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1. 发明授权

US12055484B2 Computer-implemented method and system for spectroscopic analysis of biological material 有权
公开(公告)号：US12055484B2
公开(公告)日：2024-08-06
申请号：US18106958
申请日：2023-02-07
申请人： The Automation Partnership (Cambridge) Limited
发明人： Adrian Stacey , Christian Grimm , Marek Hoehse , Thomas Regen , Angus Woodhams
IPC分类号： G01N21/359 , G01N21/05 , G01N21/84 , G01N35/00 , G01N35/10
CPC分类号： G01N21/359 , G01N21/05 , G01N35/00603 , G01N35/1095 , G01N2021/8416
摘要： A computer-implemented method for spectroscopic analysis of biological material is provided that includes analyzing samples of biological material from a plurality of sources, and delivering samples of biological material to at least one flow cell for spectroscopy, and determining whether the spectroscopic analysis for each sample of the plurality of samples is or is predicted to be ambiguous in that it is affected by at least two non-discriminable factors. If such a determination is made, a disambiguating step can be performed.

2. 发明授权

US11597904B2 Liquid filtration system with integrated bleed function 有权
公开(公告)号：US11597904B2
公开(公告)日：2023-03-07
申请号：US16312182
申请日：2017-07-18
申请人： The Automation Partnership (Cambridge) Limited
发明人： Paul Grant
IPC分类号： C12M1/00 , B01D35/26 , B01D37/04 , C12M1/34
摘要： A liquid filtration system according to the present invention comprises a bioreactor; a filter configured to filter liquid passing therethrough; a perfusion pump configured to move liquid between the bioreactor and the filter; a liquid line providing fluidic communication between the bioreactor, perfusion pump and filter; and a bleed outlet provided on the liquid line, the bleed outlet configured to provide means to remove liquid selectively from the system under the action of the perfusion pump. With the liquid filtration system according to the present invention, both the filtering and bleed functions may be performed under the action of a single pump, thereby significantly reducing the complexity and cost of the components required.

3. 发明申请

US20210025814A1 COMPUTER-IMPLEMENTED METHOD AND SYSTEM FOR SPECTROSCOPIC ANALYSIS OF BIOLOGICAL MATERIAL 有权
公开(公告)号：US20210025814A1
公开(公告)日：2021-01-28
申请号：US17042837
申请日：2019-03-29
申请人： The Automation Partnership (Cambridge) Limited
发明人： Adrian Stacey , Christian Grimm , Marek Hoehse , Thomas Regen , Angus Woodhams
IPC分类号： G01N21/359 , G01N21/05 , G01N35/00 , G01N35/10
摘要： A computer-implemented method for spectroscopic analysis of biological material is provided that includes analyzing samples of biological material from a plurality of sources, and delivering samples of biological material to at least one flow cell for spectroscopy, and determining whether the spectroscopic analysis for each sample of the plurality of samples is or is predicted to be ambiguous in that it is affected by at least two non-discriminable factors. If such a determination is made, a disambiguating step can be performed.

4. 发明申请

US20210018523A1 AUTO-ALIGNING CABLE SENSOR 有权
公开(公告)号：US20210018523A1
公开(公告)日：2021-01-21
申请号：US17040908
申请日：2019-03-21
申请人： The Automation Partnership (Cambridge) Limited
发明人： Adrian STACEY , Daren HUTTLESTONE , Edmund GRACE
IPC分类号： G01N35/00 , C12M1/34 , C12M1/00
摘要： An auto-aligning cable sensor for performing measurements on a medium contained in a vessel is provided. The cable sensor includes a cable which has an end sensor and which is adapted to be carried by a mounting fixture. The mounting fixture and the vessel are movable into a measurement position relative to each other such that a contact face of the end sensor is held in alignment against a surface of the vessel by a pressing force, thereby enabling the end sensor to sense a characteristic of the medium contained in the vessel. The cable sensor further includes an elastically deformable coupling member which is arranged to mediate transfer of the pressing force from the mounting fixture to the cable and thence to the end sensor when the mounting fixture and the vessel are moved into the measurement position. The coupling member deforms under the pressing force such that the cable can flex to tilt the end sensor relative to the surface of the vessel to accommodate misalignment of the contact face and the surface of the vessel.

