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1. 发明申请

US20140234965A1 TRIAZINE DERIVATIVES AS DIFFERENTIATION CATALYSTS 有权
标题翻译：三嗪衍生物作为差异催化剂
公开(公告)号：US20140234965A1
公开(公告)日：2014-08-21
申请号：US14346328
申请日：2012-09-21
申请人： Marko Mihovilovic , Michael Schnuerch , Karlheinz Hilber , Xaver Koenig , Thomas Linder , Agnes Mike
发明人： Marko Mihovilovic , Michael Schnuerch , Karlheinz Hilber , Xaver Koenig , Thomas Linder , Agnes Mike
IPC分类号： C12N5/077
CPC分类号： C12N5/0657 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C12N2501/999 , C12N2506/30
摘要： A method of inducing differentiation of mammalian cells into cardiomyocyte-like cells by contacting the mammalian cell with a triazine compound of formula (I), wherein X is independently —NR4— or —O—, R4 is hydrogen or C1-6-alkyl; R1 is hydroxy, C1-6-alkyl, C1-6-alkoxy, carboxy, C1-6-alkoxycarbonyl, halo, cyano, nitro, formyl, amino, C1-6-alkylamino, or di-C1-6-alkylamino, the C1-6-alkyl or -alkoxy residue being optionally substituted with one or more R5 substituents selected from hydroxy, halo, cyano, and nitro; n is 0 to 5; R2 is hydrogen, aryl, heteroaryl, or C1-6-alkyl, the aryl or heteroaryl residue being optionally substituted with one or more R1 substituents, and where the C1-6-alkyl is optionally further substituted with one or more R5 substituents; and R3 is selected from hydrogen, halo, NR4R7, OR7, SR7, and R7, where the same options apply for R7 as for R2; with the proviso that the compound of formula (I) is not 3-[(4,6-diphenoxy-1,3,5-triazin-2-yl)amino]benzoic acid.
摘要翻译：通过使哺乳动物细胞与式（I）的三嗪化合物接触，诱导哺乳动物细胞分化为心肌细胞样细胞的方法，其中X独立地是-NR 4 - 或-O-，R 4是氢或C 1-6 - 烷基; R 1是羟基，C 1-6 - 烷基，C 1-6 - 烷氧基，羧基，C 1-6 - 烷氧基羰基，卤素，氰基，硝基，甲酰基，氨基，C 1-6 - 烷基氨基或二-C 1-6 - 烷基氨基 C 1-6 - 烷基或烷氧基残基任选被一个或多个选自羟基，卤素，氰基和硝基的R 5取代基取代; n为0〜5; R 2是氢，芳基，杂芳基或C 1-6 - 烷基，芳基或杂芳基残基任选地被一个或多个R 1取代基取代，并且其中C 1-6 - 烷基任选进一步被一个或多个R 5取代基取代; 并且R 3选自氢，卤素，NR 4 R 7，OR 7，SR 7和R 7，其中与R 2相同的选择适用于R 2; 条件是式（I）化合物不是3 - [（4,6-二苯氧基-1,3,5-三嗪-2-基）氨基]苯甲酸。

2. 发明申请

US20120294835A1 SUBSTITUTED PYRIDINES AND PYRIMIDINES 有权
标题翻译：取代的吡啶和吡啶
公开(公告)号：US20120294835A1
公开(公告)日：2012-11-22
申请号：US13519690
申请日：2010-12-28
申请人： Marko Mihovilovic , Michael Schnuerch , Moumita Koley , Karlheinz Hilber , Xaver Koenig
发明人： Marko Mihovilovic , Michael Schnuerch , Moumita Koley , Karlheinz Hilber , Xaver Koenig
IPC分类号： C07D239/48 , C12N5/0775 , A61K35/12 , A61P9/00 , C07D413/12 , C07D213/74
CPC分类号： C07D239/48 , C07D213/74 , C12N5/0657 , C12N2500/40
摘要： Provided is a compound of formula (I), and/or salt thereof, wherein the radicals have various meanings, a process for producing cardiomyocyte-like cells from mammalian cells by culturing mammalian cells in the presence of the compound of formula (I), the pharmaceutical use of compounds of formula (I) for producing cardiomyocyte-like cells from omnipotent, pluripotent, or lineage committed mammalian cells, and the use of thus produced cardiomyocyte-like cells for treating disorders associated with impaired function of the heart.
摘要翻译：提供式（I）的化合物和/或其盐，其中基团具有各种含义，通过在式（I）化合物的存在下培养哺乳动物细胞从哺乳动物细胞产生心肌细胞样细胞的方法，由式（I）化合物制备用于从全能，多能性或谱系确定的哺乳动物细胞产生心肌细胞样细胞的药物用途，以及由此产生的心肌细胞样细胞用于治疗与心脏受损功能相关的疾病的药物用途。

