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1. 发明授权

US08969413B2 Methods of using (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid 有权
标题翻译：使用（1S，3S）-3-氨基-4-二氟甲基-1-戊酸的方法
公开(公告)号：US08969413B2
公开(公告)日：2015-03-03
申请号：US13581187
申请日：2011-02-25
申请人： Richard B. Silverman , Stephen L. Dewey , Steven Miller
发明人： Richard B. Silverman , Stephen L. Dewey , Steven Miller
IPC分类号： A01N37/30 , A61K31/205 , A61K31/195 , A61K31/197
CPC分类号： A61K31/205 , A61K31/195 , A61K31/197
摘要： (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid also known as CPP-115 or its pharmaceutically acceptable salts can be used to treat addiction and neurological disorders such as epilepsy without side effects such as visual field defects caused by vigabatrin (Sabril).
摘要翻译：也称为CPP-115的（1S，3S）-3-氨基-4-二氟甲基-1-戊烯酸或其药学上可接受的盐可用于治疗成瘾和神经系统疾病如癫痫，而不会引起视野缺陷等副作用通过vigabatrin（Sabril）。

2. 发明授权

US09005286B2 PLGA/HA hydroxyapatite composite bone grafts and method of making 有权
标题翻译： PLGA / HA羟基磷灰石复合骨移植物及其制备方法
公开(公告)号：US09005286B2
公开(公告)日：2015-04-14
申请号：US13772966
申请日：2013-02-21
申请人： Thierry Giorno
发明人： Thierry Giorno
IPC分类号： A61F2/28 , A61L27/40 , A61L27/46 , A61L27/56
CPC分类号： A61L27/46 , A61F2/28 , A61L27/26 , A61L27/365 , A61L27/3691 , A61L27/40 , A61L27/54 , A61L27/56 , A61L2400/12 , A61L2400/18 , A61L2430/02 , B29C33/3835 , B29C33/62 , B29C43/14 , B29K2027/18 , B29K2067/043 , B29K2067/046 , B29K2089/00 , B29K2105/0088 , B29K2509/02 , B29L2031/7532 , C08L67/04
摘要： The present invention involves tissue engineering constructs made from a new composite bone graft material made from biocompatible poly(D,L-lactic-co-glycolic acid) (PLGA) and bioceramic particles exposed on its surface using a gas foaming particle leaching (GF/PL) method and infused with collagen. Methods and apparatus for of forming scaffolds are also disclosed.
摘要翻译：本发明涉及使用由生物相容性聚（D，L-乳酸 - 共 - 乙醇酸）（PLGA）和其表面上暴露于其表面的生物陶瓷颗粒使用气体发泡颗粒浸出（GF / PL）方法并注射胶原蛋白。还公开了用于形成支架的方法和装置。

3. 发明授权

US08777698B2 Hand tool support and dust shroud 有权
标题翻译：手动工具支架和防尘罩
公开(公告)号：US08777698B2
公开(公告)日：2014-07-15
申请号：US12820626
申请日：2010-06-22
申请人： Peter O'Shannessy
发明人： Peter O'Shannessy
IPC分类号： B25B23/00
CPC分类号： B24B55/102 , B24B23/005 , B24B23/028 , B24B55/052 , B25H1/0021
摘要： An abrading tool has a grinding disc mounted to the shaft of a motor, and a dust shroud which has a depending flange which extends over and about a periphery of the grinding disc, the dust shroud having a flattened segment, and a peripheral flexible and adjustable skirt which attaches to and extends beyond the depending flange.
摘要翻译：研磨工具具有安装在电动机的轴上的研磨盘，以及防尘罩，其具有在研磨盘的周边上延伸并且围绕研磨盘的周边的悬垂凸缘，防尘罩具有扁平段，并且外围柔性和可调节裙子连接并延伸超过垂直法兰。

