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1. 发明申请

US20050182000A1 Anti-inflammatory compounds derived from Pseudopterogorgia elisabethae 失效
标题翻译：衍生自Pseudopterogorgia elisabethae的抗炎化合物
公开(公告)号：US20050182000A1
公开(公告)日：2005-08-18
申请号：US10903261
申请日：2004-08-02
申请人： Robert Jacobs , Russell Kerr
发明人： Robert Jacobs , Russell Kerr
IPC分类号： A61P29/00 , C07H15/24 , A61K31/704
CPC分类号： C07H15/24
摘要： Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formula wherein R1 is a hydrogen, alkyl, aryl, hydroxyalkyl, cycloalkyl, cycloalkenyl, carboxylic acid, alkylamino or amide group having from 2 to 20 carbon atoms, R2, R3, and R4 are each independently hydrogen or an acyl residue having from 1 to 6 carbon atoms, R5 is hydrogen, CH3, or CH2OH, and R6 is an organo group such as a hydrocarbon having from 1 to 10 carbon atoms are disclosed. Other seco-pseudopterosins and compounds related to pseudopterosins are disclosed.
摘要翻译：用于治疗，预防或抑制与炎症，细胞增殖和疼痛相关的疾病和病症的方法，包括施用具有以下结构式的化合物：其中R 1是氢，烷基，芳基，羟烷基，具有2至20个碳原子的环烷基，环烯基，羧酸，烷基氨基或酰胺基，R 2，R 3和R 4，各自独立地为氢或具有1至6个碳原子的酰基，R 5为氢，CH 3或CH 2 OH，和R 6是有机基团，例如具有1至10个碳原子的烃。公开了其他与假飞虱相关的鳞翅目和化合物。

2. 发明授权

US09781064B2 Method and system for creating and distributing electronic postcards 有权
公开(公告)号：US09781064B2
公开(公告)日：2017-10-03
申请号：US14447451
申请日：2014-07-30
申请人： Robert Jacobs , Eric D. Kroll
发明人： Robert Jacobs , Eric D. Kroll
IPC分类号： G06F15/16 , H04L12/58
CPC分类号： H04L51/10
摘要： Method and system for creating and distributing professional quality electronic postcards are provided. An accessible library of numerous photographs/videos taken by professionals is maintained, for example, on a app or website. Access to the app or website can be accomplished using any suitable input device, for example smart phones, tablets, laptops, computers etc. Following a series of simple steps, users select from an assortment of images, videos, photos, messages, etc., to create an electronic postcard. Users have their own pages on the app or website, where sent and received electronic postcards are stored. A simple method for creating albums from the user's electronic postcards is also provided.

3. 发明申请

US20090170851A1 Chroman Compounds 审中-公开
标题翻译：色甘酸化合物
公开(公告)号：US20090170851A1
公开(公告)日：2009-07-02
申请号：US12403553
申请日：2009-03-13
申请人： Peter Bernstein , Daniel Hill , David Nugiel , Edward Pierson , Ashokkumar Shenvi , Robert Jacobs
发明人： Peter Bernstein , Daniel Hill , David Nugiel , Edward Pierson , Ashokkumar Shenvi , Robert Jacobs
IPC分类号： A61K31/5377 , A61P25/22
CPC分类号： C07D311/66
摘要： Compounds according to Formula (I): wherein R1, R2, R3, and R4 are as defined in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译：根据式（I）的化合物：其中R 1，R 2，R 3和R 4如本说明书中所定义，药学上可接受的盐，制备方法，药物组合物及其使用方法。

4. 发明申请

US20070191422A1 Nicotinic acetylcholine receptor ligands 审中-公开
标题翻译：烟碱乙酰胆碱受体配体
公开(公告)号：US20070191422A1
公开(公告)日：2007-08-16
申请号：US10583581
申请日：2004-12-20
申请人： Glen Ernst , Robert Jacobs , Eifion Phillips
发明人： Glen Ernst , Robert Jacobs , Eifion Phillips
IPC分类号： A61K31/4745 , C07D453/02
CPC分类号： C07D453/02
摘要： Compounds of formula (I), wherein D, Ar1, E and Ar2 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.
摘要翻译：式（I）化合物，其中D，Ar1，E和Ar2如本说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是治疗或预防精神病和智力障碍障碍。

