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1. 发明授权

US10953043B2 Nanoparticle compositions and methods for treating or preventing tissue infections and diseases 有权
公开(公告)号：US10953043B2
公开(公告)日：2021-03-23
申请号：US15825912
申请日：2017-11-29
申请人： ATTOSTAT, INC.
发明人： Bryon J. Tarbet , William H. Niedermeyer
IPC分类号： A61K9/06 , A61K33/24 , A61L31/16 , A61K33/38 , A61L27/30 , A61K9/00 , A61K9/08 , A61K9/107 , A61K47/46 , A61K9/16 , A61L29/10 , A61L29/16 , A61L31/08 , A61K36/00
摘要： Stabilized multi-component antimicrobial compositions for treating tissue diseases, infections or conditions include a first and second set of differently sized and/or differently shaped metal nanoparticles, and a stabilizing agent. Compositions and treatment methods may be used for treating tissue diseases, infections or conditions caused by microbial infections, such as bacteria, viral, and/or fungal infections, or for preventing the infection of a wound, such as a cut, abrasion, ulcer, lesion, sore, and the like. The compositions and treatment methods disclosed herein may also be used as a prophylactic, and in some embodiments may be applied to otherwise healthy tissue in order to prevent or reduce the occurrence of a tissue disease, infection or condition.

2. 发明申请

US20160287631A1 NANOPARTICLE COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING TISSUE INFECTIONS AND DISEASES 有权
标题翻译：用于治疗或预防组织感染和疾病的纳米颗粒组合物和方法
公开(公告)号：US20160287631A1
公开(公告)日：2016-10-06
申请号：US15088863
申请日：2016-04-01
申请人： ATTOSTAT, INC.
发明人： Bryon J. Tarbet , William H. Niedermeyer
IPC分类号： A61K33/38 , A61K9/16 , A61L29/16 , A61L31/16 , A61L29/10 , A61K33/24 , A61L31/08
CPC分类号： A61K33/38 , A61K9/0014 , A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/06 , A61K9/08 , A61K9/107 , A61K9/1664 , A61K33/24 , A61K36/00 , A61K47/46 , A61L27/306 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/16 , A61L2400/06 , A61L2400/12 , A61L2420/06 , A61K2300/00
摘要： Stabilized multi-component antimicrobial compositions for treating tissue diseases, infections or conditions include a first and second set of differently sized and/or differently shaped metal nanoparticles, and a stabilizing agent. Compositions and treatment methods may be used for treating tissue diseases, infections or conditions caused by microbial infections, such as bacteria, viral, and/or fungal infections, or for preventing the infection of a wound, such as a cut, abrasion, ulcer, lesion, sore, and the like. The compositions and treatment methods disclosed herein may also be used as a prophylactic, and in some embodiments may be applied to otherwise healthy tissue in order to prevent or reduce the occurrence of a tissue disease, infection or condition.
摘要翻译：用于治疗组织疾病，感染或病症的稳定的多组分抗微生物组合物包括第一组和第二组不同尺寸和/或不同形状的金属纳米颗粒和稳定剂。组合物和治疗方法可用于治疗由细菌，病毒和/或真菌感染等微生物感染引起的组织疾病，感染或病症，或用于预防伤口感染，例如切口，磨损，溃疡，病变，疼痛等。本文公开的组合物和治疗方法也可以用作预防剂，并且在一些实施方案中可以应用于其它健康组织，以便防止或减少组织疾病，感染或病症的发生。

3. 发明授权

US10774429B2 Anti-corrosion nanoparticle compositions 有权
公开(公告)号：US10774429B2
公开(公告)日：2020-09-15
申请号：US15098071
申请日：2016-04-13
申请人： ATTOSTAT, INC.
发明人： Bryon J. Tarbet , William H. Niedermeyer
IPC分类号： C23F11/18 , F16L58/04 , C23F13/00 , C09D5/08
摘要： Anti-corrosion nanoparticle compositions include a carrier and a plurality of nonionic metal nanoparticles. The metal nanoparticles can be spherical-shaped and/or coral-shaped metal nanoparticles. The nanoparticles are selected so as to locate at the grain boundaries of a metal or metal alloy when the anti-corrosion composition is applied to the metal or alloy, thereby reducing or preventing intergranular corrosion of the metal or alloy.

4. 发明申请

US20180368417A1 ANTIMICROBIAL COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：US20180368417A1
公开(公告)日：2018-12-27
申请号：US16012508
申请日：2018-06-19
申请人： ATTOSTAT, INC.
发明人： William Harold Niedermeyer
IPC分类号： A01N59/16 , A61K33/24 , A01N25/04 , A01N25/34
摘要： Antimicrobial compositions for killing or deactivating microbes, such as viruses, bacteria, or fungi, include metal nanoparticles, a carrier, and a plurality of metal nanoparticles. The nanoparticles can be selected to have a particle size and particle size distribution to selectively and preferentially kill one of a virus, a bacterium, or a fungus. Antiviral compositions can include nanoparticles having a particle size of 8 nm or less, 1-7 nm, 2-6.5 nm, or 3-6 nm (or up to 10 nm for Ebola virus). Antibacterial compositions can include nanoparticles having a particle size of 3-14 nm, 5-13 nm, 7-12 nm, or 8-10 nm. Antifungal compositions can include nanoparticles having a particle size of 9-20 nm, 10-18 nm, 11-16 nm, or 12-15 nm. Exemplary methods of killing or deactivating microbes include: (1) applying an antimicrobial composition to a substrate containing microbes, and (2) the antimicrobial composition killing or deactivating the microbes.

