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1. 发明申请

US20200038079A1 DEVICE FOR CORRECTING UNBALANCED GROWTH PLATE ACTIVITY AND FOR ORTHODONTIC APPLICATIONS 审中-公开
公开(公告)号：US20200038079A1
公开(公告)日：2020-02-06
申请号：US16339777
申请日：2017-10-04
申请人： AO TECHNOLOGY AG
发明人： Markus WINDOLF , Michael SCHUETZ
IPC分类号： A61B17/82 , A61B17/86
摘要： An assembly for correcting unbalanced growth plate activity including: (a) an implant formed of wire having (i) a longitudinal central section (2), (ii) a first end (3) configured as a first loop (4) in a form of a first helical coil (9) having a central axis (5) that is transverse to a longitudinal axis of the central section, and (iii) a second end (6) configured as a second loop (7) having a central axis (8) that is transverse to the longitudinal axis of the central section; (b) a first bone screw having a shaft section that is insertable through the first loop; and (c) a second bone screw having a shaft section that is insertable through the second loop. A kit for correcting unbalanced growth plate activity and to a method for correcting unbalanced growth plate activity are also disclosed.

2. 发明申请

US20180310824A1 DEVICE FOR PROCESSING AND TRANSMITTING MEASURED SIGNALS FOR MONITORING AND/OR CONTROLLING MEDICAL IMPLANTS, DIAGNOSTIC DEVICES OR BIOLOGICAL PROCESSES 审中-公开
公开(公告)号：US20180310824A1
公开(公告)日：2018-11-01
申请号：US16027751
申请日：2018-07-05
申请人： AO TECHNOLOGY AG
发明人： Markus Windolf
IPC分类号： A61B5/00 , G16H40/63
CPC分类号： A61B5/0031 , A61B5/4504 , G06F19/3418 , G16H40/63
摘要： A device (1) for processing and transmitting measured signals which correspond to implant parameters or biological parameters for monitoring and/or controlling medical implants, diagnostic devices or biological processes including: a biocompatible sterilizable covering (9); an electronic signal processing device (2) electrically connectable to at least one sensor (5) for processing measured signals received from the at least one sensor; a data memory (16) electrically connected to said signal processing device for storing data received from said signal processing device; and a data transmission device (4) electrically connected to said data memory for transmitting data received from said data memory to a remote data receiving device (6) which is connectable to an external data processing device (8). The signal processing device calculates statistically relevant data obtained from the measured signals, reducing the volume of stored data. Methods for monitoring or controlling bone healing or bone distraction implants are also disclosed.

3. 发明申请

US20180271661A1 METHOD FOR MANUFACTURING AN AUXILIARY DEVICE SUITABLE FOR THE MANUFACTURE OF A PATIENT CUSTOMIZED IMPLANT 审中-公开
公开(公告)号：US20180271661A1
公开(公告)日：2018-09-27
申请号：US15542476
申请日：2015-01-12
申请人： AO Technology AG
发明人： Lukas KAMER , David EGLIN
IPC分类号： A61F2/30 , A61B34/10 , A61F2/28 , A61B17/80
CPC分类号： A61F2/30942 , A61B17/8061 , A61B34/10 , A61B2034/102 , A61B2034/105 , A61B2034/108 , A61F2/2875 , A61F2002/2878 , A61F2002/30578 , A61F2002/30948 , A61F2002/30957 , A61F2002/30962 , A61F2310/00023
摘要： Method for manufacturing an auxiliary device suitable for the manufacture of a patient customized implant comprising the steps of: 1) obtaining 3D image data, preferably a CT of a defect site of a patient's anatomy (1); 2) generating a computer model of the defect site based on the 3D image data and 3D generic reference data by using image processing techniques; 3) virtually reconstructing the defect site; 4) generating a computer template (30) which represents an auxiliary device (40) that is suitable for sizing, shaping and positioning of alloplastic implants; and 5) manufacturing an auxiliary device (40) using 3D printing. Furthermore, there is provided a method for manufacturing a patient customized implant using the auxiliary device and a method for the reconstruction of a particular anatomy by using the manufactured patient customized implant.

