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1. 发明公开

US20240103000A1 AUTOMATIC DEVICE FOR NON-INVASIVE MALARIA DIAGNOSIS THROUGH OPTICAL REFLECTANCE TECHNIQUES, METHODS AND USES THEREOF 审中-公开
公开(公告)号：US20240103000A1
公开(公告)日：2024-03-28
申请号：US18246760
申请日：2021-09-29
申请人： Universidade Do Minho
发明人： Susana OLIVEIRA CATARINO , Vitória DA CUNHA BAPTISTA , Maria Isabel MENDES VEIGA , Graça Maria HENRIQUES MINAS
IPC分类号： G01N33/569 , A61B5/00 , B01L3/00 , G01N33/72
CPC分类号： G01N33/56905 , A61B5/0075 , B01L3/502715 , G01N33/72 , A61B2560/0223 , B01L2200/18 , B01L2300/0654 , G01N2333/445
摘要： A portable device for detecting and/or quantifying hemozoin by optical reflectance spectrophotometry, directly on the patient's skin, on tissues or in a liquid sample which comprises means for calibrating the device; at least one optical emitter to excite the sample; at least eight optical detectors to detect the reflectance spectrum of the sample; at least eight bandpass optical filters to filter the reflected light for each optical detector; wherein the optical filters and optical detectors are aligned with each other, wherein the emitter and optical detectors are positioned allowing reflection of the emitted light towards the optical detectors, wherein the optical filters and optical detectors comprise wavelengths between 400 nm and 800 nm; and a microcontroller configured to calculate a ratio between the reflectance values of the sample at each wavelength to detect the reflectance peaks. Also disclosed is a method of detecting and/or quantifying hemozoin by optical reflectance spectrophotometry.

2. 再颁专利

USRE49626E1 Piezoresistive ink, methods and uses thereof 有权
公开(公告)号：USRE49626E1
公开(公告)日：2023-08-29
申请号：US17221534
申请日：2021-04-02
申请人： UNIVERSIDADE DO MINHO , DYNASOL ELASTÓMEROS, S.A.U.
发明人： Senen Lanceros Mendez , Pedro Filipe Ribeiro Da Costa , Juliana Alice Ferreira Oliveira , Bruna Ferreira Gonçalves , Sergio Corona Galvàn
IPC分类号： C09D11/52 , C09D11/106 , C09D11/033 , G01B7/16 , G01L1/18 , C09D11/037 , C08K3/04 , C08K3/08 , C08K5/41 , C08L71/02
CPC分类号： C09D11/52 , C09D11/033 , C09D11/037 , C09D11/106 , G01B7/16 , G01B7/20 , G01L1/18 , C08K3/041 , C08K3/042 , C08K3/046 , C08K3/08 , C08K5/41 , C08K2003/0806 , C08K2003/0831 , C08K2201/001 , C08K2201/011 , C08L71/02
摘要： The present disclosure relates to a piezoresistive ink composition for sensors production. This ink, change linearly their electrical resistivity with an applied deformation and can easily recover when the external applied stress is released. The composition comprises flexible polymers as thermoplastic elastomers from the styrene-butadiene-styrene family (SBS, SEBS or others), nanostructures of carbon or metal, polar solvents and dispersive agents. With this ink, the user can print the sensor with any desired geometry and use different printing techniques, including drop casting, spray, screen and inkjet printing.

3. 发明申请

US20220241203A1 METHOD FOR PRODUCTION OF LIPOSOMES 有权
公开(公告)号：US20220241203A1
公开(公告)日：2022-08-04
申请号：US17607714
申请日：2020-05-07
申请人： UNIVERSIDADE DO MINHO
发明人： DIANA ISABEL PEREIRA GUIMARÃES , EUGÉNIA SOFIA DA COSTA NOGUEIRA , ARTUR MANUEL CAVACO-PAULO
IPC分类号： A61K9/127 , A61K45/06 , A61K47/24 , A61K47/28
摘要： The present disclosure relates to a method for production of liposomes, in order to obtain high encapsulation efficiency of encapsulated agents with a reduced number of production steps, namely avoiding the extrusion step of the classical liposomal production process. The liposomes of the invention are intended to carry a therapeutic agent like an anticancer agent, antioxidant, anti-inflammatory, antipyretic, antibiotic, antiviral, antirheumatic, analgesic, growth-factor, or mixtures thereof.

