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1. 发明授权

US12130279B2 Systems and methods for meter reconfiguration, control, and operation via an insertable chip with microprocessor 有权
公开(公告)号：US12130279B2
公开(公告)日：2024-10-29
申请号：US16841921
申请日：2020-04-07
申请人： POLYMER TECHNOLOGY SYSTEMS, INC.
发明人： Jonathan A. Broadwell , James Miller
IPC分类号： G01N33/487 , B01L3/00
CPC分类号： G01N33/48785 , B01L3/502715 , B01L2300/0654 , B01L2300/0825
摘要： In one embodiment, a system for a configurable meter for analyte testing includes a meter, the meter configured to respond to commands in a first protocol and thereby control an analysis system for detecting an analyte level of an analyte, a display, and an input device. The system further includes a removable chip insertable into the meter, the removable chip configured to execute a protocol when mated with the meter and send the commands in the first protocol to control the meter, the removable chip further configured to calculate the analyte level as part of the protocol.

2. 发明授权

US11693016B2 Systems and methods for electrochemical point-of-care detection of hemoglobin 有权
公开(公告)号：US11693016B2
公开(公告)日：2023-07-04
申请号：US16698872
申请日：2019-11-27
申请人： POLYMER TECHNOLOGY SYSTEMS, INC.
发明人： Donnie Smith , Brittney L. Werner , Gary L. Hughes , Jie Chen
IPC分类号： G01N33/72 , G01N27/327 , C12N9/50
CPC分类号： G01N33/721 , C12N9/50 , G01N27/3272 , G01N33/723
摘要： A method for determining analytes includes lysing the red blood cells of a whole blood sample, oxidizing the free hemoglobin in the lysed sample, and cleaving FVH from the hemoglobin A1C to form an electrochemical test solution. In one aspect, a first portion of the electrochemical test solution is reacted with fructosyl peptide oxidase and a reduced ruthenium mediator to form a first reaction product. A first electrical property of the first reaction product is measured, the measurement being indicative of hemoglobin A1C in the blood sample. In another aspect, a second portion of the electrochemical test solution is reacted with ferrocyanide to form a second reaction product. A second electrical property of the second reaction product is measured, the measurement being indicative of total hemoglobin in the blood sample. Hemoglobin A1C, total hemoglobin, and % HbA1C are determined based on the first and second electrical properties.

3. 发明授权

US11103169B2 Systems and methods for a blood collector with enhanced volume using capillary techniques 有权
公开(公告)号：US11103169B2
公开(公告)日：2021-08-31
申请号：US15435797
申请日：2017-02-17
申请人： POLYMER TECHNOLOGY SYSTEMS, INC.
发明人： Jeffrey A. Pierce , Bao Phan
IPC分类号： A61B5/15 , A61B5/151
摘要： A blood sampler device includes a sampler body forming a hollow internal chamber with upper and lower openings, the sampler body including a sealing device disposed adjacent to the upper opening. The blood sampler device further includes a blood collector adapted to be inserted into the sampler body, the blood collector including a plurality of capillary channels.

4. 发明授权

US09180455B2 Vent configuration for a blood sampler 有权
标题翻译：血液取样器的排气口配置
公开(公告)号：US09180455B2
公开(公告)日：2015-11-10
申请号：US13587439
申请日：2012-08-16
申请人： Bao Phan , Martin Antoine Mathelier , Hoang Quoc Chau , Simin Yao , Eugene Prais
发明人： Bao Phan , Martin Antoine Mathelier , Hoang Quoc Chau , Simin Yao , Eugene Prais
IPC分类号： B01L3/00 , A61B5/151 , G01N33/49 , A61B5/15 , G01N1/00 , B01F15/00 , G01N1/38 , B01F15/02 , A61J1/20
CPC分类号： B01L3/508 , A61B5/1411 , A61B5/150022 , A61B5/150213 , A61B5/150259 , A61B5/150343 , A61B5/150755 , A61B5/15142 , B01F15/00512 , B01F15/0206 , B01L3/502 , B01L3/502715 , B01L3/502723 , B01L3/5082 , B01L2200/027 , B01L2200/0684 , B01L2200/0689 , B01L2200/087 , B01L2300/042 , B01L2300/047 , B01L2300/048 , B01L2400/0478 , B01L2400/0481 , B01L2400/0683 , G01N1/38 , G01N33/49
摘要： A blood sampler device includes a blood collector and a sampler body. The blood collector is designed to collect a sample of a fluid, such as blood, from a user and to be inserted into the sampler body, such that the collected blood can be discharged into a liquid chamber in the sampler body to mix with a liquid stored in the liquid chamber for testing. The blood collector includes vents that are designed to facilitate the flow of air out of the liquid chamber during this insertion, such that a lower and more consistent pressurization can be achieved within the liquid chamber. This design may also increase user comfort and enhance the accuracy of testing performed on the collected fluid.
摘要翻译：血液取样器装置包括血液收集器和采样器体。血液收集器被设计成从使用者收集诸如血液的流体的样品并插入取样器体中，使得所收集的血液可以排出到采样器主体中的液体室中以与液体混合储存在液体室进行测试。血液收集器包括通气口，其设计成在该插入过程中便于空气流出液体室，从而可以在液体室内实现更低和更一致的加压。这种设计还可以增加使用者的舒适度并提高对收集的流体进行的测试的准确性。