4. 发明授权

US09067875B2 Tetra-substituted NDGA derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use 有权
标题翻译：通过醚键和氨基甲酸酯键的四取代的NDGA衍生物及其合成和药物用途
公开(公告)号：US09067875B2
公开(公告)日：2015-06-30
申请号：US13470779
申请日：2012-05-14
申请人： Qingqi Chen , Rocio Alejandra Lopez , Jonathan Daniel Heller , Amanda Jean Morris
发明人： Qingqi Chen , Rocio Alejandra Lopez , Jonathan Daniel Heller , Amanda Jean Morris
IPC分类号： A61K31/5377 , A61K31/495 , A61K31/445 , A61K31/426 , A61K31/27 , A61K31/135 , A61K31/075 , C07D265/30 , C07D241/04 , C07D211/06 , C07D277/02 , C07C271/02 , C07C215/00 , C07C43/02 , C07C43/225 , C07C43/23 , C07C217/20 , C07D277/24 , C07D295/088 , C07D295/13 , C07D307/52 , C07C217/64 , C07C271/52 , C07D211/14 , C07D295/15 , C07D307/54
CPC分类号： A61K31/5377 , A61K31/09 , A61K31/138 , A61K31/325 , A61K31/341 , A61K31/427 , A61K31/4545 , A61K31/496 , C07C43/225 , C07C43/23 , C07C217/20 , C07C217/64 , C07C271/52 , C07C2601/16 , C07D211/14 , C07D277/24 , C07D295/088 , C07D295/13 , C07D295/15 , C07D307/52 , C07D307/54
摘要： Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.
摘要翻译：公开了包括通过碳原子或杂原子键合的各种端基的二脱氢愈创木酸衍生物化合物，其中通过醚键或氨基甲酸酯键与各羟基残基O基键合的侧链，药物组合物，制备方法和使用方法它们和试剂盒包括它们用于治疗疾病和病症，特别是由HIV感染，HIV感染或HSV感染引起的或与之相关的疾病，诸如各种类型的关节炎和炎性疾病肠疾病，代谢疾病如糖尿病，血管疾病如高血压和黄斑变性，或增生性疾病，如多种类型的癌症。

5. 发明授权

US08871493B2 Transformation system in the field of filamentous fungal hosts 有权
标题翻译：丝状真菌宿主的转化体系
公开(公告)号：US08871493B2
公开(公告)日：2014-10-28
申请号：US13621507
申请日：2012-09-17
申请人： Dyadic International, Inc.
发明人： Mark Aaron Emalfarb , Richard Paul Burlingame , Philip Terry Olson , Arkady Panteleimonovich Sinitsyn , Martine Parriche , Jean Christophe Bousson , Christine Marie Pynnonen , Peter Jan Punt , Cornelia Marie Johanna Van Zeijl
IPC分类号： C12N1/15 , C12N15/80 , C12N9/36 , C12N9/58 , C12N9/42 , C12N9/24
CPC分类号： C12N15/80 , C12N9/2437 , C12N9/2462 , C12N9/2482 , C12N9/58 , C12Y302/01004 , C12Y302/01008 , C12Y302/01091
摘要： A novel transformation system in the field of filamentous fungal hosts for expressing and secreting heterologous proteins or polypeptides is described. The invention also covers a process for producing large amounts of polypeptide or protein in an economical manner. The system comprises a transformed or transfected fungal strain of the genus Chrysosporium, more particularly of Chrysosporium lucknowense and mutants or derivatives thereof. It also covers transformants containing Chrysosporium coding sequences, as well expression-regulating sequences of Chrysosporium genes. Also provided are novel fungal enzymes and their encoding sequences and expression-regulating sequences.
摘要翻译：描述了用于表达和分泌异源蛋白质或多肽的丝状真菌宿主领域的新型转化系统。本发明还涵盖以经济方式生产大量多肽或蛋白质的方法。该系统包括转化或转染的Chrysosporium属的真菌菌株，更特别是Chrysosporium lucknowense及其突变体或衍生物。它还包括含有Chrysosporium编码序列的转化体，以及Chrysosporium基因的表达调节序列。还提供了新颖的真菌酶及其编码序列和表达调节序列。

