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1. 发明授权

US12138107B2 System and method for ultrasound perfusion imaging 有权
公开(公告)号：US12138107B2
公开(公告)日：2024-11-12
申请号：US17629008
申请日：2020-07-20
申请人： Exact Imaging Inc.
发明人： Brian C. Wodlinger
IPC分类号： A61B8/06 , A61B8/00 , A61B8/08 , G01S7/52 , G01S15/89 , G06T3/40 , G06T5/70 , G06T7/20 , G06T7/32 , G16H30/40 , G16H50/20
CPC分类号： A61B8/06 , A61B8/461 , A61B8/5276 , G01S7/52077 , G01S15/895 , G01S15/8977 , G06T3/40 , G06T5/70 , G06T7/20 , G06T7/32 , G16H30/40 , G16H50/20 , G06T2207/10016 , G06T2207/10132
摘要： A perfusion imaging processing method comprising collecting a plurality of digital images comprising sequential B-Mode micro-ultrasound reflectivity data, calculating decorrelation trends of autocorrelated data to determine blood flow and perfusion level, reducing the noise content in the data using the decorrelation trends, and/or forming a visual representation based on the decorrelation trends. The present system and method provides an ultrasonic imaging system and method which provides perfusion data without requiring the use of an injected contrast agent.

2. 发明授权

US12133901B2 PSMA ligand targeted compounds and uses thereof 有权
公开(公告)号：US12133901B2
公开(公告)日：2024-11-05
申请号：US17424084
申请日：2020-01-21
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： James Basilion , Clemens Burda , Dong Luo , Xinning Wang
IPC分类号： A61K49/04 , A61K9/14 , A61K33/242 , A61K41/00 , A61K47/54 , A61P35/00
CPC分类号： A61K49/0423 , A61K9/14 , A61K33/242 , A61K41/0038 , A61K47/542 , A61P35/00
摘要： Prostate-specific membrane antigen (PSMA) targeted compounds having formula (I), nanoclusters formed thereof, pharmaceutical compositions comprising a plurality of these compounds, and methods for treating and detecting cancers in a subject are described herein.

3. 发明授权

US12133736B2 Determining bipolar electrical activity 有权
公开(公告)号：US12133736B2
公开(公告)日：2024-11-05
申请号：US17336564
申请日：2021-06-02
申请人： CARDIOINSIGHT TECHNOLOGIES, INC.
发明人： Yong Wang , Qing Lou , Qingguo Zeng , Ping Jia
IPC分类号： A61B5/316 , A61B5/349 , A61N1/32
CPC分类号： A61B5/316 , A61B5/349 , A61N1/32
摘要： This disclosure provides one or more computer-readable media having computer-executable instructions for performing a method. The method includes storing geometry data representing a primary geometry of a cardiac envelope that includes nodes distributed across the cardiac envelope and geometry of a body surface that includes locations where electrical signals are measured. The body surface is spaced apart from the cardiac envelope. The method also includes perturbing the primary geometry of the cardiac envelope a given distance and direction to define the perturbed geometry of the cardiac envelope including nodes spaced from the nodes of the primary geometry. The method also includes computing reconstructed bipolar electrical signals on the nodes of the primary cardiac envelope based on the electrical signals measured from the body surface and the geometry data, including the primary and perturbed geometries of the cardiac envelope.

4. 发明授权

US12130254B2 Organic thin film transistors and the use thereof in sensing applications 有权
公开(公告)号：US12130254B2
公开(公告)日：2024-10-29
申请号：US17007764
申请日：2020-08-31
申请人： LIFE SCIENCE BIOSENSOR DIAGNOSTICS PTY. LTD.
发明人： Paul Dastoor , Warwick Belcher
IPC分类号： H01L51/00 , B82Y10/00 , C12Q1/00 , G01N27/414 , H10K10/46
CPC分类号： G01N27/4145 , C12Q1/006 , H10K10/464 , H10K10/471 , H10K10/481
摘要： The present invention relates to organic thin film transistors and the preparation and use thereof in sensing applications, and in particular in glucose sensing applications.

