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1. 发明授权

US08070466B2 Seamless capsule manufacturing apparatus 有权
标题翻译：无缝胶囊制造装置
公开(公告)号：US08070466B2
公开(公告)日：2011-12-06
申请号：US12311491
申请日：2007-09-25
申请人： Narimichi Takei , Hiroshi Nagao
发明人： Narimichi Takei , Hiroshi Nagao
IPC分类号： B01J13/02
CPC分类号： B01J13/04 , A23P10/30 , A61J3/07
摘要： In a seamless capsule manufacturing apparatus that ejects a droplet from a nozzle into hardening liquid to manufacture a seamless capsule SC, tube passages which are synthetic resin tubes are provided as flexible sections between pumps and the nozzle. The vibration caused by the pumps is absorbed in the flexible sections and thus is not transmitted to the nozzle, whereby eyes or the like of the seamless capsule caused by vibration noises can be suppressed. Instead of a synthetic resin tube, a vibration absorbing block formed of an elastic member may be attached to the tube passages. Alternatively, a vibration absorbing unit, which is provided with a pad formed of an elastic member and for holding the tube passages, may be provided.
摘要翻译：在从喷嘴喷出液滴以形成无缝胶囊SC的无缝胶囊制造装置中，作为合成树脂管的管路被设置为泵和喷嘴之间的柔性部分。由泵引起的振动被吸收在柔性部分中，因此不会传递到喷嘴，从而可以抑制由振动噪声引起的无缝胶囊的眼睛等。代替合成树脂管，由弹性构件形成的振动吸收块可以附接到管道。或者，也可以设置有设置有由弹性部件形成并用于保持管状通道的垫的振动吸收单元。

2. 发明申请

US20100247665A1 Spherical Particle and Method for Producing the Same 审中-公开
标题翻译：球形颗粒及其制造方法
公开(公告)号：US20100247665A1
公开(公告)日：2010-09-30
申请号：US12740040
申请日：2008-11-18
申请人： Terumi Takahashi
发明人： Terumi Takahashi
IPC分类号： A61K9/16
CPC分类号： A61K47/26 , A61K9/1623 , A61K9/1652 , A61K9/1676 , A61K9/1682 , A61K47/38
摘要： A spherical particle of the present invention contains a sugar alcohol and a crystalline cellulose and/or powdered cellulose, wherein the mass ratio between the sugar alcohol and the crystalline cellulose and/or powdered cellulose is within a range from 50:50 to 90:10, the particle size is within a range from 75 to 250 μm, the sphericity is not less than 0.8, and the bulk density is not less than 0.6 g/ml. Further, a method for producing the spherical particle of the present invention includes a granulation step of rolling a sugar alcohol having an average particle size of not more than 40 μm and a crystalline cellulose and/or powdered cellulose having an average particle size of not more than 50 μm while spraying a liquid thereon.
摘要翻译：本发明的球形颗粒含有糖醇和结晶纤维素和/或粉末状纤维素，其中糖醇与结晶纤维素和/或粉末状纤维素之间的质量比在50:50至90:10的范围内粒度在75〜250μm的范围内，球形度不小于0.8，堆积密度不小于0.6g / ml。此外，本发明的球形颗粒的制造方法包括将平均粒径为40μm以下的糖醇和平均粒径不大的结晶纤维素和/或粉末状纤维素进行轧制的造粒步骤同时在其上喷洒液体。