6. 发明授权

US09532902B2 Minimally-invasive method and apparatus for restructuring the retina 有权
标题翻译：用于重组视网膜的微创方法和装置
公开(公告)号：US09532902B2
公开(公告)日：2017-01-03
申请号：US13579312
申请日：2011-02-22
申请人： Rudy A. Mazzocchi , Michael Calhoun
发明人： Rudy A. Mazzocchi , Michael Calhoun
IPC分类号： A61F2/16 , A61F9/007 , A61F9/00
CPC分类号： A61F9/00727 , A61F9/0017 , A61F2210/0019
摘要： The present invention comprises an implant for placing inside the eye such that the implant comes into contact with the interior tissue of the eye such that it conforms to the inner globe geometry of the eye. Implants of the present invention may also be used to alter the focal length of the eye thereby providing a treatment method for the correction of myopia and hyperopia. The device may consist of several possible configurations, an open mesh structure, a solid metal ring, a solid polymer shape, a mesh polymer shape or combination of these. The shape may be a curve, a sphere, a ring or a combination thereof that are specifically shaped to approximate a desired portion of the interior globe of the eye in order to treat myopia or hyperopia.
摘要翻译：本发明包括用于放置在眼睛内的植入物，使得植入物与眼睛的内部组织接触，使得其符合眼睛的内球几何形状。本发明的植入物也可用于改变眼睛的焦距，从而提供矫正近视和远视的治疗方法。该装置可以由几种可能的构造，开式网状结构，固体金属环，固体聚合物形状，网状聚合物形状或它们的组合组成。该形状可以是曲线，球体，环或其组合，其特别地成形为近似眼睛的内部球体的期望部分，以便治疗近视或远视。

7. 发明授权

US08916363B2 Construction of Highly efficient cellulase compositions for enzymatic hydrolysis of cellulose 有权
标题翻译：构建纤维素酶水解的高效纤维素酶组合物
公开(公告)号：US08916363B2
公开(公告)日：2014-12-23
申请号：US12908454
申请日：2010-10-20
申请人： Alexander V. Gusakov , Tatyana N. Salanovich , Alexey I. Antonov , Boris B. Ustinov , Oleg N. Okunev , Richard P. Burlingame , Mark A. Emalfarb , Marco A. Baez , Arkady P. Sinitsyn
发明人： Alexander V. Gusakov , Tatyana N. Salanovich , Alexey I. Antonov , Boris B. Ustinov , Oleg N. Okunev , Richard P. Burlingame , Mark A. Emalfarb , Marco A. Baez , Arkady P. Sinitsyn
IPC分类号： C12P19/22 , C12P19/14 , C12N9/42
CPC分类号： C12N9/2437 , C12N9/244 , C12N9/2445 , C12P19/14 , C12Y302/01004 , C12Y302/01006 , C12Y302/01021 , C12Y302/01091 , Y02E50/16
摘要： This invention provides novel enzyme compositions using newly identified and isolated C. lucknowense enzymes, including CBH Ib CBH IIb, EG II, EG VI, β-glucosidase, and xylanase II in conjunction with previously identified enzymes CBH Ia, CBH IIa (previously described as Endo 43), and EG V. These enzyme compositions demonstrate an extremely high ability to convert lignocellulosic biomass (e.g., Avicel, cotton, Douglas fir wood pretreated by organosolv) to glucose. CBH Ia and IIb, which both have a cellulose-binding module (CBM) displayed a pronounced synergism with three major endoglucanases (EG II, EG V, EG VI) from the same fungus in hydrolysis of cotton as well as a strong synergy with each other. The enzyme compositions are effective in hydrolysis of the lignocellulosic biomass.
摘要翻译：本发明提供使用新鉴定和分离的C.幸运感酶的新型酶组合物，其包括CBH Ib CBH IIb，EG II，EG VI，葡萄糖苷酶和木聚糖酶II与先前鉴定的酶CBH 1a，CBH IIa（先前描述）作为Endo 43）和EG V.这些酶组合物显示出将木质纤维素生物质（例如，通过有机溶剂预处理的Avicel，棉花，道格拉斯冷杉木材）转化为葡萄糖的极高的能力。两者具有纤维素结合模块（CBM）的CBH 1a和IIb显示出与来自棉花水解的相同真菌的三种主要内切葡聚糖酶（EG II，EG V，EG VI）的显着协同作用，以及与每种其他。酶组合物在木质纤维素生物质的水解中是有效的。