5. 发明授权

US12123770B2 Hold operations for light-to-frequency sensors 有权
公开(公告)号：US12123770B2
公开(公告)日：2024-10-22
申请号：US17618447
申请日：2020-07-15
申请人： AMS INTERNATIONAL AG
发明人： Ravi Kumar Adusumalli
IPC分类号： G01J1/44 , G01J1/02
CPC分类号： G01J1/44 , G01J1/0233 , G01J2001/446
摘要： Methods, systems, and apparatus, including computer programs encoded on computer storage media, for a light-to-frequency sensor conversion. In some implementations, a first output waveform is generated from a light signal, a frequency of the first output waveform being based on an intensity of the light signal, including integrating the light signal across multiple clock cycles. In response to receiving a notification, a hold operation is performed to stop integrating the light signal for a period of time. In response to an end of the hold operation, a second output waveform is generated that includes integrating the intensity of the light signal starting from the end of the hold operation over a count of the multiple clock cycles that start after the end of the hold operation by a delay amount. The first output waveform and the second output waveform are summed to determine the intensity of the light signal.

6. 发明授权

US12121180B2 Temperature monitoring and control system for a kitchen device 有权
公开(公告)号：US12121180B2
公开(公告)日：2024-10-22
申请号：US17256637
申请日：2019-06-28
申请人： BREVILLE PTY LIMITED
发明人： Eddie Siu , Richard Llewelyn Jones , Warren Preston , Con Psarologos
IPC分类号： A47J36/32 , A47J27/00 , A47J43/046 , A47J43/07 , A47J44/00 , G01K13/00 , H05B1/02
CPC分类号： A47J36/32 , A47J27/004 , A47J43/046 , A47J43/0727 , A47J44/00 , G01K13/00 , H05B1/0261 , A47J2202/00 , G01K2207/06
摘要： A kitchen device comprising a cooking vessel, a heating plate, a first temperature sensor and a second temperature sensor, wherein the first temperature sensor is thermally connected to, at least part of, the heating plate of the kitchen device for measuring the temperature of the heating plate, and the second temperature sensor is located in a position to measure the temperature of one or more ingredients that are inside the cooking vessel and the second temperature sensor is thermally isolated from the cooking vessel by a sensor isolation seal.

7. 发明授权

US12109565B2 Microfluidic device and a method for provision of emulsion droplets 有权
公开(公告)号：US12109565B2
公开(公告)日：2024-10-08
申请号：US17426554
申请日：2020-01-31
申请人： SAMPLIX APS
发明人： Thomas Kvist , Soléne Cherre , Marie Just Mikkelsen
IPC分类号： B01L3/00
CPC分类号： B01L3/502769 , B01L2200/0673 , B01L2300/0883
摘要： A microfluidic device (100) comprises an emulsification section (101) comprising one or more emulsification units (170); and a container section (102) comprising one or more groups of containers comprising one group of containers for each emulsification unit; each emulsification unit (170) comprising a fluid conduit network (135) comprising: a plurality of supply conduits comprising a primary supply conduit (103) and a secondary supply conduit (106); a transfer conduit (112); and a first fluid junction (120) providing fluid communication between the primary supply conduit (103), the secondary supply conduit (106), and the transfer conduit (112); each group of containers (103) comprising a plurality of containers comprising an intermediate chamber (174), a collection container (134), and one or more supply containers (131) comprising a secondary supply container, the secondary supply container (131) defining a secondary supply cavity, the secondary supply container (131) comprising a secondary orifice (177) extending from the secondary supply cavity and a primary orifice (176) extending from the secondary supply cavity, the collection container (134) being in fluid communication with the transfer conduit (112) of the corresponding emulsification unit (170) via a collection orifice of the collection container (134), the secondary supply container (131) being in fluid communication with the secondary supply conduit (106) of the corresponding emulsification unit (170) via the secondary orifice (177), the secondary supply container (131) being in fluid communication with the intermediate chamber (174) of the same group of containers (103) via the primary orifice (176), the intermediate chamber (174) being in fluid communication with the first fluid junction (120) of the corresponding emulsification unit (170) via the primary supply conduit (103) of the corresponding emulsification unit (170). Furthermore a method of manufacturing said device and a method for providing emulsion droplets using such a microfluidic device.

