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1. 发明公开

US20240019344A1 METHOD FOR COLLECTING AND PRESERVING A BIOLOGICAL SAMPLE 审中-公开
公开(公告)号：US20240019344A1
公开(公告)日：2024-01-18
申请号：US18165681
申请日：2023-02-07
申请人： DNA GENOTEK, INC.
发明人： Youssef BIADILLAH , Stephen D. ANDREWS
IPC分类号： G01N1/30 , A61B10/00 , B01L3/00 , G01N1/10
CPC分类号： G01N1/30 , A61B10/0051 , A61B10/007 , A61B10/0096 , B01L3/502 , G01N1/10 , G01N2001/002
摘要： The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.

2. 发明授权

US11753616B2 Composition and method for stabilizing and maintaining the viability of hardy microorganisms 有权
公开(公告)号：US11753616B2
公开(公告)日：2023-09-12
申请号：US15313812
申请日：2015-05-27
申请人： DNA Genotek Inc.
发明人： H. Chaim Birnboim , Cassandra Kelly-Cirino , Bitapi Ray , Jacques Oscar Everard Niles , Olle Maarten de Bruin
IPC分类号： C12N1/04 , C12N1/20 , C12Q1/24 , C12Q1/00
CPC分类号： C12N1/20 , C12N1/04 , C12Q1/00 , C12Q1/24
摘要： The present application is to provide a composition and method for stabilizing and maintaining the viability of hardy microorganisms from sample collection to downstream analysis. In particular, there is a method for preserving viable hardy bacteria, such as Mycobacteria, Bacillus anthracis, or Clostridium difficile, in a biological sample, comprising contacting the biological sample with a stabilization composition, wherein the stabilization composition comprises a chelating agent, a denaturing, a salt and has a pH between about 6 and about 11.

3. 发明授权

US11592368B2 Method for collecting and preserving a biological sample 有权
公开(公告)号：US11592368B2
公开(公告)日：2023-02-28
申请号：US17509961
申请日：2021-10-25
申请人： DNA GENOTEK, INC.
发明人： Youssef Biadillah , Stephen D. Andrews
IPC分类号： G01N1/30 , A61B10/00 , B01L3/00 , G01N1/10 , G01N1/00
摘要： The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.

4. 发明申请

US20230051962A1 SAMPLE RECEIVING DEVICE 有权
公开(公告)号：US20230051962A1
公开(公告)日：2023-02-16
申请号：US17706442
申请日：2022-03-28
申请人： DNA Genotek Inc.
发明人： Ian Curry , Roy Sunstrum , Adele Jackson , Rod Muir , Romeo Graham , Mike Sirois
IPC分类号： B01L3/00 , A61B10/00
摘要： The present invention generally relates to a sample receiving device for releasably storing a substance. The sample receiving device includes a lid having a reservoir for retaining the substance, and a pierceable barrier sealing the substance within the reservoir; and b) a funnel for receiving a sample and configured for closure by the lid. The funnel is configured for releasable attachment to a sample receptacle such that a sample can be provided to the funnel and travel through the channel in the funnel into the sample receptacle. Further, the funnel includes one or more cutting ribs for cutting the pierceable barrier such that upon cutting of the pierceable barrier the substance is released from the reservoir, flows through the channel in the funnel and into the sample receptacle to be mixed with the sample. The present invention also provides a kit for collecting and storing biomolecules.

5. 发明授权

US11002646B2 Devices, solutions and methods for sample collection 有权
公开(公告)号：US11002646B2
公开(公告)日：2021-05-11
申请号：US16879506
申请日：2020-05-20
申请人： DNA GENOTEK, INC.
发明人： Youssef Biadillah , Stephen D. Andrews
IPC分类号： G01N1/30 , A61B10/00 , B01L3/00 , G01N1/10 , G01N1/00
摘要： The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.

6. 外观设计

USD640794S1 Sample collection tool 有权
标题翻译：样本收集工具
公开(公告)号：USD640794S1
公开(公告)日：2011-06-28
申请号：US29358425
申请日：2010-03-26
申请人： Roy Sunstrum , H. Chaim Birnboim , Adele Jackson , Rafal Michal Iwasiow , Romeo Graham , Rod Muir , Mike Sirois , Michael Beach , Ellen Joan Maclean , Rama Nadia Panford-Walsh
设计人： Roy Sunstrum , H. Chaim Birnboim , Adele Jackson , Rafal Michal Iwasiow , Romeo Graham , Rod Muir , Mike Sirois , Michael Beach , Ellen Joan Maclean , Rama Nadia Panford-Walsh