5. 发明授权

US08865089B2 Analytical systems, devices, and cartridges therefor 有权
标题翻译：分析系统，设备和墨盒
公开(公告)号：US08865089B2
公开(公告)日：2014-10-21
申请号：US12967908
申请日：2010-12-14
申请人： Joel M. Blatt , Carole R. Stivers
发明人： Joel M. Blatt , Carole R. Stivers
IPC分类号： G01N33/49 , B01L3/00 , G01N33/00 , G01N35/00 , G01N21/84 , G01N33/52 , G01N21/03
CPC分类号： B01L3/5027 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , G01N21/0303 , G01N21/8483 , G01N33/0009 , G01N33/49 , G01N33/525 , G01N35/00009 , G01N35/0099 , Y10T436/11
摘要： Described here are systems, devices, cartridges, methods, and kits for detecting or quantifying at least two different analytes using at least two different techniques, in a single sample. The cartridges typically comprise at least two test sites and the location of at least one test site is not dependent on a corresponding measurement device. The systems generally comprise a device, memory, and a processing module. The device comprises a light source, an array detector, and a port configured to accept at least a portion of a cartridge. The processing module is configured to perform an image analysis of the cartridge. The methods comprise the steps of acquiring calibration information, acquiring an image of the cartridge, performing an image analysis, and cycling through specific detection or quantification techniques corresponding to the techniques required by the test sites. Computer readable media are also described.
摘要翻译：这里描述的是在单个样品中使用至少两种不同技术检测或定量至少两种不同分析物的系统，装置，盒，方法和试剂盒。盒通常包括至少两个测试位置，并且至少一个测试位置的位置不依赖于相应的测量设备。系统通常包括设备，存储器和处理模块。该装置包括光源，阵列检测器和被配置为接纳盒的至少一部分的端口。处理模块被配置为执行盒的图像分析。这些方法包括以下步骤：获取校准信息，获取盒的图像，执行图像分析，以及循环通过与测试点所需技术相对应的特定检测或定量技术。还描述了计算机可读介质。

6. 发明申请

US20110200498A1 SYSTEM AND METHOD FOR PACKAGING DRY TEST STRIPS 审中-公开
标题翻译：用于包装干燥测试条的系统和方法
公开(公告)号：US20110200498A1
公开(公告)日：2011-08-18
申请号：US12999905
申请日：2009-06-17
申请人： Robert Huffstodt
发明人： Robert Huffstodt
IPC分类号： G01N33/48 , B65B61/20
CPC分类号： G01N33/48778
摘要： A plurality of different types of dry strips are packaged in a single-user container. Strip-specific scheduling information for using the dry test strips is placed either in or on the container. The scheduling information may be provided to the packager by a physician and may be stored on an electronically or optically readable storage device packaged with the test strips. The storage device may be a memory, which memory may be inserted into a dry test strip reader and the scheduling information may be communicated to the user either visually or audibly.
摘要翻译：多个不同类型的干条被包装在单用户容器中。将用于使用干试纸的条特定调度信息放置在容器中或容器上。调度信息可以由医师提供给包装机，并且可以存储在与测试条一起包装的电子或光学可读存储设备上。存储设备可以是存储器，该存储器可以被插入到干燥测试条读取器中，并且调度信息可以以视觉或听觉方式传送给用户。

7. 发明授权

US07374719B2 Test strip for determining concentration of multiple analytes in a single fluid sample 有权
标题翻译：用于测定单个流体样品中多种分析物浓度的测试条
公开(公告)号：US07374719B2
公开(公告)日：2008-05-20
申请号：US10873415
申请日：2004-06-22
申请人： Sunil Anaokar , Michele Jeanne Crispino , Emanuel Paul Crabtree
发明人： Sunil Anaokar , Michele Jeanne Crispino , Emanuel Paul Crabtree
IPC分类号： C12P33/06
CPC分类号： G01N33/92 , C12Q1/44 , G01N33/54386 , G01N2333/918 , G01N2800/044 , Y10T436/144444
摘要： A multilayer test strip that measures concentrations of multiple analytes from a single whole blood sample. The test strip includes a test matrix of several layers held together in constant contact by a test strip holder. The invention is characterized in that it has no moving parts, which is made possible by the novel use of an elongate disbursement layer that spreads blood throughout its entire length, despite having layers with known wicking properties adjacent to and in contact with it. Since the invention relies primarily on a vertical flow format, the test strip is advantageously quite compact. With a single 35 microliter sample of blood applied thereto, the novel test strip can provide readings of total cholesterol, HDL cholesterol and triglycerides. From these, LDL can be calculated, thereby providing a full “lipid panel.” Other analytes such as glucose and ketones may be included in the test strip in addition to or in lieu of one or more of the other analytes.
摘要翻译：测量单个全血样本中多种分析物浓度的多层测试条。测试条包括由测试条持有者恒定接触地保持在一起的若干层的测试矩阵。本发明的特征在于，它没有运动部件，这通过新颖的使用细长的支付层使其成为可能，其中血液遍及其整个长度，尽管具有与其相邻并且与之接触的已知芯吸性质的层。由于本发明主要依赖于垂直流动格式，所以测试条有利地相当紧凑。使用单次35微升血液样本，新的测试条可以提供总胆固醇，HDL胆固醇和甘油三酯的读数。从这些可以计算LDL，从而提供一个完整的“脂质面板”。除了或代替一种或多种其它分析物之外，其他分析物如葡萄糖和酮可以包括在测试条中。

