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1. 发明授权

US10233084B2 Electrochemical sensors 有权
公开(公告)号：US10233084B2
公开(公告)日：2019-03-19
申请号：US14599595
申请日：2015-01-19
申请人： ISIS Innovation LTD.
发明人： Sean P. McCormack , Richard G. Compton , Gregory George Wildgoose , Nathan Scott Lawrence
IPC分类号： C01B32/174 , B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N27/30 , C01B32/05 , C01B32/20
摘要： An electrode for use in a electrochemical sensor comprises carbon modified with a chemically sensitive redox-active compound, excluding an electrode based on carbon having derivatized thereon two redox-active species wherein at least one of said species is selected from anthraquinone, phenanthrenequinone and N,N′-diphenyl-p-phenylenediamine (DPPD). The invention further provides a pH sensor comprising: a working electrode comprising carbon modified with a chemically sensitive redox active material; and a counter electrode, wherein the ratio of the surface area of the working electrode to the surface area of the counter electrode is from 1:10 to 10:1. Also provided is a pH sensor comprising: a working electrode comprising carbon modified with a chemically sensitive redox active material, and a counter electrode, wherein the area of the working electrode is from 500 μm2 to 0.1 m2. The uses of these electrodes and sensors are also described.

2. 发明授权

US09757047B2 Fast analysis method for non-invasive imaging of blood flow using vessel-encoded arterial spin labelling 有权
公开(公告)号：US09757047B2
公开(公告)日：2017-09-12
申请号：US13815815
申请日：2013-03-14
申请人： Isis Innovation Ltd.
发明人： Michael Chappell , Mark Woolrich , Thomas Okell
IPC分类号： G01V3/00 , A61B5/026 , G01R33/563
CPC分类号： A61B5/0263 , G01R33/56333 , G01R33/56366 , G06F19/00
摘要： Arterial spin labelling (ASL) MRI offers a non-invasive means to create blood-borne contrast in vivo for dynamic angiographic imaging. By spatial modulation of the ASL process it is possible to uniquely label individual arteries over a series of measurements, allowing each to be separately identified in the resulting images. This separation requires appropriate analysis for which a general framework has previously been proposed. Here the general framework is modified for fast analysis of non-invasive imaging of blood flow using vessel encoded arterial spin labelling (VE-ASL). This specifically addresses the issues of computational speed of the analysis and the robustness required to deal with real patient data. The modification applies various approaches for estimation of one or more parameters that change the way a vessel, for example an artery, is encoded to provide the fast analysis.

3. 发明授权

US09220769B2 Composition 有权
标题翻译：组成
公开(公告)号：US09220769B2
公开(公告)日：2015-12-29
申请号：US14346669
申请日：2012-09-21
申请人： Isis Innovation, Ltd.
发明人： Alain Townsend
IPC分类号： A61K39/145 , C12N7/00 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5254 , A61K2039/58 , C07K14/005 , C12N7/00 , C12N2760/16022 , C12N2760/16062 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162
摘要： The present invention provides a modified influenza virus wherein the RNA of the haemagglutinin gene has been modified such that the haemagglutinin signal sequence is not expressed and the virus produces a haemagglutinin protein that lacks a functional signal sequence. The invention further provides composition comprising the modified virus and uses of the modified virus.
摘要翻译：本发明提供了修饰的流感病毒，其中已经修饰了血凝素基因的RNA，使得血凝素信号序列不被表达，并且病毒产生缺乏功能信号序列的血凝素蛋白。本发明还提供了包含经修饰的病毒和经修饰的病毒的用途的组合物。

4. 发明授权

US09054566B2 Electric machine—evaporative cooling 有权
标题翻译：电机 - 蒸发冷却
公开(公告)号：US09054566B2
公开(公告)日：2015-06-09
申请号：US14049322
申请日：2013-10-09
申请人： Isis Innovation Ltd.
发明人： Tim Woolmer
IPC分类号： H02K9/18 , H02K9/20 , H02K21/12 , B60K1/00 , H02K5/18 , H02K7/14 , H02K21/24 , B60K7/00 , H02K49/04
CPC分类号： H02K9/20 , B60K7/0007 , H02K5/18 , H02K7/14 , H02K21/24 , H02K49/04
摘要： An electric machine comprises a rotor, preferably having permanent magnets, although other field generation means are available, and a stator. The stator has coils wound on stator bars for interaction with the magnetic field of the rotor across an air gap defined between them. The rotor comprises a housing of a chamber containing refrigerant. The rotor housing has heat dissipating fins accessible by the open environment whereby air movement relative to the housing caused at least by rotation of the rotor absorbs heat from the fins. The machine may be an axial flux machine, the coils being wound on bars that are disposed circumferentially spaced around a fixed axle of the machine forming a rotational axis of the rotor. The machine may be a wheel motor for a vehicle, wherein the wheel is mounted directly on the rotor housing.
摘要翻译：电机包括转子，优选地具有永磁体，尽管其它现场产生装置可用，也包括定子。定子具有缠绕在定子棒上的线圈，用于与转子的磁场横跨跨它们之间限定的气隙相互作用。转子包括容纳制冷剂的室的壳体。转子壳体具有可通过开放环境访问的散热翅片，从而至少通过转子的旋转而相对于壳体的空气移动从散热片吸收热量。机器可以是轴向通量机器，线圈缠绕在杆上，所述杆围绕形成转子的旋转轴线的机器的固定轴线周向隔开设置。机器可以是用于车辆的车轮马达，其中车轮直接安装在转子壳体上。