4. 发明授权

US11288794B2 Device and method for blood analysis by image processing 有权
公开(公告)号：US11288794B2
公开(公告)日：2022-03-29
申请号：US16419067
申请日：2019-05-22
申请人： UNIVERSIDADE DO MINHO
发明人： Ana Patricia Da Silva Ferraz , Vitor Hugo Mendes Da Costa Carvalho
IPC分类号： G06T7/00 , G01N15/00 , G01N21/51 , G01N33/86 , G06T7/62 , G06T7/13 , G06T7/90 , G06T7/70 , G06K9/46 , G06K9/52 , G06K9/62 , G06T5/00 , G01N35/00 , G01N35/04
摘要： The present application describes a new device and method of use thereof, which allows identifying certain antigens and antibodies present in the blood. The device of the present invention is a closed device consisting of two parts, wherein the upper part has a chamber surrounded by LEDs illuminating the analysis plate, which is supported by the rotating platform. In turn, the rotating platform is connected to a motor that will promote the rotation thereof for mixing reagents with blood. After a period of time, the camera will capture and send the resulting image to a computer program that will analyze the sample, using image processing techniques.

5. 发明申请

US20160137693A1 PEPTIDE NUCLEIC ACID PROBE (PNA), KIT AND METHOD FOR DETECTION OF ASPERGILLUS FUMIGATUS AND APPLICATIONS THEREOF 审中-公开
标题翻译：肽类核酸探针（PNA），用于检测青蒿素的试剂盒和方法及其应用
公开(公告)号：US20160137693A1
公开(公告)日：2016-05-19
申请号：US14902375
申请日：2014-06-20
申请人： UNIVERSIDADE DO MINHO , UNIVERSIDADE DO PORTO , BIOMODE - BIOMOLECULAR DETERMINATION, S.A.
发明人： Laura Isabel Macieira CERQUEIRA , Carina Manuela Femandes ALMEIDA , Nuno Filipe Ribeiro Pinto DE OLIVEIRA AZEVEDO , Maria Joao Lopes DA COSTA VIEIRA
IPC分类号： C07K7/02 , C12Q1/68
CPC分类号： C07K7/02 , C12Q1/6895 , C12Q2525/107
摘要： The present invention refers to the development of a Peptide Nucleic Acid (PNA) probe for the detection and discrimination of Aspergillus fumigatus in different types of samples.PNA is a synthetic molecule analogue to DNA that, due to its physicochemical properties, allows a faster analysis with higher sensitivity than the DNA probes.These probes are combined with Fluorescence in situ hybridization (FISH), a molecular biology technique that allows the detection of Aspergillus fumigatus in diverse clinical samples, such as blood, serum, sputum, bronchoalveolar lavage fluid and biopsies.The combination of these two technologies rendered the FISH procedure faster, simpler and more efficient.The present invention also includes the development of the kit of detection and respective procedure for the Aspergillus fumigatus identification in clinical samples.
摘要翻译：本发明涉及用于在不同类型样品中检测和鉴别烟曲霉的肽核酸（PNA）探针的开发。 PNA是与DNA类似的合成分子，由于其物理化学性质，可以比DNA探针更快的分析灵敏度。这些探针与荧光原位杂交（FISH）组合，这是一种分子生物学技术，允许在不同临床样品如血液，血清，痰，支气管肺泡灌洗液和活组织检查中检测烟曲霉。这两种技术的组合使得FISH程序更快，更简单和更有效率。本发明还包括临床样品中烟曲霉鉴定试剂盒的开发和相应的程序。

