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1. 发明申请

US20100222267A1 RECOMBINANT TRANSFERRIN MUTANTS 审中-公开
标题翻译：重组转铁蛋白
公开(公告)号：US20100222267A1
公开(公告)日：2010-09-02
申请号：US12664454
申请日：2008-06-13
申请人： Christopher John Arthur Finnis , Darrell Sleep , Joanna Hay
发明人： Christopher John Arthur Finnis , Darrell Sleep , Joanna Hay
IPC分类号： A61K38/40 , C07K14/79 , C07H21/04 , C12N15/63 , C12P21/06 , C12N5/00 , C12N5/02
CPC分类号： C07K14/79 , A61K38/00
摘要： The present invention provides a recombinant protein comprising the sequence of a transferrin mutant, wherein Ser415 is mutated to an amino acid which does not allow glycosylation at Asn413 and/or wherein Thr613 is mutated to an amino acid which does not allow glycosylation as Asn611. It also provides polynucleotides encoding the same and methods of making and using said recombinant protein.
摘要翻译：本发明提供了包含转铁蛋白突变体序列的重组蛋白，其中Ser415突变为不允许Asn413上的糖基化和/或其中Thr613突变为不允许糖基化作为Asn611的氨基酸的氨基酸。它还提供了编码其的多核苷酸以及制备和使用所述重组蛋白的方法。

2. 发明申请

US20140128326A1 ALBUMIN VARIANTS 审中-公开
公开(公告)号：US20140128326A1
公开(公告)日：2014-05-08
申请号：US14075104
申请日：2013-11-08
申请人： Novozymes Biopharma DK A/S , University of OSLO , Novozymes Biopharma UK Limited , Novozymes A/S
发明人： Jason Cameron , Karen Ann Delahay , Jens Erik Nielsen , Andrew Plumridge , Jan Terje Andersen
IPC分类号： C07K14/765
CPC分类号： C07K14/765 , A61K38/385 , A61K39/385 , C07K2319/00 , C07K2319/31
摘要： The present invention relates to variants of a parent albumin, the variants having altered plasma half-life compared with the parent albumin. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
摘要翻译：本发明涉及亲本白蛋白的变体，该变体与母体白蛋白相比具有改变的血浆半衰期。本发明还涉及编码这些变体的多核苷酸; 核酸构建体，载体和包含多核苷酸的宿主细胞; 以及使用这些变体的方法。

3. 发明授权

US07601515B2 Process of high purity albumin production 失效
标题翻译：高纯白蛋白生产工艺
公开(公告)号：US07601515B2
公开(公告)日：2009-10-13
申请号：US11738582
申请日：2007-04-23
申请人： Andrew Robert Goodey , Darell Sleep , Hendrik Van Urk , Stephen Berezenko , John Rodney Woodrow , Richard Alan Johnson , Patricia Carol Wood , Stephen James Burton , Alan Victor Quirk
发明人： Andrew Robert Goodey , Darell Sleep , Hendrik Van Urk , Stephen Berezenko , John Rodney Woodrow , Richard Alan Johnson , Patricia Carol Wood , Stephen James Burton , Alan Victor Quirk
IPC分类号： C12N15/14 , C07K14/00
CPC分类号： C07K14/70571 , C07K14/765 , C07K2319/10
摘要： A process is provided for the preparation of albumin from a yeast culture medium which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers or aggregates of albumin and viruses, and which is essentially non-glycated, relatively high in free thiol and with an intact C-terminus. The process comprises separating the yeast from the culture medium to yield an albumin solution; subjecting the albumin solution to positive mode cation exchange, affinity, and positive mode anion exchange chromatography; and concentrating and formulating the albumin with sodium octanoate and sodium chloride.
摘要翻译：提供了一种从酵母培养基制备白蛋白的方法，其具有极低水平或基本上不含着色剂，金属离子，人蛋白质，宿主蛋白质，白蛋白片段，白蛋白和病毒聚合物或聚集体，并且其中基本上是非糖化的，游离硫醇相对高且具有完整的C末端。该方法包括将酵母与培养基分离以产生白蛋白溶液; 使白蛋白溶液进行正离子阳离子交换，亲和力和阳性阴离子交换层析; 并用辛酸钠和氯化钠浓缩和配制白蛋白。