7. 发明授权

US07482116B2 Compositions and methods for obtaining nucleic acids from sputum 有权
标题翻译：用于从痰中获得核酸的组合物和方法
公开(公告)号：US07482116B2
公开(公告)日：2009-01-27
申请号：US10455680
申请日：2003-06-05
申请人： H. Chaim Birnboim
发明人： H. Chaim Birnboim
IPC分类号： C12Q1/68 , C12P19/34 , C07H1/00 , C07H5/04 , C07H19/00 , C07H21/00
CPC分类号： C12Q1/6806 , B01L3/502 , B01L3/5082 , B01L2300/042 , B01L2300/046 , B01L2300/047 , B01L2300/0672 , B01L2300/0832 , B01L2400/0683 , C12N15/1003 , C12Q2527/125 , C12Q2527/119
摘要： The present invention relates to compositions and methods for preserving and extracting nucleic acids from saliva. The compositions include a chelating agent, a denaturing agent, buffers to maintain the pH of the composition within ranges desirable for DNA and/or RNA. The compositions may also include a reducing agent and/or antimicrobial agent. The invention extends to methods of using the compositions of the invention to preserve and isolate nucleic acids from saliva as well as to containers for the compositions of the invention.
摘要翻译：本发明涉及从唾液中保存和提取核酸的组合物和方法。组合物包括螯合剂，变性剂，将组合物的pH保持在DNA和/或RNA所需的范围内的缓冲液。组合物还可以包括还原剂和/或抗微生物剂。本发明延伸到使用本发明组合物保存和分离核酸与唾液以及用于本发明组合物的容器的方法。

8. 外观设计

USD574507S1 Vial 有权
标题翻译：小瓶
公开(公告)号：USD574507S1
公开(公告)日：2008-08-05
申请号：US29284062
申请日：2007-08-30
申请人： Rod Muir , Derek Kirkland , Roy Sunstrum , Paul Lem , Ian Curry
设计人： Rod Muir , Derek Kirkland , Roy Sunstrum , Paul Lem , Ian Curry

9. 发明公开

US20240271184A1 LOW PH COMPOSITION AND METHOD FOR STABILIZING NUCLEIC ACIDS IN BIOLOGICAL SAMPLES 审中-公开
公开(公告)号：US20240271184A1
公开(公告)日：2024-08-15
申请号：US18568538
申请日：2022-06-08
申请人： DNA Genotek Inc.
发明人： Brice Georges Le Francois , Alaya Mikalauskas , Bitapi Ray , Rafal Michal Iwasiow
IPC分类号： C12Q1/6806
CPC分类号： C12Q1/6806
摘要： An aqueous composition for stabilizing nucleic acid contained in a biological sample at ambient temperature is provided. The aqueous composition comprises: (i) a denaturing agent selected from sodium dodecyl sulphate (SDS) or a guanidinium salt; (ii) aurintricarboxylic acid (ATA); and (iii) at least one of a chelating agent and a buffering agent; wherein the composition has a pH of 4.9 or less. A method of stabilizing nucleic acid contained in a biological sample at ambient temperature is also provided, wherein the method comprises the steps of: a) obtaining a biological sample; b) contacting the biological sample with the above-noted aqueous composition to form a mixture; c) homogenizing the mixture of (b) to form a homogeneous mixture; and d)storing the homogeneous mixture at ambient temperature.

10. 发明授权

US12038434B2 Devices, solutions and methods for sample collection related applications, analysis and diagnosis 有权
公开(公告)号：US12038434B2
公开(公告)日：2024-07-16
申请号：US15549975
申请日：2016-02-09
申请人： DNA Genotek, Inc.
发明人： Stephen Andrews , Youssef Biadillah , Manasi Jain , David S. Frank , John R Zeman , Charles T. Tackney
IPC分类号： G01N33/50 , G01N33/543
CPC分类号： G01N33/5091 , G01N33/5005 , G01N33/54393 , G01N2333/16 , G01N2333/70514 , G01N2333/70517
摘要： A solution is described for preserving cells and/or extra-cellular components in naturally expressed bodily fluids (e.g. saliva, sputum, urine) for further downstream analysis and/or for diagnosis of a medical condition. The solution may be hypertonic with respect to blood. Techniques are described for enriching cells from a sample of a naturally expressed bodily fluid, and/or for analysis, e.g. to diagnose medical conditions such as cancer, obesity, infections, autism, Alzheimer disease, hetotological disorders, cardiovascular disease or disorders, diabetes, vulnerable plack, LTBI, HIV infection, COPD, ACQS.

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