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1. 发明公开

US20230394187A1 ANALYSIS OF BRIDGE-PILE FOUNDATION SYSTEM IN MULTI-LAYERED NON-LINEAR SOIL STRATA USING ENERGY-BASED METHOD 审中-公开
公开(公告)号：US20230394187A1
公开(公告)日：2023-12-07
申请号：US18204677
申请日：2023-06-01
申请人： FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES
发明人： Arvan Prakash ANKITHA , Madasamy AROCKIASAMY , Marco AMATO
IPC分类号： G06F30/13 , G01V99/00
CPC分类号： G06F30/13 , G01V99/005
摘要： Disclosed is a method for analyzing displacement responses of piles subjected to at least one loading condition selected from an axial load, a lateral load, and a bending moment. Also disclosed is a non-transitory machine-readable storage medium including instructions executable by a processing resource of a computing device to cause the processing resource to perform the inventive method.

2. 发明公开

US20230264794A1 APPARATUS AND METHOD FOR A FREE-SWIMMING SOFT UNDERWATER ROBOT USING ADAPTIVE THREE-AXIS DEPTH CONTROL TO MONITOR MARINE ENVIRONMENTS 审中-公开
公开(公告)号：US20230264794A1
公开(公告)日：2023-08-24
申请号：US18010703
申请日：2021-06-16
申请人： FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES
发明人： Erik ENGEBERG
IPC分类号： B63G8/00 , B63G8/16 , B63G8/08 , A01K29/00
CPC分类号： B63G8/001 , B63G8/16 , B63G8/08 , A01K29/00 , B63G2008/005
摘要： An underwater robot apparatus that is capable of omnidirectional lateral movement using Bluetooth, depth, temperature, and light sensors for monitoring the marine environment. The apparatus is an adaptive, three-axis control soft robotic apparatus embedded with sensors and can swim in three dimensions to record aquatic life. An adaptive controller within the soft robotic apparatus produces positive upward motion despite its negative buoyancy and additional pressure vessel mass. A submersible impellor pump is connected to each actuator grouping wherein propulsion is created by filling and emptying of nine tentacles with surrounding ambient water. The apparatus produces maximum thrust using a full stroke actuation scheme at a frequency of 0.3 Hz. In addition to upward motion, the apparatus effects lateral motion utilizing two of three sets of actuator groups for more complex travel. An onboard pressure sensor coupled with the adaptive controller, allows the apparatus to autonomously hold to a predetermined depth.

3. 发明公开

US20230211339A1 PORTABLE ELECTRICAL IMPEDANCE-BASED BLOOD TESTING DEVICE FOR DIAGNOSIS AND MONITORING SICKLE CELL DISEASE 审中-公开
公开(公告)号：US20230211339A1
公开(公告)日：2023-07-06
申请号：US18118277
申请日：2023-03-07
申请人： FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES
发明人： E Du , Darryl Dieujuste , Jia Liu , Yuhao Qiang
IPC分类号： B01L3/00 , G01N15/10 , G01N33/49
CPC分类号： B01L3/502715 , B01L3/502761 , G01N15/1031 , G01N33/4915 , B01L2300/06 , B01L2300/16 , B01L2300/025 , B01L2300/0645 , B01L2300/0809 , G01N2015/0073 , G01N2015/1006
摘要： An exemplary mobile impedance-based flow cytometer is developed for the diagnosis of sickle cell disease. The mobile cytometer may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable flow cytometer, analysis may be performed on two sickle cell samples and a healthy cell sample. The acquired results may subsequently be analyzed to extract single-cell level impedance information as well as statistics of different cell conditions. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions.

4. 发明授权

US11152795B2 Systems and methods for federated power management 有权
公开(公告)号：US11152795B2
公开(公告)日：2021-10-19
申请号：US16610336
申请日：2018-03-28
申请人： FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES
发明人： Jason O. Hallstrom , Jiannan Zhai , Chancey Kelley , Michael Brown , Alexander Roscoe
IPC分类号： H02J7/00 , H02J1/14 , A01G25/16 , H02J7/34
摘要： Systems and methods for providing federated power management in an electronic circuit. The methods comprise: performing first operations by a processing device to obtain information indicating a current level of charge for each of a plurality of capacitors which have been supplied energy from a power source; transforming, by the processing device, each capacitor's current level of charge into a number of service units for a respective electronic load device of a plurality of electronic load devices; determining, by the processing device, at least one of recharging priorities for the plurality of capacitors and discharging priorities for the plurality of capacitors at least based on the results of said transforming; and performing second operations by the processing device to cause the plurality of capacitors to be recharged in accordance with the recharging priorities or discharged in accordance with the discharging priorities.

