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1. 发明授权

US11575823B2 Imaging method, device and system 有权
公开(公告)号：US11575823B2
公开(公告)日：2023-02-07
申请号：US17746838
申请日：2022-05-17
申请人： GeneMind Biosciences Company Limited
发明人： Linsen Li , Ruitao Sun , Jiahong Xu , Zhiliang Zhou , Zefei Jiang , Qin Yan
IPC分类号： H04N5/232 , G02B21/24
摘要： The present disclosure discloses a method and a system for imaging. The method for imaging objects using the system for imaging. The system for imaging comprises a lens. The objects comprise a first object, a second object and a third object located at different positions on a first preset track. The method for imaging comprises: allowing the lens and the first preset track to move relatively in a first predetermined relationship to acquire a clear image of the third object using the system for imaging without focusing, the first predetermined relationship is determined by a focal plane position of the first object and a focal plane position of the second object. The aforementioned method for imaging is high in imaging efficiency and is capable of fast focusing according to the first predetermined relationship even if focus tracking fails so that the blurring of a photographed image due to defocusing is avoided.

2. 发明授权

US11482304B2 Alignment methods, devices and systems 有权
公开(公告)号：US11482304B2
公开(公告)日：2022-10-25
申请号：US16635996
申请日：2017-08-02
申请人： GENEMIND BIOSCIENCES COMPANY LIMITED
发明人： Weibin Xu , Huan Jin , Qin Yan , Zefei Jiang , Zhiliang Zhou
IPC分类号： G01N33/48 , G16B30/10 , G16B35/10
摘要： The disclosure discloses an alignment method, device, and system. The alignment method includes: converting each read into a set of short fragments corresponding to the read to obtain a plurality of sets of short fragments; determining a corresponding position of the short fragment in a reference library to obtain a first positioning result, wherein the reference library is a hash table constructed based on a reference sequence, the reference library includes a plurality of entries, one entry of the reference library corresponds to one seed sequence, and the seed sequence is capable of matching at least one sequence on the reference sequence, a distance between two seed sequences corresponding to two adjacent entries of the reference library on the reference sequence is less than a length of the short fragment; removing a short fragment positioned on any one of the adjacent entries of the reference library in the first positioning result to obtain a second positioning result; and extending based on short fragments from the same read in the second positioning result to obtain an alignment result of the read. The alignment method can efficiently and accurately process and position sequencing data.

3. 发明授权

US11384390B2 Method for controlling base sequence determination, base sequence determination system and control device 有权
公开(公告)号：US11384390B2
公开(公告)日：2022-07-12
申请号：US15855215
申请日：2017-12-27
申请人： GeneMind Biosciences Company Limited
发明人： Jianfeng Xu , Ruitao Sun , Zefei Jiang , Zhiliang Zhou , Qin Yan
IPC分类号： C12Q1/6869 , G01N35/00 , G02B7/28 , B01L3/00 , G01N21/64 , H04N5/235 , G01N35/10 , H04N5/232
摘要： The present disclosure relates to base sequence determination. A base sequence determination system includes a fluid device and an optical device, a reaction device includes a first component and a second component, and a repeated executable unit is defined as: a second biochemical reaction—a first biochemical reaction—photographing. A method includes, after initiation steps, using the fluid device to perform the second biochemical reaction and the first biochemical reaction of the sample on the first component, while using the optical device to photograph the sample on the second component. The initial steps include: using the fluid device to perform the first biochemical reaction of the sample on the first component, using the optical device to photograph the sample on the first component after the first biochemical reaction, and using the fluid device to perform the first biochemical reaction of the sample on the second component.