5. 发明申请

US20070006146A1 Systems and apparatus for enhanced mobile computing platforms 审中-公开
标题翻译：用于增强移动计算平台的系统和设备
公开(公告)号：US20070006146A1
公开(公告)日：2007-01-04
申请号：US11165815
申请日：2005-06-24
申请人： Wah Kwong , Prosenjit Ghosh , Katie Mills , Jim Trethewey , Robert Jacobs , Tim Nguyen , Asim Sadiq , Shreekant Thakkar , Murali Veeramoney , Truong Phan
发明人： Wah Kwong , Prosenjit Ghosh , Katie Mills , Jim Trethewey , Robert Jacobs , Tim Nguyen , Asim Sadiq , Shreekant Thakkar , Murali Veeramoney , Truong Phan
IPC分类号： G06F9/44
CPC分类号： G06F1/18
摘要： According to some embodiments, systems and apparatus for enhanced mobile computing platforms are provided. For example, an apparatus or system may comprise a universal computational package, comprising a processor, a memory coupled to the processor, a plurality of instructions stored in the memory directed to at least one specific use of the universal computational package, and a plurality of interface controllers coupled to the processor, wherein each of the plurality of interface controllers is operable to cause the processor to execute the plurality of stored instructions in accordance with the presence of a use-specific user interface cover associated with the at least one specific use of the universal computational package.
摘要翻译：根据一些实施例，提供了用于增强的移动计算平台的系统和装置。例如，装置或系统可以包括通用计算包，包括处理器，耦合到处理器的存储器，存储在存储器中的多个指令，用于至少一个特定使用的通用计算包，以及多个接口控制器，其耦合到所述处理器，其中所述多个接口控制器中的每一个可操作以使得所述处理器根据与所述至少一个特定使用相关联的使用特定用户界面覆盖的存在来执行所述多个存储的指令通用的计算包。

6. 发明授权

US5860653A Method and apparatus for playing a word game 失效
标题翻译：播放文字游戏的方法和装置
公开(公告)号：US5860653A
公开(公告)日：1999-01-19
申请号：US441493
申请日：1995-05-15
申请人： Robert Jacobs
发明人： Robert Jacobs
IPC分类号： G06Q10/10 , A63F9/22
CPC分类号： G06Q10/107
摘要： Apparatus and method for playing an anagram-type game in a game show or computer game format. One or more anagrams, each comprised of scrambled letters, are displayed on a gameboard. At least one object of the game is to guess the unscrambled solution to each anagram. When correctly guessed, the letters are moved from their scrambled configuration to their unscrambled configuration. An ultimate solution to the puzzle is preferrably revealed by some of the letters of the collective unscrambled anagrams which are moved into a predetermined alignment. Several means are included for making it easier to view, study and follow the progress of the game such as moving each letter along a path, leaving outlines of the letters in their initial positions, and indicating which anagram is to be guessed by a player.
摘要翻译：用于在游戏节目或计算机游戏格式中播放卦式游戏的装置和方法。每个包括乱码的一个或多个卦语显示在游戏板上。游戏的至少一个对象是猜测每个卦语的解扰解。当被正确猜测时，这些字母从他们的加扰配置移动到他们的未加扰配置。拼图的最终解决方案最好是通过集合的未加扰的卦语的一些字母来显示，这些字母被移动到预定的对齐位置。包括了几种手段，使其更容易查看，学习和跟踪游戏的进展，例如沿着路径移动每个字母，将字母的轮廓留在其初始位置，并指示玩家猜测哪个卦语。

