专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100304503A1 PROCESS FOR PRODUCING POLYMER PARTICLES 有权
标题翻译：生产聚合物颗粒的方法
公开(公告)号：US20100304503A1
公开(公告)日：2010-12-02
申请号：US12445881
申请日：2007-10-16
申请人： Tatsuo Taniguchi , Akihiro Mizuno , Tokio Sawai , Hiroyuki Tsubota
发明人： Tatsuo Taniguchi , Akihiro Mizuno , Tokio Sawai , Hiroyuki Tsubota
IPC分类号： G01N33/545
CPC分类号： C08F2/22 , C08F2/44 , G01N33/5432 , G01N33/5436 , G01N33/54393
摘要： A process for producing polymer particles having an antigen or an antibody introduced into the surface thereof, by carrying out miniemulsion polymerization using a monomer, a radical polymerization initiator, an emulsifier, and a hydrophobe in the presence of the antigen or antibody to thereby produce the polymer particles, is disclosed. According to the process, it is possible to provide a reagent for immunological analysis having an excellent detection sensitivity and capable of avoiding a nonspecific reaction which occurs in conventional methods.
摘要翻译：通过在抗原或抗体的存在下使用单体，自由基聚合引发剂，乳化剂和疏水物进行细乳液聚合，制备具有引入其表面的抗原或抗体的聚合物颗粒的方法，从而产生聚合物颗粒。根据该方法，可以提供具有良好的检测灵敏度的免疫学分析试剂，能够避免在常规方法中发生的非特异性反应。

2. 发明申请

US20090215198A1 Immunological Latex Turbidimetry Method and Reagent Therefor 有权
标题翻译：免疫乳胶浊度法及其试剂
公开(公告)号：US20090215198A1
公开(公告)日：2009-08-27
申请号：US12434174
申请日：2009-05-01
申请人： Atsushi Miyamoto , Tokio Sawai , Takeshi Matsuya , Tsuneo Okuyama
发明人： Atsushi Miyamoto , Tokio Sawai , Takeshi Matsuya , Tsuneo Okuyama
IPC分类号： G01N33/566
CPC分类号： G01N33/585 , G01N33/54313 , G01N2333/315 , G01N2333/765 , G01N2333/96472
摘要： An immunological latex turbidimetry method for analyzing an antigen or antibody in a sample, comprising steps of: (1) bringing a sample which may contain the antigen or antibody to be analyzed into contact with a protease-treated albumin; and (2) bringing a mixture obtained in the above step (1) into contact with latex particles carrying an antibody or antigen specifically reacting with the antigen or antibody to be assayed, and analyzing a turbidity caused by a latex agglutination reaction, is disclosed. Further, an immunological latex turbidimetry reagent comprising (1) a first component containing a protease-treated albumin, and (2) a second component containing latex particles carrying an antibody or antigen specifically reacting with an antigen or antibody to be assayed is also disclosed.
摘要翻译：一种用于分析样品中的抗原或抗体的免疫乳胶比浊法，包括以下步骤：（1）使可能含有待分析的抗原或抗体的样品与经蛋白酶处理的白蛋白接触; 和（2）将上述步骤（1）中获得的混合物与携带抗体或抗原特异性反应的胶原颗粒接触，并分析由胶乳凝集反应引起的浊度。此外，还公开了一种免疫乳胶比浊法，其包含（1）含有蛋白酶处理的白蛋白的第一成分和（2）含有携带抗体或抗原的胶乳颗粒的第二成分，所述抗体或抗原与待测定的抗原或抗体特异性反应。

