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1. 发明授权

US09630925B2 HSP90 inhibitor and preparation method and use thereof 有权
公开(公告)号：US09630925B2
公开(公告)日：2017-04-25
申请号：US13878223
申请日：2011-02-16
申请人： Yifei Wang , Guowen Xing , Huaiqiang Ju , Wenhui Lin , Chuiwen Qian , Min Xia , Xiaoping Zhou , Meiying Zhang
发明人： Yifei Wang , Guowen Xing , Huaiqiang Ju , Wenhui Lin , Chuiwen Qian , Min Xia , Xiaoping Zhou , Meiying Zhang
IPC分类号： C07D231/56 , A61K31/416
CPC分类号： C07D231/56 , A61K31/416
摘要： Disclosed are an Hsp90 inhibitor and a preparation method and use thereof. The Hsp90 inhibitor is 2-(4-(3-acetylcarnitineacyloxy)cyclohexylamino)-4-(1-(3,6,6-trimethyl-4-oxy-4,5,6,7-tetrahydroindazole))benzamide. The Hsp90 inhibitor has good water solubility and high bioavailability, and can effectively inhibit the proliferation of cancer cells, such as leukemia, cervical cancer, breast cancer, human laryngeal epithelial carcinoma, or malignant melanoma cells. It can also effectively inhibit the activity of herpes simplex virus. The maximal non-toxic concentration of the Hsp90 inhibitor on normal cells is a high, and the Hsp90 inhibitor only has specific inhibition effect on cancer cells.

2. 发明授权

US08180710B2 System, method and computer program product for an interactive business services price determination and/or comparison model 有权
标题翻译：用于交互式商业服务价格确定和/或比较模型的系统，方法和计算机程序产品
公开(公告)号：US08180710B2
公开(公告)日：2012-05-15
申请号：US11860699
申请日：2007-09-25
申请人： Adam J. Strichman , Christopher Pattacini , Kent Christian
发明人： Adam J. Strichman , Christopher Pattacini , Kent Christian
IPC分类号： G06F17/00 , G06Q40/00
CPC分类号： G06Q10/00 , G06Q10/063 , G06Q30/00 , G06Q30/0206 , G06Q30/0283 , G06Q40/00
摘要： A system, method, and computer program product are disclosed for determining a standard market pricing index for pricing user-defined business services and for comparing unique configurations of business services to the determined market pricing index and/or to other unique configurations of business services. Portions of the disclosed system, method, and/or computer program product describe a model and user interface for performing standard, objective, repeatable, and directly comparable benchmarking of business services. In general, the computerized model compiles a set of market price data and interprets specific configurations and characteristics from the market data set. The model performs a periodic analysis to determine which configurations and/or characteristics are the most common within the data set, yielding a common market configuration. The model further performs an iterative process in which all the data within the data set is normalized and adjusted to the common market configuration of similar business services. A user enters a user-defined services data set into the model, in the form of answers to questions through a user-interface, and upon running the model, receives a report indicating a likely market price for such services.
摘要翻译：公开了一种系统，方法和计算机程序产品，用于确定用于定义用户定义的业务服务的标准市场定价指数，以及将商业服务的独特配置与确定的市场定价指数和/或与其他商业服务的其他独特配置进行比较。所公开的系统，方法和/或计算机程序产品的部分描述用于执行商业服务的标准，客观，可重复和直接可比较的基准的模型和用户界面。一般来说，计算机化模型编制了一套市场价格数据，并从市场数据集中解释了具体的配置和特征。该模型执行周期性分析以确定哪些配置和/或特征在数据集中是最常见的，产生公共市场配置。该模型进一步执行一个迭代过程，其中将数据集中的所有数据归一化并调整到类似业务服务的共同市场配置。用户通过用户界面以问题的答案形式将用户定义的服务数据集输入到模型中，并且在运行模型时，接收到表示这种服务的可能的市场价格的报告。

