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1. 发明申请

US20060252687A1 Novel chemokine mimetics synthesis and their use 失效
标题翻译：新型趋化因子模拟物合成及其应用
公开(公告)号：US20060252687A1
公开(公告)日：2006-11-09
申请号：US11393769
申请日：2006-03-29
申请人： Ahmed Merzouk , Abdelkrim Habi , Donald Wong , Hassan Salari
发明人： Ahmed Merzouk , Abdelkrim Habi , Donald Wong , Hassan Salari
IPC分类号： A61K38/16
CPC分类号： A61K38/12 , C07K14/521
摘要： The present disclosure generally teaches compositions comprising SDF-1 mimetics and methods of using them to modulate an activity of a cell having an SDF-1 receptor by binding the SDF-1 receptor to an SDF-1 mimetic. The cell can be a hematopoietic cell, for example, and can be selected from a group consisting of hematopoietic stem cells, hematopoietic progenitor cells, primitive granulocytes, primitive erythroid cells, leukocytes, and neutrophils. In some embodiments, the activity can include the rate of multiplication of the cell or, where the cell is a quiescent cell, the binding can repress the activation of the quiescent cell. Other embodiments of the present invention are taught herein.
摘要翻译：本公开通常教导包含SDF-1模拟物的组合物和使用它们通过将SDF-1受体结合到SDF-1模拟物来调节具有SDF-1受体的细胞的活性的方法。细胞可以是例如造血细胞，并且可以选自造血干细胞，造血祖细胞，原始粒细胞，原始红细胞，白细胞和嗜中性粒细胞。在一些实施方案中，活性可以包括细胞的增殖速率，或者当细胞是静止细胞时，结合可以抑制静止细胞的活化。本文教导了本发明的其它实施例。

2. 发明授权

US07994114B2 Chemokine mimetics synthesis and their use 失效
标题翻译：趋化因子模拟物合成及其应用
公开(公告)号：US07994114B2
公开(公告)日：2011-08-09
申请号：US11393769
申请日：2006-03-29
申请人： Ahmed Merzouk , Abdelkrim Habi , Donald Wong , Hassan Salari
发明人： Ahmed Merzouk , Abdelkrim Habi , Donald Wong , Hassan Salari
IPC分类号： A61K38/00 , A61K31/70 , A61K45/00 , A61K48/00 , C07K14/00 , C12Q1/00 , G01N63/00 , C12N15/63 , C12N5/08 , A01N63/00
CPC分类号： A61K38/12 , C07K14/521
摘要： The present disclosure generally teaches compositions comprising SDF-1 mimetics and methods of using them to modulate an activity of a cell having an SDF-1 receptor by binding the SDF-1 receptor to an SDF-1 mimetic. The cell can be a hematopoietic cell, for example, and can be selected from a group consisting of hematopoietic stem cells, hematopoietic progenitor cells, primitive granulocytes, primitive erythroid cells, leukocytes, and neutrophils. In some embodiments, the activity can include the rate of multiplication of the cell or, where the cell is a quiescent cell, the binding can repress the activation of the quiescent cell. Other embodiments of the present invention are taught herein.
摘要翻译：本公开通常教导包含SDF-1模拟物的组合物和使用它们通过将SDF-1受体结合到SDF-1模拟物来调节具有SDF-1受体的细胞的活性的方法。例如，细胞可以是造血细胞，并且可以选自造血干细胞，造血祖细胞，原始粒细胞，原始红细胞，白细胞和嗜中性粒细胞。在一些实施方案中，活性可以包括细胞的增殖速率，或者当细胞是静止细胞时，结合可以抑制静止细胞的活化。本文教导了本发明的其它实施例。

3. 发明申请

US20070275892A9 Novel chemokine mimetics synthesis and their use 失效
标题翻译：新型趋化因子模拟物合成及其应用
公开(公告)号：US20070275892A9
公开(公告)日：2007-11-29
申请号：US11393769
申请日：2006-03-29
申请人： Ahmed Merzouk , Abdelkrim Habi , Donald Wong , Hassan Salari
发明人： Ahmed Merzouk , Abdelkrim Habi , Donald Wong , Hassan Salari
IPC分类号： A61K38/16
CPC分类号： A61K38/12 , C07K14/521
摘要： The present disclosure generally teaches compositions comprising SDF-1 mimetics and methods of using them to modulate an activity of a cell having an SDF-1 receptor by binding the SDF-1 receptor to an SDF-1 mimetic. The cell can be a hematopoietic cell, for example, and can be selected from a group consisting of hematopoietic stem cells, hematopoietic progenitor cells, primitive granulocytes, primitive erythroid cells, leukocytes, and neutrophils. In some embodiments, the activity can include the rate of multiplication of the cell or, where the cell is a quiescent cell, the binding can repress the activation of the quiescent cell. Other embodiments of the present invention are taught herein.
摘要翻译：本公开通常教导包含SDF-1模拟物的组合物和使用它们通过将SDF-1受体结合到SDF-1模拟物来调节具有SDF-1受体的细胞的活性的方法。例如，细胞可以是造血细胞，并且可以选自造血干细胞，造血祖细胞，原始粒细胞，原始红细胞，白细胞和嗜中性粒细胞。在一些实施方案中，活性可以包括细胞的增殖速率，或者当细胞是静止细胞时，结合可以抑制静止细胞的活化。本文教导了本发明的其它实施例。

