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1. 发明授权

US07910200B2 Multilayer foam composite element with recesses 有权
标题翻译：具有凹槽的多层泡沫复合材料
公开(公告)号：US07910200B2
公开(公告)日：2011-03-22
申请号：US12282449
申请日：2007-03-01
申请人： Christof Mock , Bernhard Vath
发明人： Christof Mock , Bernhard Vath
IPC分类号： B32B3/26 , B32B3/30
CPC分类号： E04B1/86 , B32B3/30 , B32B5/245 , B32B5/32 , B32B27/065 , B32B2266/0257 , B32B2266/0278 , B32B2266/0285 , B32B2266/06 , B32B2307/102 , B32B2307/304 , B32B2307/73 , B32B2605/00 , E04B2001/8476 , G10K11/168 , Y10T428/24273 , Y10T428/2495 , Y10T428/249978 , Y10T428/249979 , Y10T428/249981
摘要： A multilayer foam composite element whose total thickness d comprises at least three layers composed of an open-cell foam, where at least one of the internal layers has recesses and the two outermost layers have no recesses, wherein i) the volume of the recesses in the internal layer having recesses is from 20 to 70% by volume, and ii) the thickness of the layer having recesses is from 20 to 80% of the total thickness d.
摘要翻译：一种多层泡沫复合元件，其总厚度d包括由开孔泡沫构成的至少三层，其中至少一个内层具有凹部，两个最外层没有凹部，其中i）具有凹部的内部层为20〜70体积％，ii）具有凹部的层的厚度为总厚度d的20〜80％。

2. 发明授权

US07863393B2 Method for producing polyoxymethylenes 有权
标题翻译：聚甲醛生产方法
公开(公告)号：US07863393B2
公开(公告)日：2011-01-04
申请号：US11720414
申请日：2005-11-28
申请人： Jens Assmann , Knut Zollner , Johannes Heinemann , Elmar Stockelmann , Achim Stammer
发明人： Jens Assmann , Knut Zollner , Johannes Heinemann , Elmar Stockelmann , Achim Stammer
IPC分类号： C08F2/00
CPC分类号： B01J19/0053 , B01J19/2415 , C08G2/08 , C08G2/10 , C08G2/22 , C08G2/30
摘要： Process for preparation of polyoxymethylenes via polymerization of the monomers a) in the presence of cationic initiators b), and also, if appropriate, in the presence of regulators c), and subsequent deactivation and isolation of the polymer, which comprises undertaking the polymerization in a tubular reactor with static mixing elements and with a mixing zone, a polymerization zone, and a deactivation zone, the diameter of the tubular reactor in the mixing zone being
摘要翻译：通过单体的聚合制备聚甲醛的方法a）在阳离子引发剂b）的存在下，以及如果合适的话，在调节剂c）的存在下，以及随后的聚合物的失活和分离，其包括进行聚合反应具有静态混合元件和混合区域，聚合区域和失活区域的管式反应器，混合区域中的管式反应器的直径在聚合区域中的直径的90％。

3. 发明申请

US20090298137A1 MICROORGANISM AND PROCESS FOR THE PREPARATION OF L-METHIONINE 失效
标题翻译：用于制备L-甲硫氨酸的微生物和方法
公开(公告)号：US20090298137A1
公开(公告)日：2009-12-03
申请号：US12091948
申请日：2006-10-23
申请人： Oskar Zelder , Andreas Herold , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
发明人： Oskar Zelder , Andreas Herold , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
IPC分类号： C12P13/12 , C12N1/21
CPC分类号： C12P13/12 , A23K10/16 , A23K20/142 , A23K40/10 , C12N15/52
摘要： The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.
摘要翻译：本发明涉及用于有效制备L-氨基酸如L-甲硫氨酸的微生物和方法。特别地，本发明涉及微生物和其中甲硫氨酸途径中高山ion素的形成和/或积累减少和/或预防的方法。