8. 发明授权

US07087397B2 Method for determining HDL concentration from whole blood or plasma 有权
标题翻译：从全血或血浆中测定HDL浓度的方法
公开(公告)号：US07087397B2
公开(公告)日：2006-08-08
申请号：US10329044
申请日：2002-12-23
申请人： Sunil G. Anaokar , Gena Lynn Antonopoulos , Alexandra N. Muchnik
发明人： Sunil G. Anaokar , Gena Lynn Antonopoulos , Alexandra N. Muchnik
IPC分类号： C12Q1/60
CPC分类号： G01N33/526 , C12Q1/60 , G01N33/92
摘要： A multilayer test strip and method of using the test strip for determining concentration of HDL cholesterol in a whole blood sample. The inventive test strip includes a two-stage blood separation mechanism, including a first glass fiber matrix which separates most of the blood cells and an adjacent, second matrix preferably also containing glass fibers that separates the remainder of the blood cells. The second layer also precipates and retains non-HDL cholesterol, thereby providing plasma that is substantially free of red blood cells and substantially free of non-HDL cholesterol to a reaction layer. Precipitation and retention on non-HDLs takes place by a vertical or dead-end filtration in a single layer. The reaction layer produces a color, the intensity of which is proportional to the concentration of HDL cholesterol in the blood sample which is applied to the test strip. Advantageously, the inventive test strip is a vertical flow device, which can be made more compact and operates more efficiently than a lateral flow device.
摘要翻译：多层测试条和使用测试条来测定全血样品中HDL胆固醇浓度的方法。本发明的测试条包括两级血液分离机构，其包括分离大多数血细胞的第一玻璃纤维基质和相邻的第二基质，优选还含有分离其余血细胞的玻璃纤维。第二层还沉淀并保留非HDL胆固醇，从而提供基本上不含红血细胞并基本上不含非HDL胆固醇的血浆至反应层。在非HDL上的沉淀和保留是通过单层垂直或死端过滤进行的。反应层产生一种颜色，其强度与应用于测试条的血液样品中HDL胆固醇的浓度成比例。有利地，本发明的测试条是垂直流动装置，其可以制造得比侧流装置更紧凑并且操作更有效。

9. 发明申请

US20230041320A1 Systems and Methods for Quantifying The Specific Activity of Creatininase 有权
公开(公告)号：US20230041320A1
公开(公告)日：2023-02-09
申请号：US17816945
申请日：2022-08-02
申请人： Polymer Technology Systems, Inc.
发明人： James MURRAY
IPC分类号： C12Q1/34 , B01L3/00
摘要： A method for determining the activity of creatininase includes providing an amount of creatininase to be measured for enzyme activity and providing an excess amount of creatinine, the excess amount being greater than an amount that will ordinarily react with the amount of creatininase. The method further includes reacting the amount of creatininase with the excess amount of creatinine to produce creatine. The method further includes reacting the creatine with diacetyl and 1-naphatol and producing a pink color. The method further includes measuring an intensity of the pink color and determining an amount of the creatine that was created based on the intensity. The method further includes calculating a specific activity of the creatininase based on the amount of creatine.

10. 发明授权

US11143645B2 Systems and methods for a versatile electrochemical test strip that may include one or more assays for different analytes in the same test strip 有权
公开(公告)号：US11143645B2
公开(公告)日：2021-10-12
申请号：US15382389
申请日：2016-12-16
申请人： Polymer Technology Systems, Inc.
发明人： Gary L. Hughes , Aniruddha Patwardhan
IPC分类号： G01N27/327 , G01N33/49 , G01N33/487
摘要： A test strip for electrochemical testing of a blood analyte includes a plurality of test sites for the electrochemical testing of analytes on a single test strip. Each test site includes a first receiving port, the first receiving port for receiving a blood sample, the first receiving port at a first end of the test strip. The test site further includes a first electrode and a second electrode, the first and second electrodes proximate to the first receiving port. Each test site further includes a first contact and a second contact, the first and second contacts at a second end of the test strip, the first and second contacts interconnected with the first and second electrodes, respectively.

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