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1. 发明申请

US20110021616A1 HALOGENATED RHODAMINE DERIVATIVES AND APPLICATIONS THEREOF 审中-公开
标题翻译：恶唑罗丹明衍生物及其应用
公开(公告)号：US20110021616A1
公开(公告)日：2011-01-27
申请号：US12786280
申请日：2010-05-24
申请人： ABDELKRIM HABI , DENIS GRAVEL , LUC VILLENEUVE , HONGSHENG SU , MARC VAILLANCOURT
发明人： ABDELKRIM HABI , DENIS GRAVEL , LUC VILLENEUVE , HONGSHENG SU , MARC VAILLANCOURT
IPC分类号： A61K31/352 , A61P31/04
CPC分类号： A61K35/28 , A61K35/14 , C07D311/82
摘要： Methods for treating a bacterial infection in a tissue sample are described. Tissue samples that are harvested from a patient may be infected with bacteria. A rhodmaine compound is mixed with the infected tissue sample to form a mixture. The mixture is then exposed to radiant energy to inhibit or kill the bacteria. The exposed mixture is then transplanted into the patient. Examples of rhodamine compounds include 2′-(6-dimethylamino-3-dimethylimino-3H-xanthen-9-yl) 4′, 5′-dichloro-benzoic acid methyl ester hydrochloride; 4,5-dibromorhodamine 110 2-(2-methoxy ethoxy)ethyl ester hydrobromide; acetate salt of 2,7-dibromorhodamine B hexyl ester; acetate salt of 2,7-dibromorhodamine B methyl ester; 4,5-dibromorhodamine 6G hydrobromide; rhodamine B 3-bromopropyl; acetate salt of 2,7-dibromo-4′-carboxytetramethylrosamine methyl ester; 4-bromo-5-phenyl rhodamine B methyl ester chloride; 2,7-dibromo-4,5-dimethyl rhodamine B methyl ester bromide; 2-bromo-7-ethynyl rhodamine B methyl ester bromide; and 4,5-dibromo-2,7-di-n-butyl rhodamine B methyl ester bromide.
摘要翻译：描述了用于治疗组织样品中的细菌感染的方法。从患者收获的组织样品可能被细菌感染。与感染的组织样品混合罗丹明酸化合物以形成混合物。然后将混合物暴露于辐射能以抑制或杀死细菌。然后将暴露的混合物移植到患者体内。罗丹明化合物的实例包括2' - （6-二甲基氨基-3-二甲基亚氨基-3H-呫吨-9-基）4'，5'-二氯 - 苯甲酸甲酯盐酸盐; 4,5-二溴罗丹胺110 2-（2-甲氧基乙氧基）乙酯氢溴酸盐; 2,7-二溴罗丹明B己基酯的乙酸盐; 乙酸盐2,7-二溴罗丹明B甲酯; 4,5-二溴罗丹明6G氢溴酸盐; 罗丹明B 3 - 溴丙基; 2,7-二溴-4'-羧基四甲基甲胺甲酯的乙酸盐; 4-溴-5-苯基罗丹明B甲酯氯化物; 2,7-二溴-4,5-二甲基罗丹明B甲酯溴化物; 2-溴-7-乙炔基罗丹明B甲酯溴化物; 和4,5-二溴-2,7-二正丁基罗丹明B甲酯溴化物。

2. 发明授权

US08822413B2 Bifunctional hormone having alpha-MSH activity and natriuretic peptide activity and uses thereof 有权
标题翻译：具有α-MSH活性和利尿钠肽活性的双功能激素及其用途
公开(公告)号：US08822413B2
公开(公告)日：2014-09-02
申请号：US12168513
申请日：2008-07-07
申请人： Krishna G. Peri , Abdelkrim Habi
发明人： Krishna G. Peri , Abdelkrim Habi
IPC分类号： A61K38/22 , A61K38/16 , A61K38/00
CPC分类号： C07K14/575 , C07K14/58 , C07K14/68 , C07K14/685 , C07K2319/00
摘要： A bifunctional hormone exhibiting an alpha-MSH activity and a natriuretic peptide activity is described. The bifunctional hormone comprises for example a first domain having alpha-MSH related hormonal activity covalently linked to a second domain having natriuretic peptide related hormonal activity. The bifunctional hormone of the present invention is useful for example for the prevention and/or treatment of renal related diseases or conditions, such as acute renal failure (ARF) or acute kidney injury (AKI).
摘要翻译：描述了表现出α-MSH活性和利尿钠肽活性的双功能激素。双功能激素包括例如具有与具有利钠肽相关激素活性的第二结构域共价连接的α-MSH相关激素活性的第一结构域。本发明的双功能激素可用于例如用于预防和/或治疗肾相关疾病或病症，例如急性肾功能衰竭（ARF）或急性肾损伤（AKI）。