8. 发明授权

US08881925B1 Protective steel membrane system and method of erection for secondary containment for an above ground storage tank 有权
标题翻译：保护钢膜系统及其上部储罐二次安全壳的安装方法
公开(公告)号：US08881925B1
公开(公告)日：2014-11-11
申请号：US13113621
申请日：2011-05-23
申请人： John R. Toscano , Michael Crabb
发明人： John R. Toscano , Michael Crabb
IPC分类号： B65D90/04 , G01M3/02
CPC分类号： B23K31/02 , B65D90/50 , B65D90/503 , G01M3/223 , G01M3/225 , Y10T29/49719
摘要： An efficient, cost-saving system and method of designing, installing, testing, and monitoring a secondary containment system for new and existing Above Ground Storage Tanks (ASTs) that is comprised of a protective steel membrane for the floor of the tank, including the floor-to-wall juncture, and the lower portion of the tank shell such that the steel membrane creates one or more interstitial zones between the steel membrane and the tank shell. The steel membrane may be installed zone by zone such that the secondary containment system can encapsulate existing tank features by molding itself around the existing contours, such as repair plates, corners, sumps, etc. Furthermore, a unique testing method using a simple electronic device is provided for on-site testing of the integrity of the weld seams that may be efficiently used after each zone is installed without requiring that the entire tank be evacuated during the construction of other zones.
摘要翻译：一种高效，节省成本的系统和方法，用于设计，安装，测试和监测新的和现有的地面储存罐（AST）的二次密封系统，其包括用于罐底的保护性钢膜，包括地板到墙壁的接合部和罐壳的下部，使得钢膜在钢膜和罐壳之间产生一个或多个间隙区。钢膜可以按区域安装，使得二次容纳系统可以通过将现有的轮廓模制成现有的轮廓（例如修补板，角落，水槽等）来封装现有的箱体特征。此外，使用简单的电子装置的独特的测试方法被提供用于在每个区域安装之后可以有效地使用的焊缝的完整性的现场测试，而不需要在其他区域的构造期间整个箱体被排空。

9. 发明授权

US08846373B2 Methods of using a bacterial GlcNAc-6-P 2′- epimerase to promote sialylation of glycoconjugates 有权
标题翻译：使用细菌GlcNAc-6-P 2'-差向异构酶促进糖缀合物的唾液酸化的方法
公开(公告)号：US08846373B2
公开(公告)日：2014-09-30
申请号：US13559912
申请日：2012-07-27
申请人： Christoph Geisler , Donald Jarvis
发明人： Christoph Geisler , Donald Jarvis
IPC分类号： C12N1/20 , C12N5/07 , C12N5/071 , C12N5/04 , C12P19/18 , C12P19/04 , C12N9/04
CPC分类号： C12N9/0006 , C12P19/04 , C12P21/005
摘要： The present invention relates to new methods to promote sialylation of glycoconjugates, including recombinant glycoproteins, in glycoconjugate production systems. The invention relates to methods to promote efficient glycoconjugate sialylation in recombinant expression systems, by providing simpler and more economical ways to produce large intracellular pools of sialic acid precursors. The invention is directed to nucleic acids, vectors, and cells harboring vectors comprising nucleic acids encoding enzymes involved in the synthesis of sialic acid precursors, and cells harboring these nucleic acids in combination with nucleic acids encoding glycosyltransferases, including sialyltransferases, to facilitate the production of humanized recombinant glycoproteins in bacterial, fungal, plant, and animal cell expression systems. The engineered cells can be used to produce glycosylated proteins in virally-infected, transiently-transformed, or stably-transformed host cells, including lepidopteran insects and cultured cell lines derived from Spodoptera frugiperda, Trichoplusia ni, and Bombyx mori that can be infected by baculovirus expression vectors.
摘要翻译：本发明涉及在糖缀合物生产系统中促进糖缀合物（包括重组糖蛋白）的唾液酸化的新方法。本发明涉及在重组表达系统中促进有效的糖缀合物唾液酸化的方法，通过提供更简单和更经济的方法来产生大量的唾液酸前体的细胞内池。本发明涉及含有编码参与唾液酸前体合成的酶的核酸的载体的核酸，载体和细胞，以及携带这些核酸与编码糖基转移酶（包括唾液酸转移酶）的核酸组合的细胞，以促进生产在细菌，真菌，植物和动物细胞表达系统中的人源化重组糖蛋白。工程细胞可以用于在病毒感染的，瞬时转化的或稳定转化的宿主细胞中产生糖基化蛋白质，包括鳞翅目昆虫和源自草地夜蛾（Spodoptera frugiperda），粉纹夜蛾（Trichoplusia ni）和蚕蛾（Bombyx mori）的培养细胞系，其可被杆状病毒感染表达载体。

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