5. 发明申请

US20210007982A1 USE OF NANOPARTICLES FOR TREATING RESPIRATORY INFECTIONS ASSOCIATED WITH CYSTIC FIBROSIS 有权
公开(公告)号：US20210007982A1
公开(公告)日：2021-01-14
申请号：US16926199
申请日：2020-07-10
申请人： ATTOSTAT, INC.
发明人： William H. Niedermeyer
IPC分类号： A61K9/00 , A61K9/51 , A61K33/38 , A61M15/00
摘要： This disclosure relates to metal nanoparticle compositions and methods for treating respiratory infections associated with cystic fibrosis. An amount of nonionic, ground state metal nanoparticles are administered to a patient via inhalation. The metal nanoparticles have properties that enable effective transport through the viscous mucus layer to the epithelia and surrounding tissues, killing or deactivating infecting microbes at the targeted respiratory tissue and throughout the overlying mucus layer.

6. 发明授权

US10201571B2 Nanoparticle compositions and methods for treating onychomychosis 有权
公开(公告)号：US10201571B2
公开(公告)日：2019-02-12
申请号：US15415562
申请日：2017-01-25
申请人： ATTOSTAT, INC.
发明人： William H. Niedermeyer
IPC分类号： A61K33/38 , A61K33/24 , A61K47/20 , A61K47/12 , A61K9/14 , A61K9/06 , A61K9/00
摘要： A nanoparticle composition for treating onychomycosis includes spherical-shaped nanoparticles having a particle size and a particle size distribution and coral-shaped nanoparticles having a particle size and a particle size distribution mixed within a penetrating solvent configured to deliver the nanoparticles to target area of a nail and/or surrounding tissue. The nanoparticle composition can be mixed with a carrier to provide or augment application of the nanoparticle composition to a target area. The penetrating solvent can deliver the nanoparticles to an infected area within the nail and/or at the bed of the nail so as to kill or deactivate the fungal microbes causing the onychomycosis.

7. 发明授权

US09839652B2 Nanoparticle compositions and methods for treating or preventing tissue infections and diseases 有权
公开(公告)号：US09839652B2
公开(公告)日：2017-12-12
申请号：US15088863
申请日：2016-04-01
申请人： ATTOSTAT, INC.
发明人： Bryon J. Tarbet , William H. Niedermeyer
IPC分类号： A61K33/24 , A61K33/38 , A61K9/16 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/16 , A61L27/30 , A61K9/00 , A61K9/06 , A61K9/08 , A61K9/107 , A61K47/46 , A61K36/00
CPC分类号： A61K33/38 , A61K9/0014 , A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/06 , A61K9/08 , A61K9/107 , A61K9/1664 , A61K33/24 , A61K36/00 , A61K47/46 , A61L27/306 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/16 , A61L2400/06 , A61L2400/12 , A61L2420/06 , A61K2300/00
摘要： Stabilized multi-component antimicrobial compositions for treating tissue diseases, infections or conditions include a first and second set of differently sized and/or differently shaped metal nanoparticles, and a stabilizing agent. Compositions and treatment methods may be used for treating tissue diseases, infections or conditions caused by microbial infections, such as bacteria, viral, and/or fungal infections, or for preventing the infection of a wound, such as a cut, abrasion, ulcer, lesion, sore, and the like. The compositions and treatment methods disclosed herein may also be used as a prophylactic, and in some embodiments may be applied to otherwise healthy tissue in order to prevent or reduce the occurrence of a tissue disease, infection or condition.