7. 发明授权

US09440994B2 Boron containing small molecules as antiprotozoal agents 有权
标题翻译：含有小分子的硼作为抗原虫剂
公开(公告)号：US09440994B2
公开(公告)日：2016-09-13
申请号：US12852351
申请日：2010-08-06
申请人： Daitao Chen , Matthew Orr , Jessica Sligar , Robert Jacobs , Jacob J. Plattner
发明人： Daitao Chen , Matthew Orr , Jessica Sligar , Robert Jacobs , Jacob J. Plattner
IPC分类号： C07F5/02
CPC分类号： C07F5/025 , A01N55/08 , A61K31/69
摘要： This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent. The exemplary compounds have the following formula: wherein X is selected from the group consisting of substituted phenyl, substituted or unsubstituted heteroaryl and unsubstituted cycloalkyl; R3a is selected from the group consisting of H, unsubstituted C1 or C2 or C3 or C4 or C5 or C6 alkyl and unsubstituted C3 or C4 or C5 or C6 cycloalkyl; R3b is selected from the group consisting of H, unsubstituted C1 or C2 or C3 or C4 or C5 or C6 alkyl and unsubstituted C3 or C4 or C5 or C6 cycloalkyl; with the proviso that R3a and R3b, along with the atom to which they are attached, are optionally joined to form a 3 or 4 or 5 or 6 membered ring, with the proviso that R3a and R3b cannot both be H, or a salt thereof.

8. 发明申请

US20080311609A1 Novel Molecular Probes 审中-公开
标题翻译：新型分子探针
公开(公告)号：US20080311609A1
公开(公告)日：2008-12-18
申请号：US11721461
申请日：2005-12-14
申请人： Barry Greenberg , Daniel C. Hill , Robert Jacobs , Sangram S. Sisodia
发明人： Barry Greenberg , Daniel C. Hill , Robert Jacobs , Sangram S. Sisodia
IPC分类号： C12Q1/02 , C07D267/14 , C07D495/04 , C07F5/02
CPC分类号： C07K5/0827 , C07D267/14 , C07D413/14 , C07D495/04 , C07F5/022 , C07K5/0806
摘要： The present invention relates to novel molecular probes having the formula (I) (I) useful for the characterization, detection, localization and isolation of the γ-secretase enzyme.
摘要翻译：本发明涉及可用于表征，检测，定位和分离γ-分泌酶的具有式（I）（I）的新型分子探针。

9. 发明申请

US20070270458A1 Nicotinic Acetylcholine Receptor Ligands 审中-公开
标题翻译：烟碱乙酰胆碱受体配体
公开(公告)号：US20070270458A1
公开(公告)日：2007-11-22
申请号：US10583582
申请日：2004-12-20
申请人： Glen Ernst , Robert Jacobs , Eifion Phillips
发明人： Glen Ernst , Robert Jacobs , Eifion Phillips
IPC分类号： A61K31/439 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/34 , C07D453/02
CPC分类号： C07D453/02
摘要： Compounds of formula I: wherein D, Ar1, E and Ar2 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.
摘要翻译：式I化合物：其中D，Ar 1，E和Ar 2如说明书中所定义，制备方法，含有它们的药物组合物及其在治疗中的用途，特别是治疗或预防精神病和智力障碍。

10. 发明申请

US20070010526A1 Therapeutic isoquinoline compounds 审中-公开
标题翻译：治疗异喹啉化合物
公开(公告)号：US20070010526A1
公开(公告)日：2007-01-11
申请号：US10494424
申请日：2002-11-01
申请人： Markus Haeberlein , Christof Angst , Daniel Hill , Robert Jacobs , Gary Moore , Edward Pierson , Ashokkumar Shenvi
发明人： Markus Haeberlein , Christof Angst , Daniel Hill , Robert Jacobs , Gary Moore , Edward Pierson , Ashokkumar Shenvi
IPC分类号： A61K31/496 , A61K31/4709 , C07D403/02 , C07D401/02
CPC分类号： C07D401/04 , C07D217/04 , C07D217/06 , C07D401/12 , C07D405/06 , C07D413/10 , C07D413/12 , C07D417/12
摘要： Provided herein is a compound of the formula (I), wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.
摘要翻译：本文提供了式（I）的化合物，其中所述化合物可用于治疗精神障碍，包括但不限于抑郁症，广泛性焦虑症，进食障碍，痴呆症，惊恐障碍和睡眠障碍。该化合物还可用于治疗胃肠道疾病，心血管调节，运动障碍，内分泌障碍，血管痉挛和性功能障碍。该化合物是5HT 1B和5HT 1D 1拮抗剂。

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