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1. 发明授权

US10766652B2 Carrier element and packaging device for packaging at least one product into at least one package 有权
公开(公告)号：US10766652B2
公开(公告)日：2020-09-08
申请号：US14556479
申请日：2014-12-01
申请人： Roche Diagnostics Operations, Inc.
发明人： Thomas Jasiulek , Andreas Trapp
IPC分类号： B65B43/52 , B65B43/54 , B65G17/34 , B65B65/00 , B65G17/46 , B65G17/32 , B65G47/84
摘要： A carrier element for use in a packaging device is provided wherein the carrier element is connectable with at least one transport device of the packaging device. The carrier element comprises at least one receiving surface for receiving at least one package. The receiving surface comprises at least one suction opening for fixing the package by suction. The carrier element further comprises at least one pressure reservoir connected to the suction opening. The carrier element further comprises at least one pressure sensor for measuring a pressure inside the pressure reservoir. A packaging device for packaging at least one product into at least one package is also disclosed. The packaging device comprises at least one carrier element and at least one transport device, wherein the carrier element is connected to the transport device.

2. 发明授权

US09421279B2 Process for preparing purified nucleic acid and the use thereof 有权
标题翻译：制备纯化的核酸的方法及其用途
公开(公告)号：US09421279B2
公开(公告)日：2016-08-23
申请号：US14277415
申请日：2014-05-14
申请人： Roche Diagnostics GmbH
发明人： Wolfgang Kuhne
IPC分类号： C12N15/10 , A61K48/00 , C12N15/85
CPC分类号： A61K48/005 , A61K48/0091 , C12N15/101 , C12N15/85
摘要： The invention relates to a nucleic acid preparation with a content of below 1% protein, preferably below 0.1% protein, free of ethidium bromide, phenol, cesium chloride and detergents based on octyl phenol poly(ethylene glycol ether)n and with a content of below 1 EU/mg DNA of endotoxins. Said preparation is suitable as a drug particularly in gene therapy.
摘要翻译：本发明涉及含有低于1％蛋白质，优选低于0.1％蛋白质，不含溴化乙锭，苯酚，氯化铯和基于辛基酚聚（乙二醇醚）n的洗涤剂的核酸制剂，其含量为低于1 EU / mg内毒素DNA。所述制剂特别适用于基因治疗。

3. 发明授权

US08758747B2 Stable lyophilized pharmaceutical preparations of monoclonal or polyclonal antibodies 有权
标题翻译：稳定的冻干药物制剂的单克隆或多克隆抗体
公开(公告)号：US08758747B2
公开(公告)日：2014-06-24
申请号：US12180794
申请日：2008-07-28
申请人： Georg Kallmeyer , Gerhard Winter , Christian Klessen , Heinrich Woog
发明人： Georg Kallmeyer , Gerhard Winter , Christian Klessen , Heinrich Woog
IPC分类号： A61K39/395 , C07K16/00 , C12P21/08 , A61K9/19
CPC分类号： A61K47/10 , A61K9/0019 , A61K9/19 , A61K38/00 , A61K39/395 , A61K39/39591 , A61K47/183 , A61K47/22 , A61K47/26 , C07K16/00 , C07K16/082 , C07K16/2863
摘要： The invention concerns lyophilized pharmaceutical preparations of monoclonal or polyclonal antibodies which contain a sugar or an amino sugar, an amino acid and a surfactant as stabilizers. In addition the invention concerns a process for the production of this stable lyophilizate as well as the use of a sugar or amino sugar, an amino acid and a surfactant as stabilizers for therapeutic or diagnostic agents containing antibodies.
摘要翻译：本发明涉及含有糖或氨基糖，氨基酸和表面活性剂作为稳定剂的单克隆或多克隆抗体的冻干药物制剂。此外，本发明涉及生产这种稳定的冻干物的方法，以及使用糖或氨基糖，氨基酸和表面活性剂作为含有抗体的治疗剂或诊断剂的稳定剂。

