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1. 发明授权

US11566268B2 Process for producing (R)-3-hydroxybutyl (R)-3-hydroxybutyrate 有权
公开(公告)号：US11566268B2
公开(公告)日：2023-01-31
申请号：US14213713
申请日：2014-03-14
申请人： ISIS INNOVATION LTD , GOVERNMENT OF THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Kieran Clarke , Richard Lewis Veech , M. Todd King
IPC分类号： C12P7/62 , C07C67/03 , C07C29/147
摘要： Embodiments of the present invention are directed to processes for the production of (R)-3-hydroxybutyl (R)-3-hydroxybyrate. Poly (R)-3-hydroxybyrate is transesterified with an alcohol, to form a first ester portion and a second ester portion. The first ester portion is reduced to the diol to form a diol portion and the diol portion is reacted with the second ester portion to produce (R)-3-hydroxybutyl (R)-3-hydroxybyrate.

2. 发明授权

US09428769B2 Liposome, proteoliposome, biochip, and method for producing liposome and proteoliposome 有权
标题翻译：脂质体，蛋白脂质体，生物芯片和脂质体和蛋白脂质体的制备方法
公开(公告)号：US09428769B2
公开(公告)日：2016-08-30
申请号：US12324035
申请日：2008-11-26
申请人： Chandra Sekar Ramanujan , Nahoko Kasai , Keiichi Torimitsu , John F. Ryan
发明人： Chandra Sekar Ramanujan , Nahoko Kasai , Keiichi Torimitsu , John F. Ryan
IPC分类号： C40B40/14 , C12N15/88 , A61K9/127
CPC分类号： C12N15/88 , A61K9/1272 , B01J2219/00527 , B01J2219/00659 , B01J2219/00734 , B01J2219/0074 , Y10T428/2984
摘要： A liposome comprising a region of a lipid bilayer membrane with different membrane thicknesses, wherein each lipid bilayer membrane region is composed of a different lipid, and a thick membrane side in the region of the lipid bilayer membrane is formed of lipid having a phase transition temperature higher than that of the lipid forming a thin membrane side in the region of the lipid bilayer membrane. A proteoliposome, wherein the above-described liposome includes membrane proteins. A biochip, wherein the above-described liposome or the above-described proteoliposome is spread on a substrate. The above-described biochip, wherein the substrate includes at least one kind selected from the group consisting of mica, SiO2, SiN, Au and Pt.
摘要翻译：一种脂质体，其包含具有不同膜厚度的脂质双层膜的区域，其中每个脂质双层膜区域由不同的脂质组成，脂质双层膜区域中的厚膜侧由具有相变温度高于在脂质双层膜区域形成薄膜侧的脂质。一种蛋白脂质体，其中上述脂质体包括膜蛋白。生物芯片，其中上述脂质体或上述蛋白脂质体扩散在基底上。上述生物芯片，其中，所述基板包括选自由云母，SiO 2，SiN，Au和Pt组成的组中的至少一种。