4. 发明申请

US20050059584A1 Novel chemokine mimetics synthesis and their use 审中-公开
标题翻译：新型趋化因子模拟物合成及其应用
公开(公告)号：US20050059584A1
公开(公告)日：2005-03-17
申请号：US10222703
申请日：2002-08-16
申请人： Ahmed Merzouk , Abdelkrim Habi , Donald Wong , Hassan Salari
发明人： Ahmed Merzouk , Abdelkrim Habi , Donald Wong , Hassan Salari
IPC分类号： A61K38/19 , C07K14/52
CPC分类号： A61K38/12 , C07K14/521
摘要： The present invention is concerned with chemokine derived analogs, including SDF-1 and/or SDF-1/MIP1α hybrid analogs, that are useful for the treatment of a variety of diseases and disorders, and as an adjunct to the treatment of a variety of diseases and disorders. A therapeutically effective amount of the chemokine analog may be administered to a patient in need of such treatment.
摘要翻译：本发明涉及可用于治疗各种疾病和病症的趋化因子衍生类似物，包括SDF-1和/或SDF-1 /MIP1α杂合类似物，并且作为治疗各种各样的疾病和病症。趋化因子类似物的治疗有效量可以施用于需要这种治疗的患者。

5. 发明申请

US20070116669A1 Interferon-inducible protein-10 (IP-10 or CXCL10) chemokine analogs for the treatment of human diseases 审中-公开
标题翻译：干扰素诱导蛋白-10（IP-10或CXCL10）趋化因子类似物用于治疗人类疾病
公开(公告)号：US20070116669A1
公开(公告)日：2007-05-24
申请号：US11590210
申请日：2006-10-30
申请人： Ahmed Merzouk , Donald Wong , Hassan Salari
发明人： Ahmed Merzouk , Donald Wong , Hassan Salari
IPC分类号： A61K38/19 , C07K14/52 , C07K16/24 , A61K39/395
CPC分类号： C07K14/522 , A61K38/00
摘要： This invention is directed to peptide analogs of interferon-inducible protein-10 (IP-10 or CXCL10) chemokine that bind to the CXCR3 receptor or any other receptor in which IP-10 analogs can bind to as a ligand, such that the analogs can be designed to serve as agonists or antagonists of IP-10 chemokine. The analogs can be used to prevent, treat, or ameliorate the symptoms of, a disease.
摘要翻译：本发明涉及与CXCR3受体结合的干扰素诱导蛋白-10（IP-10或CXCL10）趋化因子的肽类似物或其中IP-10类似物可以结合作为配体的任何其它受体，使得类似物可以被设计用作IP-10趋化因子的激动剂或拮抗剂。类似物可用于预防，治疗或改善疾病的症状。

6. 发明申请

US20070066523A1 Chemokine analogs for the treatment of human diseases 审中-公开
标题翻译：趋化因子类似物用于治疗人类疾病
公开(公告)号：US20070066523A1
公开(公告)日：2007-03-22
申请号：US11494232
申请日：2006-07-26
申请人： Ahmed Merzouk , Donald Wong , Hassan Salari
发明人： Ahmed Merzouk , Donald Wong , Hassan Salari
IPC分类号： A61K38/16 , C07K14/475
CPC分类号： C07K14/4718 , A61K38/00 , C07K14/523 , C07K14/5421
摘要： The present invention is concerned with chemokine analogs, including IL-8 analogs, IP-10 analogs, MIP-1α analogs, RANTES analogs, I-309 analogs, MCP-1 analogs, and CCL28 analogs, that are useful for the treatment of a variety of diseases and disorders, and as an adjunct to the treatment of a variety of diseases and disorders. A therapeutically effective amount of the chemokine analog may be administered to a patient in need of such treatment.
摘要翻译：本发明涉及趋化因子类似物，包括IL-8类似物，IP-10类似物，MIP-1α类似物，RANTES类似物，I-309类似物，MCP-1类似物和CCL28类似物，其可用于治疗各种疾病和病症，以及作为治疗各种疾病和病症的辅助物质。趋化因子类似物的治疗有效量可以施用于需要这种治疗的患者。