4. 发明授权

US07435835B2 Method for producing enantiomer-pure aminoalcohols 有权
标题翻译：产生对映体纯氨基醇的方法
公开(公告)号：US07435835B2
公开(公告)日：2008-10-14
申请号：US10587440
申请日：2005-01-18
申请人： Rainer Stürmer
发明人： Rainer Stürmer
IPC分类号： C07D333/18 , C07D333/24
CPC分类号： C07D333/16
摘要： The invention relates to a process for preparing enantiomerically pure alcohol of the formula 1, which comprises (i) reducing the ketone of the formula 3to the racemic alcohol of the formula 4, (ii) enantioselectively acylating the racemic alcohol of the formula 4 with succinic anhydride in the presence of a lipase to give the succinic semiester of the formula 7, (iii) separating off the succinic semiester of the formula 7 from the unreacted enantiomer of the formula 4, (iv) reacting the enantiomerically pure alcohol of the formula 4 with methylamine to give the enantiomerically pure alcohol of the formula 1.
摘要翻译：本发明涉及一种制备式1对映体纯的醇的方法，其包括（i）将式3的酮还原成式4的外消旋醇，（ii）用琥珀酸对映选择性酰化式4的外消旋醇在脂肪酶存在下，得到式7的琥珀酸半酯，（iii）将式7的琥珀酸半酯与式4的未反应的对映异构体分离，（iv）使式4的对映体纯的醇与甲胺反应，得到式1的对映体纯的醇。

5. 发明申请

US20070099213A1 Corynebacterium glutamicum genes encoding novel proteins 审中-公开
公开(公告)号：US20070099213A1
公开(公告)日：2007-05-03
申请号：US11507097
申请日：2006-08-17
申请人： Markus Pompejus , Burkhard Kroger , Hartwig Schroder , Oskar Zelder , Gregor Haberhauer
发明人： Markus Pompejus , Burkhard Kroger , Hartwig Schroder , Oskar Zelder , Gregor Haberhauer
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12P13/04 , C12N9/10 , C12N1/21 , C12N15/74
CPC分类号： C07K14/34 , C07H21/02 , C07H21/04 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24
摘要： Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCP proteins, mutated MCP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCP genes in this organism.

6. 发明申请

US20070042474A1 Corynebacterium glutamicum genes encoding novel proteins 审中-公开
标题翻译：谷氨酸棒杆菌基因编码新蛋白
公开(公告)号：US20070042474A1
公开(公告)日：2007-02-22
申请号：US11092052
申请日：2005-03-28
申请人： Markus Pompejus , Burkhard Kroger , Hartwig Schroder , Oskar Zelder , Gregor Haberhauer
发明人： Markus Pompejus , Burkhard Kroger , Hartwig Schroder , Oskar Zelder , Gregor Haberhauer
IPC分类号： C12P21/06 , C12P19/28 , C12P13/04 , C07H21/04 , C12N1/21
CPC分类号： C07K14/34 , C07H21/02 , C07H21/04 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24
摘要： Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCP proteins, mutated MCP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCP genes in this organism.
摘要翻译：描述了编码来自谷氨酸棒杆菌的新型MCP蛋白质的分离的核酸分子，命名为MCP核酸分子。本发明还提供反义核酸分子，含有MCP核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。本发明还进一步提供了分离的MCP蛋白，突变的MCP蛋白，融合蛋白，抗原肽和用于根据该生物体中MCP基因的遗传工程改进从谷氨酸棒球菌生产所需化合物的方法。

