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1. 发明申请

US20030023173A1 Apparatus and method for blood pressure pulse waveform contour analysis 失效
公开(公告)号：US20030023173A1
公开(公告)日：2003-01-30
申请号：US10157551
申请日：2002-05-28
申请人： Hypertension Diagnostics, Inc.
发明人： Christopher W. Bratteli , Jay N. Cohn , Stanley M. Finkelstein , Dennis J. Morgan
IPC分类号： A61B005/02
CPC分类号： A61B5/021 , A61B5/02108 , A61B5/7239 , A61B7/00 , A61B7/045 , G06F19/00
摘要： Methods and apparatus for processing an arterial blood pressure waveform to extract clinically useful information on the state of the cardiovascular system are disclosed herein. In order to obtain the parameters of the modified Windkessel model, the diastolic portion of a subject's blood pressure waveform is scanned over a plurality of ranges and the range that produces the best fit of data and lowest error estimates are selected. In addition, multiple empirically determined starting values of the nullAnull parameters are used to find the best fit of the model data to the actual arterial blood pressure waveform data.

2. 发明申请

US20020028998A1 Method and instrument to measure vascular impedance 有权
标题翻译：测量血管阻力的方法和仪器
公开(公告)号：US20020028998A1
公开(公告)日：2002-03-07
申请号：US09954673
申请日：2001-09-17
申请人： Hypertension Diagnostics, Inc.
发明人： Charles F. Chesney , Stanley M. Finkelstein , Jay N. Cohn
IPC分类号： A61B005/02
CPC分类号： A61B5/02007 , A61B5/021 , A61B5/029 , G06F19/00 , G09B23/28 , Y10S128/92
摘要： A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.
摘要翻译：血管阻抗测量仪器包括用于获得数字化的动脉血压波形的换能器。数字化数据用于确定心输出量，并随后使用修改的动脉系统的Windkessel模型获得阻抗参数的测量值。该仪器用于诊断，治疗和监测心血管疾病患者的辅助。

3. 发明申请

US20030093301A1 Centralized clinical data management system process for analysis and billing 审中-公开
标题翻译：集中的临床数据管理系统流程进行分析和计费
公开(公告)号：US20030093301A1
公开(公告)日：2003-05-15
申请号：US10008782
申请日：2001-11-13
申请人： Hypertension Diagnostics, Inc.
发明人： Charles F. Chesney , Kevin A. Petrucelli
IPC分类号： G06F017/60
CPC分类号： G06F19/328 , G06Q10/10 , G06Q20/14 , G06Q30/04 , G06Q50/24 , G16H10/60 , G16H15/00 , G16H40/20
摘要： Method and apparatus for acquiring and analyzing signals to generate medical data pertinent to one or more individuals and storing the data in a local machine, then collecting the medical data to a centralized system for further analysis and/or creation of invoices for billing. Some embodiments include a medical-data collection apparatus for processing an arterial blood pressure waveform to extract clinically useful information on the state of the cardiovascular system of an individual. After storing medical data for one or more individuals, the medical-data collection apparatus establishes communications with a centralized information-processing system, uploads its data, and is re-enabled to collect further data. The information-processing system optionally generates bills or invoices for the services based on usage of each of the medical-data collection apparatus, and optionally aggregates the data from a plurality of individuals for further analysis.
摘要翻译：用于获取和分析信号以生成与一个或多个个体相关的医学数据并将数据存储在本地机器中的方法和装置，然后将医疗数据收集到集中式系统中，以进一步分析和/或创建用于计费的发票。一些实施例包括用于处理动脉血压波形以提取关于个体的心血管系统的状态的临床有用信息的医疗数据收集装置。在存储一个或多个个人的医疗数据之后，医疗数据收集装置与集中式信息处理系统建立通信，上传其数据，并被重新启用以收集进一步的数据。信息处理系统可以根据每个医疗数据收集装置的使用可选地为服务生成账单或发票，并且可选地聚集来自多个个人的数据用于进一步的分析。