7. 发明授权

US07091310B2 Chemokine analogs for the treatment of human disease 失效
标题翻译：趋化因子类似物用于治疗人类疾病
公开(公告)号：US07091310B2
公开(公告)日：2006-08-15
申请号：US10243795
申请日：2002-09-13
申请人： Ahmed Merzouk , Donald Wong , Hassan Salari
发明人： Ahmed Merzouk , Donald Wong , Hassan Salari
IPC分类号： C07K14/00 , A61K45/00 , C12Q1/00 , G01N33/53
CPC分类号： C07K14/4718 , A61K38/00 , C07K14/523 , C07K14/5421
摘要： The present invention is concerned with chemokine analogs, including IL-8 analogs, IP-10 analogs, MIP-1α analogs, RANTES analogs, I-309 analogs, MCP-1 analogs, and CCL28 analogs, that are useful for the treatment of a variety of diseases and disorders, and as an adjunct to the treatment of a variety of diseases and disorders. A therapeutically effective amount of the chemokine analog may be administered to a patient in need of such treatment.
摘要翻译：本发明涉及趋化因子类似物，包括IL-8类似物，IP-10类似物，MIP-1α类似物，RANTES类似物，I-309类似物，MCP-1类似物和CCL28类似物，其可用于治疗各种疾病和病症，以及作为治疗各种疾病和病症的辅助物质。趋化因子类似物的治疗有效量可以施用于需要这种治疗的患者。

8. 发明申请

US20060233748A1 Mimetics of interleukin-8 and methods of using them in the prevention, treatment, diagnosis, and ameliorization of symptoms of a disease 审中-公开
标题翻译：白细胞介素-8的模拟物及其在预防，治疗，诊断和改善疾病症状中的应用方法
公开(公告)号：US20060233748A1
公开(公告)日：2006-10-19
申请号：US10932208
申请日：2004-08-31
申请人： Ahmed Merzouk , Donald Wong , Hassan Salari
发明人： Ahmed Merzouk , Donald Wong , Hassan Salari
IPC分类号： A61K38/20
CPC分类号： A61K38/2053 , C07K14/5421
摘要： The present invention teaches compositions and uses of mimetics of IL-8 in the diagnosis, prevention, treatment, and ameliorization of symptoms of a variety of diseases.
摘要翻译：本发明教导了IL-8的模拟物在各种疾病症状的诊断，预防，治疗和改善中的组合物和用途。

9. 发明申请

US20060216765A1 Apparatus, methods and systems for rapid microbial testing 审中-公开
标题翻译：用于快速微生物测试的装置，方法和系统
公开(公告)号：US20060216765A1
公开(公告)日：2006-09-28
申请号：US11091017
申请日：2005-03-25
申请人： Thomas Grove , Stephan Thompson , Donald Wong
发明人： Thomas Grove , Stephan Thompson , Donald Wong
IPC分类号： G01N33/554 , C12Q1/04
CPC分类号： G01N33/569
摘要： A method for detecting microorganisms includes obtaining a sample from a source of interest and applying the sample to a selective growth medium to permit any microorganisms of interest in the sample to grow. Any microorganisms that have grown are harvested. An immunoassay is then conducted to detect the microorganism of interest, if any, with a high degree of sensitivity and specificity. A system that may be used to grow, harvest, and detect a microorganism of interest includes a growth plate, or dish, a lavage solution, a lavage apparatus, and an assay apparatus. The dish may include a vessel with multiple sections, at least one of which is used to grow microorganisms of interest, and another of which is configured to receive and contain harvested microorganisms of interest.
摘要翻译：用于检测微生物的方法包括从感兴趣的来源获得样品并将样品施加到选择性生长培养基以允许样品中所有感兴趣的微生物生长。收获生长的任何微生物。然后进行免疫测定以高灵敏度和特异性检测感兴趣的微生物（如果有的话）。可用于生长，收获和检测感兴趣的微生物的系统包括生长板或培养皿，灌洗溶液，灌洗装置和测定装置。该盘可以包括具有多个部分的容器，其中至少一个用于生长感兴趣的微生物，并且其中另一个构造成容纳并包含收获的感兴趣的微生物。

10. 发明授权

US08166501B2 Scheme for use with client device interface in system for providing dailies and edited video to users 有权
标题翻译：用于系统中的客户端设备接口的方案，用于向用户提供日报和编辑的视频
公开(公告)号：US08166501B2
公开(公告)日：2012-04-24
申请号：US11627218
申请日：2007-01-25
申请人： Theodore M. Shikuma , Ben Masek , Philip David Skeen , Donald Wong
发明人： Theodore M. Shikuma , Ben Masek , Philip David Skeen , Donald Wong
IPC分类号： G06F3/00 , G06F13/00 , H04N5/445 , H04N7/16 , G06F3/048 , G06F15/16
CPC分类号： G11B27/034
摘要： A method for use in providing video to a user includes establishing digital video data that includes images shot in relation to a making of content, uploading the digital video data to a server, and sending the digital video data from the server through a network to a client device for viewing by the user. The client device may be configured to allow the user to mark one or more portions of the digital video data for review or deletion. A system for use in providing video to a user is also disclosed.
摘要翻译：用于向用户提供视频的方法包括建立数字视频数据，其包括与内容制作有关的图像，将数字视频数据上传到服务器，以及通过网络将数字视频数据从服务器发送到客户端设备供用户查看。客户端设备可以被配置为允许用户标记数字视频数据的一个或多个部分以供查看或删除。还公开了一种用于向用户提供视频的系统。

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