4. 发明申请

US20180206895A1 BONE PLATE 审中-公开
公开(公告)号：US20180206895A1
公开(公告)日：2018-07-26
申请号：US15747280
申请日：2015-08-07
申请人： AO Technology AG
发明人： Markus WINDOLF , Devakara EPARI , Michael SCHUETZ , Tim POHLEMANN , Christoph NÖTZLI
IPC分类号： A61B17/80
CPC分类号： A61B17/8085 , A61B17/80 , A61B17/8033 , A61B17/8061
摘要： The bone plate (1) has a lower surface (2), an upper surface (3), a thickness T measured between the lower and upper surfaces (2;3), a longitudinal axis (4) and a plurality of plate holes (5) running from the lower surface (2) to the upper surface (3). The bone plate (1) further has a slot (6) extending from the lower surface (2) towards the upper surface (3) and having a width W measured at the lower surface (2) and parallel to the longitudinal axis (4). The slot (6) extends to a maximum distance D measured from the lower surface (2) towards the upper surface (3) of 0.4-0.9 times the thickness T of the bone plate (1). The slot (6) has a width measured parallel to the longitudinal axis (4) which at its maximum extension E is at least 0.8 mm, preferably of at least 3 mm. The slot (6) allows the plate (1) to bend longitudinally—additionally to the intrinsic bendability of the unslotted plate (1)—at most to the amount of 20°, preferably at most to the amount of 10°. Due to the bi-phasic properties of the bone plate (1) optimal bending properties and adaptability to anatomical surfaces are achieved.

5. 发明申请

US20160220685A1 THERMOSENSITIVE HYALURONIC ACID CONJUGATES AND METHODS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：耐热乙酰丙酸钠及其制备方法
公开(公告)号：US20160220685A1
公开(公告)日：2016-08-04
申请号：US15026637
申请日：2013-10-02
申请人： AO TECHNOLOGY AG
发明人： Matteo D'ESTE , David Olivier EGLIN , Robert Geoffrey RICHARDS , Mauro ALINI
IPC分类号： A61K47/36 , A61K38/18 , C08B37/08 , A61K31/192 , A61K31/381 , A61K31/7036 , A61K35/28 , A61K38/19
CPC分类号： A61K47/36 , A61K31/192 , A61K31/381 , A61K31/7036 , A61K35/28 , A61K38/1875 , A61K38/195 , A61L27/20 , A61L27/52 , A61L27/54 , A61L2400/06 , A61L2430/02 , C08B37/0072 , C08L5/08
摘要： The present invention provides for a method for preparing a thermosensitive hyaluronic acid conjugate comprising the steps of contacting, in any order, a. a predefined amount of hyaluronic acid, b. a predefined amount of one or more thermosensitive polymers having at least one terminal amine moiety and c. a predefined amount of a 1,3,5-triazine (or s-triazine) compound; as well as the conjugates obtainable thereby.
摘要翻译：本发明提供了一种制备热敏透明质酸缀合物的方法，包括以任何顺序接触a。预定量的透明质酸，b。预定量的一种或多种具有至少一个末端胺部分的热敏聚合物，和c。预定量的1,3,5-三嗪（或s-三嗪）化合物; 以及由此可获得的共轭物。

6. 发明申请

US20220315896A1 METHOD OF DETERMINING OR INFLUENCING THE CHONDROGENIC POTENTIAL OF MESENCHYMAL STROMAL CELLS 有权
公开(公告)号：US20220315896A1
公开(公告)日：2022-10-06
申请号：US17597269
申请日：2020-07-03
申请人： AO TECHNOLOGY AG
发明人： Martin STODDART , Mauro ALINI
IPC分类号： C12N5/077 , C07K14/705
摘要： A method of increasing the chondrogenic potential mediated by TGFβ of a mesenchymal stromal cell (MSC) or a population of mesenchymal stromal cells (MSCs), comprising the step of increasing the amount of TGFβR1, and/or decreasing the amount of TGFβR2, and/or decreasing the amount of and/or ACVRL1 of the MSC or a population of mesenchymal stromal cells (MSCs).

7. 发明申请

US20230000534A1 BIPHASIC BONE PLATE 有权
公开(公告)号：US20230000534A1
公开(公告)日：2023-01-05
申请号：US17780576
申请日：2020-11-24
申请人： AO Technology AG
发明人： Markus WINDOLF , Devakara EPARI
IPC分类号： A61B17/80
摘要： Bone plate (1) with a lower surface (2), an upper surface (3), a maximum thickness measured between the lower and upper surfaces a left lateral surface (4), a right lateral surface (5), a longitudinal axis (6) and a plurality of plate holes (7) miming from the lower surface to the upper surface, the bone plate further having a slot (8) in the lower surface extending from the left lateral surface to the right lateral surface having a width measured in a plane parallel to the longitudinal axis and a central plane (16) between the lateral surfaces, wherein (i) the hollow space defined by the slot extends in the form of a straight cylinder from the left lateral surface to the right lateral surface and (ii) the slot comprises an undercut feature (9) limiting the opening of the slot when the bone plate is bent longitudinally in a direction aimed at widening the slot.