4. 发明授权

US6017313A Apparatus and method for blood pressure pulse waveform contour analysis 失效
标题翻译：血压脉搏波形轮廓分析装置及方法
公开(公告)号：US6017313A
公开(公告)日：2000-01-25
申请号：US45420
申请日：1998-03-20
申请人： Christopher W. Bratteli , Jay N. Cohn , Stanley M. Finkelstein , Dennis J. Morgan
发明人： Christopher W. Bratteli , Jay N. Cohn , Stanley M. Finkelstein , Dennis J. Morgan
IPC分类号： A61B5/021 , A61B7/00 , A61B7/04 , A61N5/00
CPC分类号： A61B5/021 , A61B5/02108 , A61B7/00 , A61B7/045 , A61B5/7239
摘要： Methods and apparatus for processing an arterial blood pressure waveform to extract clinically useful information on the state of the cardiovascular system are disclosed herein. In order to obtain the parameters of the modified Windkessel model, the diastolic portion of a subject's blood pressure waveform is scanned over a plurality of ranges and the range that produces the best fit of data and lowest error estimates are selected. In addition, multiple empirically determined starting values of the `A` parameters are used to find the best fit of the model data to the actual arterial blood pressure waveform data.
摘要翻译：本文公开了用于处理动脉血压波形以提取关于心血管系统的状态的临床有用信息的方法和装置。为了获得修改的Windkessel模型的参数，选择受试者的血压波形的舒张部分在多个范围上扫描，并且选择产生数据最佳拟合的范围和最低误差估计。此外，使用多个经验确定的“A”参数的起始值来找到模型数据与实际动脉血压波形数据的最佳拟合。

5. 发明授权

US5241966A Method and apparatus for measuring cardiac output 失效
标题翻译：用于测量心输出量的方法和装置
公开(公告)号：US5241966A
公开(公告)日：1993-09-07
申请号：US978179
申请日：1992-11-17
申请人： Stanley M. Finkelstein , Jay N. Cohn
发明人： Stanley M. Finkelstein , Jay N. Cohn
IPC分类号： A61B5/024 , A61B5/029 , G06F17/00
CPC分类号： A61B5/029 , A61B5/024
摘要： Apparatus for Measuring Stroke Volume/Cardiac Output includes a transducer for measuring arterial blood pressure waveform, a digitizer for digitizing the analog signal generated by the transducer and a digital signal processor for determining ejection time and heart rate. Processor circuitry determines cardiac output using the ejection time, heart rate, the body surface area and age of the patient, with the cardiac output measure being displayed by the meter.
摘要翻译：用于测量行程体积/心脏输出的装置包括用于测量动脉血压波形的换能器，用于数字化由换能器产生的模拟信号的数字化仪和用于确定喷射时间和心率的数字信号处理器。处理器电路使用排出时间，心率，体表面积和患者的年龄来确定心输出量，心输出量度由仪表显示。

6. 发明申请

US20040167413A1 Method and apparatus for calibrating and measuring arterial compliance and stroke volume 审中-公开
标题翻译：用于校准和测量动脉顺应性和行程体积的方法和装置
公开(公告)号：US20040167413A1
公开(公告)日：2004-08-26
申请号：US10780960
申请日：2004-02-17
申请人： Hypertension Diagnostics, Inc.
发明人： Christopher W. Bratteli
IPC分类号： A61B005/02
CPC分类号： A61B5/022 , A61B5/02225 , Y10S128/92
摘要： Methods and apparatus for measuring arterial compliance using combined noninvasive arterial tonometry and cuff oscillometry. Some embodiments include a calibration method using an oscillometric signal to calibrate the pressures of tonometric signals in a contralateral arterial site. The times at which two of the three oscillometric blood pressures (systolic pressure, mean pressure, diastolic pressure) are acquired are identified with times of uncalibrated tonometric pressure waveform. These blood pressures are then used to calibrate the tonometric pressure waveform along (optionally) with adjustments for head pressure. For example, a left brachial arterial cuff oscillometric signal is acquired coincidentally with an uncalibrated right radial arterial pressure tonometric signal. The time points of mean arterial pressure and diastolic pressure are determined from the oscillometric signal and identified with coinciding time points on the tonometric signal to produce a calibration. All pressures are then adjusted by the head pressure between the brachial and radial sites.
摘要翻译：使用组合的无创动脉血压计和袖带示波器测量动脉顺应性的方法和装置。一些实施例包括使用示波器信号来校准对侧动脉部位的血压信号的压力的校准方法。三个示波血压（收缩压，平均压力，舒张压）中的两个获得的时间由未校准的血压计波形的时间确定。然后使用这些血压来校准血压压力波形（可选），以调节头部压力。例如，左肱动脉袖带示波信号与未校准的右桡动脉压力测量信号巧合地获取。平均动脉压和舒张压的时间点由示波器信号确定，并在测量信号上用一致的时间点进行鉴定，以产生校准。然后通过肱动脉和桡动脉位置之间的头部压力调节所有压力。

