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1. 发明授权

US10299467B2 Animal model for type 2 diabetes and obesity 有权
公开(公告)号：US10299467B2
公开(公告)日：2019-05-28
申请号：US14439609
申请日：2013-10-31
申请人： Universitaetsklinikum Freiburg
发明人： Roland Schüle , Delphine Duteil , Eric Metzger , Thomas Günther
IPC分类号： A01K67/027 , C12N9/02 , C12N15/113
摘要： The present invention relates to the use of a genetically modified non-human animal as an animal model for obesity or obesity-related disorders, wherein the amount of Lysine-specific Demethylase 1 (LSD1) in at least one tissue or at least one cell type of said animal is reduced.

2. 发明授权

US09795625B2 Uridine and uridine analogues for treatment of specific lung diseases, namely COPD and pulmonary fibrosis 有权
公开(公告)号：US09795625B2
公开(公告)日：2017-10-24
申请号：US15096756
申请日：2016-04-12
申请人： Universitaetsklinikum Freiburg
发明人： Marco Idzko , Stephan Sorichter
IPC分类号： A01N43/04 , A61K31/70 , A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7042 , A61K31/7052 , A61K9/00 , A61K45/06 , A61K31/7068
CPC分类号： A61K31/7072 , A61K9/0019 , A61K9/008 , A61K31/7042 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the new indications of chronic obstructive pulmonary disease (COPD) and idiophathic lung fibrosis (IPF) for uridine and uridine analogs.

3. 发明授权

US09366679B2 Method for diagnosis of pulmonary involvement in systemic sclerosis 有权
标题翻译：肺部参与系统性硬化症的诊断方法
公开(公告)号：US09366679B2
公开(公告)日：2016-06-14
申请号：US14390562
申请日：2013-03-28
申请人： Universitaetsklinikum Freiburg
发明人： Florian Kollert , Anja Saalbach
IPC分类号： G01N33/00 , G01N33/68 , G01N33/564
CPC分类号： G01N33/6872 , G01N33/564 , G01N33/6893 , G01N2333/70503 , G01N2333/70596 , G01N2800/10 , G01N2800/12 , G01N2800/20 , G01N2800/321 , G01N2800/52
摘要： A method for the diagnosis and/or therapy control of systemic sclerosis is disclosed wherein soluble CD90 is detected in body fluids. By measuring the concentration of soluble CD90 certain forms of diseases can be differentiated by applying the ex vivo method.
摘要翻译：公开了一种用于诊断和/或治疗系统性硬化症的方法，其中在体液中检测到可溶性CD90。通过测量可溶性CD90的浓度，通过应用离体法可以区分某些形式的疾病。

4. 发明授权

US08829004B2 Method for inducing tumor apoptosis by increasing nitric oxide levels 有权
标题翻译：通过增加一氧化氮水平诱导肿瘤细胞凋亡的方法
公开(公告)号：US08829004B2
公开(公告)日：2014-09-09
申请号：US13628849
申请日：2012-09-27
申请人： Universitätsklinikum Freiburg
发明人： Georg Bauer
IPC分类号： A61K31/497 , A61K31/415 , A61K31/335 , A61K31/4196 , A61K31/4174 , A61K31/19 , A61K31/195 , A61K31/496 , C12Q1/30 , G01N33/50
CPC分类号： G01N33/5011 , A61K31/19 , A61K31/195 , A61K31/415 , A61K31/4174 , A61K31/4196 , A61K31/496 , C12Q1/30 , G01N2333/908 , G01N2333/978 , G01N2510/00 , A61K2300/00
摘要： The present invention refers to a method for inducing tumor apoptosis by influencing the ROS (reactive oxygen species) signaling pathway in tumor cells. Increasing the level of ROS leads to the selective inactivation of a tumor cell catalase and subsequently to an apoptosis of these cells. The level of ROS can be increased by increasing the level of nitric oxide through inhibition of the enzymes nitric oxide dioxygenase or arginase. According to the present invention inhibitors of the nitric oxide dioxygenase or arginase can be used for the manufacture of a medicament for the treatment of cancer. The present invention further provides a method for identifying compounds which can be used for the treatment of cancer, wherein the method allows to specifically identify compounds which induce apoptosis through the ROS signaling pathway. The present invention also provides a kit for identifying compounds which induce tumor apoptosis by inactivating a catalase on the tumor cell surface.
摘要翻译：本发明涉及通过影响肿瘤细胞中的ROS（活性氧）信号通路诱导肿瘤细胞凋亡的方法。增加ROS的水平导致肿瘤细胞过氧化氢酶的选择性失活，然后导致这些细胞的细胞凋亡。可以通过抑制一氧化氮双加氧酶或精氨酸酶来增加一氧化氮的水平来增加ROS的水平。根据本发明，一氧化氮双加氧酶或精氨酸酶的抑制剂可用于制备用于治疗癌症的药物。本发明还提供了一种用于鉴定可用于治疗癌症的化合物的方法，其中所述方法允许特异性鉴定通过ROS信号通路诱导细胞凋亡的化合物。本发明还提供了一种用于鉴定通过灭活肿瘤细胞表面上的过氧化氢酶诱导肿瘤细胞凋亡的化合物的试剂盒。

