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1. 发明授权

US5571684A Assay for proline iminopeptidase and other hydrolytic activities 失效
标题翻译：测定脯氨酸亚氨基肽酶等水解活性
公开(公告)号：US5571684A
公开(公告)日：1996-11-05
申请号：US374487
申请日：1995-01-17
申请人： Paul J. Lawrence , Terrence J. Andreasen , David R. Shockey
发明人： Paul J. Lawrence , Terrence J. Andreasen , David R. Shockey
IPC分类号： C12Q1/34 , C12Q1/37 , C12N11/08 , G01N21/00
CPC分类号： C12Q1/37 , C12Q1/34 , C12Q2334/70 , C12Q2337/30 , Y10S435/805 , Y10S435/81
摘要： The presence of an enzymatically active hydrolase in a fluid sample is detected by contacting the sample with a solid-phase conjugate which is susceptible to cleavage by the hydrolase, and simultaneously or shortly thereafter, contacting the sample with an indicator which undergoes a detectable change upon the action of a reporter group. The reporter group is part of the conjugate and is liberated from it either partly or entirely by the action of the hydrolase. The indicator is susceptible to action by the reporter group only upon decoupling of the reporter group from the remainder of the conjugate, the decoupling occurring either in part or entirely upon action of the hydrolase. Also provided by this invention are various forms of a dry, self-contained test device which contains the conjugate described above plus the indicator and all other reagents and components necessary to achieve a detectable indication of the presence or absence of a catalytically active hydrolase. Preferred embodiments of the device also contain positive and negative controls.
摘要翻译：通过使样品与容易受水解酶切割的固相缀合物接触，并同时或不久之后将样品与经历可检测变化的指示剂接触，来检测流体样品中酶活性水解酶的存在记者组的行动。报告基团是缀合物的一部分，部分或完全由水解酶的作用释放。只有报告基团与缀合物的其余部分脱钩，该指示剂才能受到报告基团的作用，部分或完全在水解酶的作用下发生脱离。本发明还提供了各种形式的干燥，独立的测试装置，其包含上述缀合物加上指示剂以及实现可检测指示有无催化活性水解酶所必需的所有其它试剂和组分。该装置的优选实施方案还包含阳性和阴性对照。

2. 发明授权

US4818702A Fecal occult blood test reagent 失效
标题翻译：粪便潜血试验试剂
公开(公告)号：US4818702A
公开(公告)日：1989-04-04
申请号：US175573
申请日：1988-03-31
申请人： Paul J. Lawrence
发明人： Paul J. Lawrence
IPC分类号： C12Q1/28 , G01N21/78 , G01N33/72
CPC分类号： C12Q1/28 , Y10S436/904
摘要： Fecal occult blood tests of enhanced sensitivity, specificity, and readability are provided by employing (1) a developer or complete reagent solution that uses as a solvent system a solvent comprising at least about 50% by volume of a solvent for iron protoporphyrins such as dimethyl sulfoxide and/or (2) a multi-chromogen comprised of a mixture of guaiac and ABTS. Test results may be further improved by incorporating hemoprotein solubilizing agents, plant peroxidase inhibitors, iron/copper chelating agents, accelerators and buffers in the developer/reagent.
摘要翻译：通过采用（1）显影剂或完整试剂溶液来提供增强的灵敏度，特异性和可读性的粪便隐血试验溶液，该溶液系统使用包含至少约50体积％的铁原卟啉如二甲基甲酰胺的溶剂的溶剂亚砜和/或（2）由愈创木酮和ABTS的混合物组成的多色原子。通过在显影剂/试剂中加入血蛋白增溶剂，植物过氧化物酶抑制剂，铁/铜螯合剂，促进剂和缓冲剂可以进一步改善测试结果。