7. 发明申请

US20040024324A1 METHODS AND APPARATUS FOR MEASURING ARTERIAL COMPLIANCE, IMPROVING PRESSURE CALIBRATION, AND COMPUTING FLOW FROM PRESSURE DATA 失效
标题翻译：用于测量动脉硬化的方法和装置，改进压力校准和从压力数据计算流量
公开(公告)号：US20040024324A1
公开(公告)日：2004-02-05
申请号：US10211857
申请日：2002-08-01
申请人： Hypertension Diagnostics, Inc.
发明人： Christopher W. Bratteli
IPC分类号： A61B005/02
CPC分类号： A61B5/022 , A61B5/02225 , Y10S128/92
摘要： Methods and apparatus for non-invasively measuring arterial compliance using the combination of noninvasive arterial tonometry and noninvasive cuff oscillometry. Some embodiments include an accurate calibration method using an oscillometric signal to calibrate the pressures of tonometric signals in a contralateral arterial site. The exact time at which two of the three oscillometric blood pressures (systolic pressure, mean pressure, diastolic pressure) are acquired are identified with precise locations on the un-calibrated tonometric pressure waveform. These two blood pressures are then used to calibrate the tonometric pressure waveform along (optionally) with adjustments for head pressure. For example, a left brachial arterial cuff osciilometric signal is acquired coincidentally with an un-calibrated right radial arterial pressure tonometric signal. The time points of mean arterial pressure and diastolic pressure are determined from the oscillometric signal and identified with coinciding time points on the tonometric signal to produce a calibration. All pressures are then adjusted by the head pressure between the brachial and radial sites. In some embodiments, a simple uncorrected volume arterial compliance curve is obtained by plotting relative arterial volume under the cuff against brachial arterial transmural pressure. The transmural pressure is the difference between cuff pressure and radial arterial pressure (adjusted for pressure head). Due to shear stresses at the ends of the cuff, this uncorrected volume arterial compliance curve overestimates the in vivo compliance for the arterial segment. Further embodiments account for this bias by providing a correction for the transmural pressure that is based on stress-strain properties of the upper arm.
摘要翻译：使用非侵入性动脉血压计和无创袖带示波器组合非侵入性测量动脉顺应性的方法和装置。一些实施例包括使用示波信号校准对侧动脉部位中的血压信号的压力的精确校准方法。三个示波血压（收缩压，平均压力，舒张压）中的两个获取的确切时间是在未校准的血压计波形上的精确位置识别的。然后使用这两个血压来校准压力波形（可选），调整头部压力。例如，左肱动脉袖口心律测量信号与未校准的右桡动脉压力测量信号巧合地获得。平均动脉压和舒张压的时间点由示波器信号确定，并在测量信号上用一致的时间点进行鉴定，以产生校准。然后通过肱动脉和桡动脉位置之间的头部压力调节所有压力。在一些实施例中，通过绘制袖带下的相对动脉体积与肱动脉透壁压力来获得简单的未校正的体积动脉顺应性曲线。透壁压力是袖带压力和桡动脉压力之间的差异（针对压头调节）。由于袖带末端的剪切应力，这种未校正的体积动脉顺应性曲线高估了动脉段的体内顺应性。另外的实施例通过提供基于上臂的应力 - 应变性质的透壁压的校正来解释该偏差。