5. 发明授权

US08823372B2 Method for homogenizing resolution in magnet resonance tomography measurements using non-linear encoding fields 有权
标题翻译：使用非线性编码区域在磁共振断层摄影测量中使分辨率均匀化的方法
公开(公告)号：US08823372B2
公开(公告)日：2014-09-02
申请号：US13064277
申请日：2011-03-16
申请人： Hans Weber , Maxim Zaitsev , Daniel Gallichan , Gerrit Schultz
发明人： Hans Weber , Maxim Zaitsev , Daniel Gallichan , Gerrit Schultz
IPC分类号： G01R33/48 , G01R33/483
CPC分类号： G01R33/4833
摘要： A method for magnetic resonance (=MR) imaging, wherein non-linear gradient fields are applied for the purpose of spatial encoding to acquire images of an object to be imaged and wherein the magnet resonance signal radiated from the object to be imaged is sampled on grids in time, to thereby obtain sampling points, is characterized in that the object to be imaged is mapped completely in regions of stronger gradient fields by increasing the density of the sampling points in the center of k-space, and additional sampling points are specifically acquired in the outer regions of k-space according to a k-space sampling pattern depending on the desired distribution of the resolution in the measurement, wherein the MR measurement is calculated with the additional sampling points. An MR imaging method is thereby provided by means of which homogenized resolution is achieved in the MR measurements using non-linear gradient fields for spatial encoding.
摘要翻译：一种用于磁共振（= MR）成像的方法，其中应用非线性梯度场用于空间编码以获取待成像对象的图像，并且其中从待成像对象辐射的磁共振信号被采样在时间上的网格，从而获得采样点，其特征在于通过增加k空间中心的采样点的密度，将要成像的对象完全映射在更强的梯度场的区域中，并且附加的采样点是具体的根据k-空间采样模式在k空间的外部区域中取决于测量中的分辨率的期望分布，其中用附加采样点计算MR测量值。由此提供MR成像方法，通过这种方法，使用非线性梯度场用于空间编码的MR测量中实现了均匀分辨率。

6. 发明授权

US08821875B2 Pharmaceutical composition comprising antibodies against catalase and superoxide dismutase for tumor therapy 有权
标题翻译：药物组合物包含抗过氧化氢酶和超氧化物歧化酶用于肿瘤治疗的抗体
公开(公告)号：US08821875B2
公开(公告)日：2014-09-02
申请号：US14119177
申请日：2012-06-15
申请人： Georg Bauer
发明人： Georg Bauer
IPC分类号： A61K39/395 , C07K16/40 , C07K16/30 , A61K39/00
CPC分类号： A61K39/39558 , A61K2039/507 , C07K16/30 , C07K16/40 , C07K2317/73
摘要： The present invention is based on the unexpected finding that, in addition to catalase, SOD is also involved in protecting tumor cells, wherein the inhibition effects of the two protective enzymes support one another in a complementary manner. The invention thus relates to pharmaceutical compositions containing at least two antibodies or the biologically active fragments thereof, wherein the one antibody is directed against the catalase and the other antibody is directed against the superoxide dismutase, as well as their use for treating a tumor disease.
摘要翻译：本发明基于意想不到的发现，除了过氧化氢酶之外，SOD还参与保护肿瘤细胞，其中两种保护性酶的抑制作用以互补的方式相互支持。因此，本发明涉及含有至少两种抗体或其生物活性片段的药物组合物，其中一种抗体针对过氧化氢酶，另一种抗体针对超氧化物歧化酶，以及它们用于治疗肿瘤疾病的用途。