3. 发明授权

US6099801A pH and amine test elements and applications to diagnosis of vaginal infections 失效
标题翻译： pH和胺测试元素和应用于诊断阴道感染
公开(公告)号：US6099801A
公开(公告)日：2000-08-08
申请号：US40105
申请日：1998-03-17
申请人： Paul J. Lawrence , Peter U. Ly , David R. Shockey
发明人： Paul J. Lawrence , Peter U. Ly , David R. Shockey
IPC分类号： G01N31/00 , G01N31/22 , G01N33/50 , G01N33/52 , G01N33/84 , G01N21/00
CPC分类号： G01N31/221 , G01N33/52 , G01N33/84 , Y10T436/173845
摘要： Tests for elevated pH and volatile amines in aqueous fluids are disclosed, including tests useful in the diagnosis of bacterial vaginosis and in other biological conditions. By using formulated indicators and indicators held in matrices that are permeable to gas but not to liquid, the tests provide clear and sharp transitions detectable by visual or machine-readable device rather than by subjective judgments such as small gradations in color or olfactory determinations. The tests lend themselves readily to iconic readouts of the test indications and to the inclusion of positive and negative controls.
摘要翻译：公开了在含水流体中升高的pH和挥发性胺的测试，包括可用于诊断细菌性阴道炎和其它生物学条件的测试。通过使用在气体可渗透而不是液体的基质中保持的配方指标和指标，测试提供了可视化或机器可读设备可检测到的清晰和清晰的转变，而不是主观判断，如颜色或嗅觉测定中的小等级。测试可以轻松地标志性地读出测试指示以及包含正面和负面的控制。

4. 发明授权

US5268146A Fast response test panel 失效
标题翻译：快速响应测试面板
公开(公告)号：US5268146A
公开(公告)日：1993-12-07
申请号：US858179
申请日：1992-03-25
申请人： Paul J. Lawrence , Marian B. Buccafurni , Leah P. Lawrence
发明人： Paul J. Lawrence , Marian B. Buccafurni , Leah P. Lawrence
IPC分类号： G01N31/22 , B01L3/00 , G01N33/52 , G01N33/543
CPC分类号： B01L3/5027 , B01L2200/0684 , B01L2300/0627 , B01L2400/0406
摘要： A dry test panel for the testing of samples such as undiluted bodily fluid specimens is disclosed. The panel contains all reagents and components necessary to achieve a visible indication of the presence or absence of a suspect analyte in the sample, and preferred embodiments contain positive and negative controls as well. The device contains an internal chamber into which the specimen is introduced, and which contains all materials necessary for the reactions which produce a color change which is visible on the outer surface of the device. The materials are positioned in the chamber in such a manner that they are activated only when the chamber is filled with the specimen, and the color indicator is concentrated in a thin lamina immediately adjacent to a light-transmitting wall of the device so that a detectable color change occurs in a short period of time to produce a sensitive and yet fast test.
摘要翻译：公开了用于测试诸如未稀释的体液试样的样品的干试验板。面板包含实现样品中可疑分析物的存在或不存在的可见指示所需的所有试剂和组分，并且优选实施方案也包含阳性和阴性对照。该装置包含一个内部室，试样被引入其中，并且其中包含产生在装置的外表面上可见的颜色变化的反应所需的所有材料。这些材料以这样的方式定位在室中，即只有当室被样品填充时，它们被激活，并且颜色指示器被集中在紧邻该装置的透光壁的薄层中，使得可检测颜色变化发生在短时间内，以产生敏感且快速的测试。

5. 发明授权

US4942132A Reagent composition for fecal occult blood tests 失效
标题翻译：用于粪便隐血试验的试剂组合物
公开(公告)号：US4942132A
公开(公告)日：1990-07-17
申请号：US175738
申请日：1988-03-28
申请人： Paul J. Lawrence
发明人： Paul J. Lawrence
IPC分类号： C12Q1/28 , G01N33/72
CPC分类号： G01N33/725 , C12Q1/28 , C12Q2326/00 , C12Q2326/30 , Y10S436/904
摘要： Fecal occult blood tests of enhanced sensitivity, specificity, and readability are provided by employing (1) a developer or complete reagent solution that uses as a solvent system a solvent comprising at least about 50% by volume of a solvent for iron protoporphyrins such as dimethyl sulfoxide and/or (2) a multi-chromagen comprised of a mixture of guaiac and ABTS. Test results may be further improved by incorporating hemoprotein solubilizing agents, plant peroxidase inhibitors, iron/copper chelating agents, accelerators and buffers in the developer/reagent.
摘要翻译：通过采用（1）显影剂或完整试剂溶液来提供增强的灵敏度，特异性和可读性的粪便隐血试验溶液，该溶液系统使用包含至少约50体积％的铁原卟啉如二甲基甲酰胺的溶剂的溶剂亚砜和/或（2）由愈创木酮和ABTS的混合物组成的多色素。通过在显影剂/试剂中加入血蛋白增溶剂，植物过氧化物酶抑制剂，铁/铜螯合剂，促进剂和缓冲剂可以进一步改善测试结果。