5. 发明授权

US11149028B2 Methods for treating melanoma using small molecules 有权
公开(公告)号：US11149028B2
公开(公告)日：2021-10-19
申请号：US16469865
申请日：2017-12-15
申请人： NOVA SOUTHEASTERN UNIVERSITY , AUBURN UNIVERSITY , FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
发明人： Dmitriy Minond , Gregg B. Fields , Marcello Giulianotti
IPC分类号： A61K31/495 , C07D403/14 , A61P35/02 , G01N33/50 , G01N33/564 , G01N33/566
摘要： The invention provides methods for treating cancers, such as melanoma and/or metastatic melanoma, using compounds that interact with and/or inhibit cellular proteins lamin A/C, ATP-dependent RNA helicase DDX1 (DDX1), heterogeneous nuclear ribonuclear protein H1/H2 (hnRNP H2), and/or heterogeneous nuclear ribonuclear protein A2/B1 (hnRNP A2/B1). The invention additionally provides a method for identifying compounds active against melanoma cells.

6. 发明申请

US20210017048A1 SOLAR THERMAL MEMBRANE DISTILLATION SYSTEM FOR DRINKING WATER PRODUCTION 有权
公开(公告)号：US20210017048A1
公开(公告)日：2021-01-21
申请号：US17034866
申请日：2020-09-28
申请人： Florida Atlantic University Board of Trustees
发明人： Peng Yi , Rahamat Ullah Tanvir , Shahin Ahmed Sujon
IPC分类号： C02F1/44 , B01D61/36 , B01D69/02 , B01D67/00 , B01D71/34 , B01D71/02 , C02F1/14
摘要： A solar distillation device includes a feed water chamber having an open interior feed water compartment and a feed water inlet to the feed water compartment. A distillate chamber has a top and sides and an open interior distillate compartment, and a distillate water outlet in liquid communication with the distillate compartment. The top, the rear wall, and the sides of the distillate chamber includes a solar radiation transmissive portion. A distillation membrane separates the feed water compartment from the distillate compartment, and has a feed water facing surface and a distillate facing surface. The membrane can include a porous hydrophobic material, and the distillate surface of the distillation membrane can be black. The transmissive portion allows solar radiation to pass through the top, the rear wall, and the sides of the distillate chamber and strike the distillation membrane.

7. 发明授权

US10426143B2 Systems and methods for larval fish enumeration and growth monitoring 有权
公开(公告)号：US10426143B2
公开(公告)日：2019-10-01
申请号：US15877941
申请日：2018-01-23
申请人： Florida Atlantic University Board of Trustees
发明人： Bing Ouyang , Paul S. Wills , Fraser Dalgleish , Anni Dalgleish
IPC分类号： A01K61/90 , A01K61/95 , G06K9/00 , G06K9/20 , G06T7/62 , A01K61/10 , A01K63/06 , G06K9/36 , G06T5/00 , G06T7/11 , G06T7/174
摘要： Systems and methods for object enumeration in a culture tank. The methods comprise: obtaining an array of two dimensional images of an illuminated scene in a culture tank; correcting non-uniform background illumination in the two dimensional images; improving a color contrast between a background and object edges shown in the two dimensional images; performing a defocus analysis using the two dimensional images to generate a focus map image; generating a modified focus map image by eliminating isolated spots shown in the focus map image and merging relatively small spots with adjacent relatively large objects in the focus map image; classifying each object shown in the modified focus map image as an object of interest or an object of no interest; and counting the number of objects classified as objects of interest.