7. 发明授权

US08558545B2 Increasing spoil efficiency 有权
标题翻译：增加弃渣效率
公开(公告)号：US08558545B2
公开(公告)日：2013-10-15
申请号：US12929597
申请日：2011-02-03
申请人： Jochen Leupold
发明人： Jochen Leupold
IPC分类号： G01V3/00
CPC分类号： G01R33/5613
摘要： A method for operating a nuclear magnetic resonance imaging device, wherein a continuous sequence of radio-frequency (=RF) pulses are radiated onto a sample, Ψ being the constant phase value for all magnetization vectors, and all magnetization vectors undergo a phase progression Fn=nΨ during the n-th sequence interval, wherein P is the number of RF pulses after which the phase angle of the magnetization vectors is repeated, wherein the total gradient moment in one or more directions in space having a value greater than 0, and consecutive pulses exhibit a constant repetition time TR, wherein, after radiation of one RF pulse, one k-space row is acquired. The method is characterized in that any one- or multi-dimensional arrangement of k-space rows is repeated identically N times, and signals from identical k-space rows are averaged or added. The method increases the efficiency of the gradient spoiling and thus the efficiency of artifact suppression.
摘要翻译：一种用于操作核磁共振成像装置的方法，其中将射频（= RF）脉冲的连续序列辐射到样本上，Psi是所有磁化矢量的恒定相位值，并且所有磁化矢量经历相位进展Fn = nPsi，其中P是RF脉冲的数量，在此之后重复磁化矢量的相位角，其中空间中一个或多个方向上的总梯度矩大于0，以及连续的脉冲呈现恒定的重复时间TR，其中在一个RF脉冲的辐射之后，获取一个k空间行。该方法的特征在于，k空间行的任何一维或多维排列重复相同N次，并且来自相同k空间行的信号被平均或相加。该方法提高了梯度扰动的效率，从而提高了伪影抑制效率。

8. 发明授权

US08018230B2 Sense shimming (SSH): a fast approach for determining B0 field inhomogeneities using sensitivity encoding 有权
标题翻译：感觉匀场（SSH）：使用灵敏度编码确定B0场不均匀性的快速方法
公开(公告)号：US08018230B2
公开(公告)日：2011-09-13
申请号：US12258779
申请日：2008-10-27
申请人： Maxim Zaitsev , Daniel N. Splitthoff , Jürgen Hennig
发明人： Maxim Zaitsev , Daniel N. Splitthoff , Jürgen Hennig
IPC分类号： G01V3/00
CPC分类号： G01R33/56563 , G01R33/543 , G01R33/5611
摘要： The pursuit for ever higher field strengths and faster data acquisitions has led to the construction of coil arrays with high numbers of elements. With the SENSE technique it has been shown, how the sensitivity of those elements can be used for spatial image encoding. A method in accordance with the present invention, largely abstains from using encoding gradients. The resulting sensitivity encoded free induction decay (FID) data is then not used for imaging, but for determining field inhomogeneity distribution. The method has therefore been termed SSH for Sense SHimming.
摘要翻译：追求更高的现场优势和更快的数据采集导致了线圈阵列的构建，其数量众多。使用SENSE技术，已经显示出这些元素的灵敏度如何被用于空间图像编码。根据本发明的方法，在很大程度上不使用编码梯度。然后，所得到的灵敏度编码的自由感应衰减（FID）数据不用于成像，而是用于确定场不均匀性分布。因此，该方法被称为Sense Shimming的SSH。