3. 发明授权

US08383672B2 Halogenated rhodamine derivatives and applications thereof 有权
标题翻译：卤化罗丹明衍生物及其应用
公开(公告)号：US08383672B2
公开(公告)日：2013-02-26
申请号：US13157105
申请日：2011-06-09
申请人： Abdelkrim Habi , Denis Gravel , Luc Villeneuve , Hongsheng Su , Marc Vaillancourt
发明人： Abdelkrim Habi , Denis Gravel , Luc Villeneuve , Hongsheng Su , Marc Vaillancourt
IPC分类号： C07D311/88 , A61K31/35
CPC分类号： A61K35/28 , A61K35/14 , C07D311/82
摘要： Methods for treating a bacterial infection in a tissue sample are described. Tissue samples that are harvested from a patient may be infected with bacteria. A rhodamine compound is mixed with the infected tissue sample to form a mixture. The mixture is then exposed to radiant energy to inhibit or kill the bacteria. The exposed mixture is then transplanted into the patient. Examples of rhodamine compounds include 2′-(6-dimethylamino-3-dimethylimino-3H-xanthen-9-yl) 4′,5′-dichloro-benzoic acid methyl ester hydrochloride; 4,5-dibromorhodamine 110 2-(2-methoxy ethoxy)ethyl ester hydrobromide; acetate salt of 2,7-dibromorhodamine B hexyl ester; acetate salt of 2,7-dibromorhodamine B methyl ester; 4,5-dibromorhodamine 6G hydrobromide; rhodamine B 3-bromopropyl; acetate salt 2,7-dibromo-4′-carboxytetramethylrosamine methyl ester; 4-bromo-5-phenyl rhodamine B methyl ester chloride; 2,7-dibromo-4,5-dimethyl rhodamine B methyl ester bromide; 2-bromo-7-ethynyl rhodamine B methyl ester bromide; and 4,5-dibromo-2,7-di-n-butyl rhodamine B methyl ester bromide.
摘要翻译：描述了用于治疗组织样品中的细菌感染的方法。从患者收获的组织样品可能被细菌感染。将罗丹明化合物与感染的组织样品混合以形成混合物。然后将混合物暴露于辐射能以抑制或杀死细菌。然后将暴露的混合物移植到患者体内。罗丹明化合物的实例包括2' - （6-二甲基氨基-3-二甲基亚氨基-3H-呫吨-9-基）4'，5'-二氯 - 苯甲酸甲酯盐酸盐; 4,5-二溴罗丹胺110 2-（2-甲氧基乙氧基）乙酯氢溴酸盐; 2,7-二溴罗丹明B己基酯的乙酸盐; 乙酸盐2,7-二溴罗丹明B甲酯; 4,5-二溴罗丹明6G氢溴酸盐; 罗丹明B 3 - 溴丙基; 乙酸盐2,7-二溴-4'-羧基四甲基甲胺甲酯; 4-溴-5-苯基罗丹明B甲酯氯化物; 2,7-二溴-4,5-二甲基罗丹明B甲酯溴化物; 2-溴-7-乙炔基罗丹明B甲酯溴化物; 和4,5-二溴-2,7-二正丁基罗丹明B甲酯溴化物。

4. 发明申请

US20120270784A1 GROWTH HORMONE RELEASING FACTOR (GRF) ANALOGS AND USES THEREOF 有权
标题翻译：生长激素释放因子（GRF）模拟物及其用途
公开(公告)号：US20120270784A1
公开(公告)日：2012-10-25
申请号：US13448660
申请日：2012-04-17
申请人： Krishna G. Peri , Abdelkrim Habi
发明人： Krishna G. Peri , Abdelkrim Habi
IPC分类号： A61K38/25 , A61P5/06 , C07K14/60
CPC分类号： C07K14/60 , A61K38/00
摘要： Novel GRF analogs having GRF activity are described herein, as well as uses thereof for example as a GRF receptor agonist, e.g., to induce growth hormone secretion in a subject or biological system.
摘要翻译：本文描述了具有GRF活性的新型GRF类似物，以及其用于例如GRF受体激动剂的用途，例如诱导受试者或生物系统中的生长激素分泌。