3. 发明申请

US20100034956A1 Highly Water Dispersible Powder and Production Method Thereof 审中-公开
标题翻译：高水分散粉及其制备方法
公开(公告)号：US20100034956A1
公开(公告)日：2010-02-11
申请号：US12444732
申请日：2007-09-27
申请人： Hirotsune Yasumi , Masaru Ohmae
发明人： Hirotsune Yasumi , Masaru Ohmae
IPC分类号： A23L1/30
CPC分类号： A61K9/1658 , A61K9/1623 , A61K9/1652 , A61K31/047 , A61K31/122 , A61K31/355
摘要： Provided is a highly water dispersible powder which exhibits a high water dispersibility in spite of the inclusion of a poorly water soluble component, and maintains the high water dispersibility stably over time.The highly water dispersible powder includes a poorly water soluble component, a water soluble polymer having a protective colloid effect, and a saponin. The highly water dispersible powder can be produced by a method including: emulsifying a poorly water soluble component in an aqueous solvent under the presence of a water soluble polymer having a protective colloid effect and a saponin, thereby preparing an emulsion; and drying the obtained emulsion.
摘要翻译：提供了尽管包含难溶于水的组分，其表现出高水分散性的高度水分散性粉末，并且随着时间稳定地保持高的水分散性。高水分散性粉末包括水溶性差的组分，具有保护胶体作用的水溶性聚合物和皂苷。可以通过以下方法制备高度水分散性粉末：在具有保护胶体效应的水溶性聚合物和皂苷的存在下，将水难溶性成分乳化在水性溶剂中，由此制备乳液; 并干燥得到的乳液。

4. 发明授权

US10189054B2 Deviation handling apparatus and deviation handling method 有权
公开(公告)号：US10189054B2
公开(公告)日：2019-01-29
申请号：US15686723
申请日：2017-08-25
申请人： Freund Corporation
发明人： Shouji Fuchigami , Shigemi Isobe , Norikazu Saitou , Takashi Terada
IPC分类号： B65G53/40 , B07B13/16 , G01N33/15 , B07C5/342 , B65G53/56
摘要： A deviation handling apparatus for a continuous production system of granulated products includes a storage section for temporarily storing the products, an inspection section for inspecting selected physical properties of the products, a moving route switching section for switching the moving route of the products according to the results of the inspection and a discharge path for discharging the products judged as not meeting the specifications. The storage section has two shutoff valves and a storage chamber formed therebetween. The switching section has a switching valve having a normal position and a deviation position for causing a conveyance route to communicate with the discharge path. The deviation handling apparatus closes the shutoff valves to store products in the storage chamber and inspect properties of the products. When off-specification products are detected, the switching valve is switched to the deviation position and the products are discharged.

5. 发明申请

US20140000510A1 PAN COATING APPARATUS 审中-公开
标题翻译： PAN涂装设备
公开(公告)号：US20140000510A1
公开(公告)日：2014-01-02
申请号：US14019700
申请日：2013-09-06
申请人： FREUND CORPORATION
发明人： Yasutoyo FUSEJIMA , Takuya NAKAMURA , Takashi TERADA , Shigemi ISOBE
IPC分类号： B05C5/02
CPC分类号： B05C5/02 , A23G3/0095 , A23G3/26 , A23G4/025 , A23P20/10 , A23P20/15 , A23P20/18 , A61J3/005 , B01J2/14
摘要： A spray gun (31) is attached to a multi-function unit (32) movable in a horizontal direction and a perpendicular direction. The spray gun (31) is mounted to a support holder (33), and the support holder (33) is connected to a support arm (35) of the multi-function unit (32). The support arm (35) is attached to a unit cover (36) which is openable/closable with respect to a casing (2). The support holder (33) and the support arm (35) can hide and house a liquid hose and an air hose therein so that the hoses and the like are arranged in an apparatus in such a state as to be completely free from being exposed. An installation position of the spray gun (31) can be finely adjusted by the multi-function unit (32) during a coating process, thereby enabling a control for keeping constant distances between tablet surfaces and the spray gun (31).
摘要翻译：喷枪（31）安装在可在水平方向和垂直方向移动的多功能单元（32）上。喷枪（31）安装到支撑架（33）上，支撑架（33）连接到多功能单元（32）的支撑臂（35）。支撑臂（35）附接到相对于壳体（2）可打开/关闭的单元盖（36）。支撑架（33）和支撑臂（35）可以隐藏和容纳液体软管和空气软管，使得软管等被布置在完全没有暴露的状态下的装置中。喷涂枪（31）的安装位置可以在涂覆过程中通过多功能单元（32）进行精细调节，从而能够进行控制，以保持片剂表面和喷枪（31）之间的恒定距离。