4. 发明申请

US20090227775A1 HIV Inhibiting Proteins 审中-公开
标题翻译： HIV抑制蛋白
公开(公告)号：US20090227775A1
公开(公告)日：2009-09-10
申请号：US12401241
申请日：2009-03-10
申请人： Hans-Peter HAUSER , Thomas Weimer , Darrell Sleep
发明人： Hans-Peter HAUSER , Thomas Weimer , Darrell Sleep
IPC分类号： C07K14/76
CPC分类号： C07K14/005 , C07K14/76 , C07K2319/31 , C12N2740/16122
摘要： The invention relates to proteins comprising HIV fusion inhibiting peptides, such as T-20 and/or T-1249 peptides (including, but not limited to, fragments and variants thereof), which exhibit anti-retroviral activity, fused to albumin (including, but not limited to fragments or variants of albumin). These fusion proteins exhibit extended shelf-life and/or extended or therapeutic activity.
摘要翻译：本发明涉及包含HIV融合抑制肽的蛋白质，例如T-20和/或T-1249肽（包括但不限于其片段和变体），其表现出与白蛋白融合的抗逆转录病毒活性（包括，但不限于白蛋白的片段或变体）。这些融合蛋白具有延长的保质期和/或延长或治疗活性。

5. 发明申请

US20090197316A1 PROCESS FOR PREPARING PARTICLES OF PROTEINACEOUS MATERIAL 有权
标题翻译：制备蛋白质材料颗粒的方法
公开(公告)号：US20090197316A1
公开(公告)日：2009-08-06
申请号：US12373176
申请日：2007-07-13
申请人： Richard Alan Johnson , John Rodney Woodrow
发明人： Richard Alan Johnson , John Rodney Woodrow
IPC分类号： C12N9/98 , C07K1/10
CPC分类号： C07K1/02 , A61K9/1658 , A61K9/5169 , A61K47/64 , A61K47/643 , A61K47/6435 , A61K47/644 , A61K47/6929 , A61K49/0485 , A61K49/085 , A61K49/143 , A61K49/1881 , A61K51/081 , A61K51/1255 , B82Y5/00 , C07K1/08 , C07K1/10
摘要： Protein particles are prepared by causing or allowing protein molecules dispersed in a liquid medium at a concentration of 8 mg.mL-1 or greater to react in the presence of a zero-length crosslinker, so as to produce protein particles comprising protein molecules that are covalently bonded together. The protein particles may be produced with sizes in the sub-micron range with closely defined sizes and size distributions. The particles have applications in many fields, but are useful inter alia for the delivery of therapeutic agents and other agents, eg imaging contrast agents, to the body.
摘要翻译：通过使分散在8mg.mL-1或更高浓度的液体培养基中的蛋白质分子在零长度交联剂的存在下反应来制备蛋白质颗粒，以产生包含蛋白质分子的蛋白质颗粒，共价键合。蛋白质颗粒可以以亚微米范围内的尺寸制造，具有紧密限定的尺寸和尺寸分布。这些颗粒在许多领域中具有应用，但是尤其可用于将治疗剂和其它试剂（例如成像造影剂）递送至身体。

6. 发明授权

US07410779B2 Fusion polypeptides of human serum albumin and a therapeutically active polypeptide 失效
标题翻译：人血清白蛋白的融合多肽和治疗活性多肽
公开(公告)号：US07410779B2
公开(公告)日：2008-08-12
申请号：US11330353
申请日：2006-01-12
申请人： Reinhard Fleer , Alain Fournier , Jean-Dominique Guitton , Gérard Jung , Patrice Yeh
发明人： Reinhard Fleer , Alain Fournier , Jean-Dominique Guitton , Gérard Jung , Patrice Yeh
IPC分类号： C12N21/06 , C12N15/00 , C07H21/04 , C07K14/00
CPC分类号： B65B69/00 , A61K38/21 , A61K38/38 , A61K47/642 , A61K47/643 , C07K14/575 , C07K14/755 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/02 , C07K2319/31 , C07K2319/33 , C12N9/6456 , A61K2300/00
摘要： The invention includes biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant of human serum albumin, methods for the preparation of such fusion polypeptides, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing such fusion polypeptides.
摘要翻译：本发明包括生物活性多肽，其包含与人血清白蛋白或人血清白蛋白变体融合的治疗活性多肽，制备这种融合多肽的方法，编码这种融合多肽的核苷酸序列，包含该核苷酸序列的表达盒，自我复制含有这种表达盒的质粒和含有这种融合多肽的药物组合物。