3. 发明授权

US08486617B2 Methods for preparing freeze-dried platelets, compositions comprising freeze-dried platelets, and methods of use 有权
标题翻译：制备冷冻干燥血小板的方法，包含冷冻干燥血小板的组合物和使用方法
公开(公告)号：US08486617B2
公开(公告)日：2013-07-16
申请号：US11659708
申请日：2005-08-12
申请人： David Ho , Cindy S. Orser , Alan S. Rudolph , Keith Moskowitz , Joshua Dee
发明人： David Ho , Cindy S. Orser , Alan S. Rudolph , Keith Moskowitz , Joshua Dee
IPC分类号： A01N1/02 , A01N63/00
CPC分类号： A01N1/0284 , A01N1/02 , G01N33/86
摘要： The present invention provides processes for preparing freeze-dried platelets, freeze-dried platelets made by those processes, platelets reconstituted from those freeze-dried platelets, methods of using the platelets for therapeutic, diagnostic, and research purposes, and kits comprising the freeze-dried platelets.
摘要翻译：本发明提供了制备冻干血小板的方法，由这些方法制备的冷冻干燥血小板，由那些冻干血小板重建的血小板，使用血小板治疗，诊断和研究目的的方法，以及包含冻干血小板的试剂盒，干血小板。

4. 发明授权

US08304207B2 Method of measuring blood sample on blood test instrument using a disposable cartridge 有权
标题翻译：使用一次性药筒测量血液检测仪器上的血液样本的方法
公开(公告)号：US08304207B2
公开(公告)日：2012-11-06
申请号：US12910097
申请日：2010-10-22
申请人： Ingemar Berndtsson , Lars Svensson , Lennart Niklason
发明人： Ingemar Berndtsson , Lars Svensson , Lennart Niklason
IPC分类号： C12Q1/02
CPC分类号： G01N33/491 , B01L3/502 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L9/54 , B01L2200/027 , B01L2200/10 , B01L2300/0809 , B01L2300/0867 , B01L2400/0481 , B01L2400/0622 , B01L2400/065 , G01N1/38 , G01N33/4875
摘要： A blood test instrument using a disposable cartridge and a method of measuring a blood sample using the instrument are disclosed. The instrument includes a cell counting station for counting blood cells by electrical resistance measurement, a pressure actuating component adapted to apply a pressure alternately on two flexible receptacles of a disposable cartridge removably placed in the instrument to cause flowing of a mixture of a blood sample and a liquid agent between the two receptacles to obtain proper mixing, and a conduit adapted to deliver the mixture to the cell counting station for counting. After measuring the blood sample, the instrument withdraws a washing liquid contained in another receptacle of the disposable cartridge and uses the washing liquid to clean the instrument and to deliver the mixture back to the cartridge for disposal.
摘要翻译：公开了一种使用一次性药筒的血液检查仪器和使用该仪器测量血液样品的方法。该仪器包括用于通过电阻测量来计数血细胞的细胞计数站，压力致动部件，其适于在可拆卸地放置在仪器中的一次性药筒的两个柔性容器上交替施加压力，以引起血液样本和两个容器之间的液体试剂以获得适当的混合，以及适于将混合物输送到细胞计数站进行计数的导管。在测量血液样本之后，仪器将包含在一次性药筒的另一个容器中的洗涤液体取出并使用洗涤液清洁仪器并将混合物输送到药筒以进行处理。

5. 发明授权

US08288350B2 Methods to prevent and treat diseases 有权
标题翻译：预防和治疗疾病的方法
公开(公告)号：US08288350B2
公开(公告)日：2012-10-16
申请号：US13111571
申请日：2011-05-19
申请人： Salwa A. Elgebaly , Elliott Schiffmann
发明人： Salwa A. Elgebaly , Elliott Schiffmann
IPC分类号： A61K38/04 , A61K38/13 , A61K38/00
CPC分类号： A61K31/195 , A61K31/122 , A61K31/205 , A61K31/365 , A61K31/375 , A61K31/385 , A61K31/4164 , A61K31/4168 , A61K31/4172 , A61K38/06 , A61K38/08 , A61K38/13 , A61K38/177 , A61K38/33 , A61K38/47 , A61K45/06 , A61K2300/00
摘要： Methods and compositions that can treat a variety of tissue injuries and infections are provided. Tissue-derived leukocyte chemotactic factors are rapidly released after injury to mammalian tissue and can act as the initial signal leading to the initiation and amplification of acute and chronic inflammation associated with injury and infection. The present invention generally provides methods and compositions to prevent and treat injury of cells, tissue, or organs by blocking or inhibiting the release of leukocyte chemotactic factors, by administering certain effective compositions to the tissue.
摘要翻译：提供了可以治疗各种组织损伤和感染的方法和组合物。组织衍生的白细胞趋化因子在损伤哺乳动物组织后迅速释放，可作为导致与损伤和感染相关的急性和慢性炎症的起始和扩增的初始信号。本发明通常提供通过向组织施用某些有效组合物来阻止或抑制白细胞趋化因子的释放来预防和治疗细胞，组织或器官的损伤的方法和组合物。