3. 发明授权

US07560238B2 Immunological latex turbidimetry method and reagent therefor 有权
标题翻译：免疫乳胶比浊法及其试剂
公开(公告)号：US07560238B2
公开(公告)日：2009-07-14
申请号：US10048212
申请日：2001-05-30
申请人： Atsushi Miyamoto , Tokio Sawai , Takeshi Matsuya , Tsuneo Okuyama
发明人： Atsushi Miyamoto , Tokio Sawai , Takeshi Matsuya , Tsuneo Okuyama
IPC分类号： G01N33/00
CPC分类号： G01N33/585 , G01N33/54313 , G01N2333/315 , G01N2333/765 , G01N2333/96472
摘要： An immunological latex turbidimetry method for analyzing an antigen or antibody in a sample is disclosed, comprising steps of (1) bringing a sample which may contain the antigen or antibody to be analyzed into contact with a protease-treated albumin, and (2) bringing a mixture obtained in the above step (1) into contact with latex particles carrying an antibody or antigen specifically reacting with the antigen or antibody to be assayed, and analyzing a turbidity caused by a latex agglutination reaction. Also disclosed is an immunological latex turbidimetry reagent comprising (1) a first component containing a protease-treated albumin, and (2) a second component containing latex particles carrying an antibody or antigen specifically reacting with an antigen or antibody to be assayed.
摘要翻译：公开了一种用于分析样品中的抗原或抗体的免疫乳胶比浊法，其包括以下步骤：（1）使可能含有待分析的抗原或抗体的样品与蛋白酶处理的白蛋白接触，和（2）使将上述步骤（1）中获得的混合物与携带与要测定的抗原或抗体特异性反应的抗体或抗原的胶乳颗粒接触，并分析由胶乳凝集反应引起的浊度。还公开了一种免疫乳胶比浊法，其包含（1）含有蛋白酶处理的白蛋白的第一成分，和（2）含有携带抗体或抗原的胶乳颗粒的第二成分，所述抗体或抗原与要测定的抗原或抗体特异性反应。

4. 发明申请

US20080096221A1 Method Of Detecting Platelet Thrombosis Or Organ Failure 有权
标题翻译：检测血小板血栓形成或器官功能衰竭的方法
公开(公告)号：US20080096221A1
公开(公告)日：2008-04-24
申请号：US11718853
申请日：2005-11-08
申请人： Tomoko Ono
发明人： Tomoko Ono
IPC分类号： G01N33/573 , C12Q1/37
CPC分类号： C12Q1/56 , G01N33/573 , G01N33/86 , G01N2333/96463 , G01N2333/966 , G01N2333/968 , G01N2333/974 , G01N2800/226 , Y10S436/811 , Y10T436/25375
摘要： A method of detecting platelet thrombosis or organ failure in a patient suffering from disseminated intravascular coagulation (DIC) or systemic inflammatory response syndrome (SIRS), comprising analyzing a von Willebrand factor-cleaving protease and/or a cleaving factor thereof, is disclosed. A kit for detecting platelet thrombosis or organ failure in a patient suffering from DIC or SIRS, comprising an antibody or a fragment thereof which specifically binds to a von Willebrand factor-cleaving protease, and/or an antibody or a fragment thereof which specifically binds to a cleaving factor of the von Willebrand factor-cleaving protease, is disclosed.
摘要翻译：公开了一种检测患有弥散性血管内凝血（DIC）或全身炎症反应综合征（SIRS）的患者血小板血栓形成或器官衰竭的方法，包括分析血管性血友病因子切割蛋白酶和/或其裂解因子。一种用于检测患有DIC或SIRS的患者的血小板血栓形成或器官衰竭的试剂盒，其包含特异性结合von Willebrand因子切割蛋白酶的抗体或其片段，和/或其特异性结合于公开了冯维勒布兰德因子切割蛋白酶的切割因子。

5. 发明申请

US20060183217A1 Cartridge for automatic measurement and measuring device using the same 有权
公开(公告)号：US20060183217A1
公开(公告)日：2006-08-17
申请号：US11332269
申请日：2006-01-17
申请人： Atsushi Yanagida , Takashi Kurihara , Hiroyuki Yokoi , Atsushi Koyata , Yoshikazu Okamura , Daishi Miyamoto
发明人： Atsushi Yanagida , Takashi Kurihara , Hiroyuki Yokoi , Atsushi Koyata , Yoshikazu Okamura , Daishi Miyamoto
IPC分类号： C12M1/34
CPC分类号： B01L3/50851 , B01L3/527 , B01L2300/021 , B01L2300/0809 , B01L2300/1883 , G01N35/026 , Y10T436/25 , Y10T436/2575
摘要： An object of the present invention is to provide a cartridge for automatic measurement used in an automatic measuring device, capable of automatically performing measurement including heat treatment of a sample, and a measuring device using the cartridge. The present invention relates to a cartridge for use in measuring a component to be measured contained in a sample, comprising: at least a heat-treatment well for performing heat treatment of the sample; and a reaction well for reacting the component to be measured in the sample with a material specifically reacting therewith.