7. 发明申请

US20050208506A1 Methods and compositions for analyzing AHASL genes 有权
标题翻译：用于分析AHASL基因的方法和组合物
公开(公告)号：US20050208506A1
公开(公告)日：2005-09-22
申请号：US10805973
申请日：2004-03-22
申请人： Chengyan Zhao , Robert Ascenzi , Bijay Singh
发明人： Chengyan Zhao , Robert Ascenzi , Bijay Singh
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6876 , C12Q1/6895 , C12Q2600/156
摘要： The invention relates to methods and compositions for analyzing plant acetohydroxy acid synthase large subunit (AHASL) genes. In particular, the invention relates to methods for the detection of wild-type AHASL alleles and mutant AHASL alleles that encode imidazolinone-tolerant AHASL proteins. The methods involve the use of PCR amplification and novel compositions comprising allele-specific and gene-specific primers to detect the presence of mutant and/or wild-type alleles present at the individual AHASL genes of a plant. Specifically, the methods and compositions are useful for analyzing the three AHASL genes of Triticum aestivum and the two AHASL genes of Triticum turgidum ssp. durum.
摘要翻译：本发明涉及用于分析植物乙酰羟酸合酶大亚基（AHASL）基因的方法和组合物。特别地，本发明涉及检测野生型AHASL等位基因的方法和编码咪唑啉酮耐受性AHASL蛋白的突变型AHASL等位基因。所述方法包括使用PCR扩增和包含等位基因特异性和基因特异性引物的新型组合来检测存在于植物个体AHASL基因的突变体和/或野生型等位基因的存在。具体地说，该方法和组合物可用于分析小麦Triticum aestivum的三种AHASL基因和Twiticum turgidum ssp的两种AHASL基因。硬粒小麦

8. 发明申请

US20050153402A1 Corynebacterium glutamicum genes encoding regulatory proteins 审中-公开
标题翻译：谷氨酸棒杆菌基因编码调节蛋白
公开(公告)号：US20050153402A1
公开(公告)日：2005-07-14
申请号：US11006098
申请日：2004-12-06
申请人： Markus Pompejus , Burkhard Kroger , Hartwig Schroder , Oskar Zelder , Gregor Haberhauer
发明人： Markus Pompejus , Burkhard Kroger , Hartwig Schroder , Oskar Zelder , Gregor Haberhauer
IPC分类号： C07K14/34 , C12N9/00 , C12N9/18 , C12N9/90 , C12P13/04 , C07H21/04 , C12N1/21 , C12N15/74 , C12Q1/68
CPC分类号： C12P7/6472 , C07K14/34 , C07K2319/00 , C12N9/00 , C12N9/18 , C12N9/90 , C12P7/6409 , C12P7/6427 , C12P7/6463 , C12P13/04 , C12P17/10
摘要： Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MR proteins, mutated MR proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MR genes in this organism.
摘要翻译：描述了编码来自谷氨酸棒杆菌的新型MR蛋白质的分离的核酸分子，命名为MR核酸分子。本发明还提供反义核酸分子，含有MR核酸分子的重组表达载体和已经引入表达载体的宿主细胞。本发明还进一步提供了分离的MR蛋白，突变的MR蛋白，融合蛋白，抗原肽以及用于基于该生物体中MR基因的遗传工程改进谷氨酸棒球菌的所需化合物生产的方法。

9. 发明授权

US06855754B2 Asphalt-based formulations and method of making and using the same for paving and coating applications 有权
标题翻译：基于沥青的制剂及其制备和使用它们的铺路和涂布应用的方法
公开(公告)号：US06855754B2
公开(公告)日：2005-02-15
申请号：US10332894
申请日：2002-06-18
申请人： Koichi Takamura , Babak Golzar , Vanessa Adams , Patrick J. Mormile
发明人： Koichi Takamura , Babak Golzar , Vanessa Adams , Patrick J. Mormile
IPC分类号： C08K3/00 , C08L95/00
CPC分类号： C08L95/005 , C08K3/01 , C08K3/013 , C08K2201/014 , C08L53/02 , C08L95/00 , C08L2666/74 , C08L2666/08 , C08L53/00
摘要： An asphalt-based, cold paving/coating formulation that provides increased flexibility with respect to the choice of aggregate types, asphalt emulsion types, type and amount of the surfactants used to produce the asphalt emulsion, asphalt emulsion pH's and application temperature's than conventional cold paving/coating formulations while providing good mix times and curing behavior. The asphalt-based formulation can be formed by mixing water; an asphalt emulsion; at least one first compound in aqueous solution selected from the group consisting of alkali metal salts, alkali metal hydroxides, ammonium salts, and ammonium hydroxide; at least one second compound in aqueous solution selected from the group consisting of Group IIA salts, Group IIIA salts, Group IIIB salts, copper salts, zinc salts, cadmium salts, manganese salts, iron salts, cobalt salts, and nickel salts; and optionally aggregate. Also, a method of preparing an asphalt-based formulation using these components.
摘要翻译：一种基于沥青的冷铺路/涂层配方，在选择聚集体类型，沥青乳液类型，用于生产沥青乳液的表面活性剂的类型和用量，沥青乳液pH值和应用温度比传统冷铺 /涂料配方，同时提供良好的混合时间和固化行为。沥青基配方可以通过混合水形成; 沥青乳液; 至少一种选自碱金属盐，碱金属氢氧化物，铵盐和氢氧化铵的水溶液中的第一种化合物; 至少一种选自IIA族IIA族盐，IIIA族盐，IIIB族盐，铜盐，锌盐，镉盐，锰盐，铁盐，钴盐和镍盐的水溶液中的第二化合物; 并可选地聚集。而且，使用这些组分制备沥青基制剂的方法。