6. 发明授权

US08518662B2 Disposable cassette and method of use for blood analysis on blood analyzer 有权
标题翻译：用于血液分析仪血液分析的一次性盒式磁带和使用方法
公开(公告)号：US08518662B2
公开(公告)日：2013-08-27
申请号：US13544079
申请日：2012-07-09
申请人： Kalle Ritzen , Ingemar Berndtsson , Björn Roos , Gunnar Magnusson
发明人： Kalle Ritzen , Ingemar Berndtsson , Björn Roos , Gunnar Magnusson
IPC分类号： C12Q1/24 , C12M1/34 , C12M3/00 , C12M1/00 , C12N11/00 , C25B9/00 , C25B11/00 , C25B13/00 , G01N1/00 , G01N27/26 , G01N31/00 , G01N33/50 , G01N33/487
CPC分类号： G01N35/00029 , B01L3/502715 , B01L3/502723 , B01L2200/143 , B01L2200/16 , B01L2300/044 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2400/0481 , G01N2035/00148
摘要： A disposable cassette for blood analysis includes a housing having an upper panel and a sampling section having a filling inlet; at least one pair of chambers in a form of depression of the upper panel of the housing and sealed by a diaphragm; portions of the diaphragm over the chambers being flexible; and one or more channels adapted to interconnect the pair of chambers; one of the chambers containing a predetermined amount of a reagent for blood analysis; and a sample outlet disposed next to and connected to the chamber containing the reagent, the sample outlet including an outlet cavity recessed from the upper panel, a divider disposed therein, and a cover covering the outlet cavity; the sample outlet sealing the reagent to the chamber containing the reagent. Further disclosed is the method of using the disposable cassette for measurements of hematology parameters on a blood analyzer.
摘要翻译：用于血液分析的一次性盒包括具有上面板的壳体和具有填充入口的取样部分; 至少一对腔室，其形式为凹陷的壳体的上面板并由隔膜密封; 腔室上的隔膜的部分是柔性的; 以及适于互连所述一对腔室的一个或多个通道; 其中一个腔室含有预定量的用于血液分析的试剂; 以及旁边设置并连接到容纳所述试剂的室的样品出口，所述样品出口包括从所述上面板凹入的出口空腔，设置在其中的分隔件和覆盖所述出口腔的盖; 样品出口将试剂密封到含有试剂的室中。还公开了使用一次性盒用于血液分析仪上血液学参数测量的方法。

7. 发明授权

US08431144B2 Animal deterrent for protecting plants 失效
标题翻译：用于保护植物的动物威慑
公开(公告)号：US08431144B2
公开(公告)日：2013-04-30
申请号：US12484055
申请日：2009-06-12
申请人： Tracy D. Wilkins
发明人： Tracy D. Wilkins
IPC分类号： A01N25/24 , A01N25/00 , A61K9/14 , A61K33/00
CPC分类号： A01N59/00 , A01N25/00 , A01N25/10 , A01N2300/00
摘要： The invention provides materials, compositions, methods, and kits for deterring or repelling animals from eating plant materials. The invention relates to the use of particulate matter to deter animals from eating plant materials that are susceptible to grazing by animals. In exemplary embodiments, an adhesive is applied to target plant material and the particulate matter is then applied prior to curing or drying of the adhesive.
摘要翻译：本发明提供用于阻止或排斥动物吃植物材料的材料，组合物，方法和试剂盒。本发明涉及使用颗粒物质来阻止动物吃动物易受放牧的植物材料。在示例性实施例中，将粘合剂施加到靶植物材料上，然后在固化或干燥粘合剂之前施加颗粒物质。

8. 发明授权

US08333987B2 Nourexin-4 nano-lipid emulsions 有权
标题翻译： Nourexin-4纳米脂质乳剂
公开(公告)号：US08333987B2
公开(公告)日：2012-12-18
申请号：US12570307
申请日：2009-09-30
申请人： Salwa Elgebaly , Elliott Schiffmann , Tamer Elbayoumi
发明人： Salwa Elgebaly , Elliott Schiffmann , Tamer Elbayoumi
IPC分类号： A61K9/127 , G01N33/53 , C12Q1/70 , A61K31/197 , A61P37/04 , A61P31/14 , A61P31/04
CPC分类号： A61K31/197 , A61K9/10 , A61K9/1075 , A61K9/127 , A61K47/40 , C12Q1/6883 , G01N33/569 , G01N2333/11 , G01N2333/4703
摘要： The present invention provides compositions and methods for identifying, monitoring, and/or treating tissue inflammation caused by diseases or injury. Inflammatory mediators from the Nourin family are provided as diagnostic markers to detect or monitor a disease or injury that results in inflammation. In addition, the Nourin family antagonist, Nourexin-4 is provided as a therapy to treat diseases or injury. Further, cyclocreatine is provided as an inhibitor of Nourin formation, which can be used as a therapy to treat injury and inflammation.
摘要翻译：本发明提供用于识别，监测和/或治疗由疾病或损伤引起的组织炎症的组合物和方法。提供来自Nourin家族的炎症介质作为诊断标记，用于检测或监测导致炎症的疾病或损伤。此外，提供了Nourin家族拮抗剂Nourexin-4作为治疗疾病或损伤的治疗方法。此外，提供环磷酸作为Nourin形成的抑制剂，其可以用作治疗损伤和炎症的治疗剂。