6. 发明授权

US08555805B2 Pan coating apparatus 失效
标题翻译：泛涂装置
公开(公告)号：US08555805B2
公开(公告)日：2013-10-15
申请号：US13124716
申请日：2009-10-09
申请人： Yasutoyo Fusejima , Takuya Nakamura , Takashi Terada , Shigemi Isobe
发明人： Yasutoyo Fusejima , Takuya Nakamura , Takashi Terada , Shigemi Isobe
IPC分类号： A23G3/20 , B05C5/00 , B05C3/00 , B05B17/00 , B05B7/06 , B05B13/04
CPC分类号： B05C5/02 , A23G3/0095 , A23G3/26 , A23G4/025 , A23P20/10 , A23P20/15 , A23P20/18 , A61J3/005 , B01J2/14
摘要： A spray gun (31) is attached to a multi-function unit (32) movable in a horizontal direction and a perpendicular direction. The spray gun (31) is mounted to a support holder (33), and the support holder (33) is connected to a support arm (35) of the multi-function unit (32). The support arm (35) is attached to a unit cover (36) which is openable/closable with respect to a casing (2). The support holder (33) and the support arm (35) can hide and house a liquid hose and an air hose therein so that the hoses and the like are arranged in an apparatus in such a state as to be completely free from being exposed. An installation position of the spray gun (31) can be finely adjusted by the multi-function unit (32) during a coating process, thereby enabling a control for keeping constant distances between tablet surfaces and the spray gun (31).
摘要翻译：喷枪（31）安装在可在水平方向和垂直方向移动的多功能单元（32）上。喷枪（31）安装到支撑架（33）上，支撑架（33）连接到多功能单元（32）的支撑臂（35）。支撑臂（35）附接到相对于壳体（2）可打开/关闭的单元盖（36）。支撑架（33）和支撑臂（35）可以隐藏和容纳液体软管和空气软管，使得软管等被布置在完全没有暴露的状态下的装置中。喷涂枪（31）的安装位置可以在涂覆过程中通过多功能单元（32）进行精细调节，从而能够进行控制，以保持片剂表面和喷枪（31）之间的恒定距离。

7. 发明授权

US08506273B2 Seamless capsule manufacturing apparatus 有权
标题翻译：无缝胶囊制造装置
公开(公告)号：US08506273B2
公开(公告)日：2013-08-13
申请号：US13124210
申请日：2009-10-09
申请人： Masayuki Ikeda , Hiroshi Nagao
发明人： Masayuki Ikeda , Hiroshi Nagao
IPC分类号： B01J13/20 , B01J2/06
CPC分类号： B01J13/04 , A23P10/30 , A61J3/07
摘要： A liquid coolant supply pipe and an over flow pipe are provided on the outer side of a capsule forming pipe through which a liquid coolant flows and into which liquid droplets are dropped from a nozzle. The liquid coolant is supplied to the liquid coolant supply pipe by a low pulsatory motion type pump, and the flow is regulated by a flow straightening block in the liquid coolant supply pipe. The cooling liquid passes through a liquid coolant introducing section having a curved surface, and then flows into the capsule forming pipe from an upper portion opening in a cap mounted to the upper part of the capsule forming pipe. The liquid coolant flows into the capsule forming pipe, and the excess flows into the overflow pipe.
摘要翻译：液体冷却剂供给管和过流管设置在胶囊形成管的外侧，液体冷却剂通过该外部流动，液滴从喷嘴滴落。液体冷却剂通过低脉动式泵供给到液体冷却剂供给管，并且流动由液体冷却剂供给管中的流动矫正块调节。冷却液通过具有弯曲表面的液体冷却剂引入部分，然后从安装在胶囊形成管的上部的帽的开口上部流入胶囊形成管。液体冷却剂流入胶囊形成管，并且过量流入溢流管。

8. 外观设计

USD621426S1 Fluidized bed granulation coater 有权
标题翻译：流化床造粒涂布机
公开(公告)号：USD621426S1
公开(公告)日：2010-08-10
申请号：US29347367
申请日：2009-12-15
申请人： Iwao Fusejima , Kazuhiko Nara , Masayuki Omori
设计人： Iwao Fusejima , Kazuhiko Nara , Masayuki Omori