9. 发明申请

US20110110976A1 RIFT VALLEY FEVER VIRUS-LIKE PARTICLES AND THEIR USE FOR IMMUNIZATION AND AS TEST SYSTEM 审中-公开
标题翻译： RIFT谷病毒病毒颗粒及其用于免疫和作为测试系统的用途
公开(公告)号：US20110110976A1
公开(公告)日：2011-05-12
申请号：US12997370
申请日：2009-06-09
申请人： Friedemann Weber , Matthias Habjan , Martin Spiegel , Nicola Penski
发明人： Friedemann Weber , Matthias Habjan , Martin Spiegel , Nicola Penski
IPC分类号： A61K39/12 , C12P21/02 , C07K14/175 , A61K38/02 , C12Q1/02 , G01N33/68 , A61P37/04 , A61P31/14
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , C12N2760/12222 , C12N2760/12234 , Y02A50/397
摘要： Disclosed is a method for producing virus-like particles (VLP) that comprises the steps of (a) transfecting a mammalian cell line with several independent vectors, including (1) a vector containing at least a substantial part of the M gene from Rift Valley Fever Virus, (2) a vector containing at least a substantial part of the L gene from Rift Valley Fever Virus, (3) a vector containing at least a substantial part of the N gene from Rift Valley Fever Virus and (4) a vector containing a multicloning site flanked by the non-coding 5′- and 3′-ends of the L-, M- or S-segment of Rift Valley Fever Virus, and (b) culturing the transfected mammalian cell line under suitable conditions and obtaining the VLPs from the supernatant of the transfected cultured cell lines. The so-obtained VLPs can be used for vaccination and in methods for testing the antiviral activity of compounds.
摘要翻译：公开了一种用于生产病毒样颗粒（VLP）的方法，其包括以下步骤：（a）用几种独立载体转染哺乳动物细胞系，包括（1）至少包含来自裂谷的M基因的大部分的载体发热病毒，（2）含有至少大部分来自裂谷热病毒的L基因的载体，（3）含有至少大部分来自裂谷热病毒的N基因的载体和（4）载体其包含裂解谷热病病毒的L，M或S段的非编码5'-和3'末端的多克隆位点，和（b）在合适的条件下培养转染的哺乳动物细胞系，并获得来自转染培养细胞系的上清液的VLP。如此获得的VLP可以用于疫苗接种和用于测试化合物的抗病毒活性的方法。

10. 发明申请

US20100285026A1 PHOSPHORYLATION OF HISTONE H3 AT THREONINE 11 - A NOVEL EPIGENETIC MARK FOR TRANSCRIPTIONAL REGULATION 失效
标题翻译： HISTONE H3在THREONINE 11的磷酸化 - 一个新的重要标志进行转录调节
公开(公告)号：US20100285026A1
公开(公告)日：2010-11-11
申请号：US12669294
申请日：2008-05-27
申请人： Roland Schuele , Eric Metzger
发明人： Roland Schuele , Eric Metzger
IPC分类号： A61K39/395 , C12N5/02 , C12Q1/48 , A61P35/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/721 , C07K16/40 , C12N9/1205 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12Q1/485 , C12Y207/11013 , G01N33/57434 , G01N2333/723 , G01N2333/91215 , G01N2500/00
摘要： The present invention relates to a process for controlling at least one androgen receptor- (AR-) regulated mechanism in mammalian cells under histone-phosphorylating conditions, said process comprising allowing at least one inhibitor with specificity for at least one protein kinase C-related kinase (PRK) to act on said at least one PRK1 thereby modulating, preferably down-regulating, the activity of said at least one PRK and optionally blocking said at least one androgen receptor-regulated mechanism in said mammalian cells.
摘要翻译：本发明涉及在组蛋白 - 磷酸化条件下控制哺乳动物细胞中至少一种雄激素受体（AR））调节机制的方法，所述方法包括允许至少一种具有至少一种蛋白激酶C相关激酶特异性的抑制剂（PRK）作用于所述至少一种PRK1，从而调节，优选下调所述至少一种PRK的活性，并任选地阻断所述哺乳动物细胞中的所述至少一种雄激素受体调节机制。

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