4. 发明申请

US20130171656A1 DETECTION, IDENTIFICATION AND DIFFERENTIATION OF PROTEUS SPECIES USING THE SPACER REGION 审中-公开
标题翻译：使用间隔区域的物种的检测，鉴定和鉴定
公开(公告)号：US20130171656A1
公开(公告)日：2013-07-04
申请号：US13787593
申请日：2013-03-06
申请人： INNOGENETICS N.V. , ROCHE DIAGNOSTICS GMBH
发明人： Geert JANNES , Wouter Mijs , Gerd Haberhausen , Thomas Emrich
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12Q1/689
摘要： The present invention relates to new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Proteus species, in particular of Proteus mirabilis, Proteus vulgaris and/or Proteus penneri, in a biological sample. The present invention relates also to a method for the specific detection and/or identification of Proteus species, in particular Proteus mirabilis, Proteus vulgaris and/or Proteus penneri, using said new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Proteus species in a sample.
摘要翻译：本发明涉及从用于特异性检测和/或鉴定变形菌属物种的16S和23S核糖核糖核酸（rRNA）或rRNA基因之间的ITS（内转录间隔区）衍生的新核酸序列，特别是奇异变形杆菌（Proteus mirabilis），普通变形杆菌（Proteus vulgaris）和/或变形杆菌（Proteus penneri）。本发明还涉及使用衍生自ITS（内部转录间隔物）区的所述新的核酸序列来特异性检测和/或鉴定变形杆菌物种，特别是奇异变形杆菌，普通变形杆菌和/或变形杆菌的方法。它还涉及用于扩增样品中变形杆菌物种的所述间隔区的核酸引物。

5. 发明申请

US20110293708A1 PROCESS FOR PREPARING PURIFIED NUCLEIC ACID AND THE USE THEREOF 审中-公开
标题翻译：制备纯化的核酸的方法及其用途
公开(公告)号：US20110293708A1
公开(公告)日：2011-12-01
申请号：US13197225
申请日：2011-08-03
申请人： Wolfgang KUHNE
发明人： Wolfgang KUHNE
IPC分类号： A61K9/127 , A61P11/00 , A61K31/711 , C07H21/04 , C12P19/34
CPC分类号： A61K48/005 , A61K48/0091 , C12N15/101 , C12N15/85
摘要： The invention relates to a nucleic acid preparation with a content of below 1% protein, preferably below 0.1% protein, free of ethidium bromide, phenol, cesium chloride and detergents based on octyl phenol poly(ethylene glycol ether)n and with a content of below 1 EU/mg DNA of endotoxins. Said preparation is suitable as a drug particularly in gene therapy.
摘要翻译：本发明涉及含有低于1％蛋白质，优选低于0.1％蛋白质，不含溴化乙锭，苯酚，氯化铯和基于辛基酚聚（乙二醇醚）n的洗涤剂的核酸制剂，其含量为低于1 EU / mg内毒素DNA。所述制剂特别适用于基因治疗。

6. 发明申请

US20100074946A1 PROCESS FOR PREPARING PURIFIED NUCLEIC ACID AND THE USE THEREOF 审中-公开
标题翻译：制备纯化的核酸的方法及其用途
公开(公告)号：US20100074946A1
公开(公告)日：2010-03-25
申请号：US12627449
申请日：2009-11-30
申请人： Wolfgang KUHNE
发明人： Wolfgang KUHNE
IPC分类号： A61K9/127 , A61K38/16 , C12P19/34 , A61P11/16
CPC分类号： A61K48/005 , A61K48/0091 , C12N15/101 , C12N15/85
摘要： The invention relates to a nucleic acid preparation with a content of below 1% protein, preferably below 0.1% protein, free of ethidium bromide, phenol, cesium chloride and detergents based on octyl phenol poly(ethylene glycol ether)n and with a content of below 1EU/mg DNA of endotoxins. Said preparation is suitable as a drug particularly in gene therapy.
摘要翻译：本发明涉及含有低于1％蛋白质，优选低于0.1％蛋白质，不含溴化乙锭，苯酚，氯化铯和基于辛基酚聚（乙二醇醚）n的洗涤剂的核酸制剂，其含量为低于1EU / mg内毒素DNA。所述制剂特别适用于基因治疗。

7. 发明授权

US07612187B2 2-azapurine compounds and their uses 有权
标题翻译： 2-氮杂嘌呤化合物及其用途
公开(公告)号：US07612187B2
公开(公告)日：2009-11-03
申请号：US11441755
申请日：2006-05-25
申请人： Frank Seela , Helmut Rosemeyer , Enno Schweinberger , Dieter Heindl , Frank Bergmann
发明人： Frank Seela , Helmut Rosemeyer , Enno Schweinberger , Dieter Heindl , Frank Bergmann
IPC分类号： C07H21/02 , C07H21/04 , C07H21/00 , C12Q1/68 , C12P19/34
CPC分类号： C12N15/113 , C07H19/04 , C07H19/10 , C07H19/20 , C07H21/00 , C12N2310/333 , C12Q1/6813
摘要： Within oligonucleotides 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than a guanine-cytosine base pair. Therefore, the incorporation of 2-azaadenine residues into oligonucleotides instead of cytosine leads specifically to hybridization complexes with nucleic acids with homogenous stability. This is useful for the adaptation of the stabilities of different oligonucleotide sequences in all kinds of hybridization techniques, for example in oligomer chip technology.
摘要翻译：寡核苷酸2-氮杂嘌呤，特别是2-氮杂腺嘌呤碱基与鸟嘌呤特异性碱基对形成。该碱基对具有与腺嘌呤 - 胸腺嘧啶类似的稳定性，但不如鸟嘌呤 - 胞嘧啶碱基对稳定。因此，将2-氮杂腺嘌呤残基并入寡核苷酸而不是胞嘧啶，特别导致与具有均匀稳定性的核酸的杂交复合物。这对于在各种杂交技术中适应不同寡核苷酸序列的稳定性是有用的，例如在低聚物芯片技术中。