8. 发明授权

US6159166A Sensor and method for sensing arterial pulse pressure 失效
标题翻译：用于感测动脉脉压的传感器和方法
公开(公告)号：US6159166A
公开(公告)日：2000-12-12
申请号：US45018
申请日：1998-03-20
申请人： Charles F. Chesney , Dennis J. Morgan , Eugene A. O'Rourke , Michael T. Riggs , Fred Randall Thornton
发明人： Charles F. Chesney , Dennis J. Morgan , Eugene A. O'Rourke , Michael T. Riggs , Fred Randall Thornton
IPC分类号： A61B5/021 , A61B7/00 , A61B7/04 , A61B5/02
CPC分类号： A61B7/00 , A61B5/021 , A61B5/02108 , A61B7/045
摘要： A method and a pulse pressure sensor for sensing an arterial pulse pressure waveform. In one embodiment, the pulse pressure sensor includes a housing, a diaphragm, a piezoelectric device, and a self-contained amplifier. The skin-contact diaphragm is attached across a recess or opening in the housing. The piezoelectric device has a first portion mounted in a fixed relationship to the housing and a second portion displacementally coupled to the diaphragm. The solid-state amplifier has a signal input coupled to the piezoelectric device, wherein the piezoelectric device and amplifier together have a frequency response at least including a range from below approximately 0.1 hertz to above approximately 250 hertz. In one such embodiment, the housing and the skin-contact diaphragm of the sensor are stainless steel. In one such embodiment, the diaphragm has a skin-contact surface with a skin-contact dimension of between approximately 0.4 inch and 0.6 inch. In one embodiment, the sensor includes a solid-state amplifier that includes a high-input-impedance MOSFET input stage having an input resistance high enough to provide a frequency response that extends below approximately 0.1 hertz.
摘要翻译：一种用于感测动脉脉压波形的方法和脉搏压力传感器。在一个实施例中，脉冲压力传感器包括外壳，隔膜，压电装置和独立放大器。皮肤接触隔膜穿过外壳中的凹槽或开口。压电装置具有以与壳体成固定关系的方式安装的第一部分和与隔膜成一体的第二部分。固态放大器具有耦合到压电器件的信号输入，其中压电器件和放大器一起具有频率响应，至少包括从低于约0.1赫兹到大约250赫兹的范围。在一个这样的实施例中，传感器的外壳和皮肤接触隔膜是不锈钢。在一个这样的实施例中，隔膜具有皮肤接触表面，皮肤接触尺寸在大约0.4英寸和0.6英寸之间。在一个实施例中，传感器包括固态放大器，其包括高输入阻抗MOSFET输入级，其具有足够高的输入电阻以提供延伸到大约0.1赫兹以下的频率响应。

9. 发明授权

US6132383A Apparatus for holding and positioning an arterial pulse pressure sensor 失效
标题翻译：用于保持和定位动脉脉压传感器的装置
公开(公告)号：US6132383A
公开(公告)日：2000-10-17
申请号：US45449
申请日：1998-03-20
申请人： Charles F. Chesney , Bernard M. Graham , E. Paul Maloney , Dennis J. Morgan , Andrew L. Von Duyke
发明人： Charles F. Chesney , Bernard M. Graham , E. Paul Maloney , Dennis J. Morgan , Andrew L. Von Duyke
IPC分类号： A61B5/022 , A61B5/02
CPC分类号： A61B5/411 , A61B5/022 , A61B5/6824
摘要： A sensor holding and positioning device. In one embodiment, the device includes a sensor base having two feet, the base forming a raised bridge between the two feet. The bridge has one or more cross members spanning all or part of the space between the two feet. A sensor suspension including a sensor holder and sensor-height-adjustment mechanism is coupled by a pivot-arm axle to the sensor base, such that the sensor suspension is able to rotate in an arc about the long axis of the axle. In one such embodiment, the device further includes a pressure sensor attached to the sensor holder of the sensor suspension. In another such embodiment, the sensor suspension is able to slide back and forth along a line parallel to the long axis of the axle. Another aspect is for positioning the sensor over the radial artery, for example in a human's wrist. Yet another aspect is a pulse-waveform acquisition system. In one embodiment, such a system includes a wrist stabilizer, the stabilizer comprising a first member shaped on a forearm portion to conform to contours of a forearm, shaped on a wrist portion to contours of a wrist, and shaped on a hand portion to the contours of a hand, and forming an angle of approximately 150 degrees between the forearm portion and the hand portion, the stabilizer further including straps for holding the forearm and hand to the stabilizer.
摘要翻译：传感器保持定位装置。在一个实施例中，该装置包括具有两个脚的传感器基座，该基座在两个脚之间形成升高的桥。桥梁具有跨越两脚之间的全部或部分空间的一个或多个横梁。包括传感器保持器和传感器高度调节机构的传感器悬架通过枢转臂轴耦合到传感器基座，使得传感器悬架能够围绕轴的长轴线旋转。在一个这样的实施例中，该装置还包括附接到传感器悬架的传感器保持器的压力传感器。在另一个这样的实施例中，传感器悬架能够沿着与轴的长轴平行的线来回滑动。另一方面是将传感器定位在桡动脉上，例如在人的手腕上。另一方面是脉冲波形采集系统。在一个实施例中，这种系统包括腕部稳定器，该稳定器包括形成在前臂部分上的第一构件，以与前臂成形的轮廓线形成手腕部分的轮廓，并在手部形成手的轮廓，并且在前臂部分和手部分之间形成大约150度的角度，所述稳定器还包括用于将前臂和手保持在稳定器上的带子。

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