5. 发明申请

US20070275892A9 Novel chemokine mimetics synthesis and their use 失效
标题翻译：新型趋化因子模拟物合成及其应用
公开(公告)号：US20070275892A9
公开(公告)日：2007-11-29
申请号：US11393769
申请日：2006-03-29
申请人： Ahmed Merzouk , Abdelkrim Habi , Donald Wong , Hassan Salari
发明人： Ahmed Merzouk , Abdelkrim Habi , Donald Wong , Hassan Salari
IPC分类号： A61K38/16
CPC分类号： A61K38/12 , C07K14/521
摘要： The present disclosure generally teaches compositions comprising SDF-1 mimetics and methods of using them to modulate an activity of a cell having an SDF-1 receptor by binding the SDF-1 receptor to an SDF-1 mimetic. The cell can be a hematopoietic cell, for example, and can be selected from a group consisting of hematopoietic stem cells, hematopoietic progenitor cells, primitive granulocytes, primitive erythroid cells, leukocytes, and neutrophils. In some embodiments, the activity can include the rate of multiplication of the cell or, where the cell is a quiescent cell, the binding can repress the activation of the quiescent cell. Other embodiments of the present invention are taught herein.
摘要翻译：本公开通常教导包含SDF-1模拟物的组合物和使用它们通过将SDF-1受体结合到SDF-1模拟物来调节具有SDF-1受体的细胞的活性的方法。例如，细胞可以是造血细胞，并且可以选自造血干细胞，造血祖细胞，原始粒细胞，原始红细胞，白细胞和嗜中性粒细胞。在一些实施方案中，活性可以包括细胞的增殖速率，或者当细胞是静止细胞时，结合可以抑制静止细胞的活化。本文教导了本发明的其它实施例。

6. 发明申请

US20050059584A1 Novel chemokine mimetics synthesis and their use 审中-公开
标题翻译：新型趋化因子模拟物合成及其应用
公开(公告)号：US20050059584A1
公开(公告)日：2005-03-17
申请号：US10222703
申请日：2002-08-16
申请人： Ahmed Merzouk , Abdelkrim Habi , Donald Wong , Hassan Salari
发明人： Ahmed Merzouk , Abdelkrim Habi , Donald Wong , Hassan Salari
IPC分类号： A61K38/19 , C07K14/52
CPC分类号： A61K38/12 , C07K14/521
摘要： The present invention is concerned with chemokine derived analogs, including SDF-1 and/or SDF-1/MIP1α hybrid analogs, that are useful for the treatment of a variety of diseases and disorders, and as an adjunct to the treatment of a variety of diseases and disorders. A therapeutically effective amount of the chemokine analog may be administered to a patient in need of such treatment.
摘要翻译：本发明涉及可用于治疗各种疾病和病症的趋化因子衍生类似物，包括SDF-1和/或SDF-1 /MIP1α杂合类似物，并且作为治疗各种各样的疾病和病症。趋化因子类似物的治疗有效量可以施用于需要这种治疗的患者。

7. 发明授权

US07994114B2 Chemokine mimetics synthesis and their use 失效
标题翻译：趋化因子模拟物合成及其应用
公开(公告)号：US07994114B2
公开(公告)日：2011-08-09
申请号：US11393769
申请日：2006-03-29
申请人： Ahmed Merzouk , Abdelkrim Habi , Donald Wong , Hassan Salari
发明人： Ahmed Merzouk , Abdelkrim Habi , Donald Wong , Hassan Salari
IPC分类号： A61K38/00 , A61K31/70 , A61K45/00 , A61K48/00 , C07K14/00 , C12Q1/00 , G01N63/00 , C12N15/63 , C12N5/08 , A01N63/00
CPC分类号： A61K38/12 , C07K14/521
摘要： The present disclosure generally teaches compositions comprising SDF-1 mimetics and methods of using them to modulate an activity of a cell having an SDF-1 receptor by binding the SDF-1 receptor to an SDF-1 mimetic. The cell can be a hematopoietic cell, for example, and can be selected from a group consisting of hematopoietic stem cells, hematopoietic progenitor cells, primitive granulocytes, primitive erythroid cells, leukocytes, and neutrophils. In some embodiments, the activity can include the rate of multiplication of the cell or, where the cell is a quiescent cell, the binding can repress the activation of the quiescent cell. Other embodiments of the present invention are taught herein.
摘要翻译：本公开通常教导包含SDF-1模拟物的组合物和使用它们通过将SDF-1受体结合到SDF-1模拟物来调节具有SDF-1受体的细胞的活性的方法。例如，细胞可以是造血细胞，并且可以选自造血干细胞，造血祖细胞，原始粒细胞，原始红细胞，白细胞和嗜中性粒细胞。在一些实施方案中，活性可以包括细胞的增殖速率，或者当细胞是静止细胞时，结合可以抑制静止细胞的活化。本文教导了本发明的其它实施例。