8. 发明授权

US07547417B2 Storage container for analytical devices 有权
公开(公告)号：US07547417B2
公开(公告)日：2009-06-16
申请号：US10263266
申请日：2002-10-02
申请人： Klaus-Dieter Sacherer
发明人： Klaus-Dieter Sacherer
IPC分类号： B01L9/00
CPC分类号： B01L99/00 , G01N33/48778 , Y10T436/2575
摘要： A storage container for holding analytical devices, the storage container being made of a rigid material and containing separate chambers in each of which at most one analytical device can be accommodated, wherein the chambers are in a regular geometric arrangement in relation to one another and each of the chambers has at least two opposite openings each sealed by a foil, wherein at least one of the chambers comprises a means for fixing the position of an analytical device in the chamber. In addition the invention concerns a system for storing analytical devices containing a storage container according to the invention and two or more analytical devices.

9. 发明申请

US20090017456A1 DETECTION, IDENTIFICATION AND DIFFERENTIATION OF EUBACTERIAL TAXA USING A HYBRIDIZATION ASSAY 审中-公开
标题翻译：使用杂交测定法检测，鉴定和鉴定非特异性毒素
公开(公告)号：US20090017456A1
公开(公告)日：2009-01-15
申请号：US12045183
申请日：2008-03-10
申请人： Hilde DE HENAU , Joachim Van Crombruggen , Geert Jannes , Gerd Haberhausen , Thomas Emrich
发明人： Hilde DE HENAU , Joachim Van Crombruggen , Geert Jannes , Gerd Haberhausen , Thomas Emrich
IPC分类号： C12Q1/68 , C07H21/04 , C07H21/02
CPC分类号： C12Q1/689
摘要： The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Enterococcus species, in particular of Enterococcus faecalis and/or Enterococcus faecium, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Enterococcus species in a sample.
摘要翻译：本发明涉及使用源自ITS（内转录间隔区）的新核酸序列来特异性检测和/或鉴定肠球菌属物种，特别是粪肠球菌和/或屎肠球菌的方法。本发明还涉及用于特异性检测和/或鉴定肠球菌属物种的16S和23S核糖核糖核酸（rRNA）或rRNA基因之间的来自ITS区的所述新核酸序列，特别是生物样品中的粪肠球菌和/或屎肠球菌。它还涉及用于扩增样品中肠球菌种间隔区域的核酸引物。

10. 发明申请

US20070292314A1 Bent Microstructures For Sampling, Transporting Or Dispensing A Fluid Media 有权
标题翻译：用于采样，运输或分配流体介质的弯曲微结构
公开(公告)号：US20070292314A1
公开(公告)日：2007-12-20
申请号：US11791251
申请日：2005-11-22
申请人： Carlo Effenhauser , Emad Sarofim , Stephan Korner
发明人： Carlo Effenhauser , Emad Sarofim , Stephan Korner
IPC分类号： B01L3/02
CPC分类号： G01N1/20 , B01L3/0244 , B01L3/502707 , B01L3/502715 , B01L2200/025 , B01L2400/025 , B01L2400/0406 , Y10T29/49826 , Y10T436/110833 , Y10T436/2575
摘要： A device for sampling, transporting and/or disposal of fluid media in the nl and μl-range comprises a substrate with and open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.
摘要翻译：用于在n1和m范围内采样，运输和/或处理流体介质的装置包括分别具有和开放或封闭的毛细管状沟槽或通道的基板，分别具有开放或封闭的凹槽或毛细管的基板被弯曲或至少在一个位置弧形。衬底包括至少一个端部，开放或封闭的毛细管状沟槽或沟槽分别延伸到其中，该端部根据其应用或用途被成形为例如形状。针状，直线切割，尖端状，至少半圆形，圆形等

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