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1. 发明申请

US20070125098A1 SYSTEMS AND METHODS FOR FREEZING, STORING AND THAWING BIOPHARMACEUTICAL MATERIAL 审中-公开
标题翻译：用于冷冻，储存和治疗生物材料的系统和方法
公开(公告)号：US20070125098A1
公开(公告)日：2007-06-07
申请号：US11548182
申请日：2006-10-10
申请人： Nicolas VOUTE , Maxime LOK , David BROWN , James KENDALL , Edward GEISELHART
发明人： Nicolas VOUTE , Maxime LOK , David BROWN , James KENDALL , Edward GEISELHART
IPC分类号： F25D25/00 , F25D3/08
CPC分类号： F25D25/005 , A01N1/00 , A01N1/02 , A01N1/0257 , A01N1/0263 , A01N31/02 , A23L3/364 , A23L3/365 , A61G12/001 , A61J1/165 , A61M1/0272 , A61M1/0277 , A61M1/0281 , A61M2209/084 , F25B2600/07 , F25D25/00 , F25D31/001 , F25D2331/801 , F25D2331/8014 , F25D2400/20 , F25D2400/30 , F25D2500/02 , Y10S165/919 , A01N2300/00
摘要： A system for controlled freezing, storing and thawing a biopharmaceutical material includes a flexible container and a supporting structure. The flexible container is adapted to receive the biopharmaceutical material therein for freezing, storing and thawing. The container further includes a flange and the supporting structure is engageable with the flange to receive the container. The supporting structure may position the container for freezing and may protect it during transport and storage.
摘要翻译：用于受控冷冻，储存和解冻生物药物材料的系统包括柔性容器和支撑结构。柔性容器适于容纳其中的生物药物用于冷冻，储存和解冻。容器还包括凸缘，并且支撑结构可与凸缘接合以容纳容器。支撑结构可以将容器定位成冷冻并且可以在运输和储存期间保护它。

2. 发明申请

US20070084222A1 Systems and methods for freezing, storing, transporting, and thawing biopharmacuetical material 失效
标题翻译：冷冻，储存，运输和解冻生物药物学材料的系统和方法
公开(公告)号：US20070084222A1
公开(公告)日：2007-04-19
申请号：US11501329
申请日：2006-08-09
申请人： Nicolas Voute , Eric Lee , James DeBeers , Brian Woodard , Ngee Lee
发明人： Nicolas Voute , Eric Lee , James DeBeers , Brian Woodard , Ngee Lee
IPC分类号： F25D25/00 , F25C1/00
CPC分类号： F25D25/005 , A01N1/00 , A01N1/02 , A01N1/0257 , A01N1/0263 , A01N31/02 , A23L3/364 , A23L3/365 , A61G12/001 , A61J1/165 , A61M1/0272 , A61M1/0277 , A61M1/0281 , A61M2209/084 , F25B2600/07 , F25D25/00 , F25D31/001 , F25D2331/801 , F25D2331/8014 , F25D2400/20 , F25D2400/30 , F25D2500/02 , Y10S165/919 , A01N2300/00
摘要： A system for freezing, thawing, transporting, and storing a biopharmaceutical material, which includes a container, a supporting structure, a temperature control unit, and a transportation cart. The container is adapted to receive the biopharmaceutical material therein for freezing, thawing, storing, and transporting, with the container also being receivable in the supporting structure. The temperature control unit has a cavity for receiving the supporting structure, when the supporting structure supports the container, and the transportation cart has a channel for receiving the supporting structure, when the supporting structure supports the container.
摘要翻译：一种用于冷冻，解冻，运输和储存生物药物材料的系统，其包括容器，支撑结构，温度控制单元和运输车。容器适于容纳其中的生物药物用于冷冻，解冻，储存和运输，容器也可接收在支撑结构中。当支撑结构支撑容器时，温度控制单元具有用于接收支撑结构的空腔，并且当支撑结构支撑容器时，运输车具有用于接收支撑结构的通道。