6. 发明授权

US5910447A pH and amine test to diagnosis of vaginal infections 失效
标题翻译： pH和胺测试以诊断阴道感染
公开(公告)号：US5910447A
公开(公告)日：1999-06-08
申请号：US819789
申请日：1997-03-18
申请人： Paul J. Lawrence , Peter U. Ly , David R. Shockey
发明人： Paul J. Lawrence , Peter U. Ly , David R. Shockey
IPC分类号： G01N31/00 , G01N31/22 , G01N33/50 , G01N33/52 , G01N33/84 , G01N33/48
CPC分类号： G01N31/221 , G01N33/52 , G01N33/84 , Y10T436/173845
摘要： Tests for elevated pH and volatile amines in aqueous fluids are disclosed, including tests useful in the diagnosis of bacterial vaginosis and in other biological conditions. By using formulated indicators and indicators held in matrices that are permeable to gas but not to liquid, the tests provide clear and sharp transitions detectable by visual or machine-readable means rather than by subjective judgments such as small gradations in color or olfactory determinations. The tests lend themselves readily to iconic readouts of the test indications and to the inclusion of positive and negative controls.
摘要翻译：公开了在含水流体中升高的pH和挥发性胺的测试，包括可用于诊断细菌性阴道炎和其它生物学条件的测试。通过使用在气体可渗透而不是液体的矩阵中进行配制的指标和指标，测试可以通过视觉或机器可读方式进行检测，而不是主观判断，例如颜色或嗅觉测定中的小等级。测试可以轻松地标志性地读出测试指示以及包含正面和负面的控制。

7. 发明授权

US5585273A Test device for assays for hydrolytic enzyme activity 失效
标题翻译：用于水解酶活性测定的测试装置
公开(公告)号：US5585273A
公开(公告)日：1996-12-17
申请号：US347763
申请日：1994-11-30
申请人： Paul J. Lawrence , Aulena Churhuri , Terrence J. Andreasen
发明人： Paul J. Lawrence , Aulena Churhuri , Terrence J. Andreasen
IPC分类号： C12Q1/34 , C12M1/40 , C12N11/02 , C12N11/06 , C12Q1/37 , G01N31/22
CPC分类号： C12N11/02 , C12N11/06 , C12Q1/37 , C12M21/18 , C12M41/46 , G01N2333/4731 , G01N2333/805
摘要： A dry, self-contained test device for assaying for the presence of an enzymatically active hydrolase in a sample is disclosed. The test device combines a reporter enzyme immobilized on a solid support, an indicator, and all other reagents and components necessary to achieve a detectable indication of the presence or absence of the enzymatically active hydrolase in the sample. Preferred devices contain positive and negative controls as well.
摘要翻译：公开了一种用于测定样品中酶活性水解酶的存在的干燥，独立的测试装置。测试装置结合固定在固体支持物上的报道酶，指示剂以及实现样品中酶活性水解酶存在或不存在的可检测指示所必需的所有其它试剂和组分。首选设备也包含正负控件。