6. 发明申请

US20100197042A1 REAGENT AND METHOD FOR IMMUNOLOGICAL ANALYSIS 审中-公开
标题翻译：用于免疫分析的试剂和方法
公开(公告)号：US20100197042A1
公开(公告)日：2010-08-05
申请号：US12445863
申请日：2007-10-16
申请人： Tokio Sawai , Hiroyuki Tsubota , Tatsuo Taniguchi , Akihiro Mizuno
发明人： Tokio Sawai , Hiroyuki Tsubota , Tatsuo Taniguchi , Akihiro Mizuno
IPC分类号： G01N33/546
CPC分类号： G01N33/54313 , G01N33/531 , G01N33/5436 , G01N33/54393
摘要： A reagent for immunological analysis, comprising a suspension of latex particles having an antigen or an antibody specific for a substance to be analyzed introduced into the surface of the latex particles, produced by polymerizing a monomer in the presence of the antigen or antibody to thereby synthesize the latex particles; and a method for immunological analysis, comprising the step of bringing, in a liquid, (1) a sample suspected of containing a substance to be analyzed, into contact with (2) latex particles having an antigen or an antibody specific for the substance introduced into the surface of the latex particles, produced by polymerizing a monomer in the presence of the antigen or antibody to thereby synthesize the latex particles; are disclosed. The reagent and the method have an excellent detection sensitivity, and can avoid a nonspecific reaction which occurs in conventional methods.
摘要翻译：一种用于免疫学分析的试剂，其包含将具有抗原或抗体特异性的抗体的胶乳颗粒的悬浮液引入到胶乳颗粒的表面中，所述抗体或抗体通过在抗原或抗体存在下聚合单体而产生，从而合成胶乳颗粒; 和一种免疫学分析方法，包括以下步骤：在（1）怀疑含有待分析物质的样品的液体中与（2）具有抗原或引入物质特异性抗体的胶乳颗粒接触通过在抗原或抗体的存在下聚合单体而产生的胶乳颗粒的表面，从而合成胶乳颗粒; 被披露。试剂和方法具有良好的检测灵敏度，可以避免在常规方法中发生的非特异性反应。

7. 发明申请

US20090068682A1 IMMUNOLOGICAL ASSAY FOR PLASMIN-DIGESTED PRODUCTS OF STABILIZED FIBRIN 有权
标题翻译：用于稳定纤维素的消泡产品的免疫测定
公开(公告)号：US20090068682A1
公开(公告)日：2009-03-12
申请号：US11912474
申请日：2006-04-27
申请人： Takeshi Matsuya
发明人： Takeshi Matsuya
IPC分类号： G01N33/53
CPC分类号： G01N33/86 , G01N21/76 , G01N33/54326 , G01N2333/75 , G01N2333/968 , G01N2800/12 , G01N2800/226 , Y10S435/81 , Y10S435/975
摘要： A method of immunologically analyzing plasmin-digested products of stabilized fibrin, characterized by using a combination of a monoclonal antibody (a) which does not react with stabilized fibrin, fibrinogen, and plasmin-digested products of fibrinogen, but reacts with a neoantigen which is newly exposed in a D domain by digesting stabilized fibrin with plasmin, and a monoclonal antibody (b) which recognizes a site different from that recognized by the monoclonal antibody (a), and specifically reacts with plasmin-digested products of stabilized fibrin, wherein one of the monoclonal antibodies (a) and (b) is carried on a magnetic particle, and the other is labeled with an enzyme, and a chemiluminescent substrate is used as a substrate for the enzyme, is disclosed.
摘要翻译：一种免疫分析稳定纤维蛋白溶解纤溶酶消化产物的方法，其特征在于使用不与纤维蛋白原的稳定的纤维蛋白，纤维蛋白原和纤维蛋白溶解的产物反应的单克隆抗体（a）的组合，但与新抗原反应通过用纤溶酶消化稳定的纤维蛋白而在D结构域中新近暴露，以及识别与单克隆抗体（a）识别的位点不同的位点的单克隆抗体（b），并且与纤维蛋白溶解的稳定的纤维蛋白产物特异性反应，其中一个的单克隆抗体（a）和（b）携带在磁性颗粒上，另一种用酶标记，化学发光底物用作酶的底物。