3. 发明申请

US20050180998A1 Systems and methods for freezing, mixing and thawing biopharmaceutical material 有权
公开(公告)号：US20050180998A1
公开(公告)日：2005-08-18
申请号：US11085314
申请日：2005-03-21
申请人： David Brown , Jonathan Cutting , Erik Lee , Nicolas Voute , Brian Woodard
发明人： David Brown , Jonathan Cutting , Erik Lee , Nicolas Voute , Brian Woodard
IPC分类号： A01N1/02 , A01N31/02 , A23L3/36 , A23L3/365 , A61M1/02 , F25C1/04 , F25D25/00 , F25D31/00 , G01N1/42 , A61K9/14 , F25C1/00
CPC分类号： A01N1/02 , A01N1/0257 , A01N1/0263 , A01N31/02 , A23L3/364 , A23L3/365 , A61M1/0272 , A61M1/0277 , A61M1/0281 , F25B2600/07 , F25C1/04 , F25C2600/04 , F25D25/00 , F25D25/005 , F25D31/001 , F25D2331/8014 , F25D2400/20 , F25D2400/30 , G01N1/42 , A01N2300/00
摘要： A system for controlled freezing, storing and thawing of a biopharmaceutical material includes a cavity for receiving a container for holding the biopharmaceutical material. Further included are at least a pair of opposed surfaces facing the biopharmaceutical material holding container. At least one of the opposed surfaces includes a moveable contacting surface configured to contact the container to inhibit a clearance between the container and the movable contacting surface. Also included is at least one heat transfer surface which is thermally coupled to the biopharmaceutical material holding container when the moveable contacting surface contacts the container. Also, the cavity may be configured to receive a frame for supporting the container holding the biopharmaceutical material. Further, the system may include a driver to move the frame holding the container inside the cavity.

4. 发明申请

US20040129003A1 Systems and methods for freezing and storing biopharmaceutical material 有权
标题翻译：用于冷冻和储存生物药物材料的系统和方法
公开(公告)号：US20040129003A1
公开(公告)日：2004-07-08
申请号：US10724793
申请日：2003-12-01
申请人： Integrated Biosystems, Inc.
发明人： Nicolas Voute , Maxime N. Lok , Leonidas Cartwright Leonard , Timothy Gerard Hughes , Richard Wisniewski
IPC分类号： B65D025/00 , F25D025/00 , A47J039/00 , A47J041/00 , B65D081/38 , B65D083/72 , B65D088/74
CPC分类号： A01N1/00 , A01N1/02 , A01N1/0263 , A01N31/02 , A23L3/364 , A23L3/365 , A61M1/0272 , A61M1/0277 , A61M1/0281 , F25B2600/07 , F25C1/04 , F25C5/22 , F25C2600/04 , F25D23/02 , F25D23/028 , F25D25/00 , F25D25/005 , F25D31/001 , F25D2331/8014 , F25D2400/20 , F25D2400/30 , G01N1/42 , A01N2300/00
摘要： The present invention provides a system for freezing, thawing, and storing biopharmaceutical materials which includes a flexible container, a conduit, and a temperature control unit. The flexible container is adapted to receive a biopharmaceutical material therein for freezing, thawing, and storing. The container is formed of a first substantially flat sheet of flexible material joined together by a seam with a second substantially flat sheet of flexible material so as to lie substantially flat when empty. The container fully encloses an interior portion for receiving the biopharmaceutical material. Also, the container is configured to form a three dimensional shape when filled with the biopharmaceutical material, wherein the three dimensional shape has a first side and a second side opposite the first side. The conduit is connected to the flexible container with the outside of the container being in fluid communication with the interior portion via the conduit. The temperature control unit includes a first surface and a second surface facing the first surface and the temperature control unit is configured to receive the flexible container therein, when the container is filled with the biopharmaceutical material. The container conforms to the shape of the interior of the temperature control unit and the first side and the second side of the container contact the first surface and the second surface of the temperature control unit. The first surface and/or the second surface of temperature control unit include heat transfer surface(s).
摘要翻译：本发明提供一种用于冷冻，解冻和储存包括柔性容器，导管和温度控制单元的生物药物材料的系统。柔性容器适于在其中容纳生物药物用于冷冻，解冻和储存。容器由具有第二基本平坦的柔性材料片的接缝连接在一起的第一基本平坦的柔性材料片形成，以便在空的时基本平坦。容器完全包围用于接收生物药物材料的内部部分。此外，容器被配置为当填充有生物药物材料时形成三维形状，其中三维形状具有与第一侧相对的第一侧和第二侧。导管连接到柔性容器，容器的外部经由导管与内部部分流体连通。温度控制单元包括面向第一表面的第一表面和第二表面，并且温度控制单元构造成当容器填充有生物药物材料时将柔性容器接纳在其中。容器符合温度控制单元的内部形状，并且容器的第一侧和第二侧接触温度控制单元的第一表面和第二表面。温度控制单元的第一表面和/或第二表面包括传热表面。