3. 发明授权

US09318938B2 Electric machine-modular 有权
标题翻译：电机模块化
公开(公告)号：US09318938B2
公开(公告)日：2016-04-19
申请号：US13148897
申请日：2010-02-12
申请人： Nicholas Carpenter , Simon Dowson , Tim Woolmer , Chee Yeow Leong , William Treharne , Malcolm McCulloch
发明人： Nicholas Carpenter , Simon Dowson , Tim Woolmer , Chee Yeow Leong , William Treharne , Malcolm McCulloch
IPC分类号： H02K5/16 , H02K7/08 , H02K21/24 , H02K1/18 , H02K1/28 , H02K5/128 , H02K5/20 , H02K9/197 , H02K1/14 , H02K3/24
CPC分类号： H02K21/24 , H02K1/148 , H02K1/182 , H02K1/28 , H02K3/24 , H02K5/1282 , H02K5/20 , H02K7/083 , H02K9/197
摘要： An electric machine (100) comprises a stator (112) and a rotor (114a, b) mounted for rotation about a rotor axis (120) with respect to the stator. Permanent magnets (124a, b) are carried by the rotor. The rotor has an output (190). The stator has coils (122) wound on stator bars (116) for interaction with the magnets. The rotor has two stages (114a,b) arranged one at either end of the stator bars, with two air gaps (126a,b) between the ends of the bars and the rotor stages. An annular housing (102, 142a, b, 146) retains and mounts the stator. A bearing (164a, b) is between the rotor and stator, the rotor being hollow around said rotor axis. There are two significant magnetic flux paths (30,30′) of the motor. The first passes between adjacent coils in a circuit on a substantially circumferential plane with respect to the axis (120). A second path 30′ is in an axial plane, passing around the bearing. The stator coils are spaced around the rotor axis and approach the rotor axis no closer than a first, stator radius (R1) of the stator. The bearing comprises rolling elements rolling on a surface of the rotor that is no closer to the rotor axis than a second, rotor radius (r), which rotor radius is between 60% and 90% of the stator radius.
摘要翻译：电机（100）包括定子（112）和安装成围绕转子轴线（120）相对于定子旋转的转子（114a，b）。永磁体（124a，b）由转子承载。转子具有输出（190）。定子具有缠绕在定子棒（116）上的线圈（122），用于与磁体相互作用。转子具有两个级（114a，b），它们在定子杆的任一端设置一个，在杆的端部和转子级之间具有两个气隙（126a，b）。环形壳体（102,142a，b，146）保持和安装定子。轴承（164a，b）位于转子和定子之间，转子围绕所述转子轴线是中空的。电动机有两个明显的磁通路径（30,30'）。电路中的相邻线圈之间的第一通路相对于轴线（120）在基本上圆周的平面上。第二路径30'处于轴向平面中，绕轴承穿过。定子线圈围绕转子轴线间隔开并且接近转子轴线不比定子的第一定子半径（R1）更近。该轴承包括在不超过定子半径的转子半径在60％至90％之间的转子半径（r）不超过转子轴线的转子表面上滚动的滚动元件。

4. 发明授权

US08921321B2 Therapeutic strategies for prevention and treatment of alzheimer's disease 有权
标题翻译：预防和治疗阿尔茨海默病的治疗策略
公开(公告)号：US08921321B2
公开(公告)日：2014-12-30
申请号：US13690646
申请日：2012-11-30
申请人： Isis Innovation Ltd.
发明人： Zsuzsanna Nagy
IPC分类号： A61P25/28 , A61K31/19 , A61K31/56 , A61K31/439 , A61K31/395 , A61K31/517 , A61K31/704 , G01N33/50 , G01N33/68 , A61K31/573 , A61K31/496 , A61K45/06
CPC分类号： A61K31/19 , A61K31/395 , A61K31/439 , A61K31/496 , A61K31/517 , A61K31/56 , A61K31/573 , A61K31/704 , A61K45/06 , G01N33/5005 , G01N33/5008 , G01N33/5044 , G01N33/6896 , G01N2500/00 , G01N2500/10
摘要： The invention relates to therapeutic agents for use in the prevention or treatment of Alzheimer's disease. In particular the invention relates to use of inhibitors of cell cycle reentry and progression to the G1/S transition or inhibitors of progression of the cell cycle through the G1/S transition point in the prevention or treatment of Alzheimer's disease.
摘要翻译：本发明涉及用于预防或治疗阿尔茨海默病的治疗剂。特别地，本发明涉及在预防或治疗阿尔茨海默氏病中通过G1 / S转变点使用细胞周期再进入抑制剂和进展至G1 / S转换或抑制细胞周期进展的抑制剂。