6. 发明授权

US08314722B2 Keyboard based in polymer, copolymer or composites with piezo- and/or pyroelectric properties and respective use 失效
标题翻译：基于聚合物，共聚物或具有压电和/或热电性质的复合材料的键盘和各自的用途
公开(公告)号：US08314722B2
公开(公告)日：2012-11-20
申请号：US12669602
申请日：2008-07-17
申请人： Senentxu Lanceros Mendez , José Gerardo Vieira Rocha , Vitor Joao Gomes Da Silva Sencadas
发明人： Senentxu Lanceros Mendez , José Gerardo Vieira Rocha , Vitor Joao Gomes Da Silva Sencadas
IPC分类号： H03M11/00 , H03K17/94
CPC分类号： G06F3/023 , H03K17/9643 , H03K2217/96015
摘要： The invention refers to a new keyboard based in a polymeric, copolymeric or composite film (11) with piezo- and pyroelectric properties capable of receiving a tactile signal and giving a respond in the form of an electrical signal. The system described in this invention includes one or more keys (10), being each one of them made by a piezoelectric film (11) with electric conductive contacts, transparent or not, above and below the piezoelectric film and with the inferior layer of grounded electrodes (13). The present invention allows the use of just one piezoelectric film (11) without external power supply, the use of electrode connections which form the keys (10) that converge in one side of the keyboard and are available in the spots (12) to make the connection to the active filter circuits instead of amplifiers in the electronic readout, as well as the possibility of introduction of new functionalities in these keyboards identical to the ones of tactile sensors, upon distinction between a pyroelectric and a piezoelectric signal from a particular key, differing the signals generated by pressure variation or by temperature variation.
摘要翻译：本发明涉及一种基于聚合物，共聚物或复合膜（11）的新型键盘，其具有能够接收触觉信号并以电信号形式给出响应的压电和热释电特性。本发明描述的系统包括一个或多个键（10），它们各自由具有导电触点的压电膜（11）制成，其具有透明或不透明的压电膜上方和下方，并且下层接地电极（13）。本发明允许在没有外部电源的情况下仅使用一个压电膜（11），使用形成在键盘的一侧收敛并且可以在点（12）中可用的键（10）的电极连接与有源滤波器电路的连接代替电子读出器中的放大器，以及在区分热电与来自特定键的压电信号之间的可触发传感器中引入与这些键盘相同的新功能的可能性，不同的压力变化或温度变化产生的信号。

7. 发明申请

US20060188582A1 Double walled microcapsules with an outer thermoplastic wall and application process thereof 有权
标题翻译：具有外部热塑性壁的双壁微胶囊及其应用方法
公开(公告)号：US20060188582A1
公开(公告)日：2006-08-24
申请号：US10544772
申请日：2003-08-26
申请人： Jaime Naylor Da Rocha Gomes
发明人： Jaime Naylor Da Rocha Gomes
IPC分类号： A61K9/50 , A61K8/18
CPC分类号： D06M23/12 , B01J13/22 , Y10T442/2525
摘要： The present invention concerns double-walled microcapsules with an outer thermoplastic wall and an application process thereof on substrates, namely textile substrate. The microcapsules are applied to fibres so as to produce a slow release of products such as fragrances, antimicrobial, insecticides, antioxidants, vitamins or they can be used as materials such as thermochromic pigments, that change colour when heated, or “phase change materials” (PCM), that convey thermal insulation/control.
摘要翻译：本发明涉及具有外部热塑性壁的双壁微胶囊及其在基材上的涂布方法，即织物基材。将微胶囊施用于纤维，以产生缓慢释放的产品如香料，抗微生物剂，杀虫剂，抗氧化剂，维生素，或者它们可以用作诸如热变色颜料的材料，其在加热时变色，或“相变材料” （PCM），传达绝热/控制。