5. 发明申请

US20040109385A1 Systems and methods for thawing, mixing, and processing biopharmaceutical materials 审中-公开
标题翻译：用于解冻，混合和加工生物药物材料的系统和方法
公开(公告)号：US20040109385A1
公开(公告)日：2004-06-10
申请号：US10634231
申请日：2003-08-05
申请人： Integrated Biosystems, Inc.
发明人： Richard Wisniewski
IPC分类号： B01F009/00
CPC分类号： B62B3/08 , A61M1/025 , A61M1/0254 , A61M5/445 , A61M2205/366 , A61M2205/368 , A61M2205/3686 , A61M2209/084
摘要： The present invention provides a system for thawing, mixing and processing a biopharmaceutical material, which includes a moveable platform and a container for holding the biopharmaceutical material. The container is operably mounted on the platform to allow the container to be skewed relative to the platform. Further, the container may be tilted relative to the platform.
摘要翻译：本发明提供了用于解冻，混合和加工生物药物材料的系统，其包括可移动平台和用于保持生物药物材料的容器。容器可操作地安装在平台上以允许容器相对于平台倾斜。此外，容器可以相对于平台倾斜。

6. 发明授权

US06945056B2 Systems and methods for freezing, mixing and thawing biopharmaceutical material 有权
标题翻译：用于冷冻，混合和解冻生物药物材料的系统和方法
公开(公告)号：US06945056B2
公开(公告)日：2005-09-20
申请号：US10455222
申请日：2003-06-04
申请人： David C. Brown , Jonathan Cutting , Eric K. Lee , Nicolas Voute , Brian J. Woodard
发明人： David C. Brown , Jonathan Cutting , Eric K. Lee , Nicolas Voute , Brian J. Woodard
IPC分类号： A01N1/02 , A01N31/02 , A23L3/36 , A23L3/365 , A61M1/02 , F25C1/04 , F25D25/00 , F25D31/00 , G01N1/42 , F25C1/00
CPC分类号： A01N1/02 , A01N1/0257 , A01N1/0263 , A01N31/02 , A23L3/364 , A23L3/365 , A61M1/0272 , A61M1/0277 , A61M1/0281 , F25B2600/07 , F25C1/04 , F25C2600/04 , F25D25/00 , F25D25/005 , F25D31/001 , F25D2331/8014 , F25D2400/20 , F25D2400/30 , G01N1/42 , A01N2300/00
摘要： A system for controlled freezing, storing and thawing of a biopharmaceutical material includes a cavity for receiving a container for holding the biopharmaceutical material. Further included are at least a pair of opposed surfaces facing the biopharmaceutical material holding container. At least one of the opposed surfaces includes a moveable contacting surface configured to contact the container to inhibit a clearance between the container and the movable contacting surface. Also included is at least one heat transfer surface which is thermally coupled to the biopharmaceutical material holding container when the moveable contacting surface contacts the container. Also, the cavity may be configured to receive a frame for supporting the container holding the biopharmaceutical material. Further, the system may include a driver to move the frame holding the container inside the cavity.
摘要翻译：用于受控冷冻，储存和解冻生物药物材料的系统包括用于容纳用于保持生物药物材料的容器的空腔。还包括面向生物药物材料保持容器的至少一对相对表面。相对表面中的至少一个包括可移动的接触表面，其构造成与容器接触以阻止容器和可动接触表面之间的间隙。还包括至少一个热传递表面，当可移动接触表面接触容器时，热传递表面热耦合到生物药物材料保持容器。此外，空腔可以被配置为容纳用于支撑容纳生物药物材料的容器的框架。此外，系统可以包括驱动器，以将保持容器的框架移动到腔体内。

