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    • 1. 发明申请
    • Spherical Particle and Method for Producing the Same
    • 球形颗粒及其制造方法
    • US20100247665A1
    • 2010-09-30
    • US12740040
    • 2008-11-18
    • Terumi Takahashi
    • Terumi Takahashi
    • A61K9/16
    • A61K47/26A61K9/1623A61K9/1652A61K9/1676A61K9/1682A61K47/38
    • A spherical particle of the present invention contains a sugar alcohol and a crystalline cellulose and/or powdered cellulose, wherein the mass ratio between the sugar alcohol and the crystalline cellulose and/or powdered cellulose is within a range from 50:50 to 90:10, the particle size is within a range from 75 to 250 μm, the sphericity is not less than 0.8, and the bulk density is not less than 0.6 g/ml. Further, a method for producing the spherical particle of the present invention includes a granulation step of rolling a sugar alcohol having an average particle size of not more than 40 μm and a crystalline cellulose and/or powdered cellulose having an average particle size of not more than 50 μm while spraying a liquid thereon.
    • 本发明的球形颗粒含有糖醇和结晶纤维素和/或粉末状纤维素,其中糖醇与结晶纤维素和/或粉末状纤维素之间的质量比在50:50至90:10的范围内 粒度在75〜250μm的范围内,球形度不小于0.8,堆积密度不小于0.6g / ml。 此外,本发明的球形颗粒的制造方法包括将平均粒径为40μm以下的糖醇和平均粒径不大的结晶纤维素和/或粉末状纤维素进行轧制的造粒步骤 同时在其上喷洒液体。