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1. 发明申请

US20120294835A1 SUBSTITUTED PYRIDINES AND PYRIMIDINES 有权
标题翻译：取代的吡啶和吡啶
公开(公告)号：US20120294835A1
公开(公告)日：2012-11-22
申请号：US13519690
申请日：2010-12-28
申请人： Marko Mihovilovic , Michael Schnuerch , Moumita Koley , Karlheinz Hilber , Xaver Koenig
发明人： Marko Mihovilovic , Michael Schnuerch , Moumita Koley , Karlheinz Hilber , Xaver Koenig
IPC分类号： C07D239/48 , C12N5/0775 , A61K35/12 , A61P9/00 , C07D413/12 , C07D213/74
CPC分类号： C07D239/48 , C07D213/74 , C12N5/0657 , C12N2500/40
摘要： Provided is a compound of formula (I), and/or salt thereof, wherein the radicals have various meanings, a process for producing cardiomyocyte-like cells from mammalian cells by culturing mammalian cells in the presence of the compound of formula (I), the pharmaceutical use of compounds of formula (I) for producing cardiomyocyte-like cells from omnipotent, pluripotent, or lineage committed mammalian cells, and the use of thus produced cardiomyocyte-like cells for treating disorders associated with impaired function of the heart.
摘要翻译：提供式（I）的化合物和/或其盐，其中基团具有各种含义，通过在式（I）化合物的存在下培养哺乳动物细胞从哺乳动物细胞产生心肌细胞样细胞的方法，由式（I）化合物制备用于从全能，多能性或谱系确定的哺乳动物细胞产生心肌细胞样细胞的药物用途，以及由此产生的心肌细胞样细胞用于治疗与心脏受损功能相关的疾病的药物用途。

2. 发明申请

US20140234965A1 TRIAZINE DERIVATIVES AS DIFFERENTIATION CATALYSTS 有权
标题翻译：三嗪衍生物作为差异催化剂
公开(公告)号：US20140234965A1
公开(公告)日：2014-08-21
申请号：US14346328
申请日：2012-09-21
申请人： Marko Mihovilovic , Michael Schnuerch , Karlheinz Hilber , Xaver Koenig , Thomas Linder , Agnes Mike
发明人： Marko Mihovilovic , Michael Schnuerch , Karlheinz Hilber , Xaver Koenig , Thomas Linder , Agnes Mike
IPC分类号： C12N5/077
CPC分类号： C12N5/0657 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C12N2501/999 , C12N2506/30
摘要： A method of inducing differentiation of mammalian cells into cardiomyocyte-like cells by contacting the mammalian cell with a triazine compound of formula (I), wherein X is independently —NR4— or —O—, R4 is hydrogen or C1-6-alkyl; R1 is hydroxy, C1-6-alkyl, C1-6-alkoxy, carboxy, C1-6-alkoxycarbonyl, halo, cyano, nitro, formyl, amino, C1-6-alkylamino, or di-C1-6-alkylamino, the C1-6-alkyl or -alkoxy residue being optionally substituted with one or more R5 substituents selected from hydroxy, halo, cyano, and nitro; n is 0 to 5; R2 is hydrogen, aryl, heteroaryl, or C1-6-alkyl, the aryl or heteroaryl residue being optionally substituted with one or more R1 substituents, and where the C1-6-alkyl is optionally further substituted with one or more R5 substituents; and R3 is selected from hydrogen, halo, NR4R7, OR7, SR7, and R7, where the same options apply for R7 as for R2; with the proviso that the compound of formula (I) is not 3-[(4,6-diphenoxy-1,3,5-triazin-2-yl)amino]benzoic acid.
摘要翻译：通过使哺乳动物细胞与式（I）的三嗪化合物接触，诱导哺乳动物细胞分化为心肌细胞样细胞的方法，其中X独立地是-NR 4 - 或-O-，R 4是氢或C 1-6 - 烷基; R 1是羟基，C 1-6 - 烷基，C 1-6 - 烷氧基，羧基，C 1-6 - 烷氧基羰基，卤素，氰基，硝基，甲酰基，氨基，C 1-6 - 烷基氨基或二-C 1-6 - 烷基氨基 C 1-6 - 烷基或烷氧基残基任选被一个或多个选自羟基，卤素，氰基和硝基的R 5取代基取代; n为0〜5; R 2是氢，芳基，杂芳基或C 1-6 - 烷基，芳基或杂芳基残基任选地被一个或多个R 1取代基取代，并且其中C 1-6 - 烷基任选进一步被一个或多个R 5取代基取代; 并且R 3选自氢，卤素，NR 4 R 7，OR 7，SR 7和R 7，其中与R 2相同的选择适用于R 2; 条件是式（I）化合物不是3 - [（4,6-二苯氧基-1,3,5-三嗪-2-基）氨基]苯甲酸。