4. 发明授权

US11368614B2 Imaging method, device and system 有权
公开(公告)号：US11368614B2
公开(公告)日：2022-06-21
申请号：US17262663
申请日：2019-07-23
申请人： GeneMind Biosciences Company Limited
发明人： Linsen Li , Ruitao Sun , Jiahong Xu , Zhiliang Zhou , Zefei Jiang , Qin Yan
IPC分类号： H04N5/232 , G02B21/24
摘要： The present disclosure discloses a method and a system for imaging. The method for imaging objects using the system for imaging. The system for imaging comprises a lens. The objects comprise a first object, a second object and a third object located at different positions on a first preset track. The method for imaging comprises: allowing the lens and the first preset track to move relatively in a first predetermined relationship to acquire a clear image of the third object using the system for imaging without focusing, the first predetermined relationship is determined by a focal plane position of the first object and a focal plane position of the second object. The aforementioned method for imaging is high in imaging efficiency and is capable of fast focusing according to the first predetermined relationship even if focus tracking fails so that the blurring of a photographed image due to defocusing is avoided.

5. 发明申请

US20210301331A1 BIOCHIP AND MANUFACTURING METHOD THEREFOR 有权
公开(公告)号：US20210301331A1
公开(公告)日：2021-09-30
申请号：US17227211
申请日：2021-04-09
申请人： GeneMind Biosciences Company Limited
发明人： Jinhong GAO , Zhi ZHAO , Luyang ZHAO , Qi WANG , Fang CHEN
IPC分类号： C12Q1/6837
摘要： A chip and a manufacturing method for the chip, comprising a weak passivation treatment following a fixing treatment. The weak passivation treatment comprises putting a weak passivation reaction solution containing a catalyst into contact with a chip for the fixing treatment, so as to promote a DNA or protein to bond with a substrate surface, thus allowing the DNA or protein to be fully fixed on the substrate surface. Moreover, on such basis, a small molecule or protein is added for manufacturing the chip. The utilization of the manufacturing method, with the step of weak passivation treatment added after the fixing treatment, allows the DNA or protein to be fully fixed on the substrate surface, not only increases the quality and efficiency of the fixing of the DNA or protein, but also reduces nucleotide and protein non-specific adsorption, thus allowing the volume of the DNA or protein being fixed to be highly controllable and to have good repeatability; moreover, when the chip is utilized for sequencing, the interference of a non-specific signal is reduced, thus laying the foundation for manufacturing a high-quality available DNA or protein chip.

6. 发明申请

US20210217186A1 METHOD AND DEVICE FOR IMAGE REGISTRATION, AND COMPUTER PROGRAM PRODUCT 有权
公开(公告)号：US20210217186A1
公开(公告)日：2021-07-15
申请号：US17270423
申请日：2018-08-22
申请人： GENEMIND BIOSCIENCES COMPANY LIMITED
发明人： Linsen LI , Weibin XU , Huan JIN , Zefei JIANG , Zhiliang ZHOU , Qin YAN
IPC分类号： G06T7/33 , G06T7/38 , G06T7/37 , G06T7/194 , G06T5/00 , G06T5/20 , G06T7/00
摘要： A method and device for image registration, and a computer program product. The method includes performing, based on a reference image, a first registration of an image to be registered, including determining a first offset between predetermined areas on the image and the reference image, and moving all bright spots on the image based on the first offset; performing, based on the reference image, a second registration with respect to the first registered image, including merging the first registered image and the reference image, calculating the offset of all overlapped bright spots in the predetermined area on the merged image to determine a second offset, two or more bright spots distanced by less than a predetermined number of pixels being one overlapped bright spot, and moving, on the basis of the second offset, all bright spots on the first registered image, thus implementing the registration of the image.

7. 发明公开

US20240294901A1 SEQUENCING METHOD 审中-公开
公开(公告)号：US20240294901A1
公开(公告)日：2024-09-05
申请号：US18563218
申请日：2022-04-26
申请人： GENEMIND BIOSCIENCES COMPANY LIMITED
发明人： Lei LIU , Weiwei LUO , Jicai FAN , Yongyi LU , Fang CHEN , Lei SUN
IPC分类号： C12N15/10 , C12Q1/6874
CPC分类号： C12N15/1065 , C12Q1/6874
摘要： Disclosed is a sequencing method, the method comprising providing a solid phase substrate that has a plurality of single-stranded nucleic acids attached to a surface thereof, wherein the 5′ ends of the single-stranded nucleic acids are attached to the surface, the single-stranded nucleic acids are polynucleotides that contain an insert-first sequence, the insert is a nucleic acid sequence from a sample to be tested, the first sequence is a preset sequence containing an index-first site, the index is a preset sequence that specifically corresponds to the sample to be tested; providing a first sequencing primer, wherein the sequencing primer can hybridize with the 5′ end of the first site; hybridizing the first sequencing primer with the single-stranded nucleic acids and placing same under a condition suitable for polymerized sequencing, so as to determine part of the sequence of the single-stranded nucleic acids by extending the first sequencing primer, so as to obtain a sequencing result. Said multiplex sequencing method can effectively reduce the level of index hopping, and is particularly suitable for a situation in which trace species or rare variants in a mixed sample need to be accurately detected.