5. 发明授权

US10876963B2 Devices and methods for improving and evaluating stability of pumped protein solutions in bioprocessing systems 有权
公开(公告)号：US10876963B2
公开(公告)日：2020-12-29
申请号：US16641224
申请日：2018-10-05
申请人： The Automation Partnership (Cambridge) Limited
发明人： Adrian Neil Bargh , John Paul James Betts
IPC分类号： G01N21/00 , G01N21/53 , F04B43/12 , G01N33/68
CPC分类号： G01N21/53 , F04B43/1284 , G01N33/6803
摘要： The present invention relates to devices and methods for improving and evaluating stability of pumped protein solutions in cross-flow filtration applications. Inter alia, the present invention provides a peristaltic pump for cross-flow filtration having a pump head, wherein the pump head comprises a stepped occlusion plate and at least one pump roller, wherein a tubing is to be arranged between the stepped occlusion plate and the at least one pump roller, wherein the stepped occlusion plate has a specific configuration.

6. 发明授权

US07674433B2 Tube for storing fluid 失效
标题翻译：用于储存流体的管
公开(公告)号：US07674433B2
公开(公告)日：2010-03-09
申请号：US10802871
申请日：2004-03-18
申请人： Philip Russel James Smith , Adrian Neil Bargh
发明人： Philip Russel James Smith , Adrian Neil Bargh
IPC分类号： B01L3/00
CPC分类号： B01L3/50855 , B01L3/5082 , B01L9/06 , B01L2200/025 , B01L2300/021 , B01L2300/041 , B01L2300/0851 , G01N21/03
摘要： A tube for storing micro-liter volumes is provided. The tube is open at one end and comprises a body portion of substantially square cross section; a shoulder portion at one end of the body portion and providing the open end of the tube, the cross section of the shoulder portion being greater than that of the body portion; and a formation providing a snap fit connector portion at the other end.
摘要翻译：提供了用于存储微量体积的管。管在一端开口并且包括基本正方形横截面的主体部分; 在主体部分的一端处的肩部并且提供管的开口端，肩部的横截面大于主体部分的横截面; 以及在另一端提供卡扣配合连接器部分的结构。

7. 发明申请

US20060105450A1 Vessel loading/unloading 审中-公开
标题翻译：船舶装卸
公开(公告)号：US20060105450A1
公开(公告)日：2006-05-18
申请号：US11272073
申请日：2005-11-14
申请人： Stephen Owen
发明人： Stephen Owen
IPC分类号： C12M1/36 , C12M1/02
CPC分类号： G01N35/0099 , G01N2035/0465
摘要： Apparatus is described for loading or unloading a vessel, say a flask, on to or from a selected position on a support arranged to oscillate substantially in a plane. The apparatus includes a transporter in the form of a robotic arm having a gripper unit for gripping the flask. A mechanism, preferably a flexible restraint mechanism, is arranged to accommodate lost movement between the transporter and the support when the gripper unit releases or grips the flask to load it on to or unload it from the support respectively.
摘要翻译：描述了装置，用于将容器（例如烧瓶）装载或卸载到布置成基本上在平面中振荡的支撑件上的选定位置或从选定位置卸载。该装置包括具有用于夹紧烧瓶的夹持器单元的机器手臂形式的运送器。布置了一种机构，优选地是柔性约束机构，以便当夹具单元释放或夹住烧瓶以将其装载到支架上或从支架分别卸载时，容纳运送器和支撑件之间的运动。