8. 发明申请

US20160083665A1 FUEL ADDITIVE COMPOSITION AND RELATED METHODS 有权
标题翻译：燃料添加剂组合物及相关方法
公开(公告)号：US20160083665A1
公开(公告)日：2016-03-24
申请号：US14861562
申请日：2015-09-22
申请人： ATTOSTAT, INC.
发明人： William Harold Niedermeyer
IPC分类号： C10L1/12
CPC分类号： C10L1/1208 , C10L2200/0204 , C10L2200/0209 , C10L2200/0222 , C10L2200/0227 , C10L2200/0231 , C10L2200/0236 , C10L2200/024 , C10L2200/0245 , C10L2250/06 , C10L2290/24
摘要： Fuel additive compositions include a plurality of metal nanoparticles and a carrier that is dispersible in a hydrocarbon fuel. The metal nanoparticles can be spherical-shaped and/or coral-shaped metal nanoparticles. The carrier can be liquid, gel or solid and can be readily miscible or soluble in a hydrocarbon fuel such as gasoline, diesel, jet fuel, or fuel oil. The carrier can be a solid carrier configured to allow the hydrocarbon fuel to dissolve the solid carrier in order to release and disperse the metal nanoparticles within the hydrocarbon fuel.
摘要翻译：燃料添加剂组合物包括多个金属纳米颗粒和可分散在烃燃料中的载体。金属纳米颗粒可以是球形和/或珊瑚形金属纳米颗粒。载体可以是液体，凝胶或固体，并且可以容易地混溶或溶解在烃燃料如汽油，柴油，喷气燃料或燃料油中。载体可以是固体载体，其被配置为允许烃燃料溶解固体载体，以便将金属纳米颗粒释放并分散在烃燃料中。

9. 发明申请

US20160081346A1 ANTIMICROBIAL COMPOSITIONS AND METHODS 审中-公开
标题翻译：抗微生物组合物和方法
公开(公告)号：US20160081346A1
公开(公告)日：2016-03-24
申请号：US14861243
申请日：2015-09-22
申请人： ATTOSTAT, INC.
发明人： William Harold Niedermeyer
IPC分类号： A01N59/16 , A01N25/02
CPC分类号： A01N59/16 , A61K33/24 , A01N25/04 , A01N25/34
摘要： Antimicrobial compositions for killing or deactivating microbes, such as viruses, bacteria, or fungi, include metal nanoparticles, a carrier, and a plurality of metal nanoparticles. The nanoparticles can be selected to have a particle size and particle size distribution to selectively and preferentially kill one of a virus, a bacterium, or a fungus. Antiviral compositions can include nanoparticles having a particle size of 8 nm or less, 1-7 nm, 2-6.5 nm, or 3-6 nm (or up to 10 nm for Ebola virus). Antibacterial compositions can include nanoparticles having a particle size of 3-14 nm, 5-13 nm, 7-12 nm, or 8-10 nm. Antifungal compositions can include nanoparticles having a particle size of 9-20 nm, 10-18 nm, 11-16 nm, or 12-15 nm. Exemplary methods of killing or deactivating microbes include: (1) applying an antimicrobial composition to a substrate containing microbes, and (2) the antimicrobial composition killing or deactivating the microbes.
摘要翻译：用于杀死或失活微生物（例如病毒，细菌或真菌）的抗微生物组合物包括金属纳米颗粒，载体和多种金属纳米颗粒。可以选择纳米颗粒具有粒度和粒度分布，以选择性地优先杀死病毒，细菌或真菌之一。抗病毒组合物可以包括粒径为8nm或更小，1-7nm，2-6.5nm或3-6nm（或对于埃博拉病毒至多10nm）的纳米颗粒。抗菌组合物可以包括粒度为3-14nm，5-13nm，7-12nm或8-10nm的纳米颗粒。抗真菌组合物可以包括粒径为9-20nm，10-18nm，11-16nm或12-15nm的纳米颗粒。杀死或灭活微生物的示例性方法包括：（1）将抗微生物组合物施用于含有微生物的底物，和（2）抗微生物组合物杀死或灭活微生物。

10. 发明申请

US20140288194A1 METHOD AND APPARATUS FOR PRODUCTION OF UNIFORMLY SIZED NANOPARTICLES 审中-公开
标题翻译：用于生产均匀的纳米粒子的方法和装置
公开(公告)号：US20140288194A1
公开(公告)日：2014-09-25
申请号：US14298594
申请日：2014-06-06
申请人： Attostat, Inc.
发明人： William Niedermeyer
IPC分类号： B22F9/04
CPC分类号： B22F9/04 , B01J13/0043 , B22F1/0018 , B22F3/003 , B22F2009/045 , B22F2999/00 , B82Y40/00 , Y10T428/2982 , B22F2202/11 , B22F2202/06 , B22F2202/05
摘要： An apparatus and process for creating uniformly sized, spherical nanoparticles from a solid target. The solid target surface is ablated to create an ejecta event containing nanoparticles moving away from the surface. Ablation may be caused by laser or electrostatic discharge. At least one electromagnetic field is placed in front of the solid target surface being ablated. The electromagnetic field manipulates at least a portion of the nanoparticles as they move away from the target surface through the electromagnetic field to increase size and spherical shape uniformity of the nanoparticles. The manipulated nanoparticles are collected.
摘要翻译：用于从固体靶产生均匀尺寸的球形纳米粒子的装置和方法。固体靶表面被烧蚀以产生包含从表面移开的纳米颗粒的喷射事件。可能由激光或静电放电引起消融。至少一个电磁场被放置在被烧蚀的固体靶表面的前面。当电磁场通过电磁场离开目标表面时，电磁场操纵至少一部分纳米颗粒，以增加纳米颗粒的尺寸和球形均匀性。收集操纵的纳米粒子。

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