9. 发明授权

US08178057B2 Apparatus for filling a sample volume defining device 有权
标题翻译：用于填充样品体积限定装置的装置
公开(公告)号：US08178057B2
公开(公告)日：2012-05-15
申请号：US12782201
申请日：2010-05-18
申请人： Ingemar Berndtsson , Lennart Niklason
发明人： Ingemar Berndtsson , Lennart Niklason
IPC分类号： B01L3/00 , G01N1/18
CPC分类号： G01N1/38 , B01L3/502715 , B01L3/50273 , B01L2200/027 , B01L2200/0605 , B01L2200/0684 , B01L2300/0654 , B01L2300/0825 , B01L2400/0406 , B01L2400/0475 , B01L2400/0478 , B01L2400/065 , B01L2400/0688 , Y10T436/25375 , Y10T436/2575
摘要： An apparatus for filling a sample volume defining device for separating at least one small defined volume of a liquid sample from a relatively larger undefined volume of said sample, said device including a first body and a second body movable relative to each other, whereby said first body has at least one cavity in a surface thereof, said at least one cavity having said defined volume. One of said first or said second body has at least one inlet opening adapted to be placed in a drop of the liquid sample. A defined channel is provided between said first and second body, which channel has fluid connection with said at least one opening and at least beyond said at least one cavity whereby the dimensions of said channel being such that said channel and said at least one cavity is filled with said liquid sample.
摘要翻译：一种用于填充样品体积限定装置的设备，用于从相对较大的未定义体积的所述样品中分离出至少一个小的限定体积的液体样品，所述装置包括可相对于彼此移动的第一体和第二体，主体在其表面中具有至少一个空腔，所述至少一个空腔具有所述限定的体积。所述第一或所述第二主体中的一个具有适于放置在液体样品的液滴中的至少一个入口。限定的通道设置在所述第一和第二主体之间，该通道与所述至少一个开口具有流体连接，并且至少超过所述至少一个空腔，由此所述通道的尺寸使得所述通道和所述至少一个空腔是填充所述液体样品。

10. 发明授权

US09126047B2 Intrathoracic pacemaker 有权
标题翻译：胸腔内起搏器
公开(公告)号：US09126047B2
公开(公告)日：2015-09-08
申请号：US13375983
申请日：2010-06-05
申请人： Yaniv Bar-Cohen , Ramen Chmait , Michael J. Silka , Mark Sklansky
发明人： Yaniv Bar-Cohen , Ramen Chmait , Michael J. Silka , Mark Sklansky
IPC分类号： A61B19/00 , A61N1/362 , A61N1/375 , A61N1/372
CPC分类号： A61N1/362 , A61B17/3468 , A61N1/37205 , A61N1/3756
摘要： The present invention provides a fully intrathoracic artificial pacemaker. The pacemaker is of sufficiently compact size to allow for implantation of both the electrode and the power source within the chest cavity. In exemplary embodiments, a screw-type electrode is used for connection to heart tissue, and a relatively short lead is used to connect the electrode to a battery unit, which can comprise electronics for control of the pacemaker. An assembly for implanting the pacemaker, as well as methods of implanting the pacemaker, are disclosed. In embodiments, the device is designed as a fetal pacemaker.
摘要翻译：本发明提供一种完全胸腔内的人造起搏器。起搏器具有足够紧凑的尺寸，以允许在胸腔内植入电极和电源。在示例性实施例中，使用螺旋型电极连接到心脏组织，并且使用相对短的引线将电极连接到电池单元，电池单元可以包括用于控制起搏器的电子装置。公开了用于植入起搏器的组件以及植入起搏器的方法。在实施例中，设备被设计为胎儿起搏器。

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