8. 发明授权

US08232266B2 Use of manzamine compounds in anti-cancer therapeutic regimens 有权
标题翻译：使用manzamine化合物在抗癌治疗方案
公开(公告)号：US08232266B2
公开(公告)日：2012-07-31
申请号：US11708767
申请日：2007-02-20
申请人： Esther A. Guzman , Jacob D. Johnson , Amy E. Wright
发明人： Esther A. Guzman , Jacob D. Johnson , Amy E. Wright
IPC分类号： A01N43/00 , A01N43/42 , A61K31/33 , A61K31/44
CPC分类号： A61K31/33 , A61K31/44 , A61K31/4745 , A61K45/06 , A61K2300/00
摘要： Manzamine compounds have been discovered to decrease cell dissociation and cell migration associated with the metastatic potential of cancer cells and a restoration of cancer cell susceptibility to agents, such as TRAIL, which can induce apoptosis. Specifically, Manzamine A has a formerly unrecognized utility in both blocking tumor cell invasion and tumor metastasis as well in restoring cancer cell susceptibility to standard chemotherapeutic agents which induce apoptosis and, therefore, has utility in treating cancer.
摘要翻译：已经发现曼烷胺化合物减少与癌细胞的转移潜能相关的细胞解离和细胞迁移，并恢复癌细胞对可诱导细胞凋亡的药物如TRAIL的易感性。具体来说，Manzamine A在阻断肿瘤细胞侵袭和肿瘤转移以及恢复癌细胞对诱导细胞凋亡的标准化学治疗剂的敏感性方面具有以前未被认识的用途，因此具有治疗癌症的效用。

9. 发明授权

US07626043B2 Antiproliferative activity of the leiodermatolide class of macrolides 失效
标题翻译：大环内酯类Liodermatolide类的抗增殖活性
公开(公告)号：US07626043B2
公开(公告)日：2009-12-01
申请号：US11890686
申请日：2007-08-06
申请人： Amy E. Wright , John K. Reed , Jill Roberts , Ross E. Longley
发明人： Amy E. Wright , John K. Reed , Jill Roberts , Ross E. Longley
IPC分类号： C07D313/04 , A01N43/02
CPC分类号： C07D407/06
摘要： The subject invention provides novel biologically active compounds that have utility for use in inhibiting cellular proliferation. Pharmaceutical compositions comprising these compounds are also provided. In a specific embodiment, the compounds and compositions of the subject invention can be used in the treatment of cancer.
摘要翻译：本发明提供了可用于抑制细胞增殖的新型生物活性化合物。还提供了包含这些化合物的药物组合物。在具体实施方案中，本发明的化合物和组合物可用于治疗癌症。

10. 发明申请

US20050182000A1 Anti-inflammatory compounds derived from Pseudopterogorgia elisabethae 失效
标题翻译：衍生自Pseudopterogorgia elisabethae的抗炎化合物
公开(公告)号：US20050182000A1
公开(公告)日：2005-08-18
申请号：US10903261
申请日：2004-08-02
申请人： Robert Jacobs , Russell Kerr
发明人： Robert Jacobs , Russell Kerr
IPC分类号： A61P29/00 , C07H15/24 , A61K31/704
CPC分类号： C07H15/24
摘要： Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formula wherein R1 is a hydrogen, alkyl, aryl, hydroxyalkyl, cycloalkyl, cycloalkenyl, carboxylic acid, alkylamino or amide group having from 2 to 20 carbon atoms, R2, R3, and R4 are each independently hydrogen or an acyl residue having from 1 to 6 carbon atoms, R5 is hydrogen, CH3, or CH2OH, and R6 is an organo group such as a hydrocarbon having from 1 to 10 carbon atoms are disclosed. Other seco-pseudopterosins and compounds related to pseudopterosins are disclosed.
摘要翻译：用于治疗，预防或抑制与炎症，细胞增殖和疼痛相关的疾病和病症的方法，包括施用具有以下结构式的化合物：其中R 1是氢，烷基，芳基，羟烷基，具有2至20个碳原子的环烷基，环烯基，羧酸，烷基氨基或酰胺基，R 2，R 3和R 4，各自独立地为氢或具有1至6个碳原子的酰基，R 5为氢，CH 3或CH 2 OH，和R 6是有机基团，例如具有1至10个碳原子的烃。公开了其他与假飞虱相关的鳞翅目和化合物。

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