5. 发明申请

US20140308719A1 PROCESS FOR PRODUCING (R)-3-HYDROXYBUTYL (R)-3-HYDROXYBUTYRATE 审中-公开
标题翻译：制备（R）-3-羟基丁基-3-羟基丁酸酯的方法
公开(公告)号：US20140308719A1
公开(公告)日：2014-10-16
申请号：US14213713
申请日：2014-03-14
申请人： GOVERNMENT OF THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , ISIS INNOVATION LTD
发明人： Kieran Clarke , Richard Lewis Veech , M. Todd King
IPC分类号： C12P7/62 , C07C67/02
CPC分类号： C12P7/62 , C07B2200/07 , C07C29/147 , C07C67/03 , C07C69/675 , C07C31/207
摘要： Embodiments of the present invention are directed to processes for the production of (R)-3-hydroxybutyl (R)-3-hydroxybyrate. Poly (R)-3-hydroxybyrate is transesterified with an alcohol, to form a first ester portion and a second ester portion. The first ester portion is reduced to the diol to form a diol portion and the diol portion is reacted with the second ester portion to produce (R)-3-hydroxybutyl (R)-3-hydroxybyrate.
摘要翻译：本发明的实施方案涉及制备（R）-3-羟基丁基（R）-3-羟基丁酸酯的方法。聚（R）-3-羟基丁酸酯用醇酯交换，形成第一酯部分和第二酯部分。将第一酯部分还原成二醇以形成二醇部分，并且将二醇部分与第二酯部分反应以制备（R）-3-羟基丁基（R）-3-羟基丁酸酯。

6. 发明申请

US20140050731A1 Vaccine 审中-公开
标题翻译：疫苗
公开(公告)号：US20140050731A1
公开(公告)日：2014-02-20
申请号：US13965430
申请日：2013-08-13
申请人： Isis Innovation Ltd.
发明人： Joyce Susan Plested , Michael Paul Jennings , Margaret Ann Jaqueline Gidney , Andrew David Cox , James Clare Richards , Edward Richard Moxon
IPC分类号： A61K39/385 , A61K39/40 , C07K14/22
CPC分类号： A61K39/385 , A61K39/095 , A61K39/40 , A61K2039/505 , A61K2039/53 , C07K14/22 , C07K16/1217 , C07K2317/76
摘要： The invention relates to a vaccine for the treatment of disease caused by Neisseria, the vaccine including one or more immunogenic components for Neisseria serogroups, as well as antibodies to the immunogenic components and methods of preventing and treating Neisseria infections. The immunogens are based on elements of the inner core lipopolysaccharide.
摘要翻译：本发明涉及用于治疗由奈瑟氏球菌引起的疾病的疫苗，该疫苗包括奈瑟氏球菌血清群的一种或多种免疫原性成分，以及针对免疫原性成分的抗体以及预防和治疗奈瑟氏球菌感染的方法。免疫原基于内核脂多糖的元件。

7. 发明授权

US09501620B2 Quantification of blood volume flow rates from dynamic angiography data 有权
公开(公告)号：US09501620B2
公开(公告)日：2016-11-22
申请号：US13815854
申请日：2013-03-14
申请人： Isis Innovation Ltd.
发明人： Thomas Okell , Michael Chappell , Peter Jezzard
IPC分类号： G06F19/00 , A61B6/00
CPC分类号： G16H50/50 , A61B6/504 , A61B6/507 , A61B6/5217
摘要： Systems and methods are disclosed for quantifying absolute blood volume flow rates by fitting a kinetic model incorporating blood volume, bolus dispersion and signal attenuation to dynamic angiographic data. A self-calibration method is described for both 2D and 3D data sets to convert the relative blood volume parameter into absolute units. The parameter values are then used to simulate the signal arising from a very short bolus, in the absence of signal attenuation, which can be readily encompassed within a vessel mask of interest. The volume flow rate can then be determined by calculating the blood volume within the vessel mask and dividing by the simulated bolus duration. This method is exemplified using non-contrast magnetic resonance imaging data from a flow phantom and the cerebral arteries of healthy volunteers and a patient with Moya-Moya disease acquired using a 2D vessel-encoded pseudo-continuous arterial spin labeling pulse sequence. This allows flow quantification in downstream vessels from each brain-feeding artery separately. The systems and methods can be of use in patients with a variety of cerebrovascular diseases, such as the assessment of collateral flow in patients with steno-occlusive disease or the evaluation of arteriovenous malformations.