3. 发明公开

US20240241423A1 QUANTUM OPTICAL MEMRISTOR 审中-公开
公开(公告)号：US20240241423A1
公开(公告)日：2024-07-18
申请号：US18559327
申请日：2022-05-06
申请人： UNIVERSITAET WIEN
发明人： Michele SPAGNOLO , Francesco MASSA , Philip WALTHER
IPC分类号： G02F1/21 , G02F1/01
CPC分类号： G02F1/212 , G02F1/0121
摘要： A quantum optical memristor for manipulating photon quantum states includes a Mach-Zehnder interferometer having a first optical input and a first optical output and a second optical output. The first optical input and the first optical output of the Mach-Zehnder interferometer are a first optical input and a first optical output of the quantum optical memristor respectively. A detector is configured to detect a time-dependent optical signal at the second optical output of the Mach-Zehnder interferometer. A controller is configured to compute a target reflectivity of the Mach-Zehnder interferometer, wherein the controller is configured to update the reflectivity of the Mach-Zehnder interferometer to match the computed target reflectivity. The controller is configured to compute the target reflectivity based on the derivative of the reflectivity with respect to time. The derivative of the reflectivity with respect to time is a linear function of the detected signal.

4. 发明授权

US11655314B2 Photoinitiators for light-curable compositions 有权
公开(公告)号：US11655314B2
公开(公告)日：2023-05-23
申请号：US17719757
申请日：2022-04-13
申请人： Technische Universitaet Wien
发明人： Robert Liska , Patrick Knaack , Paul Gauss , Roland Taschner
IPC分类号： C08F2/50 , C08F22/10 , C07C69/716 , C07D307/60 , C08F22/20 , C08F22/22 , C08F222/10
CPC分类号： C08F2/50 , C07C69/716 , C07D307/60 , C08F22/1006 , C08F22/20 , C08F22/22 , C08F222/102
摘要： Compounds of formula (I) are photoinitiators or photosensitizers in a photopolymerizable composition:

R1 represents a monovalent, linear, branched or cyclic, aliphatic hydrocarbon group having 1 to 20 carbon atoms, optionally substituted with substituent(s) selected from —Cl, —Br, —OH, ═O, —NH—CO—OR2, —NH—CO—R2 or free-radically or ionically polymerizable groups. Each R2 is independently —H or C1-6 alkyl; n is ≥1. If n=1, Z and Y are absent and X represents —OR3; if n is >1, Z represents —OR4—, Y represents —OR5— and X represents —H or —OH. R3 represents —H or R1; and R4 and R5 each independently represent a bivalent hydrocarbon group. The polymerizable moieties as optional substituents of R1 are polymerizable double or triple bonds, lactam, lactone and epoxide moieties, which are subjectable to ring-opening polymerization; and two of R1 to R5 may be linked to one another to form a ring or a dimer.

5. 发明授权

US11492464B2 Light-curable composition 有权
公开(公告)号：US11492464B2
公开(公告)日：2022-11-08
申请号：US16607992
申请日：2018-04-27
申请人： Technische Universitaet Wien
发明人： Bernhard Steyrer , Robert Liska , Jürgen Stampfl
IPC分类号： C08L9/00 , B33Y70/00
摘要： A light-curable composition is provided which may be used as a photopolymerizable material in an additive manufacturing process. The additive manufacturing process involves heating the light-curable composition which has a viscosity at 20° C. of at least 20 Pa·s. The light-curable composition includes a photopolymerizable matrix material, at least one thermoplastic polymer dissolved therein, and at least one photoinitiator. Polycaprolactone or a derivative thereof is used as the dissolved thermoplastic polymer.

6. 发明授权

US11243162B2 Method for spectroscopically or spectrometrically examining a sample, and interferometric device 有权
公开(公告)号：US11243162B2
公开(公告)日：2022-02-08
申请号：US16634075
申请日：2018-07-26
申请人： TECHNISCHE UNIVERSITAET WIEN
发明人： Bernhard Lendl , Jakob Hayden , Bettina Baumgartner , Christian Kristament
IPC分类号： G01N21/3577 , G01N21/359 , G01N21/39 , G01N21/45 , G01N21/17
摘要： A method and an interferometric device for spectroscopically or spectrometrically examining a sample, comprising: a) generating a laser beam having a wavelength, b) splitting the laser beam into a measurement beam and a reference beam, c) interacting the sample with the measurement beam, d) interacting a reference with the reference beam, e) overlaying the measurement beam and the reference beam, f) detecting a first output beam, g) detecting a second output beam, h) forming a differential signal between the first output signal and the second output signal, i) controlling the differential signal to a predefined target value, j) determining a refractive index of the sample from the adjustment of the phase difference between the measurement beam and the reference beam, k) repeating steps a) to j) for additional wavelengths of the laser beam.

