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1. 发明申请

US20030093301A1 Centralized clinical data management system process for analysis and billing 审中-公开
标题翻译：集中的临床数据管理系统流程进行分析和计费
公开(公告)号：US20030093301A1
公开(公告)日：2003-05-15
申请号：US10008782
申请日：2001-11-13
申请人： Hypertension Diagnostics, Inc.
发明人： Charles F. Chesney , Kevin A. Petrucelli
IPC分类号： G06F017/60
CPC分类号： G06F19/328 , G06Q10/10 , G06Q20/14 , G06Q30/04 , G06Q50/24 , G16H10/60 , G16H15/00 , G16H40/20
摘要： Method and apparatus for acquiring and analyzing signals to generate medical data pertinent to one or more individuals and storing the data in a local machine, then collecting the medical data to a centralized system for further analysis and/or creation of invoices for billing. Some embodiments include a medical-data collection apparatus for processing an arterial blood pressure waveform to extract clinically useful information on the state of the cardiovascular system of an individual. After storing medical data for one or more individuals, the medical-data collection apparatus establishes communications with a centralized information-processing system, uploads its data, and is re-enabled to collect further data. The information-processing system optionally generates bills or invoices for the services based on usage of each of the medical-data collection apparatus, and optionally aggregates the data from a plurality of individuals for further analysis.
摘要翻译：用于获取和分析信号以生成与一个或多个个体相关的医学数据并将数据存储在本地机器中的方法和装置，然后将医疗数据收集到集中式系统中，以进一步分析和/或创建用于计费的发票。一些实施例包括用于处理动脉血压波形以提取关于个体的心血管系统的状态的临床有用信息的医疗数据收集装置。在存储一个或多个个人的医疗数据之后，医疗数据收集装置与集中式信息处理系统建立通信，上传其数据，并被重新启用以收集进一步的数据。信息处理系统可以根据每个医疗数据收集装置的使用可选地为服务生成账单或发票，并且可选地聚集来自多个个人的数据用于进一步的分析。

2. 发明申请

US20040167413A1 Method and apparatus for calibrating and measuring arterial compliance and stroke volume 审中-公开
标题翻译：用于校准和测量动脉顺应性和行程体积的方法和装置
公开(公告)号：US20040167413A1
公开(公告)日：2004-08-26
申请号：US10780960
申请日：2004-02-17
申请人： Hypertension Diagnostics, Inc.
发明人： Christopher W. Bratteli
IPC分类号： A61B005/02
CPC分类号： A61B5/022 , A61B5/02225 , Y10S128/92
摘要： Methods and apparatus for measuring arterial compliance using combined noninvasive arterial tonometry and cuff oscillometry. Some embodiments include a calibration method using an oscillometric signal to calibrate the pressures of tonometric signals in a contralateral arterial site. The times at which two of the three oscillometric blood pressures (systolic pressure, mean pressure, diastolic pressure) are acquired are identified with times of uncalibrated tonometric pressure waveform. These blood pressures are then used to calibrate the tonometric pressure waveform along (optionally) with adjustments for head pressure. For example, a left brachial arterial cuff oscillometric signal is acquired coincidentally with an uncalibrated right radial arterial pressure tonometric signal. The time points of mean arterial pressure and diastolic pressure are determined from the oscillometric signal and identified with coinciding time points on the tonometric signal to produce a calibration. All pressures are then adjusted by the head pressure between the brachial and radial sites.
摘要翻译：使用组合的无创动脉血压计和袖带示波器测量动脉顺应性的方法和装置。一些实施例包括使用示波器信号来校准对侧动脉部位的血压信号的压力的校准方法。三个示波血压（收缩压，平均压力，舒张压）中的两个获得的时间由未校准的血压计波形的时间确定。然后使用这些血压来校准血压压力波形（可选），以调节头部压力。例如，左肱动脉袖带示波信号与未校准的右桡动脉压力测量信号巧合地获取。平均动脉压和舒张压的时间点由示波器信号确定，并在测量信号上用一致的时间点进行鉴定，以产生校准。然后通过肱动脉和桡动脉位置之间的头部压力调节所有压力。