8. 发明授权

US12106187B2 Data transformation in ingestion processes via workflows utilizing sequences of atomic functions 有权
公开(公告)号：US12106187B2
公开(公告)日：2024-10-01
申请号：US16940713
申请日：2020-07-28
申请人： Oracle International Corporation
发明人： Carlos E. Hernández Rincón , Andrew Richard Rundell , Terence Joseph Munday , James Edward Bridges, Jr. , Mariana Dayanara Alanis Tamez , Josue Emmanuel Gomez Carrillo
IPC分类号： G06N20/00 , G06F16/215 , G06F16/25
CPC分类号： G06N20/00 , G06F16/215 , G06F16/254
摘要： Systems and method are provided for data flattening. A corpus of data is extracted from at least one data source and stored at a data warehousing platform. A workflow is applied to the extracted corpus of data to provide a transformed corpus of data. The workflow includes a sequence of atomic functions selected from a library of atomic functions to perform an associated task on the corpus of data. The transformed corpus of data is provided from the data warehousing platform to a machine learning model as a set of training data.

9. 发明授权

US12091448B2 Binding molecule able to neutralize PROX1 protein 有权
公开(公告)号：US12091448B2
公开(公告)日：2024-09-17
申请号：US18089393
申请日：2022-12-27
申请人： Korea Advanced Institute of Science and Technology
发明人： Jin Woo Kim , Eun Jung Lee
IPC分类号： C07K16/18 , C12N15/86
CPC分类号： C07K16/18 , C12N15/86 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C12N2750/14143
摘要： The present disclosure relates to a PROX1 (Prospero homeobox protein 1) protein binding molecule. More specifically, the binding molecule of the present disclosure relates to a binding molecule having excellent binding ability to the PROX1 protein and having an excellent neutralizing effect on the PROX1 protein, and it is very useful for diagnosis, prevention or treatment of retinal neurodegenerative diseases.

10. 发明授权

US12084567B2 Polypropylene based composition with improved paintability 有权
公开(公告)号：US12084567B2
公开(公告)日：2024-09-10
申请号：US17269208
申请日：2019-08-23
申请人： BOREALIS AG
发明人： Jingbo Wang , Klaus Bernreitner , Daniela Mileva , Georg Grestenberger , Markus Gahleitner
IPC分类号： C08L23/14 , C08K3/34 , C08L23/08 , C08L23/16 , C08L23/18
CPC分类号： C08L23/142 , C08K3/34 , C08L23/0815 , C08L23/16 , C08L23/14 , C08L23/18 , C08L2205/03 , C08L2205/22 , C08L2207/02
摘要： The present invention relates to a polypropylene based composition comprising: (A) from 40.0 to 85.0 wt % of a heterophasic propylene copolymer having a content of xylene cold soluble (XCS) fraction in the range of 15 wt % to 35 wt %, based on the total weight of the heterophasic propylene copolymer; (B) from 5.0 to 15.0 wt % of a random copolymer of propylene with comonomer units selected from ethylene and alpha-olefins having from 4 to 12 carbon atoms which has been polymerized in the presence of a single-site catalyst system and has a melting temperature Tm as measured in differential scanning calorimetry (DSC) of less than 140° C.; (C) from 5.0 to 25.0 wt % of an ethylene copolymer with alpha-olefin comonomer units having from 4 to 12 carbon atoms with a density of from 850 kg/m3 to 900 kg/m3; and (D) from 5.0 to 25.0 wt % of an inorganic filler, wherein the amounts of components (A), (B), (C), and (D) are all based on the total weight amount of the polypropylene based composition, said polypropylene based composition having a melt flow rate (MFR2) as measured at 230° C. and 2.16 kg load in accordance with ISO 1133 in the range of 2.0 g/10 min to 20.0 g/10 min, an article comprising said polypropylene based composition and the use of said copolymer (B) for reducing the paint adhesion failure of an article comprising said polypropylene based composition.

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