8. 发明申请

US20160266362A1 Compact Microscope 审中-公开
标题翻译：紧凑型显微镜
公开(公告)号：US20160266362A1
公开(公告)日：2016-09-15
申请号：US15031807
申请日：2014-10-27
申请人： ISIS INNOVATION LTD.
发明人： Achillefs KAPANIDIS , Bo JING , Robert CRAWFORD
IPC分类号： G02B21/00 , G02B21/36 , G02B21/24 , G02B21/26 , G02B21/06
CPC分类号： G02B21/0008 , G02B21/0088 , G02B21/06 , G02B21/244 , G02B21/26 , G02B21/36
摘要： A compact microscope including an enclosure, a support element, a primary optical support element located within the enclosure and supported by the support element, at least one vibration isolating mount between the support element and the primary optical support element, an illumination section, an objective lens system, a sample stage mounted on the primary optical support element, an illumination optical system to direct an illumination light beam from the illumination section to the sample stage, and a return optical system to receive returned light from sample stage and transmit returned light to a detection apparatus, wherein the illumination optical system and return optical system are mounted on the primary optical support element.
摘要翻译：一种紧凑型显微镜，包括外壳，支撑元件，位于外壳内并由支撑元件支撑的主要光学支撑元件，支撑元件和主光学支撑元件之间的至少一个防振安装件，照明部分，物镜透镜系统，安装在主光学支撑元件上的样品台，将来自照明部分的照明光束引导到样品台的照明光学系统，以及返回光学系统，用于接收来自样品台的返回光并将返回的光传输到检测装置，其中照明光学系统和返回光学系统安装在主光学支撑元件上。

9. 发明申请

US20160151347A1 PHARMACEUTICAL COMPOUNDS 审中-公开
标题翻译：药物化合物
公开(公告)号：US20160151347A1
公开(公告)日：2016-06-02
申请号：US14904005
申请日：2014-07-10
申请人： ISIS Innovation LTD
发明人： Rebecca Burton
IPC分类号： A61K31/4706 , A61K45/06
CPC分类号： A61K31/4706 , A61K31/165 , A61K31/505 , A61K45/06 , A61K2300/00
摘要： The present invention provides hydroxychloroquine or a pharmaceutically acceptable salt thereof for use in the prevention and/or treatment of systolic heart failure, sincus tachycardia, cardiac syndrome X and/or essential hypertension.
摘要翻译：本发明提供用于预防和/或治疗收缩期心力衰竭，心绞痛心动过速，心脏综合征X和/或原发性高血压的羟氯喹或其药学上可接受的盐。

10. 发明申请

US20150309134A1 DIFFUSION-INSENSTIVE VELOCITY SELECTIVE LABELLING MODULE FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用于磁共振成像的扩散速度选择性标签模块
公开(公告)号：US20150309134A1
公开(公告)日：2015-10-29
申请号：US14660576
申请日：2015-03-17
申请人： ISIS INNOVATION LTD
发明人： James MEAKIN , Peter JEZZARD
IPC分类号： G01R33/48 , A61B5/026
CPC分类号： A61B5/0263 , A61B5/4058 , A61B2576/026 , G01R33/56366 , G01R33/56509
摘要： A velocity selective preparation method, for Velocity Selective Magnetisation Transfer Insensitive labelling technique (VS-TILT), said VS-TILT method using non-selective RadioFrequency (RF) pulses and magnetic field gradients to modulate the longitudinal magnetization of moving spins in magnetic resonance imaging that is insensitive to diffusion effects, said method comprising the steps of: a) play out two velocity selective pulses: VS-A and VS-B, sequentially without any spoiling between said pulses; b) each individual pulse VS-A and VS-B having half the first gradient moment m1 of the original velocity selective pulse; c) assigning the VS-TILT tag condition gradients to have the same polarity, such that total m1 is perserved; and d) assigning the VS_TILT control condition, negating the n gradients in the first pulse such total m1=0, but the b-value remains unchanged.
摘要翻译：用于速度选择性磁化转移不敏感标记技术（VS-TILT）的速度选择性制备方法，所述VS-TILT方法使用非选择性射频（RF）脉冲和磁场梯度来调节磁共振成像中移动自旋的纵向磁化对扩散效应不敏感，所述方法包括以下步骤：a）顺序地播放两个速度选择脉冲：VS-A和VS-B，而不会在所述脉冲之间发生任何破坏; b）每个独立脉冲VS-A和VS-B具有原始速度选择脉冲的第一梯度矩m1的一半; c）将VS-TILT标签条件梯度分配为具有相同的极性，使得总共m1被持续; 和d）分配VS_TILT控制条件，否定第一脉冲中的n个梯度，总共m1 = 0，但是b值保持不变。

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