7. 发明授权

US07228688B2 Scaled down freezing and thawing system for biopharmaceuticals and biologics 有权
标题翻译：缩小生物制药和生物制剂的冷冻和解冻系统
公开(公告)号：US07228688B2
公开(公告)日：2007-06-12
申请号：US10735378
申请日：2003-12-12
申请人： Nicolas Voute , Richard Wisniewski , Eric K. Lee , Jonathan N. Webb
发明人： Nicolas Voute , Richard Wisniewski , Eric K. Lee , Jonathan N. Webb
IPC分类号： F25D25/00 , F25D23/12 , F25D11/00
CPC分类号： A01N1/00 , F25D31/006 , F25D2331/809 , F25D2500/02 , F28D7/08 , F28F1/22 , G06F19/00
摘要： A freezing and thawing unit for small amounts of biopharmaceuticals and biologics. The freezing and thawing unit is reduced in scale, as compared to a corresponding commercial or large-scale process. The freezing and thawing unit can be used for testing, preservation and/or processing of small quantities of biopharmaceuticals and biologics.
摘要翻译：用于少量生物制药和生物制剂的冷冻和解冻装置。与相应的商业或大规模过程相比，冷冻和解冻单元的规模缩小。冷冻和解冻单元可用于测试，保存和/或加工少量生物药物和生物制剂。

8. 发明授权

US07137261B2 Systems and methods for freezing, mixing and thawing biopharmaceutical material 有权
标题翻译：用于冷冻，混合和解冻生物药物材料的系统和方法
公开(公告)号：US07137261B2
公开(公告)日：2006-11-21
申请号：US11085314
申请日：2005-03-21
申请人： David C. Brown , Jonathan Cutting , Eric K. Lee , Nicolas Voute , Brian J. Woodard
发明人： David C. Brown , Jonathan Cutting , Eric K. Lee , Nicolas Voute , Brian J. Woodard
IPC分类号： F25C1/00
CPC分类号： A01N1/02 , A01N1/0257 , A01N1/0263 , A01N31/02 , A23L3/364 , A23L3/365 , A61M1/0272 , A61M1/0277 , A61M1/0281 , F25B2600/07 , F25C1/04 , F25C2600/04 , F25D25/00 , F25D25/005 , F25D31/001 , F25D2331/8014 , F25D2400/20 , F25D2400/30 , G01N1/42 , A01N2300/00
摘要： A system for controlled freezing, storing and thawing of a biopharmaceutical material includes a cavity for receiving a container for holding the biopharmaceutical material. Further included are at least a pair of opposed surfaces facing the biopharmaceutical material holding container. At least one of the opposed surfaces includes a moveable contacting surface configured to contact the container to inhibit a clearance between the container and the movable contacting surface. Also included is at least one heat transfer surface which is thermally coupled to the biopharmaceutical material holding container when the moveable contacting surface contacts the container. Also, the cavity may be configured to receive a frame for supporting the container holding the biopharmaceutical material. Further, the system may include a driver to move the frame holding the container inside the cavity.
摘要翻译：用于受控冷冻，储存和解冻生物药物材料的系统包括用于容纳用于保持生物药物材料的容器的空腔。还包括面向生物药物材料保持容器的至少一对相对表面。相对表面中的至少一个包括可移动的接触表面，其构造成与容器接触以阻止容器和可动接触表面之间的间隙。还包括至少一个热传递表面，当可移动接触表面接触容器时，热传递表面热耦合到生物药物材料保持容器。此外，空腔可以被配置为容纳用于支撑容纳生物药物材料的容器的框架。此外，系统可以包括驱动器，以将保持容器的框架移动到腔体内。