5. 发明申请

US20130249547A1 Fast analysis method for non-invasive imaging of blood flow using vessel-encoded arterial spin labelling 有权
标题翻译：使用血管编码动脉自旋标记的血流非侵入性成像快速分析方法
公开(公告)号：US20130249547A1
公开(公告)日：2013-09-26
申请号：US13815815
申请日：2013-03-14
申请人： ISIS INNOVATION LTD.
发明人： Michael Chappell , Mark Woolrich , Thomas Okell
IPC分类号： A61B5/026
CPC分类号： A61B5/0263 , G01R33/56333 , G01R33/56366 , G06F19/00
摘要： Arterial spin labelling (ASL) MRI offers a non-invasive means to create blood-borne contrast in vivo for dynamic angiographic imaging. By spatial modulation of the ASL process it is possible to uniquely label individual arteries over a series of measurements, allowing each to be separately identified in the resulting images. This separation requires appropriate analysis for which a general framework has previously been proposed. Here the general framework is modified for fast analysis of non-invasive imaging of blood flow using vessel encoded arterial spin labelling (VE-ASL). This specifically addresses the issues of computational speed of the analysis and the robustness required to deal with real patient data. The modification applies various approaches for estimation of one or more parameters that change the way a vessel, for example an artery, is encoded to provide the fast analysis.
摘要翻译：动脉自旋标记（ASL）MRI提供了非侵入性手段，用于在动态血管造影成像中产生血源性对比。通过ASL过程的空间调制，可以通过一系列测量来独特地标记单个动脉，从而允许每个动脉在所得到的图像中单独识别。这种分离需要适当的分析，以前提出了一个总体框架。在这里，使用血管编码的动脉自旋标记（VE-ASL）修改用于快速分析血流非侵入性成像的一般框架。这具体解决了分析的计算速度和处理真实患者数据所需的鲁棒性的问题。该修改应用各种方法来估计一个或多个参数，这些参数改变了血管（例如动脉）被编码以提供快速分析的方式。

6. 发明申请

US20130191033A1 Analyzing spectra 审中-公开
标题翻译：分析光谱
公开(公告)号：US20130191033A1
公开(公告)日：2013-07-25
申请号：US13694708
申请日：2012-12-26
申请人： Isis Innovation Ltd.
发明人： Nina Morgner
IPC分类号： G01N33/68 , G06F17/10
CPC分类号： G01N33/68 , G06F17/10 , H01J49/0036
摘要： Systems and methods for analyzing spectra are described. In analyzing the spectra, peaks are identified, and complexes and sub-complexes are assigned to their respective peaks.
摘要翻译：描述了用于分析光谱的系统和方法。在分析光谱时，鉴定出峰，并将复合物和亚配合物分配给它们各自的峰。

7. 发明申请

US20120265165A1 Tissue Expander 有权
标题翻译：组织扩张器
公开(公告)号：US20120265165A1
公开(公告)日：2012-10-18
申请号：US13499972
申请日：2010-11-01
申请人： David Bucknall , Jan Czernuszk , Jinhyun Lee , Zamri Radzi , Marc Swan
发明人： David Bucknall , Jan Czernuszk , Jinhyun Lee , Zamri Radzi , Marc Swan
IPC分类号： C08L67/04 , A61K47/32 , A61M5/00
CPC分类号： A61L27/26 , A61B90/02 , A61L27/50 , A61L27/52 , A61L27/58 , A61L31/04 , A61L31/14 , A61L31/148
摘要： This invention relates to a tissue expander for use in medical, veterinary and dental applications. The tissue expander comprises a self-inflating polymer network and a biodegradable polymer having a non-degraded state and a degraded state which in the non-degraded state constrains the inflation of the self-inflating polymer network and in the degraded state allows inflation of the self-inflating polymer network. In a preferred embodiment, the self-inflating polymer network and the biodegradable polymer form an interpenetrating polymer network or a semi-interpenetrating polymer network. Alternatively or in addition, the self-inflating polymer network forms a core and the biodegradable polymer forms coating which partially or fully surrounds the core.
摘要翻译：本发明涉及一种用于医疗，兽医和牙科应用的组织扩张器。组织膨胀机包括自充气聚合物网络和具有非降解状态和降解状态的生物可降解聚合物，其在非退化状态下约束自充气聚合物网络的膨胀并且在退化状态下允许自充气聚合物网络。在优选的实施方案中，自充气聚合物网络和可生物降解聚合物形成互穿聚合物网络或半互穿聚合物网络。或者或另外，自充气聚合物网络形成芯，并且可生物降解的聚合物形成部分或完全围绕芯的涂层。