7. 发明申请

US20090175893A1 Albumin-Fused Anti-Angiogenesis Peptides 审中-公开
标题翻译：白蛋白融合抗血管生成肽
公开(公告)号：US20090175893A1
公开(公告)日：2009-07-09
申请号：US12358815
申请日：2009-01-23
申请人： Peter Mertins , Ilhan Celik , Oliver Kisker , Darrell Sleep , Joanna Hay , Hans-Peter Hauser
发明人： Peter Mertins , Ilhan Celik , Oliver Kisker , Darrell Sleep , Joanna Hay , Hans-Peter Hauser
IPC分类号： A61K39/00 , A61K38/16
CPC分类号： A61K38/39 , A01K2217/05 , A61K9/0019 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K47/643 , A61K48/00 , A61K2039/53 , C07K14/005 , C07K14/47 , C07K14/765 , C07K14/78 , C07K14/8114 , C07K2319/00 , C07K2319/31 , C12N15/62 , C12N2740/16122 , C12Y301/26003
摘要： The invention relates to proteins comprising angiogenesis inhibiting peptides, such as endostatin peptides (including, but not limited to, fragments and variants thereof), which exhibit anti-retroviral activity, fused or conjugated to albumin (including, but not limited to fragments or variants of albumin). These fusion proteins are herein collectively referred to as “albumin fusion proteins of the invention.” These fusion proteins are herein collectively referred to as “albumin fusion proteins of the invention.” These fusion proteins exhibit extended shelf-life and/or extended or therapeutic activity in solution. The invention encompasses therapeutic albumin fusion proteins, compositions, pharmaceutical compositions, formulations and kits. The invention also encompasses nucleic acid molecules encoding the albumin fusion proteins of the invention, as well as vectors containing these nucleic acids, host cells transformed with these nucleic acids and vectors, and methods of making the albumin fusion proteins of the invention using these nucleic acids, vectors, and/or host cells. The invention also relates to compositions and methods for inhibiting proliferation of vascular endothelial cells and tumor angiogenesis induced cell fusion. The invention further relates to compositions and methods preventing growth of, or promoting regression of, primary tumors and metastases; and for treating cancer, diabetic retinopathy, progressive macular degeneration or rheumatoid arthritis.
摘要翻译：本发明涉及包含血管生成抑制肽（例如内皮抑素肽（包括但不限于其片段和变体））的蛋白质，其表现出与白蛋白融合或缀合的抗逆转录病毒活性（包括但不限于片段或变体的白蛋白）。这些融合蛋白在本文中统称为“本发明的白蛋白融合蛋白”。这些融合蛋白在本文中统称为“本发明的白蛋白融合蛋白”。这些融合蛋白在溶液中表现出延长的保质期和/或延长或治疗活性。本发明包括治疗性白蛋白融合蛋白，组合物，药物组合物，制剂和试剂盒。本发明还包括编码本发明的白蛋白融合蛋白的核酸分子以及含有这些核酸的载体，用这些核酸和载体转化的宿主细胞，以及使用这些核酸制备本发明的白蛋白融合蛋白的方法，载体和/或宿主细胞。本发明还涉及抑制血管内皮细胞增殖和肿瘤血管生成诱导的细胞融合的组合物和方法。本发明还涉及预防原发性肿瘤和转移瘤的生长或促进消退的组合物和方法; 并用于治疗癌症，糖尿病性视网膜病变，进行性黄斑变性或类风湿性关节炎。