9. 发明授权

US07025911B2 Manufacturing method for oral quick-dissolving seamless capsule 失效
标题翻译：口服快速溶解无缝胶囊的制造方法
公开(公告)号：US07025911B2
公开(公告)日：2006-04-11
申请号：US10659511
申请日：2003-09-10
申请人： Katsuhiko Suzuki , Masayuki Ikeda
发明人： Katsuhiko Suzuki , Masayuki Ikeda
IPC分类号： B29B9/10
CPC分类号： A61K9/4833
摘要： A manufacturing method for oral quick-dissolving capsules, includes the steps of: preparing a core liquid that contains a filler material; preparing a shell liquid by having dissolved therein a shell material that includes one or more plasticizer and a shell forming agent; supplying to a multiple nozzle having an inner nozzle and an outer nozzle, and forming multilayer liquid drops by extruding the multilayer liquid drops from the multiple nozzle; hardening the shell liquid by bringing the multilayer liquid drops into contact with a hardening liquid; separating the seamless capsules from the hardening liquid; and drying their surface to form seamless capsules. The seamless capsules have a particle diameter of 1 to 10 mm, a mass ratio of shell material to filler material of 5:95 to 70:30, and the amount of added plasticizer is 20 to 70% by mass with respect to the total amount of the shell material, excluding water.
摘要翻译：口服快速溶解胶囊的制造方法包括以下步骤：制备含有填充材料的芯液; 通过在其中溶解包含一种或多种增塑剂和成壳剂的壳材料来制备壳液; 供给具有内喷嘴和外喷嘴的多喷嘴，通过从多喷嘴挤出多层液滴形成多层液滴; 通过使多层液滴与硬化液体接触来硬化壳液; 将无缝胶囊与硬化液分离; 并干燥其表面以形成无缝胶囊。无缝胶囊的粒径为1〜10mm，壳材与填料的质量比为5:95〜70:30，增塑剂的添加量相对于总量为20〜70质量％的外壳材料，不含水。

10. 发明授权

US08992196B2 Seamless capsule manufacturing apparatus 有权
标题翻译：无缝胶囊制造装置
公开(公告)号：US08992196B2
公开(公告)日：2015-03-31
申请号：US13129875
申请日：2009-10-09
申请人： Masayuki Ikeda , Hiroshi Nagao
发明人： Masayuki Ikeda , Hiroshi Nagao
IPC分类号： A23P1/04 , B29B9/00 , A61J3/07
CPC分类号： A23P1/04 , A23P10/30 , A61J3/07
摘要： A seamless capsule manufacturing apparatus (1) manufactures a seamless capsule by means of nozzles (2a-2d). A core liquid (5) and a coating liquid (6) are supplied to each of the nozzles (2a-2d) from pumps (16, 18) through distributors (21, 22). The distributors (21, 22) and the nozzles (2a-2d) are connected to each other by core liquid distributing tubes (23a-23d) and coating liquid distributing tubes (25a-25d), and each of the core liquid distributing tubes (23a-23d) and each of the coating liquid distributing tubes (25a-25d) have the same length. A vibrator (24) is mounted to the distributor (21), and the core liquid (5) is supplied to the nozzles (2a-2d) while being vibrated. Each of the distributors (21, 22) is provided with an air vent device (35), and air vent is performed appropriately.
摘要翻译：无缝胶囊制造装置（1）通过喷嘴（2a-2d）制造无缝胶囊。通过分配器（21,22）从泵（16,18）向每个喷嘴（2a-2d）供给芯液（5）和涂液（6）。分配器（21,22）和喷嘴（2a-2d）通过芯液分配管（23a-23d）和涂布液分配管（25a-25d）彼此连接，并且每个芯液分配管 23a-23d）和每个涂布液分配管（25a-25d）具有相同的长度。振动器（24）安装到分配器（21）上，并且芯体（5）在被振动的同时被供应到喷嘴（2a-2d）。每个分配器（21,22）设置有排气装置（35），并且适当地执行排气口。

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