8. 发明申请

US20110237550A1 5-AZAINDOLE BISPHOSPHONATES 有权
标题翻译： 5-氮杂双膦酸酯
公开(公告)号：US20110237550A1
公开(公告)日：2011-09-29
申请号：US13120090
申请日：2009-09-22
申请人： Frank Hallock Ebetino , Adam Mazur , Mark Walden Lundy , Robert Graham Russell
发明人： Frank Hallock Ebetino , Adam Mazur , Mark Walden Lundy , Robert Graham Russell
IPC分类号： A61K31/675 , C07F9/38 , A61P19/00 , A61P35/00 , A61P29/00 , A61P37/02 , A61P33/06
CPC分类号： C07F9/6561
摘要： Novel 5-azaindole bisphosphonate compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating abnormal calcium and phosphate metabolism, including bone and joint diseases and other disorders.
摘要翻译：公开了新的5-氮杂吲哚双膦酸化合物，以及制备化合物的方法，包括该化合物的药物组合物，以及在治疗异常钙和磷酸盐代谢（包括骨和关节疾病等）疾病的方法中给予化合物。

9. 发明授权

US07910117B2 Vaccine 有权
标题翻译：疫苗
公开(公告)号：US07910117B2
公开(公告)日：2011-03-22
申请号：US12508683
申请日：2009-07-24
申请人： Joyce Susan Plested , Michael Paul Jennings , Margaret Ann Jaqueline Gidney , Andrew David Cox , James Clare Richards , Richard Edward Moxon
发明人： Joyce Susan Plested , Michael Paul Jennings , Margaret Ann Jaqueline Gidney , Andrew David Cox , James Clare Richards , Richard Edward Moxon
IPC分类号： A61K39/095 , A61K39/02 , A61K31/70 , C07H1/00
CPC分类号： A61K39/385 , A61K39/095 , A61K39/40 , A61K2039/505 , A61K2039/53 , C07K14/22 , C07K16/1217 , C07K2317/76
摘要： The invention relates to a vaccine for the treatment of disease caused by Neisseria, the vaccine including one or more immunogenic components for Neisseria serogroups, as well as antibodies to the immunogenic components and methods of preventing and treating Neisseria infections. The immunogens are based on elements of the inner core lipopolysaccharide.
摘要翻译：本发明涉及用于治疗由奈瑟氏球菌引起的疾病的疫苗，该疫苗包括奈瑟氏球菌血清群的一种或多种免疫原性成分，以及针对免疫原性成分的抗体以及预防和治疗奈瑟氏球菌感染的方法。免疫原基于内核脂多糖的元件。

10. 发明申请

US20100291061A1 PROCESS FOR MAKING OLIGOPEPTIDES 有权
标题翻译：制备寡核苷酸的方法
公开(公告)号：US20100291061A1
公开(公告)日：2010-11-18
申请号：US12298835
申请日：2007-04-30
申请人： Shisong Jiang
发明人： Shisong Jiang
IPC分类号： A61K31/7088 , C12P21/02 , C07K2/00 , C12N15/11 , A61K38/48 , A61K38/02 , C12Q1/68 , A61P31/12
CPC分类号： C12N15/62 , C07K14/005 , C07K2319/50 , C12N2740/16322
摘要： There is described a method of synthesising a family of oligopeptides of predetermined amino acid sequence, which together make up from 7 amino acids to the complete amino acid sequence of a target protein, which comprises: synthesising a nucleic acid construct which codes for a fusion protein composed of overlapping peptides derived from the desired portion of the target protein, interspersed with regions which code for protease cleavage sites, expressing the nucleic acid construct in a suitable expression vector, harvesting the fusion protein corresponding to the nucleic acid sequence, and digesting the fusion protein with a protease selective for the cleavage sites to generate the oligopeptides. The oligopeptides may be generated in vitro or in vitro and may be used as vaccines against viral infections and in epitope mapping.
摘要翻译：描述了一种合成预定氨基酸序列的寡肽家族的方法，其由7个氨基酸组成，与靶蛋白的完整氨基酸序列组成，其包括：合成编码融合蛋白的核酸构建体由衍生自靶蛋白的所需部分的重叠肽组成，散布有编码蛋白酶切割位点的区域，在合适的表达载体中表达核酸构建体，收获对应于核酸序列的融合蛋白，并消化融合物具有选择性地用于切割位点以产生寡肽的蛋白质。寡肽可以在体外或体外产生，并且可以用作抗病毒感染和表位作图的疫苗。

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