8. 发明公开

US20240115481A1 FRAGRANCE RELEASE MECHANISM, METHOD AND USES THEREOF 审中-公开
公开(公告)号：US20240115481A1
公开(公告)日：2024-04-11
申请号：US18520428
申请日：2023-11-27
申请人： Universidade do Minho
发明人： Artur Manuel CAVACO PAULO , Filipa Daniela GOMES GONÇALVES , Artur Jorge ARAÚJO MAGALHÃES RIBEIRO , Carla Manuela PEREIRA MARINHO DA SILVA
IPC分类号： A61K8/64 , A61K8/11 , A61Q15/00
CPC分类号： A61K8/64 , A61K8/11 , A61Q15/00
摘要： The present disclosure relates to a release composition comprising a protein and an active agent, wherein the active agent is released when in presence of an electrolyte solution. A kit and an article comprising the release composition of the present-subject matter are also encompassed.

9. 发明公开

US20230338263A1 PEPTIDE COMPOSITION AND RESPECTIVE USES 审中-公开
公开(公告)号：US20230338263A1
公开(公告)日：2023-10-26
申请号：US18194372
申请日：2023-03-31
申请人： Universidade do Minho
发明人： Artur Manuel CAVACO PAULO , Celia FREITAS DA CRUZ , Margarida Maria MACEDO FRANCESKO FERNANDES
IPC分类号： A61K8/64 , A61Q5/00 , A61Q5/04 , A61Q5/06
CPC分类号： A61K8/64 , A61Q5/002 , A61K8/645 , A61Q5/04 , A61Q5/065 , A61Q5/06 , A61K2800/30
摘要： The current application discloses a composition that comprises at least one peptide with a sequence length of 6-12 amino acids, where 2-5 of those amino acids are cysteines for the treatment and cosmetics of animal hair, in preference human hair. There are several hair styling methods that involve breakage and reestablishment of disulfide bonds, allowing relaxation and straightening of the hair. However, the most effective methods currently used to modulate hair contain harmful chemicals. Thus there is a constant demand for formulations that efficiently model the hair fiber without damage. Thus, the present invention aims to provide a composition for treatment of the hair, including animal and human hair, without the use of chemicals harmful to the hair fiber and consumer health and uses of said compositions in shampoo, lotion, serum, cream, conditioner, foam, elixir, oil, aerosol or mask.

10. 发明授权

US11435284B2 Optical system for parameter characterization of an element of body fluid or tissue 有权
公开(公告)号：US11435284B2
公开(公告)日：2022-09-06
申请号：US16275791
申请日：2019-02-14
申请人： UNIVERSIDADE DO MINHO , Nuno Jorge Carvalho Sousa , Rui Miguel Da Costa Martins
发明人： Nuno Jorge Carvalho Sousa , Rui Miguel Da Costa Martins , Ricardo Alberto Alvarez Osorio
IPC分类号： G01N21/25 , A61B5/00 , G01N21/31 , A61B5/145 , A61B5/1455 , A61B5/1495 , G01N21/65 , G01N33/483
摘要： Biophotonic device for the point-of-care, real-time, non-invasive determination of parameters with diagnostic relevance, in particular an optical system for parameter characterization of an element of body fluid or tissue comprising an optical device which comprises: a light source for emitting light onto the element; and a spectrometer for recording the spectrum of light from the element, said light from the element being of transmittance, reflectance or Raman scattering of the emitted light by said element; the optical system further comprising a data processing module configured to: convert the recorded spectrum by a conversion matrix into a standardized spectrum, wherein said conversion matrix has been obtained by calibrating the optical system spectrum response against a spectrum reference; pre-process the converted spectrum; correlate, for parameter quantification, the converted pre-processed spectrum with pre-obtained spectral bands for each parameter; said spectrum being contained within uv-vis-nir wavelengths. Also methods of operating said system.

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