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    • 5. 发明授权
    • Method for automatic dosing of drugs
    • 药物自动给药方法
    • US5782799A
    • 1998-07-21
    • US797296
    • 1997-02-07
    • Stephen C. JacobsenGaylen M. Zentner
    • Stephen C. JacobsenGaylen M. Zentner
    • A61D7/00A61M31/00
    • A61M31/002A61D7/00
    • The method for automatic dosing of drugs utilizes a microdelivery device which may be implanted in or otherwise administered to an animal or human. A microdelivery device is configured to have a plurality of compartments, each containing at least one drug so that a plurality of doses of the drug(s) are held within the device. In accordance with the present invention, the microdelivery device selectively actuates the compartments to selectively release doses of the drug(s) to provide an efficacious dosing pattern. One primary function of the present invention is to release two or more pesticides in such a pattern that parasites are effectively controlled while preventing the development of tolerance to the drugs within the parasites. Preferably, the microdelivery device is programmable to effectuate the release of the drug(s) at a desired time to maintain efficacious levels of the drug while minimizing the amount of drug which must be used.
    • 用于药物自动给药的方法使用可以植入或以其它方式施用于动物或人的微量输送装置。 微量输送装置被配置为具有多个隔室,每个隔间包含至少一种药物,使得多个剂量的药物保持在该装置内。 根据本发明,微量输送装置选择性地致动隔室以选择性地释放药物的剂量以提供有效的给药模式。 本发明的一个主要功能是以这样的模式释放两种或更多种杀虫剂,即在有效地控制寄生虫的同时防止对寄生虫内的药物的耐受性的发展。 优选地,微量输送装置是可编程的,以在期望的时间实现药物的释放,以保持药物的有效水平,同时最小化必须使用的药物的量。
    • 7. 发明授权
    • Electric field machine
    • 电场机
    • US4736127A
    • 1988-04-05
    • US940264
    • 1986-12-11
    • Stephen C. Jacobsen
    • Stephen C. Jacobsen
    • H02N11/00H02N1/00
    • H02N1/004
    • A microgeometric electric field machine includes arrays of conductors formed on or carried by a plurality of substrates. The conductors on a first group of substrates carry electrical charges, with alternate conductors being charged positively and the other conductors being charged negatively. A second group of substrates are interleaved with the first group in close proximity therewith. Also included is a voltage source for successively supplying alternate positive and negative electrical charges to the conductors of the second group of substrates. Effectively a pattern of alternate positively and negatively charged conductors is established for the second group of substrates and these patterns are caused to move, relative to the substrates, along the arrays of conductors to produce "moving" electric force fields which cause one group of substrates to move with respect to the other group. The substrates may be in the form of stacked discs with the conductors being radially positioned thereon, where one group of discs is caused to rotate with respect to another group. Alternatively, the substrates may be in the form of stacked planes with the conductors positioned in parallel thereon, where one group of planes is caused to move linearly with respect to the other group, and in a direction perpendicular to the conductors. The configuration of the substrates, positioning of the conductors, and interleaving of the substrates and conductors could take a variety of forms.
    • 微电子电场机包括形成在多个基板上或由多个基板承载的导体阵列。 第一组基板上的导体携带电荷,交替的导体被正向充电,而其他导体被负电荷充电。 第二组衬底与第一组非常接近地交错。 还包括用于连续地向第二组基板的导体提供交替的正电荷和负电荷的电压源。 有效地为第二组衬底建立了替代的带正电荷和带负电荷的导体的图案,并且使这些图案相对于衬底沿着导体阵列移动以产生“移动”电场,这导致一组衬底 相对于另一组移动。 衬底可以是堆叠盘的形式,其中导体径向地定位在其上,其中一组盘相对于另一组旋转。 或者,衬底可以是堆叠平面的形式,其中导体位于其上,其中使一组平面相对于另一组线性移动,并且在垂直于导体的方向上移动。 衬底的配置,导体的定位以及衬底和导体的交错可以采取各种形式。
    • 8. 发明授权
    • Body-powered prosthetic arm
    • 身体动力的假肢
    • US5888235A
    • 1999-03-30
    • US779456
    • 1997-01-07
    • Stephen C. JacobsenDavid F. Knutti
    • Stephen C. JacobsenDavid F. Knutti
    • A61F2/54A61F2/58A61F2/68
    • A61F2/68A61F2/54A61F2/582A61F2/583A61F2/588A61F2002/543A61F2002/6854A61F2002/6872
    • A body-powered prosthetic arm is mountable on a socket attached to the arm stump of a person. The prosthetic arm includes a base for attachment to the socket, a forearm section having a proximal end and a distal end, a terminal device such as a hook, anthropomorphic hand, etc. attached to the distal end of the forearm section for selectively opening or closing, and an elbow joint for joining the proximal end of the forearm section to the base, the elbow joint being pivotable to enable moving the forearm section upwardly or downwardly. Control straps and cables fitted on the person are responsive to body movements of the person for selectively locking the elbow joint to prevent it from pivoting while allowing the terminal device to open or close or locking the terminal device to prevent it from opening or closing while allowing the elbow joint to pivot.