9. 发明授权

US07104074B2 Systems and methods for freezing, storing, transporting and thawing biopharmaceutical material 有权
标题翻译：冷冻，储存，运输和解冻生物药物材料的系统和方法
公开(公告)号：US07104074B2
公开(公告)日：2006-09-12
申请号：US10455223
申请日：2003-06-04
申请人： Nicolas Voute , Eric K. Lee , James Edward DeBeers , Brian J. Woodward , Ngee Jenn Lee
发明人： Nicolas Voute , Eric K. Lee , James Edward DeBeers , Brian J. Woodward , Ngee Jenn Lee
IPC分类号： F25D15/00
CPC分类号： F25D25/005 , A01N1/00 , A01N1/02 , A01N1/0257 , A01N1/0263 , A01N31/02 , A23L3/364 , A23L3/365 , A61G12/001 , A61J1/165 , A61M1/0272 , A61M1/0277 , A61M1/0281 , A61M2209/084 , F25B2600/07 , F25D25/00 , F25D31/001 , F25D2331/801 , F25D2331/8014 , F25D2400/20 , F25D2400/30 , F25D2500/02 , Y10S165/919 , A01N2300/00
摘要： A system for freezing, thawing, transporting, and storing a biopharmaceutical material, which includes a container, a supporting structure, a temperature control unit, and a transportation cart. The container is adapted to receive the biopharmaceutical material therein for freezing, thawing, storing, and transporting, with the container also being receivable in the supporting structure. The temperature control unit has a cavity for receiving the supporting structure, when the supporting structure supports the container, and the transportation cart has a channel for receiving the supporting structure, when the supporting structure supports the container.
摘要翻译：一种用于冷冻，解冻，运输和储存生物药物材料的系统，其包括容器，支撑结构，温度控制单元和运输车。容器适于容纳其中的生物药物用于冷冻，解冻，储存和运输，容器也可接收在支撑结构中。当支撑结构支撑容器时，温度控制单元具有用于接收支撑结构的空腔，并且当支撑结构支撑容器时，运输车具有用于接收支撑结构的通道。

10. 发明申请

US20030066295A1 Cryopreservation system with controlled dendritic freezing front velocity 有权
标题翻译：冷冻保存系统具有受控的树枝状冻结前速
公开(公告)号：US20030066295A1
公开(公告)日：2003-04-10
申请号：US10188639
申请日：2002-07-15
申请人： Integrated Biosystems, Inc.
发明人： Richard Wisniewski , Eric K. Lee
IPC分类号： F25C001/00
CPC分类号： F25C1/04 , F25B2600/07 , F25C2600/04 , G01N1/42
摘要： A biopharmaceutical cryopreservation system includes a container having an outer surface area with the container being adapted to contain a biopharmaceutical material for freezing and thawing therein. The container may be received in a cryocooling enclosure having an interior cavity configured to receive it. The cryocooling enclosure includes at least one heat transfer surface configured to contact the outer surface area of the container when the cryocooling enclosure interior cavity receives the container. Also, a cryocooler is thermally coupled to the cryocooling enclosure and is configured to flow a fluid to the at least one heat transfer surface to control the temperature of the heat transfer surface and the biopharmaceutical material within the container. The fluid is isolated from contacting the container. Further, a temperature sensor is thermally coupled to the cryocooling enclosure, the at least one heat transfer surface, the fluid and/or the cryocooler.
摘要翻译：生物制药冷冻保存系统包括具有外表面区域的容器，容器适于包含用于在其中冷冻和解冻的生物药物材料。容器可以容纳在具有被配置为容纳它的内部空腔的低温冷却箱中。所述低温冷却箱包括至少一个传热表面，所述传热表面构造成当所述低温冷却箱室内容纳所述容器时接触所述容器的外表面区域。此外，低温冷却器热耦合到低温冷却壳体并且被配置为使流体流动到至少一个传热表面以控制容器内的传热表面和生物药物材料的温度。流体与容器隔离。此外，温度传感器热耦合到低温冷却箱，至少一个传热表面，流体和/或低温冷却器。

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