8. 发明申请

US20230027811A1 METHOD FOR IDENTIFYING BASE IN NUCLEIC ACID AND SYSTEM 有权
公开(公告)号：US20230027811A1
公开(公告)日：2023-01-26
申请号：US17787824
申请日：2020-09-10
申请人： GeneMind Biosciences Company Limited
发明人： Linsen LI , Huan JIN , Zefei JIANG , Lei SUN
IPC分类号： G16B30/10 , G06T7/73 , G06T7/33
摘要： A method for identifying a base in nucleic acid, a computer-readable storage medium, a computer program product, and a system. The method for identifying a base in nucleic acid comprises: mapping a coordinate of each bright spot in a bright spot set corresponding to a template onto an image to be inspected, and determining the position of a corresponding coordinate on said image (S11); determining the intensity of a signal at the position of the corresponding coordinate on said image, the intensity being a corrected intensity (S21); and comparing the intensity of the signal at the position of the corresponding coordinate on said image with the size of a first preset value, and determining a base type corresponding to the position on the basis of the comparison result, so as to achieve base calling (S31). The method may quickly and accurately identify a base, and achieve the determination of an order of nucleotides/bases of at least part of a sequence of a template.

9. 发明申请

US20220373780A1 VIBRATION DAMPENING STRUCTURE, DETECTION SYSTEM AND SEQUENCING SYSTEM 有权
公开(公告)号：US20220373780A1
公开(公告)日：2022-11-24
申请号：US17763164
申请日：2020-07-14
申请人： GeneMind Biosciences Company Limited
发明人： Jiao ZHENG , Zefei JIANG , Zhiliang ZHOU , Guangming WANG , Songzhen ZHANG
IPC分类号： G02B21/36 , C12Q1/6869 , G02B27/64 , G02B21/18 , G02B21/06
摘要： A vibration damping structure (60), a detection system and a sequencing system. The vibration damping structure (60) is used in the detection system. The vibration damping structure (60) comprises a main body (62) and a support body (64), the main body (62) is connected to the detection system by means of the support body (64), the main body (62) comprises an imaging module (10), an upper layer structure (66), a lower layer structure (68) and an intermediate structure (70), the imaging module (10) is mounted on the upper layer structure (66), the lower layer structure (68) bears the upper layer structure (66) by means of the intermediate structure (70), and the natural frequency of the main body (62) is greater than or equal to √{square root over (2)} times the internal excitation frequency.

10. 发明申请

US20220279130A1 IMAGING METHOD, DEVICE AND SYSTEM 有权
公开(公告)号：US20220279130A1
公开(公告)日：2022-09-01
申请号：US17746838
申请日：2022-05-17
申请人： GeneMind Biosciences Company Limited
发明人： Linsen LI , Ruitao SUN , Jiahong XU , Zhiliang ZHOU , Zefei JIANG , Qin YAN
IPC分类号： H04N5/232 , G02B21/24
摘要： The present disclosure discloses a method and a system for imaging. The method for imaging objects using the system for imaging. The system for imaging comprises a lens. The objects comprise a first object, a second object and a third object located at different positions on a first preset track. The method for imaging comprises: allowing the lens and the first preset track to move relatively in a first predetermined relationship to acquire a clear image of the third object using the system for imaging without focusing, the first predetermined relationship is determined by a focal plane position of the first object and a focal plane position of the second object. The aforementioned method for imaging is high in imaging efficiency and is capable of fast focusing according to the first predetermined relationship even if focus tracking fails so that the blurring of a photographed image due to defocusing is avoided.

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