7. 发明申请

US20210290458A1 MECHANICAL WHEELCHAIR DRIVE AND WHEELCHAIR HAVING SUCH A MECHANICAL WHEELCHAIR 有权
公开(公告)号：US20210290458A1
公开(公告)日：2021-09-23
申请号：US17260980
申请日：2019-07-16
申请人： TECHNISCHE UNIVERSITAET WIEN
发明人： Margit GFOEHLER , Nithin Babu Rajendra KURUP , Markus PUCHINGER
IPC分类号： A61G5/02
摘要： The invention relates to a mechanical wheelchair drive, comprising a rotatably mounted lever, a handle fastened to the lever, and a force transfer unit for transferring rotational motion of the lever to a wheelchair wheel, wherein the lever has a variable length and is guided along a closed guide of a guide plate, said guide deviating from the circular form, such that the length of the lever changes during the rotational motion.

8. 发明授权

US10921345B2 Method for the contactless determining of flow parameters using laser doppler anemometry and Raman spectroscopy through a same optical lens system 有权
公开(公告)号：US10921345B2
公开(公告)日：2021-02-16
申请号：US16606726
申请日：2018-04-18
申请人： TECHNISCHE UNIVERSITAET WIEN
发明人： Michael Harasek , Bernhard Lendl , Christoph Gasser , Bahram Haddadi , Christian Jordan
IPC分类号： G01P5/26 , G01J3/44 , G01N21/65 , G01N21/85 , G01S17/58
摘要： The invention relates to a method for the contactless determining of the speed of a fluid flow and the concentration of at least one analyte therein, wherein a) the flow speed is measured by means of laser Doppler anemometry (LDA) using tracer particles which pass through an interference fringe pattern in the intersection region of two coherent monochromatic light beams and thereby generate a scattered light signal; and b) the concentration of the at least one analyte is measured by means of Raman spectroscopy, wherein a monochromatic light beam is radiated in and the Raman spectrum of the light inelastically scattered on the analyte molecules in the flow is recorded; wherein c) a single light source is used for both the LDA and the Raman spectroscopy, such that both measurements are carried out in the intersection region of two two coherent light beams coming from the light source, wherein the speed is measured by photons elastically scattered onto the tracer particles, and the concentration is measured by photons inelastically scattered onto analyte molecules; and d) for the purposes of speed measurement, the elastically back-scattered photons are detected by the same lens optic that is also used for the radiation of the light beams.

9. 发明授权

US10266643B2 Initiators and use thereof for cationic photopolymerization 有权
公开(公告)号：US10266643B2
公开(公告)日：2019-04-23
申请号：US15757008
申请日：2016-09-02
申请人： Technische Universitaet Wien , Albert-Ludwigs-Universitaet Freiburg
发明人： Robert Liska , Daniel Bomze , Ingo Krossing , Patrick Knaack
IPC分类号： C08G59/68 , C08G65/10 , C01F7/02 , C01F7/50
摘要： The invention relates to the use of aryliodonium and/or arylsulfonium salts of the tetrakis(perfluoro-t-butyloxy)aluminate anion of the following formula (I): as cationic initiators cleavable by light and/or free radicals for polymerizing cationically polymerizable monomers.

10. 发明授权

US09375460B2 Use of GSTP1 有权
标题翻译：使用GSTP1
公开(公告)号：US09375460B2
公开(公告)日：2016-06-28
申请号：US14275923
申请日：2014-05-13
申请人： MEDIZINISCHE UNIVERSITAET WIEN
发明人： Seyedhossein Aharinejad
IPC分类号： C12Q1/68 , A61K38/45
CPC分类号： A61K38/45 , C12Q1/6883 , C12Q2600/158 , G01N2333/91177 , G01N2800/325 , Y02A50/414
摘要： The invention discloses the use of glutathione S-transferase Pb (GSTP1) for the prevention or treatment of cardiomyopathies or ischemic heart diseases and for the diagnosis thereof.
摘要翻译：本发明公开了谷胱甘肽S-转移酶Pb（GSTP1）用于预防或治疗心肌病或缺血性心脏病的用途及其诊断。

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