠装置引导到二尖瓣环的下瓣区域的适当位置的装置。第三，折叠装置然后用于在二尖瓣环的亚瓣膜区域进行。肿。第四，通过打浆装置展开具有可变形端部的“C”形保持器，以便将复制的组织保持在复制形式中。经口途径可用于将二尖瓣心房侧的组织挽留并保留，以减少二尖瓣反流。

9. 发明申请

US20210228354A1 DEVICES, SYSTEMS AND METHODS FOR REPAIRING LUMENAL SYSTEMS 有权
公开(公告)号：US20210228354A1
公开(公告)日：2021-07-29
申请号：US17086106
申请日：2020-10-30
申请人： Nasser Rafiee , G. Randall Green , Adam Groothuis
发明人： Nasser Rafiee , G. Randall Green , Adam Groothuis
IPC分类号： A61F2/24 , A61B17/04
摘要： The disclosure provides valve prostheses and methods of installation. One embodiment of the prosthesis has a generally tubular body adapted for placement proximate a mitral annulus. The tubular body has a generally tubular upper portion adapted to substantially reside in the left atrium above the mitral annulus. The generally tubular upper portion has a first circumferential wall that is outwardly biased to urge against cardiac tissue of the left atrium. The tubular body also includes a lower portion extending downwardly from the generally tubular upper portion, the lower portion being configured to substantially reside in the left ventricle below the mitral annulus. The lower portion of this embodiment can be defined by an generally circumferential wall that extends downwardly from the generally tubular upper portion. The generally circumferential wall has a first circumferential end and a second circumferential end, and defines a circumferential extent therebetween.

10. 发明申请

US20190060070A1 SYSTEMS AND METHODS FOR TREATING LUMENAL VALVES 审中-公开
公开(公告)号：US20190060070A1
公开(公告)日：2019-02-28
申请号：US16036618
申请日：2018-07-16
申请人： Adam Groothuis , Adrian Ebner , Peter Markham , Elazer Edelman
发明人： Adam Groothuis , Adrian Ebner , Peter Markham , Elazer Edelman
IPC分类号： A61F2/24
摘要： A partial valve prosthesis includes a framework configured for following a shape of a portion of the native valve annulus when implanted into the native valve annulus, the framework including securement features for anchoring the framework to an inner periphery of the native valve annulus and retaining at least one leaflet configured to replace a corresponding one of the plurality of native leaflets; and at least one leaflet secured to the framework. Additional embodiments and methods are disclosed.

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