3. 发明授权

US08986994B2 Substituted pyridines and pyrimidines 有权
标题翻译：取代的吡啶和嘧啶
公开(公告)号：US08986994B2
公开(公告)日：2015-03-24
申请号：US13519690
申请日：2010-12-28
申请人： Marko Mihovilovic , Michael Schnuerch , Moumita Koley , Karlheinz Hilber , Xaver Koenig
发明人： Marko Mihovilovic , Michael Schnuerch , Moumita Koley , Karlheinz Hilber , Xaver Koenig
IPC分类号： C12N5/071 , C07D239/48 , C07D213/74 , C12N5/077
CPC分类号： C07D239/48 , C07D213/74 , C12N5/0657 , C12N2500/40
摘要： Provided are compounds of formula (I) and/or salts thereof, of the class of substituted pyridines and pyrimidines, useful for inducing cardiomyogenesis, a process for producing cardiomyocyte-like cells from mammalian cells by culturing mammalian cells in the presence of the compound of formula (I), the pharmaceutical use of compounds of formula (I) for producing cardiomyocyte-like cells from omnipotent, pluripotent, or lineage committed mammalian cells, and the use of thus produced cardiomyocyte-like cells for treating disorders associated with impaired function of the heart.
摘要翻译：本发明提供了可用于诱导心肌发生的取代的吡啶类和嘧啶类的式（I）和/或其盐的化合物，通过在哺乳动物细胞中存在下培养哺乳动物细胞从哺乳动物细胞中产生心肌细胞样细胞的方法式（I），式（I）化合物用于从全能，多能性或谱系确定的哺乳动物细胞产生心肌细胞样细胞的药物用途，以及由此产生的心肌细胞样细胞用于治疗与功能障碍相关的疾病心脏

4. 发明授权

US09611457B2 Triazine derivatives as differentiation catalysts 有权
公开(公告)号：US09611457B2
公开(公告)日：2017-04-04
申请号：US14346328
申请日：2012-09-21
申请人： Marko Mihovilovic , Michael Schnuerch , Karlheinz Hilber , Xaver Koenig , Thomas Linder , Agnes Mike
发明人： Marko Mihovilovic , Michael Schnuerch , Karlheinz Hilber , Xaver Koenig , Thomas Linder , Agnes Mike
IPC分类号： C12N5/071 , C12N5/077 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50
CPC分类号： C12N5/0657 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C12N2501/999 , C12N2506/30
摘要： A method of inducing differentiation of mammalian cells into cardiomyocyte-like cells by contacting the mammalian cell with a triazine compound of formula (I), wherein X is independently —NR4—or —O—, R4 is hydrogen or C1-6-alkyl; R1 is hydroxy, C1-6-alkyl, C1-6-alkoxy, carboxy, C1-6-alkoxycarbonyl, halo, cyano, nitro, formyl, amino, C1-6-alkylamino, or di-C1-6-alkylamino, the C1-6-alkyl or -alkoxy residue being optionally substituted with one or more R5 substituents selected from hydroxy, halo, cyano, and nitro; n is 0 to 5; R2 is hydrogen, aryl, heteroaryl, or C1-6-alkyl, the aryl or heteroaryl residue being optionally substituted with one or more R1 substituents, and where the C1-6-alkyl is optionally further substituted with one or more R5 substituents; and R3 is selected from hydrogen, halo, NR4R7, OR7, SR7, and R7, where the same options apply for R7 as for R2; with the proviso that the compound of formula (I) is not 3-[(4,6-diphenoxy-1,3,5-triazin-2-yl)amino]benzoic acid.

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