8. 发明授权

US4820646A Fecal occult blood test method 失效
标题翻译：粪便潜血检测方法
公开(公告)号：US4820646A
公开(公告)日：1989-04-11
申请号：US174108
申请日：1988-03-28
申请人： Paul J. Lawrence
发明人： Paul J. Lawrence
IPC分类号： C12Q1/28 , G01N33/72 , G01N21/78
CPC分类号： C12Q1/28 , G01N33/725 , C12Q2326/00 , C12Q2326/30 , Y10S436/904
摘要： Fecal occult blood tests of enhanced sensitivity, specificity, and readability are provided by employing (1) a developer or complete reagent solution that uses as a solvent system a solvent comprising at least about 50% by volume of a solvent for iron protoporphyrins such as dimethyl sulfoxide and/or (2) a multi-chromogen comprised of a mixture of guaiac and ABTS. Test results may be further improved by incorporating hemoprotein solubilizing agents, plant peroxidase inhibitors, iron/copper chelating agents, accelerators and buffers in the developer/reagent.
摘要翻译：通过采用（1）显影剂或完整试剂溶液来提供增强的灵敏度，特异性和可读性的粪便隐血试验溶液，该溶液系统使用包含至少约50体积％的铁原卟啉如二甲基甲酰胺的溶剂的溶剂亚砜和/或（2）由愈创木酮和ABTS的混合物组成的多色原子。通过在显影剂/试剂中加入血蛋白增溶剂，植物过氧化物酶抑制剂，铁/铜螯合剂，促进剂和缓冲剂可以进一步改善测试结果。

9. 发明授权

US4777143A Method of detecting carboxylic acids in a specimen 失效
标题翻译：检测样品中羧酸的方法
公开(公告)号：US4777143A
公开(公告)日：1988-10-11
申请号：US940775
申请日：1986-12-12
申请人： Neil H. Price , Paul J. Lawrence
发明人： Neil H. Price , Paul J. Lawrence
IPC分类号： G01N33/50 , G01N21/78 , G01N31/00 , G01N31/10 , G01N33/52 , G01N33/569 , G01N33/53
CPC分类号： G01N33/52 , Y10T436/201666
摘要： A method for detecting the presence of carboxylic acids in a specimen is provided. A specimen is contacted with a developing system containing a metal salt reactive with carboxylic acids present in the specimen to form metal-carboxylic acid complexes. Any such complexes are colorimetrically detected by their activity in catalyzing oxidation of a chromogen such as guaiac. The method is useful in detecting intestinal helminth infestation.
摘要翻译：提供了检测试样中羧酸存在的方法。试样与含有与样品中存在的羧酸反应的金属盐的显影系统接触以形成金属 - 羧酸络合物。任何这样的复合物通过它们在催化铬（如愈创木瓜）的色原子的氧化中的活性进行比色测定。该方法可用于检测肠蠕虫感染。

10. 发明授权

US5660790A PH and amine test elements 失效
标题翻译： PH和胺测试元件
公开(公告)号：US5660790A
公开(公告)日：1997-08-26
申请号：US689758
申请日：1996-08-13
申请人： Paul J. Lawrence , Peter U. Ly , David R. Shockey
发明人： Paul J. Lawrence , Peter U. Ly , David R. Shockey
IPC分类号： G01N31/00 , G01N31/22 , G01N33/50 , G01N33/52 , G01N33/84 , G01N33/48
CPC分类号： G01N31/221 , G01N33/52 , G01N33/84 , Y10T436/173845
摘要： Tests for elevated pH and volatile amines in aqueous fluids are disclosed, including tests useful in the diagnosis of bacterial vaginosis and in other biological conditions. By using formulated indicators and indicators held in matrices that are permeable to gas but not to liquid, the tests provide clear and sharp transitions detectable by visual or machine-readable means rather than by subjective judgments such as small gradations in color or olfactory determinations. The tests lend themselves readily to iconic readouts of the test indications and to the inclusion of positive and negative controls.
摘要翻译：公开了在含水流体中升高的pH和挥发性胺的测试，包括可用于诊断细菌性阴道炎和其它生物学条件的测试。通过使用在气体可渗透而不是液体的矩阵中进行配制的指标和指标，测试可以通过视觉或机器可读方式进行检测，而不是主观判断，例如颜色或嗅觉测定中的小等级。这些测试可以很容易地显示测试指示的标志性读数，以及包含正面和负面控制。

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