3. 发明申请

US20040024324A1 METHODS AND APPARATUS FOR MEASURING ARTERIAL COMPLIANCE, IMPROVING PRESSURE CALIBRATION, AND COMPUTING FLOW FROM PRESSURE DATA 失效
标题翻译：用于测量动脉硬化的方法和装置，改进压力校准和从压力数据计算流量
公开(公告)号：US20040024324A1
公开(公告)日：2004-02-05
申请号：US10211857
申请日：2002-08-01
申请人： Hypertension Diagnostics, Inc.
发明人： Christopher W. Bratteli
IPC分类号： A61B005/02
CPC分类号： A61B5/022 , A61B5/02225 , Y10S128/92
摘要： Methods and apparatus for non-invasively measuring arterial compliance using the combination of noninvasive arterial tonometry and noninvasive cuff oscillometry. Some embodiments include an accurate calibration method using an oscillometric signal to calibrate the pressures of tonometric signals in a contralateral arterial site. The exact time at which two of the three oscillometric blood pressures (systolic pressure, mean pressure, diastolic pressure) are acquired are identified with precise locations on the un-calibrated tonometric pressure waveform. These two blood pressures are then used to calibrate the tonometric pressure waveform along (optionally) with adjustments for head pressure. For example, a left brachial arterial cuff osciilometric signal is acquired coincidentally with an un-calibrated right radial arterial pressure tonometric signal. The time points of mean arterial pressure and diastolic pressure are determined from the oscillometric signal and identified with coinciding time points on the tonometric signal to produce a calibration. All pressures are then adjusted by the head pressure between the brachial and radial sites. In some embodiments, a simple uncorrected volume arterial compliance curve is obtained by plotting relative arterial volume under the cuff against brachial arterial transmural pressure. The transmural pressure is the difference between cuff pressure and radial arterial pressure (adjusted for pressure head). Due to shear stresses at the ends of the cuff, this uncorrected volume arterial compliance curve overestimates the in vivo compliance for the arterial segment. Further embodiments account for this bias by providing a correction for the transmural pressure that is based on stress-strain properties of the upper arm.
摘要翻译：使用非侵入性动脉血压计和无创袖带示波器组合非侵入性测量动脉顺应性的方法和装置。一些实施例包括使用示波信号校准对侧动脉部位中的血压信号的压力的精确校准方法。三个示波血压（收缩压，平均压力，舒张压）中的两个获取的确切时间是在未校准的血压计波形上的精确位置识别的。然后使用这两个血压来校准压力波形（可选），调整头部压力。例如，左肱动脉袖口心律测量信号与未校准的右桡动脉压力测量信号巧合地获得。平均动脉压和舒张压的时间点由示波器信号确定，并在测量信号上用一致的时间点进行鉴定，以产生校准。然后通过肱动脉和桡动脉位置之间的头部压力调节所有压力。在一些实施例中，通过绘制袖带下的相对动脉体积与肱动脉透壁压力来获得简单的未校正的体积动脉顺应性曲线。透壁压力是袖带压力和桡动脉压力之间的差异（针对压头调节）。由于袖带末端的剪切应力，这种未校正的体积动脉顺应性曲线高估了动脉段的体内顺应性。另外的实施例通过提供基于上臂的应力 - 应变性质的透壁压的校正来解释该偏差。

4. 发明申请

US20030023173A1 Apparatus and method for blood pressure pulse waveform contour analysis 失效
公开(公告)号：US20030023173A1
公开(公告)日：2003-01-30
申请号：US10157551
申请日：2002-05-28
申请人： Hypertension Diagnostics, Inc.
发明人： Christopher W. Bratteli , Jay N. Cohn , Stanley M. Finkelstein , Dennis J. Morgan
IPC分类号： A61B005/02
CPC分类号： A61B5/021 , A61B5/02108 , A61B5/7239 , A61B7/00 , A61B7/045 , G06F19/00
摘要： Methods and apparatus for processing an arterial blood pressure waveform to extract clinically useful information on the state of the cardiovascular system are disclosed herein. In order to obtain the parameters of the modified Windkessel model, the diastolic portion of a subject's blood pressure waveform is scanned over a plurality of ranges and the range that produces the best fit of data and lowest error estimates are selected. In addition, multiple empirically determined starting values of the nullAnull parameters are used to find the best fit of the model data to the actual arterial blood pressure waveform data.

5. 发明申请

US20020028998A1 Method and instrument to measure vascular impedance 有权
标题翻译：测量血管阻力的方法和仪器
公开(公告)号：US20020028998A1
公开(公告)日：2002-03-07
申请号：US09954673
申请日：2001-09-17
申请人： Hypertension Diagnostics, Inc.
发明人： Charles F. Chesney , Stanley M. Finkelstein , Jay N. Cohn
IPC分类号： A61B005/02
CPC分类号： A61B5/02007 , A61B5/021 , A61B5/029 , G06F19/00 , G09B23/28 , Y10S128/92
摘要： A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.
摘要翻译：血管阻抗测量仪器包括用于获得数字化的动脉血压波形的换能器。数字化数据用于确定心输出量，并随后使用修改的动脉系统的Windkessel模型获得阻抗参数的测量值。该仪器用于诊断，治疗和监测心血管疾病患者的辅助。

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