8. 发明申请

US20070141645A1 Measuring method using whole blood 有权
标题翻译：使用全血的测量方法
公开(公告)号：US20070141645A1
公开(公告)日：2007-06-21
申请号：US11300867
申请日：2005-12-15
申请人： Yoshikazu Okamura , Takashi Kurihara , Hiroyuki Yokoi , Junichi Ogawa
发明人： Yoshikazu Okamura , Takashi Kurihara , Hiroyuki Yokoi , Junichi Ogawa
IPC分类号： G01N33/542
CPC分类号： G01N33/581 , G01N2333/916 , Y10T436/25125 , Y10T436/25375
摘要： A method for measuring an analyte in a whole blood sample comprising the steps of (1) bringing the whole blood sample into contact with a first substance which is carried on an insoluble carrier and specifically binds to the analyte to be measured and a second substance which is labeled with an alkaline phosphatase and specifically binds to the analyte to be measured, and (2) measuring a resulting complex on the basis of an enzyme reaction of the alkaline phosphatase, the measuring step (2) being carried out in the presence of an inhibitor of endogenous alkaline phosphatases, is disclosed.
摘要翻译：一种测定全血样品中的分析物的方法，包括以下步骤：（1）使全血样品与携带在不溶性载体上的第一物质接触并且特异性结合待测量的分析物和第二物质，用碱性磷酸酶标记并且特异性地结合待测量的分析物，和（2）基于碱性磷酸酶的酶反应测量所得的复合物，测量步骤（2）在存在下进行公开了内源性碱性磷酸酶抑制剂。

9. 发明申请

US20090075298A1 METHOD OF ANALYZING ENZYME 审中-公开
标题翻译：分析酶的方法
公开(公告)号：US20090075298A1
公开(公告)日：2009-03-19
申请号：US11915050
申请日：2006-05-19
申请人： Tomoko Ono , Minoru Ogura
发明人： Tomoko Ono , Minoru Ogura
IPC分类号： G01N33/573
CPC分类号： G01N33/585 , C12Q1/00 , C12Q1/34 , G01N33/573
摘要： A method of analyzing an enzyme, comprising (1) bringing a sample suspected of containing an enzyme to be analyzed into contact with an enzyme substrate which is immobilized on an insoluble carrier and can be cleaved by the enzyme, in a liquid, (2) separating the insoluble carrier from the liquid, and (3) analyzing a substrate or a fragment thereof which remains on the insoluble carrier and/or a fragment of the substrate which is released from the insoluble carrier into the liquid; and a kit for analyzing an enzyme, comprising at least an enzyme substrate which is immobilized on an insoluble carrier and can be cleaved by the enzyme, are disclosed.
摘要翻译：一种分析酶的方法，包括：（1）将待测分析的样品与固定在不溶性载体上并可被酶切割的酶底物接触;（2）从液体中分离不溶性载体，和（3）分析残留在不溶性载体和/或从不溶性载体释放到液体中的基质片段的底物或其片段; 以及用于分析酶的试剂盒，其至少包含固定在不溶性载体上并可被酶切割的酶底物。

10. 发明申请

US20090004673A1 Method for Determining Condition of Disseminated Intravascular Coagulation 审中-公开
标题翻译：确定弥散性血管内凝血状况的方法
公开(公告)号：US20090004673A1
公开(公告)日：2009-01-01
申请号：US12162879
申请日：2007-01-30
申请人： Tomoko Ono , Shinichiro Watanabe , Fumio Furusaki , Ko Igami
发明人： Tomoko Ono , Shinichiro Watanabe , Fumio Furusaki , Ko Igami
IPC分类号： G01N33/53 , C12Q1/56
CPC分类号： C12Q1/37 , G01N33/573 , G01N33/6893 , G01N2333/755 , G01N2333/96486 , G01N2800/32 , Y10T436/106664
摘要： A method for determining a condition of disseminated intravascular coagulation (DIC), by analyzing the amount and/or enzyme activity of a von Willebrand factor (vWF)-cleaving protease (ADAMTS13) (preferably also the amount of vWF) in a patient suffering from DIC, and a kit for determining a condition of DIC, comprising an antibody or a fragment thereof which specifically binds to ADAMTS13, are disclosed. According to the present invention, a differential diagnosis of patients with thrombotic thrombocytopenic purpura (TTP) can be carried out from among patients with DIC, which could not be distinguished on the basis of only clinical findings or known markers.
摘要翻译：通过分析患有血管内血栓凝固（vICF）的von Willebrand因子（vWF） - 切割蛋白酶（ADAMTS13）（优选vWF的量）的量和/或酶活性来确定弥漫性血管内凝血（DIC）的状况的方法 DIC和用于确定DIC的条件的试剂盒，其包含特异性结合ADAMTS13的抗体或其片段。根据本发明，可以从具有DIC的患者中进行血栓性血小板减少性紫癜（TTP）患者的鉴别诊断，其不能仅基于临床发现或已知标记来区分。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式