10. 发明授权

US5789156A Tetracycline-regulated transcriptional inhibitors 失效
标题翻译：四环素调节的转录抑制剂
公开(公告)号：US5789156A
公开(公告)日：1998-08-04
申请号：US383754
申请日：1995-02-03
申请人： Hermann Bujard , Manfred Gossen
发明人： Hermann Bujard , Manfred Gossen
IPC分类号： A01K67/027 , C07K14/035 , C07K14/245 , C12N1/21 , C12N15/63 , C12N15/67 , C12N15/85 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/8509 , C07K14/005 , C07K14/245 , C12N15/63 , C12N15/635 , C12N15/67 , C12N15/85 , A01K2217/05 , A01K2217/075 , A01K2217/20 , A01K2267/01 , A01K2267/02 , A01K2267/03 , A01K2267/0393 , C07K2319/00 , C07K2319/09 , C07K2319/61 , C07K2319/71 , C07K2319/80 , C12N2710/16622 , C12N2830/003 , C12N2830/006 , Y10S435/81
摘要： Nucleic acid molecules and proteins useful for regulating the expression of genes in eukaryotic cells and organisms in a highly controlled manner are disclosed. In the regulatory system of the invention, transcription of a tet operator-linked nucleotide sequence is inhibited by a transcriptional inhibitor fusion protein composed of two polypeptides, a first polypeptide which binds to tet operator sequences either (i) in the absence but not the presence of tetracycline (or an analogue thereof) or (ii) in the presence but not the absence of tetracycline (or an analogue thereof), and a second polypeptide which directly or indirectly inhibits transcription in eukaryotic cells. In one embodiment, the fusion protein comprises a Tet repressor operatively linked to a transcriptional silencer polypeptide. In another embodiment, the fusion protein comprises a mutated Tet repressor operatively linked to a transcriptional silencer polypeptide. The fusion proteins of the invention are useful for reducing the level of transcription of a tet operator-linked target gene. Moreover, the fusion proteins of the invention can be used in combination with tetracycline-regulated transcriptional activator fusion proteins to allow for precise regulation of the expression of one or multiple target genes. Kits including the components of the regulatory system of the invention are also encompassed by the invention.
摘要翻译：公开了用于以高度受控的方式调节真核细胞和生物体中基因表达的核酸分子和蛋白质。在本发明的调节系统中，tet操纵子连接的核苷酸序列的转录受到由两个多肽组成的转录抑制剂融合蛋白的抑制，所述两个多肽是结合tet操纵子序列的第一个多肽，（i）在不存在但不存在的情况下的四环素（或其类似物）或（ii）在存在但不存在四环素（或其类似物）的情况下，以及在真核细胞中直接或间接抑制转录的第二多肽。在一个实施方案中，融合蛋白包含可操作地连接到转录沉默子多肽的Tet阻遏物。在另一个实施方案中，融合蛋白包含与转录沉默子多肽有效连接的突变Tet阻遏物。本发明的融合蛋白可用于降低与tet操纵子连接的靶基因的转录水平。此外，本发明的融合蛋白可以与四环素调节的转录激活物融合蛋白组合使用，以允许精确调节一个或多个靶基因的表达。包括本发明的调节系统的组分的试剂盒也包括在本发明中。

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