    • 身体动力的假肢臂可安装在连接到人的手臂残端的插座上。 假肢臂包括用于附接到插座的基座,具有近端和远端的前臂部分,附接到前臂部分的远端的终端装置,例如钩子,拟人手等,用于选择性地打开或 关闭,以及用于将前臂部分的近端连接到基部的肘关节,肘关节可枢转,以使得前臂部分能够向上或向下移动。 安装在人身上的控制带和电缆响应于人的身体运动,以选择性地锁定肘关节以防止其枢转,同时允许终端设备打开或关闭或锁定终端设备,以防止其打开或关闭,同时允许 肘关节枢转。
    • 10. 发明授权
    • Disposable automatic injection device
    • 一次性自动注射装置
    • US6086562A
    • 2000-07-11
    • US165164
    • 1998-10-01
    • Stephen C. JacobsenAaron M. BestTomasz J. Petelenz
    • Stephen C. JacobsenAaron M. BestTomasz J. Petelenz
    • A61M5/142A61M5/20A61M5/24A61M5/28A61M5/30A61M5/31A61M5/315A61M5/32A61M5/34A61N1/30
    • A61M5/282A61M5/14248A61M5/2046A61N1/30A61M2005/14252A61M2005/206A61M2005/3022A61M2005/3123A61M2005/3128A61M2005/341A61M2205/583A61M5/2066A61M5/286A61M5/3234
    • An automatic injection device includes a drug-filled vessel having a flexible membrane over a first opening thereof and a puncturable seal in a wall thereof, a hollow needle attached at a first end to the flexible membrane and having a sharp end positioned proximate the puncturable seal housing. A pressure source such as a combustible propellant provides a compressed gas above the flexible membrane to force the membrane into the drug-filled vessel, forcing the hollow needle through the puncturable seal and the drug contained in the vessel through the hollow needle. After the drug has been substantially evacuated from the vessel, the membrane is allowed to return to its pre-expanded state thus retracting the hollow needle into the vessel. Preferably, the flexible membrane is an elastomeric material having a plurality of concentrically configured corrugations to allow expansion of the membrane into the vessel. The inner surface of the vessel may have a dome-like shape such that expansion of the membrane into the vessel substantially matches the dome-like shape and thus forces substantially the entire amount of the drug from the vessel.
    • 自动注射装置包括在其第一开口上具有柔性膜的药物填充容器和在其壁中的可刺破的密封件,中空针头在第一端附接到柔性膜并且具有靠近可穿刺密封件定位的尖端 住房。 诸如可燃推进剂的压力源在柔性膜之上提供压缩气体,以迫使膜进入药物填充的容器,迫使空心针穿过可穿刺的密封和通过中空针头容纳在容器中的药物。 在药物已经从血管基本上排出之后,允许膜返回到其预扩张状态,从而将中空针缩回到容器中。 优选地,柔性膜是具有多个同心配置的波纹的弹性体材料,以允许膜膨胀到容器中。 容器的内表面可以具有圆顶形状,使得膜进入容器的膨胀基本上与圆顶状形状匹配,因此迫使药物从容器的基本上全部量。