8. 发明授权

US07538185B2 Glucagon-like peptide-1 analogs with long duration of action 失效
标题翻译：具有长期作用的胰高血糖素样肽-1类似物
公开(公告)号：US07538185B2
公开(公告)日：2009-05-26
申请号：US11031851
申请日：2005-01-07
申请人： Krishna Peri , Daniel Abran , Abdelkrim Habi
发明人： Krishna Peri , Daniel Abran , Abdelkrim Habi
IPC分类号： A61K38/26
CPC分类号： C07K14/605 , A61K38/26
摘要： Novel GLP-1 analogs having improved biological potency as well as extended pharmacological activity are described herein. More specifically, the present invention relates to GLP-1 analogs (28 or 29 aa long) comprising amino acid substitutions at one or more of the following positions: 8, 20, 27, 30 and 33.
摘要翻译：本文描述了具有改善的生物学效力以及延长的药理活性的新型GLP-1类似物。更具体地说，本发明涉及在一个或多个以下位置上包含氨基酸取代的GLP-1类似物（28或29a a long）：8,20,27,30和33。

9. 发明申请

US20090011997A1 BIFUNCTIONAL HORMONE AND USES THEREOF 有权
标题翻译：双功能胡蜂及其用途
公开(公告)号：US20090011997A1
公开(公告)日：2009-01-08
申请号：US12168513
申请日：2008-07-07
申请人： Krishna G. Peri , Abdelkrim Habi
发明人： Krishna G. Peri , Abdelkrim Habi
IPC分类号： C07K14/575 , C07K5/10 , C07K7/06 , A61K38/10 , A61K38/07 , A61P13/12 , A61K38/08 , A61K38/22 , C07K7/08
CPC分类号： C07K14/575 , C07K14/58 , C07K14/68 , C07K14/685 , C07K2319/00
摘要： A bifunctional hormone exhibiting an alpha-MSH activity and a natriuretic peptide activity is described. The bifunctional hormone comprises for example a first domain having alpha-MSH related hormonal activity covalently linked to a second domain having natriuretic peptide related hormonal activity. The bifunctional hormone of the present invention is useful for example for the prevention and/or treatment of renal related diseases or conditions, such as acute renal failure (ARF) or acute kidney injury (AKI).
摘要翻译：描述了表现出α-MSH活性和利尿钠肽活性的双功能激素。双功能激素包括例如具有与具有利钠肽相关激素活性的第二结构域共价连接的α-MSH相关激素活性的第一结构域。本发明的双功能激素可用于例如用于预防和/或治疗肾相关疾病或病症，例如急性肾功能衰竭（ARF）或急性肾损伤（AKI）。

10. 发明授权

US07067488B2 Modified GLP-1 peptides with increased biological potency 失效
标题翻译：具有增加的生物效能的修饰的GLP-1肽
公开(公告)号：US07067488B2
公开(公告)日：2006-06-27
申请号：US10671340
申请日：2003-09-25
申请人： Denis Gravel , Krishna Peri , Thierry Abribat , Abdelkrim Habi
发明人： Denis Gravel , Krishna Peri , Thierry Abribat , Abdelkrim Habi
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： C07K14/605 , A61K38/26
摘要： The present invention relates to a GLP-1 peptide having the following formula, or a pharmaceutically acceptable salt thereof: X-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-lle-Ala-Trp-Leu-val-Lys-Gly-Arg-Y (SEQ ID NO. 1) wherein X is a rigidifying hydrophobic moiety and wherein Y is selected from the group consisting of OH, NH2 and Gly-OH. Moreover, the present invention relates to pharmaceutical compositions comprising a therapeutically effective amount of a peptide of the present invention, or a pharmaceutically acceptable salt thereof, in association with at least one constituent selected from a pharmaceutically acceptable carrier, diluent, and excipient.
摘要翻译：本发明涉及具有下式的GLP-1肽或其药学上可接受的盐：<？in-line-formula description =“In-line formula”end =“lead”？> X-His-Ala- Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ala-Ala-Trp-Leu-val- Lys-Gly-Arg-Y（SEQ ID NO.1）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中X是刚性疏水部分，其中Y选自由OH，NH 2和Gly-OH组成的组。此外，本发明涉及包含治疗有效量的本发明的肽或其药学上可接受的盐与至少一种选自药学上可接受的载体，稀释剂和赋形剂的成分的药物组合物。

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