8. 发明授权

US11687856B2 Scaling tool 有权
公开(公告)号：US11687856B2
公开(公告)日：2023-06-27
申请号：US17858923
申请日：2022-07-06
申请人： The Automation Partnership (Cambridge) Limited
发明人： Adrian Stacey , Jochen Scholz
IPC分类号： G06Q10/06 , G05B19/418 , G06Q50/04 , G06Q10/0631 , C12Q3/00
CPC分类号： G06Q10/06313 , C12Q3/00 , G05B19/41885 , G06Q50/04 , G05B2219/32287 , G05B2219/32301
摘要： The present application generally pertains to scaling of a production process to produce a chemical, pharmaceutical and/or biotechnological product and/or of a production state of a respective production equipment. Particularly, there is provided a computer-implemented method of scaling a production process to produce a chemical, pharmaceutical and/or biotechnological product, the scaling being from a source scale to a target scale, wherein the production process is defined by a plurality of steps specified by one or more process parameters controlling an execution of the production process, the method comprising: (a) retrieving: parameter evolution information that describes the time evolution of the process parameter(s); a plurality of recipe templates, wherein a recipe comprises the plurality of steps defining the production process, and wherein a recipe template is a recipe in which at least one of the process parameters specifying the plurality of steps is a parameter being variable and having no predetermined value at the outset; (b) receiving: a source setup specification of a source setup to be used for executing the production process at the source scale, the source setup specification comprising the source scale value; a target setup specification of a target setup to be used for executing the production process at the target scale, the target setup specification comprising the target scale value; a source recipe defining the production process at the source scale; at least one acceptability function defining conditions for the values of the process parameter(s) at the source scale and/or at the target scale; (c) simulating the execution of the production process at the source scale using the source setup specification, the source recipe and the parameter evolution information; (d) determining, from the simulation, one or more source trajectories for the process parameter(s), wherein a trajectory corresponds to a time-based profile of values recordable during the simulated execution of the production process; (e) performing a target determination step comprising: selecting a recipe template pertinent to the production process out of the plurality of recipe templates; providing an input value for the at least one variable parameter in the selected recipe template; simulating the execution of the production process at the target scale using the target setup specification, the selected recipe template, the input value for the at least one variable parameter and the parameter evolution information; determining, from the simulation, one or more target trajectories for the process parameters; comparing the source trajectory(ies) and the target trajectory(ies); computing, based on the comparison and on the at least one acceptability function, an acceptability score for the selected recipe template; computing an optimal value for the at least one variable parameter in the selected recipe template by optimising the acceptability score and/or computing an acceptable range for the at least one variable parameter, wherein values within the acceptable range yield an acceptability score above a specific threshold; (f) if there is at least another pertinent recipe template, repeating the target determination step for at least another pertinent recipe template; (g) selecting at least one of the plurality of recipe templates and corresponding computed value(s) for variable parameter(s) as target recipe based on the acceptability scores computed for one or more recipe templates.

9. 发明公开

US20230184673A1 COMPUTER-IMPLEMENTED METHOD AND SYSTEM FOR SPECTROSCOPIC ANALYSIS OF BIOLOGICAL MATERIAL 审中-公开
公开(公告)号：US20230184673A1
公开(公告)日：2023-06-15
申请号：US18106958
申请日：2023-02-07
申请人： The Automation Partnership (Cambridge) Limited
发明人： Adrian Stacey , Christian Grimm , Marek Hoehse , Thomas Regen , Angus Woodhams
IPC分类号： G01N21/359 , G01N21/05 , G01N35/00 , G01N35/10
CPC分类号： G01N21/359 , G01N21/05 , G01N35/00603 , G01N35/1095 , G01N2021/8416
摘要： A computer-implemented method for spectroscopic analysis of biological material is provided that includes analyzing samples of biological material from a plurality of sources, and delivering samples of biological material to at least one flow cell for spectroscopy, and determining whether the spectroscopic analysis for each sample of the plurality of samples is or is predicted to be ambiguous in that it is affected by at least two non-discriminable factors. If such a determination is made, a disambiguating step can be performed.

10. 发明授权

US11525836B2 Automated bioprocess development 有权
公开(公告)号：US11525836B2
公开(公告)日：2022-12-13
申请号：US16095981
申请日：2017-05-12
申请人： The Automation Partnership (Cambridge) Limited
发明人： Richard Wales , Patrick Courtney
IPC分类号： G01N35/00 , G05B13/02 , G05B15/02 , G01N31/00
摘要： A method for automating process development in a bioprocessing environment is provided. The method comprising: executing a first experiment run according to a set of parameters; retrieving a first real-time set of data of the experiment run while the experiment run is being executed; retrieving a second real-time set of data of an experiment run being executed in parallel, analysing the retrieved first real-time set of data and the second real-time set of data to determine an adjusted set of parameters; and, modifying, based on the analysis, the parameters upon which the experiment run is being executed during execution of the run such that the run continues to be executed according to the modified set of parameters. A system, computer program and computer readable medium are also provided.

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