8. 发明授权

US07435410B2 Methods of treatment with interferson and albumin fusion protein 失效
标题翻译：干扰素和白蛋白融合蛋白治疗方法
公开(公告)号：US07435410B2
公开(公告)日：2008-10-14
申请号：US11146077
申请日：2005-06-07
申请人： Reinhard Fleer , Alain Fournier , Jean-Dominique Guitton , Gérard Jung , Patrice Yeh
发明人： Reinhard Fleer , Alain Fournier , Jean-Dominique Guitton , Gérard Jung , Patrice Yeh
IPC分类号： A61K38/21 , A61K38/00 , A61K39/00 , C07K14/00
CPC分类号： B65B69/00 , A61K38/21 , A61K38/38 , A61K47/642 , A61K47/643 , C07K14/575 , C07K14/755 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/02 , C07K2319/31 , C07K2319/33 , C12N9/6456 , A61K2300/00
摘要： Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.
摘要翻译：包含与人血清白蛋白或其变体融合的治疗活性多肽的生物活性多肽，其制备方法，编码这种融合多肽的核苷酸序列，包含该核苷酸序列的表达盒，含有该表达盒的自体复制质粒和药物组合物含有所述融合多肽。

9. 发明申请

US20090171070A1 Process for the Purification of Recombinant Albumin 有权
标题翻译：纯化重组白蛋白的方法
公开(公告)号：US20090171070A1
公开(公告)日：2009-07-02
申请号：US12207325
申请日：2008-09-09
申请人： Hendrik Van Urk , David John Mead , Philip Harvey Morton , Andrew John Cartwright , Jason Cameron , David James Ballance , Michel Gaston Joseph Grandgeorge , Stephen Berezenko , John Rodney Woodrow , Darrell Sleep , Jean-Luc Bernard Veron
发明人： Hendrik Van Urk , David John Mead , Philip Harvey Morton , Andrew John Cartwright , Jason Cameron , David James Ballance , Michel Gaston Joseph Grandgeorge , Stephen Berezenko , John Rodney Woodrow , Darrell Sleep , Jean-Luc Bernard Veron
IPC分类号： C07K14/765
CPC分类号： B01D15/3804 , B01D15/362 , B01D15/363 , C07K14/76 , C07K14/765
摘要： A process is provided for the preparation of a highly pure recombinant albumin solution having a nickel ion content of less than 100 ng per gram of albumin. The process comprises subjecting a recombinant albumin to a series of chromatography, concentration, and diafiltration steps.
摘要翻译：提供了一种制备具有小于100ng /克白蛋白的镍离子含量的高纯度重组白蛋白溶液的方法。该方法包括使重组白蛋白进行一系列色谱，浓缩和渗滤步骤。

10. 发明授权

US07550432B2 Recombinant fusion proteins to growth hormone and serum albumin 失效
标题翻译：重组融合蛋白与生长激素和血清白蛋白
公开(公告)号：US07550432B2
公开(公告)日：2009-06-23
申请号：US11315035
申请日：2005-12-23
申请人： David James Ballance
发明人： David James Ballance
IPC分类号： A61K38/00 , C07K14/765 , C12N1/00 , C12N1/20 , C12N15/11 , C12N5/04 , C12N5/06
CPC分类号： A61K38/27 , C07K14/61 , C07K14/765 , C07K2319/00
摘要： The invention describes albumin fusion proteins comprising growth hormone and serum albumin. The invention also describes nucleic acid molecules encoding the albumin fusion proteins of the invention, as well as vectors containing these nucleic acid molecules, host cells transformed with these vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally, the invention describes compositions comprising the albumin fusion proteins, and methods of treating patients in need of growth hormone, comprising administering the albumin fusion proteins of the invention.
摘要翻译：本发明描述了包含生长激素和血清白蛋白的白蛋白融合蛋白。本发明还描述了编码本发明的白蛋白融合蛋白的核酸分子以及含有这些核酸分子的载体，用这些载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法，载体和/或宿主细胞。另外，本发明描述了包含白蛋白融合蛋白的组合物和治疗需要生长激素的患者的方法，包括施用本发明的白蛋白融合蛋白。

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