8. 发明授权

US10772557B2 Kit for assembling a medical device provided with data acquisition means 有权
公开(公告)号：US10772557B2
公开(公告)日：2020-09-15
申请号：US15565972
申请日：2015-04-27
申请人： AO Technology AG
发明人： Markus Windolf
IPC分类号： A61B5/00 , A61B5/103 , A61B5/01 , A61B5/07 , A61B17/80
摘要： Kit for assembling an implantable medical device (30) provided with a data acquisition device (1), the kit comprising: a medical implant (100); a data acquisition device (1) which includes: one or more sensors (5); an electronic data processing device (2) electrically connectable or connected to the one or more sensors (5); a data memory (16); a data transmission device (4); and a biocompatible sterilisable housing (9) encapsulating at least the data processing device (2), the data memory (16) and the data transmission device (4); wherein the housing (9) comprises means (10) for releasably affixing the housing (9) to the implant (100), the data processing device (2) is programmed to calculate statistical data based on measurement data received from the one or more sensors (5) and to store the statistical data in the data memory (16); and wherein the one or more sensors (5) are either arranged in the housing (9); or the one or more sensors (5) are separately fixable to the implant (100) in a selected position.

9. 发明授权

US10695113B2 Bone plate 有权
公开(公告)号：US10695113B2
公开(公告)日：2020-06-30
申请号：US15747280
申请日：2015-08-07
申请人： AO Technology AG
发明人： Markus Windolf , Devakara Epari , Michael Schuetz , Tim Pohlemann , Christoph Nötzli
IPC分类号： A61B17/80
摘要： The bone plate (1) has a lower surface (2), an upper surface (3), a thickness T measured between the lower and upper surfaces (2;3), a longitudinal axis (4) and a plurality of plate holes (5) running from the lower surface (2) to the upper surface (3). The bone plate (1) further has a slot (6) extending from the lower surface (2) towards the upper surface (3) and having a width W measured at the lower surface (2) and parallel to the longitudinal axis (4). The slot (6) extends to a maximum distance D measured from the lower surface (2) towards the upper surface (3) of 0.4-0.9 times the thickness T of the bone plate (1). The slot (6) has a width measured parallel to the longitudinal axis (4) which at its maximum extension E is at least 0.8 mm, preferably of at least 3 mm. The slot (6) allows the plate (1) to bend longitudinally—additionally to the intrinsic bendability of the unslotted plate (1)—at most to the amount of 20°, preferably at most to the amount of 10°. Due to the bi-phasic properties of the bone plate (1) optimal bending properties and adaptability to anatomical surfaces are achieved.

10. 发明申请

US20180055444A1 KIT FOR ASSEMBLING A MEDICAL DEVICE PROVIDED WITH DATA ACQUISITION MEANS 审中-公开
公开(公告)号：US20180055444A1
公开(公告)日：2018-03-01
申请号：US15565972
申请日：2015-04-27
申请人： AO Technology AG
发明人： Markus WINDOLF
IPC分类号： A61B5/00 , A61B5/01 , A61B5/07 , A61B17/80
CPC分类号： A61B5/4851 , A61B5/0031 , A61B5/01 , A61B5/076 , A61B5/103 , A61B5/4504 , A61B5/686 , A61B5/6878 , A61B17/80 , A61B2560/0214 , A61B2562/0219 , A61B2562/0247 , A61B2562/0252 , A61B2562/0261 , A61B2562/162
摘要： Kit for assembling an implantable medical device (30) provided with a data acquisition device (1), the kit comprising: a medical implant (100); a data acquisition device (1) which includes: one or more sensors (5); an electronic data processing device (2) electrically connectable or connected to the one or more sensors (5); a data memory (16); a data transmission device (4); and a biocompatible sterilisable housing (9) encapsulating at least the data processing device (2), the data memory (16) and the data transmission device (4); wherein the housing (9) comprises means (10) for releasably affixing the housing (9) to the implant (100), the data processing device (2) is programmed to calculate statistical data based on measurement data received from the one or more sensors (5) and to store the statistical data in the data memory (16); and wherein the one or more sensors (5) are either arranged in the housing (9); or the one or more sensors (5) are separately fixable to the implant (100) in a selected position.

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